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1. 发明授权

US09164689B2 Data storage system and method of processing a data access request 有权
标题翻译：数据存储系统和处理数据访问请求的方法
公开(公告)号：US09164689B2
公开(公告)日：2015-10-20
申请号：US12414084
申请日：2009-03-30
申请人： John Timothy O'Brien , Michael Steven Milillo , George Franklin DeTar, Jr. , Carl Thomas Madison, Jr.
发明人： John Timothy O'Brien , Michael Steven Milillo , George Franklin DeTar, Jr. , Carl Thomas Madison, Jr.
IPC分类号： G06F15/16 , G06F15/167 , G06F15/173 , G06F13/00 , G06F3/06
CPC分类号： G06F3/0643 , G06F3/0611 , G06F3/0635 , G06F3/067 , G06F3/0688
摘要： A data storage system includes a plurality of servers, a plurality of external interface providers each deployed on one of the servers, and a plurality of data storage controllers each deployed on one of the servers. Each of the providers is configured to receive a data access request, to identify one of the controllers that can satisfy the request, and to forward the request to the identified controller. The system further includes a plurality of data storage modules independent of the servers. The providers, controllers and modules are in communication with each other. Each of the controllers exclusively manages a portion of data content in at least one of the modules, and satisfies data access requests received from the providers by accessing the portion of data content in the at least one module.
摘要翻译：数据存储系统包括多个服务器，每个部署在其中一个服务器上的多个外部接口提供器，以及每个部署在其中一个服务器上的多个数据存储控制器。每个提供者被配置为接收数据访问请求，以识别可以满足该请求的一个控制器，并将该请求转发给所识别的控制器。该系统还包括独立于服务器的多个数据存储模块。提供者，控制器和模块彼此通信。每个控制器专门管理至少一个模块中的一部分数据内容，并且通过访问至少一个模块中的数据内容的一部分来满足从提供者接收的数据访问请求。

2. 发明申请

US20140242142A1 CELL SECRETED PROTEINS FOR THE TREATMENT OF MYOCARDIAL INFARCTION 有权
标题翻译：细胞分泌蛋白治疗心肌梗塞
公开(公告)号：US20140242142A1
公开(公告)日：2014-08-28
申请号：US14127991
申请日：2012-06-25
申请人： Timothy O'Brien , Frank Barry , Claire Kavanagh
发明人： Timothy O'Brien , Frank Barry , Claire Kavanagh
IPC分类号： A61K35/54 , A61K35/28 , A61L27/28 , A61K35/44 , A61L15/44 , A61K38/21 , A61L27/54 , A61L27/38 , A61L29/16 , A61K38/36 , A61K38/39 , A61K38/19 , A61K38/17 , A61L29/08
CPC分类号： A61K35/545 , A61K35/28 , A61K35/44 , A61K38/1709 , A61K38/1735 , A61K38/177 , A61K38/179 , A61K38/1891 , A61K38/19 , A61K38/195 , A61K38/217 , A61K38/363 , A61K38/39 , A61L15/44 , A61L27/28 , A61L27/3804 , A61L27/54 , A61L29/08 , A61L29/16
摘要： The present invention relates to the use of secreted proteins from mesenchymal stem cells and other cells for the treatment of myocardial infarction. In particular, the invention provides compositions and methods based on secreted proteins from mesenchymal stem cells and the genes encoding them.
摘要翻译：本发明涉及来自间充质干细胞和其他细胞的分泌蛋白质用于治疗心肌梗死的用途。特别地，本发明提供了基于来自间充质干细胞的分泌蛋白质的组合物和方法以及编码它们的基因。

3. 发明申请

US20100331536A1 CA125 gene and its use for diagnostic and therapeutic interventions 有权
标题翻译： CA125基因及其在诊断和治疗干预中的应用
公开(公告)号：US20100331536A1
公开(公告)日：2010-12-30
申请号：US12455366
申请日：2009-06-01
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.
摘要翻译：已经克隆了CA125基因，并且已经鉴定了多个重复序列以及羧基末端。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域（Domain 1）; 一个大的多重重复域（域2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。氨基末端结构域以其O-糖基化的能力为主，其结果是丝氨酸和苏氨酸残基的丰富度。提供氨基末端延伸，其包含四个基因组外显子。分子结构由包含156个氨基酸重复单元的重复结构域所支配，其包含表位结合位点。已经确定，排序和连续地排列在CA125领域结构中的60多个重复单位。更具体地，本发明涉及可以引入动物或人类细胞以实现cDNA转录或表达的CA125 cDNA序列。

4. 发明申请

US20100250831A1 DATA STORAGE SYSTEM MANAGER AND METHOD FOR MANAGING A DATA STORAGE SYSTEM 有权
标题翻译：用于管理数据存储系统的数据存储系统管理器和方法
公开(公告)号：US20100250831A1
公开(公告)日：2010-09-30
申请号：US12414121
申请日：2009-03-30
申请人： John Timothy O'Brien , Michael Steven Milillo , Carl Thomas Madison, JR.
发明人： John Timothy O'Brien , Michael Steven Milillo , Carl Thomas Madison, JR.
IPC分类号： G06F12/00 , G06F12/16 , G06F12/02
CPC分类号： G06F11/3433 , G06F11/1662 , G06F11/202 , G06F11/2094 , G06F2201/87 , G06F2201/885
摘要： A data storage system manager includes one or more servers, at least one data collector deployed on at least one of the servers, at least one policy engine deployed on at least one of the servers, and at least one configuration manager deployed on at least one the servers. The at least one data collector is configured to collect resource utilization information including data storage wear rate of data storage system data storage modules. The at least one policy engine is configured to evaluate the collected information and to initiate changes to a configuration of the data storage system based on data storage wear rate and work load distribution policies. The at least one configuration manager is configured to implement the changes initiated by the at least one policy engine to control the data storage wear rate and a skew of the work load distribution within the data storage system.
摘要翻译：数据存储系统管理器包括一个或多个服务器，部署在至少一个服务器上的至少一个数据收集器，部署在至少一个服务器上的至少一个策略引擎，以及部署在至少一个服务器上的至少一个配置管理器服务器。所述至少一个数据收集器被配置为收集包括数据存储系统数据存储模块的数据存储磨损率的资源利用信息。所述至少一个策略引擎被配置为基于数据存储磨损率和工作负载分配策略来评估所收集的信息并且启动对所述数据存储系统的配置的改变。至少一个配置管理器被配置为实现由至少一个策略引擎启动的改变，以控制数据存储磨损率和数据存储系统内的工作负载分布的偏斜。

5. 发明申请

US20100237013A1 AUTONOMOUS FILTER ELEMENT 审中-公开
标题翻译：自动过滤器元件
公开(公告)号：US20100237013A1
公开(公告)日：2010-09-23
申请号：US12699996
申请日：2010-02-04
申请人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
发明人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
IPC分类号： B01D61/22 , B01D35/18 , B01D35/14 , B01D35/143
CPC分类号： B01D53/22 , B01D61/22 , B01D63/08 , B01D65/02 , B01D65/08 , B01D2311/103 , B01D2311/16 , B01D2313/22 , B01D2321/40 , G01F1/6888 , G01F1/69 , G01F15/125
摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics or parameters of the fluid, such as temperature, pressure, or flow rate. In response to the measured characteristic or parameter, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response to this, the control logic may initiate a specific response designed to alleviate the blockage. This response may be a temperature change, a vibration, a change in fluid flow path, or some other action. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.
摘要翻译：公开了一种自主的过滤装置和用于提高过滤器寿命和性能的方法。过滤元件配备有一个或多个传感器，适于测量流体的一个或多个特性或参数，例如温度，压力或流速。响应于测量的特性或参数，滤波器元件内的控制逻辑能够确定适当的响应。例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。响应于此，控制逻辑可以发起旨在减轻阻塞的特定响应。该响应可能是温度变化，振动，流体流动路径的变化或某些其他动作。然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。基于此，控制逻辑可以警告操作者必须更换过滤元件。或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。

6. 发明申请

US20100062038A1 Markers, Antibodies and Recombinant scFvs for Mesenchymal Stem Cell Sub-populations and Osteoclasts 审中-公开
标题翻译：标记，抗体和重组scFv用于间充质干细胞亚群和破骨细胞
公开(公告)号：US20100062038A1
公开(公告)日：2010-03-11
申请号：US12529789
申请日：2008-03-12
申请人： Tyrone Villalard Bowes , Udo Greiser , William James Johnathan Finlay , Timothy O'Brien , Frank Barry
发明人： Tyrone Villalard Bowes , Udo Greiser , William James Johnathan Finlay , Timothy O'Brien , Frank Barry
IPC分类号： A61F2/00 , C07K7/06 , C07H21/04 , C07K16/00 , C12N15/63 , G01N33/566 , C12N5/00 , A61K35/12
CPC分类号： C07K14/705 , A61K38/00
摘要： Abstract Markers, antibodies and recombinant scFvs for Mesenchymal Stem Cell sub-populations and osteoclasts. The present invention relates to specific epitopes of surface membrane bound glycoproteins expressed by mesenchymal stem cells and pre-osteoclasts and relates to antibodies such as monoclonal antibodies and recombinant scFv or fragments thereof, raised to the particular epitope and their use in identifying, isolating, and characterization of mesenchymal stem cell sub-populations such as that termed “Stromal Progenitor Cells” (SPCs) in bone marrow and identifying, isolating, and characterization of pre-osteoclasts in peripheral blood. By binding to a specific epitope on the cell surface, limbin/EVC-2 detection and separation by conventional cell sorting methodologies are facilitated.
摘要翻译：摘要标记，抗体和重组scFvs用于间充质干细胞亚群和破骨细胞。本发明涉及由间充质干细胞和破骨细胞表达的表面膜结合的糖蛋白的特异性表位，涉及产生特定表位的抗体如单克隆抗体和重组scFv或其片段，以及它们在鉴定，分离和间质干细胞亚群的表征，如骨髓中称为“间质祖细胞”（SPCs），并鉴定，分离和表征外周血中破骨细胞。通过结合细胞表面上的特异性表位，促进了常规细胞分选方法的limbin / EVC-2检测和分离。

7. 发明授权

US07541045B2 Concentrated, non-foaming solution of quaternary ammonium compounds and methods of use 有权
标题翻译：浓缩，不发泡的季铵化合物溶液及使用方法
公开(公告)号：US07541045B2
公开(公告)日：2009-06-02
申请号：US10943217
申请日：2004-09-17
申请人： Cesar Compadre , Philip Breen , Hamid Salari , E. Kim Fifer , Danny L. Lattin , Michael Slavik , Yanbin Li , Timothy O'Brien , Amy L. Waldroup , Thomas F. Berg
发明人： Cesar Compadre , Philip Breen , Hamid Salari , E. Kim Fifer , Danny L. Lattin , Michael Slavik , Yanbin Li , Timothy O'Brien , Amy L. Waldroup , Thomas F. Berg
IPC分类号： A01N25/02
CPC分类号： A23L3/3526 , A01N33/12 , A01N43/40 , A23B4/20 , A23B4/30 , A23B7/154 , A23B7/158 , A23L3/3544 , Y02A50/486 , A01N31/02 , A01N25/30 , A01N25/02 , A01N2300/00
摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.
摘要翻译：公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。稀释的QAC溶液用于接触食品，以防止食品中的微生物生长受到广泛的食源性微生物污染。公开了一种将食品与稀释的QAC接触至少0.1秒的施用时间的方法。可以通过这种方法处理的食物是肉类和肉制品，海鲜，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以处理，仍然保持其外观和质感的食物。其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

8. 发明申请

US20090121449A1 Overmolded magnesium 有权
标题翻译：包覆成镁
公开(公告)号：US20090121449A1
公开(公告)日：2009-05-14
申请号：US11983283
申请日：2007-11-08
申请人： Christopher J. Kuntze , Timothy O'Brien , Steven Giles
发明人： Christopher J. Kuntze , Timothy O'Brien , Steven Giles
IPC分类号： B60R3/00
CPC分类号： B60R3/00
摘要： A method of manufacturing an assembly, including a structural member and an appearance feature formed therealong, is provided utilizing first and second molds. The method includes the steps of: injecting magnesium into the first mold to form the structural member; removing the structural member from the first mold; placing the structural member in the second mold; and injecting thermoplastic material into the second mold to overmold the appearance feature along a portion of the structural member.
摘要翻译：使用第一和第二模具来提供制造包括结构构件和沿其形成的外观特征的组件的方法。该方法包括以下步骤：将镁注入第一模具中以形成结构件; 从所述第一模具移除所述结构构件; 将结构构件放置在第二模具中; 以及将热塑性材料注入所述第二模具中以使所述外观特征沿所述结构构件的一部分包覆模制。

9. 发明申请

US20080027330A1 RISK ASSESSMENT METHOD FOR ACUTE CARDIOVASCULAR EVENTS 审中-公开
标题翻译：急性心血管事件风险评估方法
公开(公告)号：US20080027330A1
公开(公告)日：2008-01-31
申请号：US11749105
申请日：2007-05-15
申请人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson , Naser Ahmadi , Haider Hassan
发明人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson , Naser Ahmadi , Haider Hassan
IPC分类号： A61B5/02
CPC分类号： A61B5/0402 , A61B5/02 , A61B8/06
摘要： Methods and apparatus are provided for assessing the risk of an acute cardiovascular event that includes providing an endothelial or vascular function test to identify higher risk from lower risk individuals in a population of symptomatic individuals presenting with chest pain that have inconclusive results in ECG and cardiovascular marker tests, such as a tropinin test, and are administered for triage in hospital and additional tests such as ECG exercise and nuclear stress tests. The invention further provides methods and apparatus for assessing the vascular status and response of patients in clinical trials for cardiovascular therapies.
摘要翻译：提供了用于评估急性心血管事件风险的方法和装置，其包括提供内皮或血管功能测试，以鉴定呈现胸痛的症状性个体群体中较低风险个体的高风险，其具有心电图和心血管标志物不确定的结果测试，如托特罗测试，并在医院进行分诊并进行额外的测试，如心电图运动和核压力测试。本发明还提供了用于评估患者在心血管疗法临床试验中的血管状态和反应的方法和装置。

10. 发明申请

US20070225614A1 METHOD AND APPARATUS FOR DETERMINING VASCULAR HEALTH CONDITIONS 审中-公开
标题翻译：用于确定血管健康状况的方法和装置
公开(公告)号：US20070225614A1
公开(公告)日：2007-09-27
申请号：US11563676
申请日：2006-11-27
申请人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
发明人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
IPC分类号： A61B5/01 , A61B5/00
CPC分类号： A61B5/01 , A61B5/0008 , A61B5/02007 , A61B5/02416 , A61B5/1455 , A61B5/4035 , A61B8/08 , A61B8/488 , A61B2560/0242
摘要： The present invention provides methods and apparatus for assessing a patient's vascular health including endothelial function by monitoring changes in hemodynamic parameters responsive to the introduction of a vasostimulant. The invention provides a thermal energy measurement apparatus including a thermal energy sensor adapted to measure temperature of a body part while not substantially changing the temperature of the body part, and a display or recorder coupled to the thermal energy sensor, wherein the thermal energy sensor measures the temperature of the body part before and subsequent to the provision of a vasostimulant, and the display or recorder reports the temperature of the body part prior to the provision of the stimulant and the temperature of the body part after provision of the stimulant. Also provides are methods and apparatus providing for a second thermal energy sensor on a corresponding contralateral site to the site subject to the vasostimulant and simultaneously monitoring and recording of temperature of the contralateral site as a measure of neurovascular status and microvascular reactivity.
摘要翻译：本发明提供了通过监测血管动力学参数的变化来响应于引入血管兴奋剂来评估患者血管健康（包括内皮功能）的方法和装置。本发明提供了一种热能测量装置，其包括适于测量身体部位的温度而不显着改变身体部位的温度的热能传感器，以及耦合到热能传感器的显示器或记录器，其中热能传感器测量在提供血管增生剂之前和之后的身体部位的温度，并且显示器或记录器在提供兴奋剂之前报告在提供兴奋剂之前身体部位的温度和身体部位的温度。还提供了将方法和装置提供给对应于血管增生物的部位的相应对侧部位上的第二热能传感器，同时监测和记录对侧部位的温度，作为神经血管状态和微血管反应性的量度。

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