专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08124728B2 CA125 gene and its use for diagnostic and therapeutic interventions 有权
标题翻译： CA125基因及其在诊断和治疗干预中的应用
公开(公告)号：US08124728B2
公开(公告)日：2012-02-28
申请号：US10475117
申请日：2003-10-17
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07K14/00 , C07K14/435
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The CA125 gene has been cloned. The CA125 molecule comprises three major domains: an extracellular amino terminal domain; a large multiple repeat domain; and a carboxy terminal domain which includes a transmembrane anchor with a short cytoplasmic domain. Additionally, an amino terminal extension is present. The molecular structure is dominated by a repeat domain comprising more than sixty 156-amino-acid repeat units The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The structure has potential for use as a new gold standard for detecting the CA125 antigen, and can provide a basis for the development of a vaccine useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.
摘要翻译：已经克隆了CA125基因。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域; 一个大的多重重复域; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域。此外，存在氨基末端延伸。分子结构由包含多于六十六个156个氨基酸重复单元的重复结构域所支配。重复单元包含交互式二硫键桥接的C-封闭物和OC125和M11结合位点。 CA125分子在其羧基末端通过跨膜结构域和短的胞质尾部锚定。该结构有可能用作检测CA125抗原的新金标准，可为开发可用于治疗CA125升高的卵巢癌和其他癌症的疫苗提供依据。

2. 发明申请

US20100331536A1 CA125 gene and its use for diagnostic and therapeutic interventions 有权
标题翻译： CA125基因及其在诊断和治疗干预中的应用
公开(公告)号：US20100331536A1
公开(公告)日：2010-12-30
申请号：US12455366
申请日：2009-06-01
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.
摘要翻译：已经克隆了CA125基因，并且已经鉴定了多个重复序列以及羧基末端。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域（Domain 1）; 一个大的多重重复域（域2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。氨基末端结构域以其O-糖基化的能力为主，其结果是丝氨酸和苏氨酸残基的丰富度。提供氨基末端延伸，其包含四个基因组外显子。分子结构由包含156个氨基酸重复单元的重复结构域所支配，其包含表位结合位点。已经确定，排序和连续地排列在CA125领域结构中的60多个重复单位。更具体地，本发明涉及可以引入动物或人类细胞以实现cDNA转录或表达的CA125 cDNA序列。

3. 发明申请

US20170305980A1 CA125 GENE AND ITS USE FOR DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS 审中-公开
公开(公告)号：US20170305980A1
公开(公告)日：2017-10-26
申请号：US15420068
申请日：2017-01-30
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07K14/47 , C12Q1/68 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.

4. 发明授权

US08895703B2 CA125 gene and its use for diagnostic and therapeutic interventions 有权
标题翻译： CA125基因及其在诊断和治疗干预中的应用
公开(公告)号：US08895703B2
公开(公告)日：2014-11-25
申请号：US11975668
申请日：2007-10-19
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07K16/00 , C12P21/08 , C07K14/705 , C07K16/30
CPC分类号： C07K14/705 , C07K16/3092
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. An amino terminal extension is present. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in E. coli. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail.
摘要翻译：已经克隆了CA125基因，并且已经鉴定了多个重复序列以及羧基末端。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域（Domain 1）; 一个大的多重重复域（域2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。存在氨基末端延伸。分子结构由包含156个氨基酸重复单元的重复结构域所支配。已经确定，排序和连续地排列在CA125领域结构中的60多个重复单位。重复单元包括交互式二硫键桥接的C-封闭物和OC125和M11结合位点。重复序列显示了70-85％的同源性。在大肠杆菌中证实了重复的表达。 CA125分子在其羧基末端通过跨膜结构域和短的胞质尾部锚定。

5. 发明申请

US20060205054A1 Extracellular serine protease 失效
公开(公告)号：US20060205054A1
公开(公告)日：2006-09-14
申请号：US10652846
申请日：2003-08-29
申请人： Timothy O'Brien , Lowell Underwood , John Beard , Kazushi Shigemasa
发明人： Timothy O'Brien , Lowell Underwood , John Beard , Kazushi Shigemasa
IPC分类号： C12Q1/68 , G01N33/574 , C12P21/06 , C12N9/48
CPC分类号： C07K14/4748 , C12N9/6424 , G01N33/57407 , G01N2333/96433 , G01N2500/00
摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.

6. 发明授权

US09556245B2 CA125 gene and its use for diagnostic and therapeutic interventions 有权
标题翻译： CA125基因及其在诊断和治疗干预中的应用
公开(公告)号：US09556245B2
公开(公告)日：2017-01-31
申请号：US12455366
申请日：2009-06-01
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C12Q1/68 , C07K14/47 , C07H21/00 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.
摘要翻译：已经克隆了CA125基因，并且已经鉴定了多个重复序列以及羧基末端。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域（Domain 1）; 一个大的多重重复域（域2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。氨基末端结构域以其O-糖基化的能力为主，其结果是丝氨酸和苏氨酸残基的丰富度。提供氨基末端延伸，其包含四个基因组外显子。分子结构由包含156个氨基酸重复单元的重复结构域所支配，其包含表位结合位点。已经确定，排序和连续地排列在CA125领域结构中的60多个重复单位。更具体地，本发明涉及可以引入动物或人类细胞以实现cDNA转录或表达的CA125 cDNA序列。

7. 发明申请

US20090035819A1 CA125 gene and its use for diagnostic and therapeutic interventions 有权
公开(公告)号：US20090035819A1
公开(公告)日：2009-02-05
申请号：US11975668
申请日：2007-10-19
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C12P21/06 , C07H21/00 , C07K16/18 , C12N5/00
CPC分类号： C07K14/705 , C07K16/3092
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in E. coli. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The carboxy terminal also contains a proteolytic cleavage site approximately 50 amino acids upstream from the transmembrane domain, which allows for proteolytic cleavage and release of the CA125 molecule. Any one of the repeat domains has the potential for use as a new gold standard for detecting and monitoring the presence of the CA125 antigen. Further, the repeat domains or other domains, especially the c-terminal to the repeat domain also provide a basis for the development of a vaccine, which would be useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

8. 发明申请

US20070015907A1 Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions 有权
公开(公告)号：US20070015907A1
公开(公告)日：2007-01-18
申请号：US10475117
申请日：2002-04-12
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07K14/705 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in E. coli. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The carboxy terminal also contains a proteolytic cleavage site approximately 50 amino acids upstream from the transmembrane domain, which allows for proteolytic cleavage and release of the CA125 molecule. Any one of the repeat domains has the potential for use as a new gold standard for detecting and monitoring the presence of the CA125 antigen. Further, the repeat domains or other domains, especially the c-terminal to the repeat domain also provide a basis for the development of a vaccine, which would be useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

9. 发明申请

US20060154279A1 Extracellular serine protease 有权
公开(公告)号：US20060154279A1
公开(公告)日：2006-07-13
申请号：US11295040
申请日：2005-12-05
申请人： Lowell Underwood , Timothy O'Brien
发明人： Lowell Underwood , Timothy O'Brien
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12N9/6424 , Y10T436/25
摘要： The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.

10. 发明申请

US20060068483A1 Extracellular serine protease 失效
公开(公告)号：US20060068483A1
公开(公告)日：2006-03-30
申请号：US11251455
申请日：2005-10-14
申请人： Lowell Underwood , Timothy O'Brien
发明人： Lowell Underwood , Timothy O'Brien
IPC分类号： C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12N9/6424
摘要： The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式