专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20220033768A1 LIVING MAMMALIAN CELLS MODIFIED WITH FUNCTIONAL MODULAR NANOPARTICLES 有权
公开(公告)号：US20220033768A1
公开(公告)日：2022-02-03
申请号：US17277256
申请日：2019-09-24
申请人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu , Jacob Ongudi Agola
发明人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu , Jacob Ongudi Agola
IPC分类号： C12N5/00 , C12N5/071
摘要： An encapsulated living (viable) mammalian cell, and methods of making and using that cell, are provided.

2. 发明申请

US20210315822A1 BIOMIMETIC REBUILDING OF MULTIFUNCTIONAL RED BLOOD CELLS 有权
公开(公告)号：US20210315822A1
公开(公告)日：2021-10-14
申请号：US17264452
申请日：2019-07-30
申请人： Jimin Guo , C. Jeffrey Brinker , Jacob Ongudi Agola
发明人： Jimin Guo , C. Jeffrey Brinker , Jacob Ongudi Agola
IPC分类号： A61K9/127 , C12N5/078 , A61K35/18 , A61K47/69
摘要： Methods of preparing red blood cell mimetics and functionalized red blood cell mimetics, and methods of making and using those mimetics, are provided.

3. 发明申请

US20200276286A1 SILICIFIED CELL REPLICAS, METHODS OF MAKING, AND METHODS OF USING 审中-公开
公开(公告)号：US20200276286A1
公开(公告)日：2020-09-03
申请号：US16647245
申请日：2018-09-13
申请人： Rita E. Serda , C. Jeffrey Brinker , Jacob Ongudi Agola , Jimin Guo , Sarah Adams , STC.UNM
发明人： Rita E. Serda , C. Jeffrey Brinker , Jacob Ongudi Agola , Jimin Guo , Sarah Adams
IPC分类号： A61K39/00 , A61K39/39
摘要： A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.

4. 发明申请

US20220151924A1 MODULAR METAL–ORGANIC POLYHEDRA SUPERASSEMBLY COMPOSITIONS 有权
公开(公告)号：US20220151924A1
公开(公告)日：2022-05-19
申请号：US17434363
申请日：2020-02-27
申请人： C. Jeffrey Brinker , Jimin Guo , Wei Zhu
发明人： C. Jeffrey Brinker , Jimin Guo , Wei Zhu
IPC分类号： A61K9/107 , A61K33/242 , A61K47/69 , A61P35/00 , A61K47/68 , A61K47/10 , A61K47/24 , A61K31/704
摘要： A method to prepare a population of metal-organic polyhedra (MOP) supported micelle nanoparticles (NPs), and a composition comprising MOP supported micelle NPs, are provided.

5. 发明申请

US20220033767A1 ARMORED CELLS 有权
公开(公告)号：US20220033767A1
公开(公告)日：2022-02-03
申请号：US17277260
申请日：2019-09-24
申请人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
发明人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
IPC分类号： C12N5/00 , C12N5/078 , C12N5/0789 , A61K47/69
摘要： A modified vertebrate cell comprising a vertebrate cell encased in reversibly interlinked metal-organic framework (MOF) nanoparticles, and methods of making and using the modified cell, are provided.

6. 发明申请

US20210386055A1 Metal-organic Framework-Assisted Cryopreservation of Red Blood-Cells 有权
公开(公告)号：US20210386055A1
公开(公告)日：2021-12-16
申请号：US17309152
申请日：2019-10-30
申请人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
发明人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
IPC分类号： A01N1/02 , B01J20/22 , B01J20/28
摘要： Zr-based MOF NPs for cryopreservation of cells including, for example, red blood cells.

7. 发明授权

US08864045B1 Aerosol fabrication methods for monodisperse nanoparticles 有权
标题翻译：单分散纳米粒子的气溶胶制备方法
公开(公告)号：US08864045B1
公开(公告)日：2014-10-21
申请号：US13300069
申请日：2011-11-18
申请人： Xingmao Jiang , C. Jeffrey Brinker
发明人： Xingmao Jiang , C. Jeffrey Brinker
IPC分类号： B05B1/24
CPC分类号： B05B1/24 , B22F1/0018 , B22F1/02 , B22F9/06 , B22F2001/0092 , C01B13/34 , C01B21/06 , C01P2004/32 , C01P2004/34 , C01P2004/64 , C22C2202/02 , C23C18/08 , C23C18/1204 , C23C18/1241 , C23C18/1245 , C23C18/127 , C23C18/1295
摘要： Exemplary embodiments provide materials and methods for forming monodisperse particles. In one embodiment, the monodisperse particles can be formed by first spraying a nanoparticle-containing dispersion into aerosol droplets and then heating the aerosol droplets in the presence of a shell precursor to form core-shell particles. By removing either the shell layer or the nanoparticle core of the core-shell particles, monodisperse nanoparticles can be formed.
摘要翻译：示例性实施方案提供了用于形成单分散颗粒的材料和方法。在一个实施方案中，单分散颗粒可以通过首先将含纳米颗粒的分散体喷雾到气溶胶液滴中，然后在壳前体的存在下加热气溶胶液滴形成核 - 壳颗粒来形成。通过去除核 - 壳颗粒的壳层或纳米颗粒芯，可以形成单分散纳米颗粒。

8. 发明申请

US20140079774A1 POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME 有权
标题翻译：用于定向输送的多孔纳米脂质载体（PROTOCELLS）及其使用方法
公开(公告)号：US20140079774A1
公开(公告)日：2014-03-20
申请号：US14113371
申请日：2012-04-27
申请人： C. Jeffrey Brinker , Eric C. Carnes , Carleen Erin Ashley
发明人： C. Jeffrey Brinker , Eric C. Carnes , Carleen Erin Ashley
IPC分类号： A61K9/127 , A61K45/06 , A61K31/704 , A61K31/711
CPC分类号： A61K9/1271 , A61K31/704 , A61K31/711 , A61K33/24 , A61K38/00 , A61K39/05 , A61K45/06 , A61K47/62 , A61K47/6901 , A61K48/0016 , C07K14/47 , C12N15/1135 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2810/40
摘要： The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.
摘要翻译：本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 促进癌细胞死亡的至少一种试剂（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力（凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内体逃逸的融合肽原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

9. 发明授权

US07947579B2 Method of making dense, conformal, ultra-thin cap layers for nanoporous low-k ILD by plasma assisted atomic layer deposition 有权
标题翻译：通过等离子体辅助原子层沉积制备纳米多孔低k ILD的致密，共形，超薄盖层的方法
公开(公告)号：US07947579B2
公开(公告)日：2011-05-24
申请号：US11673190
申请日：2007-02-09
申请人： Ying-Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
发明人： Ying-Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
IPC分类号： H01L21/4763
CPC分类号： A61K45/06 , A61K31/167 , A61K31/7048 , H01L21/76814 , H01L21/76826 , H01L21/76831 , Y10S977/89 , A61K2300/00
摘要： Barrier layers and methods for forming barrier layers on a porous layer are provided. The methods can include chemically adsorbing a plurality of first molecules on a surface of the porous layer in a chamber and forming a first layer of the first molecules on the surface of the porous layer. A plasma can then be used to react a plurality of second molecules with the first layer of first molecules to form a first layer of a barrier layer. The barrier layers can seal the pores of the porous material, function as a diffusion barrier, be conformal, and/or have a negligible impact on the overall ILD k value of the porous material.
摘要翻译：提供了阻挡层和在多孔层上形成阻挡层的方法。所述方法可以包括在多孔层的多孔层的表面上化学吸附多个第一分子并在多孔层的表面上形成第一分子的第一层。然后可以使用等离子体来使多个第二分子与第一分子的第一层反应以形成阻挡层的第一层。阻挡层可以密封多孔材料的孔，用作扩散阻挡层，保形，和/或对多孔材料的整体ILD k值具有可忽略的影响。

10. 再颁专利

USRE41612E1 Method for making surfactant-templated thin films 有权
标题翻译：制备表面活性剂模板薄膜的方法
公开(公告)号：USRE41612E1
公开(公告)日：2010-08-31
申请号：US10670187
申请日：2003-09-23
申请人： C. Jeffrey Brinker , Yunfeng Lu , Hong You Fan
发明人： C. Jeffrey Brinker , Yunfeng Lu , Hong You Fan
IPC分类号： B05D3/02 , B05D1/02 , B05D1/18 , B05D3/10 , B05D3/12
CPC分类号： B82Y30/00
摘要： An evaporation-induced self-assembly method to prepare a porous, surfactant-templated, thin film by mixing a silica sol, a solvent, a surfactant, and an interstitial compound, evaporating a portion of the solvent to form a liquid, crystalline thin film mesophase material, and then removal of the surfactant template. Coating onto a substrate produces a thin film with the interstitial compound either covalently bonded to the internal surfaces of the ordered or disordered mesostructure framework or physically entrapped within the ordered or disordered mesostructured framework. Particles can be formed by aerosol processing or spray drying rather than coating onto a substrate. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
摘要翻译：通过混合硅溶胶，溶剂，表面活性剂和间隙化合物制备多孔表面活性剂模板化薄膜的蒸发诱导自组装方法，蒸发溶剂的一部分以形成液体，晶体薄膜中间相材料，然后除去表面活性剂模板。涂覆在基材上产生薄膜，其中间隙化合物共价键合到有序或无序的介观结构框架的内表面或物理地截留在有序或无序的介观结构框架内。颗粒可以通过气溶胶处理或喷雾干燥形成，而不是涂覆在基材上。间隙化合物的选择提供了一种用于开发用于包括膜，传感器，低介电常数膜，光子材料和光学主体的薄膜的薄膜的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式