会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 8. 发明申请
    • POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME
    • 用于定向输送的多孔纳米脂质载体(PROTOCELLS)及其使用方法
    • US20140079774A1
    • 2014-03-20
    • US14113371
    • 2012-04-27
    • C. Jeffrey BrinkerEric C. CarnesCarleen Erin Ashley
    • C. Jeffrey BrinkerEric C. CarnesCarleen Erin Ashley
    • A61K9/127A61K45/06A61K31/704A61K31/711
    • A61K9/1271A61K31/704A61K31/711A61K33/24A61K38/00A61K39/05A61K45/06A61K47/62A61K47/6901A61K48/0016C07K14/47C12N15/1135C12N15/88C12N2310/14C12N2320/32C12N2810/40
    • The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.
    • 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞,其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 促进癌细胞死亡的至少一种试剂(例如传统的小分子,大分子货物(例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链)和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内(优选超螺旋以更有效地将DNA包装到原细胞中),其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞,以及表达参与治疗的肽的能力 (凋亡/细胞死亡)或作为报告物,靶向肽靶向待治疗的组织中的癌细胞,使得原细胞与靶细胞的结合是特异性和增强的,并且促进内体逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症,特别是包括肝细胞(肝)癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽(c-MET肽),包括癌症治疗和药物发现。
    • 10. 再颁专利
    • Method for making surfactant-templated thin films
    • 制备表面活性剂模板薄膜的方法
    • USRE41612E1
    • 2010-08-31
    • US10670187
    • 2003-09-23
    • C. Jeffrey BrinkerYunfeng LuHong You Fan
    • C. Jeffrey BrinkerYunfeng LuHong You Fan
    • B05D3/02B05D1/02B05D1/18B05D3/10B05D3/12
    • B82Y30/00
    • An evaporation-induced self-assembly method to prepare a porous, surfactant-templated, thin film by mixing a silica sol, a solvent, a surfactant, and an interstitial compound, evaporating a portion of the solvent to form a liquid, crystalline thin film mesophase material, and then removal of the surfactant template. Coating onto a substrate produces a thin film with the interstitial compound either covalently bonded to the internal surfaces of the ordered or disordered mesostructure framework or physically entrapped within the ordered or disordered mesostructured framework. Particles can be formed by aerosol processing or spray drying rather than coating onto a substrate. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
    • 通过混合硅溶胶,溶剂,表面活性剂和间隙化合物制备多孔表面活性剂模板化薄膜的蒸发诱导自组装方法,蒸发溶剂的一部分以形成液体,晶体薄膜 中间相材料,然后除去表面活性剂模板。 涂覆在基材上产生薄膜,其中间隙化合物共价键合到有序或无序的介观结构框架的内表面或物理地截留在有序或无序的介观结构框架内。 颗粒可以通过气溶胶处理或喷雾干燥形成,而不是涂覆在基材上。 间隙化合物的选择提供了一种用于开发用于包括膜,传感器,低介电常数膜,光子材料和光学主体的薄膜的薄膜的方法。