专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06413726B1 Antibodies that specifically bind Cytostatin III 失效
标题翻译：特异性结合细胞抑素III的抗体
公开(公告)号：US06413726B1
公开(公告)日：2002-07-02
申请号：US09734036
申请日：2000-12-12
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： G01N3350
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

2. 发明授权

US5952197A DNA encoding the chemotactic cytokine III 失效
标题翻译：编码趋化性细胞因子III的DNA
公开(公告)号：US5952197A
公开(公告)日：1999-09-14
申请号：US812003
申请日：1997-03-05
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick J. Dillon
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick J. Dillon
IPC分类号： A61K38/00 , C07K14/52 , C12N15/19 , C12N15/00 , C12N15/63
CPC分类号： C07K14/52 , C07K14/521 , A61K38/00
摘要： Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途也被披露。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

3. 发明授权

US5874240A Human 4-1BB receptor splicing variant 失效
公开(公告)号：US5874240A
公开(公告)日：1999-02-23
申请号：US816605
申请日：1997-03-13
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： A61K38/00 , C07K14/715 , C12N15/12 , C12N5/10 , C07K14/705
CPC分类号： C07K14/715 , A61K38/00
摘要： The invention relates to h4-1BBSV receptor polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

4. 发明授权

US06232291B1 Cytostatin III 有权
标题翻译：细胞抑素III
公开(公告)号：US06232291B1
公开(公告)日：2001-05-15
申请号：US09307817
申请日：1999-05-10
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K14435
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

5. 发明授权

US06509170B1 Polynucleotides encoding human tumor necrosis factor delta 失效
标题翻译：编码人肿瘤坏死因子δ的多核苷酸
公开(公告)号：US06509170B1
公开(公告)日：2003-01-21
申请号：US08815783
申请日：1997-03-12
申请人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
IPC分类号： C12P2106
CPC分类号： G01N33/6863 , C07K16/2875 , G01N2333/525
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

6. 发明授权

US06506882B2 Antibodies that bind tumor necrosis factor delta 有权
标题翻译：结合肿瘤坏死因子δ的抗体
公开(公告)号：US06506882B2
公开(公告)日：2003-01-14
申请号：US10082260
申请日：2002-02-26
申请人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K1600
CPC分类号： G01N33/6863 , C07K16/2875 , G01N2333/525
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

7. 发明授权

US5945309A Cytostatin III nucleic acids encoding 失效
标题翻译：细胞抑素III核酸编码
公开(公告)号：US5945309A
公开(公告)日：1999-08-31
申请号：US820825
申请日：1997-03-19
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K14/475 , C12N1/21 , C07K14/435 , C12N5/10
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

8. 发明申请

US20100266533A1 Death Domain Containing Receptors 有权
标题翻译：死亡域包含受体
公开(公告)号：US20100266533A1
公开(公告)日：2010-10-21
申请号：US12771910
申请日：2010-04-30
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , C07K16/18 , A61K38/20 , A61K38/21 , C07K14/435 , A61K38/17 , A61P35/00 , A61P37/00 , A61P37/06 , A61P29/00
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了结合本发明多肽的抗体及其片段。本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

9. 发明授权

US5981220A Epidermal differentiation factor 失效
标题翻译：表皮分化因子
公开(公告)号：US5981220A
公开(公告)日：1999-11-09
申请号：US815718
申请日：1997-03-12
申请人： Jian Ni , Ping Feng , Patrick J. Dillon , Reiner Gentz
发明人： Jian Ni , Ping Feng , Patrick J. Dillon , Reiner Gentz
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/485 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人表皮分化因子多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗和/或预防皮肤疾病的方法。还公开了用于检测编码本发明多肽的核酸序列中的突变并用于检测本发明多肽的改变水平的诊断测定。

10. 发明申请

US20090005301A1 207 Human Secreted Proteins 审中-公开
标题翻译： 207人类分泌蛋白
公开(公告)号：US20090005301A1
公开(公告)日：2009-01-01
申请号：US11759448
申请日：2007-06-07
申请人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
发明人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
IPC分类号： C07K14/47 , C12N15/12 , C12N15/85 , C07K16/18 , C12Q1/68 , A61K38/14 , A61K31/7088 , G01N33/68 , C12P21/02 , C12N15/00 , C12N5/10
CPC分类号： C07K14/47 , A61K48/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式