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1. 发明授权

US09441042B2 Anti-KDR antibodies and methods of use 有权
标题翻译：抗KDR抗体及其使用方法
公开(公告)号：US09441042B2
公开(公告)日：2016-09-13
申请号：US14356120
申请日：2012-11-01
申请人： Yaohuang Ke , Sum Wai Pierre Lee , Yongke Zhang , Guo-Liang Yu , Weimin Zhu
发明人： Yaohuang Ke , Sum Wai Pierre Lee , Yongke Zhang , Guo-Liang Yu , Weimin Zhu
IPC分类号： C07K16/28 , C07K14/71 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/71 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides anti-KDR monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of a variety of cancers, rheumatoid arthritis, diabetic retinopathy and other diseases associated with aberrant VEGF or KDR expression and/or activity.
摘要翻译：本发明提供抗KDR单克隆抗体和相关组合物，其可用于治疗各种癌症，类风湿性关节炎，糖尿病性视网膜病变和与异常VEGF或KDR表达相关的其它疾病的各种治疗方法中的任何一种， /或活动。

2. 发明授权

US09365644B2 Anti-TNFα antibody 有权
标题翻译：抗TNFα抗体
公开(公告)号：US09365644B2
公开(公告)日：2016-06-14
申请号：US12425763
申请日：2009-04-17
申请人： Yaohuang Ke , Guo-Liang Yu
发明人： Yaohuang Ke , Guo-Liang Yu
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An antibody that binds TNF α and neutralizes its activity is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO. 1, and b) a light chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID No. 2.
摘要翻译：提供结合TNFα并中和其活性的抗体。在某些情况下，抗体包含：a）重链可变结构域，其包含与SEQ ID NO：1的氨基酸序列至少95％相同的氨基酸序列。 1，和b）轻链可变结构域，其包含与SEQ ID No.2的氨基酸序列至少95％相同的氨基酸序列。

3. 发明申请

US20140377282A1 ANTI-KDR ANTIBODIES AND METHODS OF USE 有权
标题翻译：抗KDR抗体和使用方法
公开(公告)号：US20140377282A1
公开(公告)日：2014-12-25
申请号：US14356120
申请日：2012-11-01
申请人： Yaohuang Ke , Sum Wai Pierre Lee , Yongke Zhang , Guo-Liang Yu , Weimin Zhu
发明人： Yaohuang Ke , Sum Wai Pierre Lee , Yongke Zhang , Guo-Liang Yu , Weimin Zhu
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/71 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides anti-KDR monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of a variety of cancers, rheumatoid arthritis, diabetic retinopathy and other diseases associated with aberrant VEGF or KDR expression and/or activity.
摘要翻译：本发明提供抗KDR单克隆抗体和相关组合物，其可用于治疗各种癌症，类风湿性关节炎，糖尿病性视网膜病变和与异常VEGF或KDR表达相关的其它疾病的各种治疗方法中的任何一种， /或活动。

4. 发明授权

US08426685B2 Yield-related polynucleotides and polypeptides in plants 有权
标题翻译：植物中产量相关多核苷酸和多肽
公开(公告)号：US08426685B2
公开(公告)日：2013-04-23
申请号：US12638750
申请日：2009-12-15
申请人： Oliver J. Ratcliffe , Jose Luis Riechmann , Luc Adam , Jacqueline E. Heard , Marsha L. Pilgrim , Cai-Zhong Jiang , T. Lynne Reuber , Robert A. Creelman , Omaira Pineda , Guo-Liang Yu
发明人： Oliver J. Ratcliffe , Jose Luis Riechmann , Luc Adam , Jacqueline E. Heard , Marsha L. Pilgrim , Cai-Zhong Jiang , T. Lynne Reuber , Robert A. Creelman , Omaira Pineda , Guo-Liang Yu
IPC分类号： A01H5/00 , A01H5/10 , C12N15/82
CPC分类号： A01H5/10 , C07K14/415 , C12N15/8247 , C12N15/8261 , C12N15/8262 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12N15/8282 , Y02A40/146
摘要： The invention relates to plant AP2 protein family polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including greater tolerance to freezing, as compared to a reference plant.
摘要翻译：本发明涉及植物AP2蛋白家族多肽，编码它们的多核苷酸，来自各种植物物种的同源物，以及使用多核苷酸和多肽产生具有有利性质的转基因植物的方法厂。

5. 发明申请

US20120301488A1 ANTI-CD40 ANTIBODIES AND METHODS OF USE 有权
标题翻译：抗CD40抗体及其使用方法
公开(公告)号：US20120301488A1
公开(公告)日：2012-11-29
申请号：US13458730
申请日：2012-04-27
申请人： Yongke Zhang , Guo-Liang Yu , Weimin Zhu
发明人： Yongke Zhang , Guo-Liang Yu , Weimin Zhu
IPC分类号： C07K16/28 , C12N15/70 , C12N1/21 , A61P35/00 , A61P35/02 , A61P29/00 , C12N15/13 , A61K39/395
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.
摘要翻译：本发明提供高亲和力的抗CD40单克隆抗体和相关组合物，其可用于治疗癌症和其它疾病的各种治疗方法中的任何一种。

6. 发明授权

US08303951B2 Neutrokine-alpha antibodies and methods of use thereof 有权
标题翻译：中性粒细胞α抗体及其使用方法
公开(公告)号：US08303951B2
公开(公告)日：2012-11-06
申请号：US12393693
申请日：2009-02-26
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C07K16/18 , C12P21/08
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译：本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

7. 发明授权

US08003386B1 Tumor necrosis factor receptors 6α and 6β 失效
标题翻译：肿瘤坏死因子受体6α和6＆bgr;
公开(公告)号：US08003386B1
公开(公告)日：2011-08-23
申请号：US09006352
申请日：1998-01-13
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
IPC分类号： C12N15/28 , C12N15/09 , C12N15/06 , C12N15/12 , C12N5/10 , C12P21/00
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Tumor Necorsis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α＆-6＆bgr的分离的核酸分子; 蛋白质。 TNFR-6α＆-6＆bgr; 还提供多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定TNFR-6α和-6β的激动剂和拮抗剂的筛选方法。活动。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

8. 发明申请

US20110135639A1 B LYMPHOCYTE STIMULATOR ASSAYS 审中-公开
标题翻译： B LYMPHOCYTE刺激仪测定
公开(公告)号：US20110135639A1
公开(公告)日：2011-06-09
申请号：US12952091
申请日：2010-11-22
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , G01N33/68 , A61K39/00 , G01N33/53 , A61P37/00 , A61P37/06 , A61P35/00
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

9. 发明申请

US20110008367A1 ANTI-VEGF ANTIBODY 有权
标题翻译：抗VEGF抗体
公开(公告)号：US20110008367A1
公开(公告)日：2011-01-13
申请号：US12847757
申请日：2010-07-30
申请人： Yaohuang KE , Weimin Zhu , Guo-Liang Yu
发明人： Yaohuang KE , Weimin Zhu , Guo-Liang Yu
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395 , A61P35/04 , A61P9/00 , A61P29/00
CPC分类号： C07K16/22 , C07K2317/565 , C07K2317/76
摘要： An antibody is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain that comprises CDR regions that are substantially identical to the heavy chain CDR regions of a selected antibody and b) a light chain variable domain that comprises CDR regions that are substantially identical to the light chain CDR regions of the selected antibody, where the antibody binds a selected target.
摘要翻译：提供抗体。在某些情况下，抗体包含：a）重链可变结构域，其包含与所选抗体的重链CDR区基本相同的CDR区，和b）轻链可变结构域，其包含基本上与所选抗体的轻链CDR区，其中抗体结合所选择的靶。

10. 发明申请

US20110003399A1 Tumor Necrosis Factor-Gamma 失效
标题翻译：肿瘤坏死因子 - 伽玛
公开(公告)号：US20110003399A1
公开(公告)日：2011-01-06
申请号：US12879210
申请日：2010-09-10
申请人： GUO-LIANG YU , JIAN NI , CRAIG A. ROSEN , JUN ZHANG
发明人： GUO-LIANG YU , JIAN NI , CRAIG A. ROSEN , JUN ZHANG
IPC分类号： G01N33/53 , C07K16/00 , C07K16/24 , C12N5/10
CPC分类号： A61K51/08 , C07K16/241 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译：公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病，示例再狭窄。还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

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