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1. 发明申请

US20120064519A1 SYSTEM AND METHOD FOR DUAL-DETECTION OF A CELLULAR RESPONSE 审中-公开
标题翻译：用于双重检测细胞响应的系统和方法
公开(公告)号：US20120064519A1
公开(公告)日：2012-03-15
申请号：US13300029
申请日：2011-11-18
申请人： Ye Fang , Ann M. Ferrie , Joydeep Lahiri , Deepti J. Mudaliar , Qi Wu
发明人： Ye Fang , Ann M. Ferrie , Joydeep Lahiri , Deepti J. Mudaliar , Qi Wu
IPC分类号： C12Q1/68 , G01N33/566 , C12Q1/02
CPC分类号： G01N21/648 , G01N21/7743
摘要： A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.
摘要翻译：本文所定义的系统和方法，用于在光学生物传感器中双重检测ev逝波无标记光和ev逝波激发荧光标记发射光。

2. 发明授权

US08129198B2 Porous substrate plates and the use thereof 有权
标题翻译：多孔基板及其用途
公开(公告)号：US08129198B2
公开(公告)日：2012-03-06
申请号：US12854588
申请日：2010-08-11
申请人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
发明人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
IPC分类号： G01N33/543
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
摘要翻译：公开了适用于生物或化学测定的底物板或装置。该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。还描述了一种方法及其变体。

3. 发明授权

US07384779B2 Porous substrate plates and the use thereof 失效
标题翻译：多孔基板及其用途
公开(公告)号：US07384779B2
公开(公告)日：2008-06-10
申请号：US10822385
申请日：2004-04-12
申请人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
发明人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
IPC分类号： C12M1/34
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
摘要翻译：公开了适用于生物或化学测定的底物板或装置。该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。还描述了一种方法及其变体。

4. 发明申请

US20080119370A1 POROUS SUBSTRATE PLATES AND THE USE THEREOF 失效
标题翻译：多孔基板及其使用
公开(公告)号：US20080119370A1
公开(公告)日：2008-05-22
申请号：US11870742
申请日：2007-10-11
申请人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
发明人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
IPC分类号： C40B30/04 , C40B50/18
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
摘要翻译：公开了适用于生物或化学测定的底物板或装置。该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。还描述了一种方法及其变体。

5. 发明授权

US06590075B2 Secreted protein HODAZ50 失效
标题翻译：分泌蛋白HODAZ50
公开(公告)号：US06590075B2
公开(公告)日：2003-07-08
申请号：US09148545
申请日：1998-09-04
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号： C07K100
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

6. 发明授权

US06525174B1 Precerebellin-like protein 失效
标题翻译：类似前脑苷脂的蛋白质
公开(公告)号：US06525174B1
公开(公告)日：2003-02-25
申请号：US09205258
申请日：1998-12-04
申请人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
发明人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
IPC分类号： C07K1447
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

7. 发明授权

US08148092B2 System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors 有权
标题翻译：使用波导光栅传感器进行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：US08148092B2
公开(公告)日：2012-04-03
申请号：US12469054
申请日：2009-05-20
申请人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Joydeep Lahiri , Po Ki Yuen
发明人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Joydeep Lahiri , Po Ki Yuen
IPC分类号： G01N33/567 , C12Q1/02
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器实时监测活细胞内激动剂诱导的GPCR信号事件的系统和方法。特别地，本发明包括使用光学LID生物传感器基于由于激动剂诱导的GPCR活化导致的质量再分布来筛选活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自参考光学LID生物传感器以消除对环境温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在又一个扩展的实施方案中，本发明公开了在单一培养基溶液中的多种类型的细胞中单种类型细胞或多种GPCR筛选多种GPCR的不同方式。在又一个延伸的实施方案中，本发明公开了确定化合物对活细胞内特异性GPCR的生理或药理作用的不同方式。

8. 发明申请

US20120071351A1 LABEL FREE BIOSENSORS AND CELLS 有权
标题翻译：标签免费生物传感器和细胞
公开(公告)号：US20120071351A1
公开(公告)日：2012-03-22
申请号：US13281996
申请日：2011-10-26
申请人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Joydeep Lahiri , Po Ki Yuen
发明人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Joydeep Lahiri , Po Ki Yuen
IPC分类号： C40B30/06 , C12Q1/18 , C12Q1/02
CPC分类号： G01N33/5008 , G01N33/54373 , G01N33/554
摘要： Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.
摘要翻译：公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。在某些实施方案中，所述测定可以以放置方式进行并且可以被复用。

9. 发明授权

US07871811B2 Method for eliminating crosstalk between waveguide grating-based biosensors located in a microplate and the resulting microplate 失效
标题翻译：用于消除位于微板中的基于波导光栅的生物传感器与所得微板之间的串扰的方法
公开(公告)号：US07871811B2
公开(公告)日：2011-01-18
申请号：US11101096
申请日：2005-04-07
申请人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Anthony G. Frutos , Eric J. Mozdy , Chuan-Che Wang , Po Ki Yuen
发明人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Anthony G. Frutos , Eric J. Mozdy , Chuan-Che Wang , Po Ki Yuen
IPC分类号： C12M1/00 , C12Q1/68 , G01N1/00
CPC分类号： G01N21/7743 , G01N21/253
摘要： The present invention includes several methods for modifying the current processes of manufacturing optical sensing microplates that use continuous waveguide films to reduce/eliminate crosstalk between the biosensors that are incorporated within wells. The methods include (1) physically deteriorating/removing the waveguide film between individual biosensors; (2) chemically depositing highly absorbing materials within the waveguide film between individual biosensors; (3) patterning disordered (scattering) regions between the diffraction gratings that define individual biosensors; (4) using a specific mask and depositing individual patches of waveguide film, where each patch defines at least one biosensor. Each of these methods and several other methods described herein prevent the propagation of light between individual sensing regions, thereby eliminating optical crosstalk between the biosensors. The present invention also includes the resulting microplate.
摘要翻译：本发明包括几种用于修改制造光学感测微板的当前工艺的方法，其使用连续波导膜来减少/消除结合在孔内的生物传感器之间的串扰。所述方法包括（1）在各个生物传感器之间物理劣化/去除波导膜; （2）在各个生物传感器之间在波导膜内化学沉积高吸收材料; （3）在限定单个生物传感器的衍射光栅之间图形化无序（散射）区域; （4）使用特定掩模并沉积波导膜的各个贴片，其中每个贴片限定至少一个生物传感器。这些方法和本文所描述的其它方法中的每一种都防止光在各个感测区域之间的传播，从而消除了生物传感器之间的光学串扰。本发明还包括所得到的微孔板。

10. 发明授权

US07867700B2 Porous substrate plates and the use thereof 失效
标题翻译：多孔基板及其用途
公开(公告)号：US07867700B2
公开(公告)日：2011-01-11
申请号：US11870742
申请日：2007-10-11
申请人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
发明人： Ye Fang , Ann M. Ferrie , Yulong Hong , Brian L. Webb
IPC分类号： C12Q1/00
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
摘要翻译：公开了适用于生物或化学测定的底物板或装置。该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。还描述了一种方法及其变体。

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