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1. 发明申请

US20130137679A1 Novel Functionally Selective Ligands of Dopamine D2 Receptors 有权
标题翻译：新型功能选择性配体多巴胺D2受体
公开(公告)号：US20130137679A1
公开(公告)日：2013-05-30
申请号：US13807347
申请日：2011-07-01
申请人： Jian Jin , Bryan Roth , Stephen Frye
发明人： Jian Jin , Bryan Roth , Stephen Frye
IPC分类号： C07D403/12 , A61K31/551 , A61K31/4725 , C07D417/12 , C07D405/14 , A61K31/55 , A61K31/538 , A61K31/4965 , A61K45/00 , A61K31/454 , C07D471/04 , C07D413/14 , C07D241/04 , C07D401/12 , A61K31/496 , C07D217/22 , C07D403/02
CPC分类号： C07D403/12 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/4965 , A61K31/538 , A61K31/55 , A61K45/00 , C07D215/20 , C07D217/24 , C07D231/56 , C07D235/26 , C07D241/04 , C07D277/62 , C07D295/088 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention relates to novel functionally selective ligands of dopamine D2 receptors, FIG. 1 including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.
摘要翻译：本发明涉及多巴胺D2受体的新型功能选择性配体， 1包括激动剂，拮抗剂和反向激动剂。本发明还涉及这些化合物用于治疗与D2受体相关的中枢神经系统疾病的用途。

2. 发明授权

US09156822B2 Functionally selective ligands of dopamine D2 receptors 有权
标题翻译：多巴胺D2受体的功能选择性配体
公开(公告)号：US09156822B2
公开(公告)日：2015-10-13
申请号：US13807347
申请日：2011-07-01
申请人： Jian Jin , Bryan Roth , Stephen Frye
发明人： Jian Jin , Bryan Roth , Stephen Frye
IPC分类号： A61K31/551 , C07D401/02 , C07D401/14 , C07D403/02 , C07D403/14 , C07D417/02 , C07D417/14 , C07D471/04 , C07D403/12 , C07D215/20 , C07D217/24 , C07D231/56 , C07D235/26 , C07D277/62 , C07D295/088 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/4965 , A61K31/538 , A61K31/55 , A61K45/00 , C07D241/04 , C07D405/14 , C07D413/14
CPC分类号： C07D403/12 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/4965 , A61K31/538 , A61K31/55 , A61K45/00 , C07D215/20 , C07D217/24 , C07D231/56 , C07D235/26 , C07D241/04 , C07D277/62 , C07D295/088 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention relates to novel functionally selective ligands of dopamine D2 receptors, including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.
摘要翻译：本发明涉及多巴胺D2受体的新型功能选择性配体，包括激动剂，拮抗剂和反向激动剂。本发明还涉及这些化合物用于治疗与D2受体相关的中枢神经系统疾病的用途。

3. 发明授权

US09053673B2 Scalable intra-panel interface 有权
标题翻译：可扩展的面板内接口
公开(公告)号：US09053673B2
公开(公告)日：2015-06-09
申请号：US13070416
申请日：2011-03-23
申请人： Zhengyu Yuan , Jian Jin , Ming Qu , Ding Lu , Zhanpeng Zhang , Qing Ouyang
发明人： Zhengyu Yuan , Jian Jin , Ming Qu , Ding Lu , Zhanpeng Zhang , Qing Ouyang
IPC分类号： G06F3/038 , G09G3/36 , G09G3/20
CPC分类号： G09G3/3611 , G09G3/20 , G09G2300/0426 , G09G2310/027 , G09G2330/06 , G09G2330/12 , G09G2352/00 , G09G2370/08 , G09G2370/14
摘要： A system and a method are disclosed for an intra-panel communication interface which, among other advantages, enhances system reliability and reduces bus width. A timing controller initializes communication with a plurality of source drivers by transmitting link data through a plurality of data channels and monitors source driver status through an auxiliary status channel. The plurality of source drivers share the auxiliary status channel to indicate their status. The timing controller transmits display data to a source driver through a data channel. The display data includes a request for status data from the source driver. The source driver transmits the requested status data to the timing controller via the auxiliary status channel.
摘要翻译：公开了用于面板内通信接口的系统和方法，其特征在于提高了系统可靠性并减少了总线宽度。定时控制器通过多个数据信道发送链路数据并通过辅助状态信道监视源驱动器状态来初始化与多个源驱动器的通信。多个源驱动器共享辅助状态通道以指示其状态。定时控制器通过数据通道将显示数据发送到源驱动器。显示数据包括来自源驱动器的状态数据请求。源驱动器通过辅助状态通道将所请求的状态数据发送到定时控制器。

4. 发明授权

US08481566B2 Compounds which have activity at M1 receptor and their uses in medicine 失效
标题翻译：具有M1受体活性的化合物及其在药物中的用途
公开(公告)号：US08481566B2
公开(公告)日：2013-07-09
申请号：US11852455
申请日：2007-09-10
申请人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Graham Walker
发明人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Graham Walker
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D405/12 , C07D235/26
摘要： Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）化合物和盐和溶剂合物：其中R4是氟，R5选自氢，卤素，氰基，C1-6烷基，被一个或多个氟原子取代的C1-6烷基，C1-6烷氧基和C1- 6个被一个或多个氟原子取代的烷氧基; 并且R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和被一个或多个氟原子取代的C 1-6烷氧基更多的氟原子，Q是氢或C 1-6烷基。预期化合物可用于治疗，例如治疗精神病和认知障碍。

5. 发明授权

US08405828B2 Spatial positioning of spectrally labeled beads 有权
公开(公告)号：US08405828B2
公开(公告)日：2013-03-26
申请号：US12620475
申请日：2009-11-17
申请人： Stephen Empedocles , Andrew Watson , Jian Jin
发明人： Stephen Empedocles , Andrew Watson , Jian Jin
IPC分类号： G01J3/28 , G01J3/00 , G01J3/30 , G01J3/42 , G01N21/29
CPC分类号： G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
摘要： Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.

6. 发明申请

US20130037712A1 OPTICAL-CAVITY PHASE PLATE FOR TRANSMISSION ELECTRON MICROSCOPY 审中-公开
标题翻译：用于传输电子显微镜的光学相位板
公开(公告)号：US20130037712A1
公开(公告)日：2013-02-14
申请号：US13487831
申请日：2012-06-04
申请人： Robert GLAESER , Jian Jin , Radostin Danev , Holger Mueller , John Spence
发明人： Robert GLAESER , Jian Jin , Radostin Danev , Holger Mueller , John Spence
IPC分类号： H01J37/22
CPC分类号： H01J37/26 , H01J2237/2482 , H01J2237/2614
摘要： An optical phase plate system and method for enhancing phase contrast in electron beam imaging includes a transmission electron microscope (TEM) having a back focal plane; an optical cavity having a high internal surface reflectance, the center of the optical cavity located at the back focal plane of the TEM, the optical cavity having first and second ports arranged oppositely along a symmetrical axis of the optical cavity to admit an electron beam provided by the TEM through the first port to pass through and focus at the center of the optical cavity, and to exit through the second port, and wherein the optical cavity further has an optical port on an axis transverse to and intersecting the electron beam axis to admit a laser beam; a laser coupled to the optical cavity to provide a laser beam of a selected wavelength to enter the optical cavity through the optical port, wherein the laser beam is multiply reflected from the high internal surface reflectance to provide a high intensity standing wave optical phase plate focused at the back focal plane of the TEM to cause a modulation of the electron beam; and an image plane of the TEM placed opposite the second port of the optical cavity to receive the electron beam modulated by the high intensity standing wave optical phase plate.
摘要翻译：用于增强电子束成像中的相位差的光学相位板系统和方法包括具有后焦平面的透射电子显微镜（TEM）具有高内表面反射率的光学腔，光腔的中心位于TEM的后焦平面处，光腔具有沿着光腔的对称轴线相对布置的第一和第二端口，以允许提供的电子束通过TEM通过第一端口通过并聚焦在光腔的中心，并且通过第二端口离开，并且其中光学腔还具有横向于电子束轴线和与电子束轴线交叉的轴线上的光学端口承认激光束; 激光器，其耦合到光腔以提供选定波长的激光束以通过光学端口进入光腔，其中激光束从高内表面反射率反射，以提供高强度驻波光相位板聚焦在TEM的后焦平面处引起电子束的调制; 以及与光腔的第二端口相对放置的TEM的像面，以接收由高强度驻波光学相位板调制的电子束。

7. 发明申请

US20120316202A1 Compounds which have activity at M1 receptor and their uses in medicine 审中-公开
标题翻译：具有M1受体活性的化合物及其在药物中的用途
公开(公告)号：US20120316202A1
公开(公告)日：2012-12-13
申请号：US13584956
申请日：2012-08-14
申请人： David Gwyn COOPER , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
发明人： David Gwyn COOPER , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
IPC分类号： A61K31/454 , A61P25/00 , A61P25/28 , C07D401/04
CPC分类号： C07D235/26
摘要： Compounds of the general formula And their use in the treatment of psychotic disorders and cognitive impairment are disclosed.
摘要翻译：公开了通式的化合物及其在治疗精神病和认知障碍中的用途。

8. 发明授权

US08288413B2 Benzimidazolones which have activity at M1 receptor 失效
标题翻译：具有M1受体活性的苯并咪唑酮
公开(公告)号：US08288413B2
公开(公告)日：2012-10-16
申请号：US12088489
申请日：2006-09-27
申请人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
发明人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
IPC分类号： A61K31/454 , C07D405/04
CPC分类号： C07D401/04 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）和盐的化合物：其中R 6选自氢，卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基， C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基和氰基，Q是氢或C 1-6烷基。化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

9. 发明授权

US08283364B2 Compounds which have activity at M1 receptor and their uses in medicine 有权
标题翻译：具有M1受体活性的化合物及其在药物中的用途
公开(公告)号：US08283364B2
公开(公告)日：2012-10-09
申请号：US12088465
申请日：2006-09-27
申请人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
发明人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
IPC分类号： A61K31/454 , C07D405/04
CPC分类号： C07D405/12 , C07D235/26
摘要： Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）和盐的化合物：其中R 4是氟，R 5选自氢，卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基和C 1-6烷氧基取代具有一个或多个氟原子; 并且R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和被一个或多个氟原子取代的C 1-6烷氧基更多的氟原子，Q是氢或C 1-6烷基。预期化合物可用于治疗，例如治疗精神病和认知障碍。

10. 发明申请

US20100308556A1 Bicycles driven through driver units 审中-公开
标题翻译：自行车由司机单位驱动
公开(公告)号：US20100308556A1
公开(公告)日：2010-12-09
申请号：US12385226
申请日：2009-04-02
申请人： Qi Nong Jin , Jian Jin , Gang Guo
发明人： Qi Nong Jin , Jian Jin , Gang Guo
IPC分类号： B62M9/04
CPC分类号： B62M23/00 , B62M1/12 , B62M1/32
摘要： This invention relates to the drive technique of bicycles, particularly two-wheel and rear-wheel driven ones. This invention comprises a front-wheel driver unit which moves rectilinearly and directly matches the front-wheel ratchet wheel, to drive the front wheel. It also contains a curvilinear rear-wheel driver unit which moves along a curve and directly matches the rear-wheel ratchet wheel to drive the rear wheel. The two-wheel driven bicycle has a head tube in the front to form a bracket to support the cyclist's shoulders so that the cyclist, while using his or her arms to steer the bicycle and drive the front wheel, does not have to make big effort to support his/her upper body. In the case of the rear-wheel driven bicycle, the identical rear-wheel driver unit used for said two-wheel driven bicycle is used, and the front wheel and the handlebars are just the same as that of a conventional bicycle. Higher drive efficiency can be achieved by using driver units to directly drive cycle wheels, because it converts the maximum effort of the cyclist's arms and/or legs into the rotational moment to drive the bicycle forward. Moreover, the bicycle structure is simple.
摘要翻译：本发明涉及自行车，特别是两轮和后轮驱动的自行车的驱动技术。本发明包括前轮驱动单元，其直线运动并直接匹配前轮棘轮以驱动前轮。它还包含一个曲线后轮驱动单元，沿着曲线移动，直接匹配后轮棘轮驱动后轮。两轮驱动的自行车在前面有一个头管，形成一个支架，用于支撑骑自行车者的肩膀，以便骑自行车的人在用自己的手臂引导自行车并驾驶前轮时，不必付出巨大的努力支持他/她的上半身。在后轮自行车的情况下，使用用于所述两轮自行车的相同的后轮驱动单元，前轮和把手与常规自行车的相同。通过使用驱动单元来直接驱动循环轮可以实现更高的驱动效率，因为它将骑自行车者的手臂和/或腿的最大努力转换为旋转时刻以向前驱动自行车。此外，自行车结构简单。

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