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1. 发明申请

US20140011703A1 AUTOMATIC INJECTION DEVICE FOR MICROARRAY CHIP AND AUTOMATIC INJECTION HYBRIDIZATION MICROARRAY CHIP 有权
标题翻译：微胶囊自动注射装置和自动注射微胶囊芯片
公开(公告)号：US20140011703A1
公开(公告)日：2014-01-09
申请号：US14006488
申请日：2012-02-10
申请人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
发明人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
IPC分类号： G01N1/10
CPC分类号： G01N1/10 , C12Q1/6813 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/543 , G01N33/68 , G01N35/1095
摘要： An automatic injection device comprises at least an injection unit (1). The said injection unit (1) is formed by sealing a cover plate layer (3) with hydrophilic surfaces and a microfluid layer (4). The said cover plate layer (3) is provided with at least two through holes (5). he said microfluid layer (4) is provided with a hollow-out hybridization chamber (7) and at least two hollow-out microfluid channels (6). One end of each channel (6) is connected with the hybridization chamber (7), and the other end is connected with a through hole (5) of the cover plate layer (3) respectively. Taking advantage of the hydrophilicity of the cover plate, the automatic injection device makes a solution automatically enter and fill the hybridization chamber (7) and the microfluid channels (6) by the driving force of liquid surface tension. The flow uniformity of sample solution in microarray chip is achieved by the structural design of the hybridization chamber (7) and the microfluid channels (6). The automatic injection device has advantages of simple manufacture, easy operation, high hybridization efficiency, low sample cost, and automatic quantificational injection.
摘要翻译：自动注射装置至少包括注射单元（1）。所述注射单元（1）通过密封具有亲水表面的盖板层（3）和微流体层（4）而形成。所述盖板层（3）设置有至少两个通孔（5）。他表示微流体层（4）设置有中空杂交室（7）和至少两个中空的微流体通道（6）。每个通道（6）的一端与杂交室（7）连接，另一端分别与盖板层（3）的通孔（5）连接。利用盖板的亲水性，自动注射装置通过液面张力的驱动力使溶液自动进入并填充杂交室（7）和微流体通道（6）。微阵列芯片中样品溶液的流动均匀性通过杂交室（7）和微流体通道（6）的结构设计来实现。自动注射装置制造简单，操作简便，杂交效率高，样品成本低，自动定量注射等优点。

2. 发明授权

US09671317B2 Automatic injection device for microarray chip and automatic injection hybridization microarray chip 有权
公开(公告)号：US09671317B2
公开(公告)日：2017-06-06
申请号：US14006488
申请日：2012-02-10
申请人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
发明人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
IPC分类号： G01N1/10 , G01N35/10 , C12Q1/68 , G01N33/543 , G01N33/68 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12
CPC分类号： G01N1/10 , C12Q1/6813 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/543 , G01N33/68 , G01N35/1095
摘要： An automatic injection device comprises at least an injection unit (1). The said injection unit (1) is formed by sealing a cover plate layer (3) with hydrophilic surfaces and a microfluid layer (4). The said cover plate layer (3) is provided with at least two through holes (5). The said microfluid layer (4) is provided with a hollow-out hybridization chamber (7) and at least two hollow-out microfluid channels (6). One end of each channel (6) is connected with the hybridization chamber (7), and the other end is connected with a through hole (5) of the cover plate layer (3) respectively. Taking advantage of the hydrophilicity of the cover plate, the automatic injection device makes a solution automatically enter and fill the hybridization chamber (7) and the microfluid channels (6) by the driving force of liquid surface tension. The flow uniformity of sample solution in microarray chip is achieved by the structural design of the hybridization chamber (7) and the microfluid channels (6). The automatic injection device has advantages of simple manufacture, easy operation, high hybridization efficiency, low sample cost, and automatic quantificational injection.

3. 发明授权

US09677133B2 Biological chip hybridization system 有权
公开(公告)号：US09677133B2
公开(公告)日：2017-06-13
申请号：US14006540
申请日：2012-02-10
申请人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Liqing Duan , Kaijun Zhao , Jinxiu Zhang , Xiumei Song , Dong Wang , Huafang Gao , Wanli Xing
发明人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Liqing Duan , Kaijun Zhao , Jinxiu Zhang , Xiumei Song , Dong Wang , Huafang Gao , Wanli Xing
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/543 , B01L3/00 , B01L7/00 , G01N35/00
CPC分类号： C12Q1/6876 , B01L3/5027 , B01L7/52 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0622 , G01N33/543 , G01N2035/00158
摘要： A hybridization system is provided, which comprises a biological chip having a substrate (1) with a probe dot matrix (3) and a cover plate (2) with at least two through-holes (4), where a hybrid chamber (5) is formed between the substrate (1) and the cover plate (2), at least two fluid channels (6) are interconnected respectively with the hybrid chamber (5) by the two through-holes (4), and a fluid control device is interconnected with the fluid channels (6). The biological chip hybridization system integrates hybridizing, cleaning and drying functions, uses power provided by the fluid control device as the drive force for promoting the liquid flow for automatically reciprocation flow in the fluid channels (6) and the chamber (5) to achieve a dynamic hybridization, thus improving the hybrid efficiency and uniformity, and achieving automatic control.

4. 发明授权

US09101924B2 Interface device for bio-chip 有权
标题翻译：生物芯片接口装置
公开(公告)号：US09101924B2
公开(公告)日：2015-08-11
申请号：US14006512
申请日：2012-02-10
申请人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
发明人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
IPC分类号： G01N15/06 , G01N33/00 , G01N33/49 , B01L3/00
CPC分类号： B01L3/502 , B01L3/502715 , B01L3/502784 , B01L2200/0689 , B01L2200/141 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487
摘要： An interface device for bio-chip at least comprises an interface unit, said interface unit consisting of instrument interface layer, fluid channel layer and sample interface layer. The instrument interface layer has at least one instrument interface. The fluid channel layer has one hollow-out fluid channel. The sample interface layer has at least one sample interface, and both ends of said fluid channel connect to the sample interface and the instrument interface respectively. The interface device separates sample solutions from the instrument interface by gas or liquid in the fluid channel, thus to avoid direct contacts between sample solutions and instrument interface which will cause pollution, and omitting cleaning processes after using instruments. With simple structure, easy operation and low cost, it applies to chemistry field, biology field and medical analysis field.
摘要翻译：用于生物芯片的接口装置至少包括接口单元，所述接口单元由仪器接口层，流体通道层和样品界面层组成。仪器界面层至少有一个仪器界面。流体通道层具有一个中空的流体通道。样品接口层具有至少一个样品接口，并且所述流体通道的两端分别连接到样品接口和仪器接口。界面设备通过气体或液体在流体通道中将样品溶液与仪器界面分离，从而避免样品溶液与仪器界面之间的直接接触，这将导致污染，并在使用仪器后省略清洁过程。结构简单，操作方便，成本低，适用于化学领域，生物学领域和医学分析领域。

5. 发明申请

US20140011707A1 BIOLOGICAL CHIP HYBRIDIZATION SYSTEM 有权
标题翻译：生物芯片混合系统
公开(公告)号：US20140011707A1
公开(公告)日：2014-01-09
申请号：US14006540
申请日：2012-02-10
申请人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Liqing Duan , Kaijun Zhao , Jinxiu Zhang , Xiumei Song , Dong Wang , Huafang Gao , Wanli Xing
发明人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Liqing Duan , Kaijun Zhao , Jinxiu Zhang , Xiumei Song , Dong Wang , Huafang Gao , Wanli Xing
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , B01L3/5027 , B01L7/52 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0622 , G01N33/543 , G01N2035/00158
摘要： A hybridization system is provided, which comprises a biological chip having a substrate (1) with a probe dot matrix (3) and a cover plate (2) with at least two through-holes (4), where a hybrid chamber (5) is formed between the substrate (1) and the cover plate (2), at least two fluid channels (6) are interconnected respectively with the hybrid chamber (5) by the two through-holes (4), and a fluid control device is interconnected with the fluid channels (6). The biological chip hybridization system integrates hybridizing, cleaning and drying functions, uses power provided by the fluid control device as the drive force for promoting the liquid flow for automatically reciprocation flow in the fluid channels (6) and the chamber (5) to achieve a dynamic hybridization, thus improving the hybrid efficiency and uniformity, and achieving automatic control.
摘要翻译：提供了一种杂交系统，其包括具有带有探针点阵（3）的基底（1）和具有至少两个通孔（4）的盖板（2）的生物芯片，其中混合室（5）形成在基板（1）和盖板（2）之间，至少两个流体通道（6）分别通过两个通孔（4）与混合室（5）相互连接，并且流体控制装置与流体通道（6）互连。生物芯片杂交系统集成了杂交，清洁和干燥功能，使用由流体控制装置提供的电力作为促进液体流动的驱动力，用于在流体通道（6）和腔室（5）中自动往复流动，以实现动态杂交，从而提高混合效率和均匀性，实现自动控制。

6. 发明申请

US20140010733A1 INTERFACE DEVICE FOR BIO-CHIP 有权
标题翻译：用于生物芯片的界面设备
公开(公告)号：US20140010733A1
公开(公告)日：2014-01-09
申请号：US14006512
申请日：2012-02-10
申请人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
发明人： Jiaming Ye , Pinhong Wang , Guoqing Wang , Wanli Xing
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L3/502715 , B01L3/502784 , B01L2200/0689 , B01L2200/141 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487
摘要： An interface device for bio-chip at least comprises an interface unit, said interface unit consisting of instrument interface layer, fluid channel layer and sample interface layer. The instrument interface layer has at least one instrument interface. The fluid channel layer has one hollow-out fluid channel. The sample interface layer has at least one sample interface, and both ends of said fluid channel connect to the sample interface and the instrument interface respectively. The interface device separates sample solutions from the instrument interface by gas or liquid in the fluid channel, thus to avoid direct contacts between sample solutions and instrument interface which will cause pollution, and omitting cleaning processes after using instruments. With simple structure, easy operation and low cost, it applies to chemistry field, biology field and medical analysis field.
摘要翻译：用于生物芯片的接口装置至少包括接口单元，所述接口单元由仪器接口层，流体通道层和样品界面层组成。仪器界面层至少有一个仪器界面。流体通道层具有一个中空的流体通道。样品接口层具有至少一个样品接口，并且所述流体通道的两端分别连接到样品接口和仪器接口。界面设备通过液体通道中的气体或液体将样品溶液与仪器界面分离，从而避免样品溶液与仪器界面之间的直接接触，从而造成污染，并在使用仪器后省略清洗过程。结构简单，操作方便，成本低，适用于化学领域，生物学领域和医学分析领域。

7. 发明申请

US20080124251A1 Sample Preparation Device for Extracting Drug Residue 有权
标题翻译：用于提取药物残留物的样品制备装置
公开(公告)号：US20080124251A1
公开(公告)日：2008-05-29
申请号：US11661019
申请日：2004-11-22
申请人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
发明人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
IPC分类号： B01L9/06 , B01L11/00 , B01L7/02
CPC分类号： G01N1/40 , G01N2001/2866
摘要： The present invention provides a sample preparation device for extracting drug residue. It comprises a case, in which a water bath, a vortex mixer, and a homogenizer are integrated. The case also has on it an integrated control panel for controlling heating temperature of the water bath and homogenization time of the homogenizer.
摘要翻译：本发明提供了用于提取药物残留物的样品制备装置。它包括其中集成了水浴，涡流混合器和均化器的壳体。该情况还具有用于控制水浴的加热温度和均化器的均化时间的集成控制面板。

8. 发明申请

US20130210675A1 COMPOSITIONS AND METHODS FOR CONTROLLED RELEASE OF BIOMOLECULES 审中-公开
标题翻译：用于控制释放生物分子的组合物和方法
公开(公告)号：US20130210675A1
公开(公告)日：2013-08-15
申请号：US13811136
申请日：2011-07-13
申请人： Su Guo , Guoqing Wang , Guohao Zhang , Can Wang , Bei Han , Miao Liu , Jinxiu Zhang , Tao Deng , Wanli Xing , Jing Cheng
发明人： Su Guo , Guoqing Wang , Guohao Zhang , Can Wang , Bei Han , Miao Liu , Jinxiu Zhang , Tao Deng , Wanli Xing , Jing Cheng
IPC分类号： C12Q1/68 , C08G69/10 , C08B37/00 , C08B37/08 , C07H21/04
CPC分类号： C12Q1/6853 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/6455 , C07H21/04 , C07K17/02 , C07K17/14 , C08B37/003 , C08B37/0039 , C08G69/10 , C08H1/00 , C08H1/06 , C08L71/02 , C08L2203/02
摘要： Provided are compositions for controlled release of biomolecules, which comprise conjugates of polymers and biomolecules conjugated through non-covalent interactions. Also provided are methods for controlled release of biomolecules and their use in biochips.
摘要翻译：提供了用于控制释放生物分子的组合物，其包含通过非共价相互作用缀合的聚合物和生物分子的缀合物。还提供了用于控制释放生物分子的方法及其在生物芯片中的应用。

9. 发明申请

US20130206250A1 BUBBLE-BASED MICROVALVE AND ITS USE IN MICROFLUIDIC CHIP 审中-公开
标题翻译：基于泡沫的微孔及其在微流控芯片中的应用
公开(公告)号：US20130206250A1
公开(公告)日：2013-08-15
申请号：US13805323
申请日：2011-07-01
申请人： Guohao Zhang , Su Guo , Can Wang , Guoqing Wang , Miao Liu , Jinxiu Zhang , Bei Han , Tao Deng , Wanli Xing , Jing Cheng
发明人： Guohao Zhang , Su Guo , Can Wang , Guoqing Wang , Miao Liu , Jinxiu Zhang , Bei Han , Tao Deng , Wanli Xing , Jing Cheng
IPC分类号： F04B43/00
CPC分类号： F04B43/00 , B01L3/502738 , B01L9/527 , B01L2200/027 , B01L2200/16 , B01L2300/1827 , B01L2400/0633 , B01L2400/0638 , B01L2400/0677 , B01L2400/0688 , F16K99/0001 , F16K99/0015 , F16K99/0019 , F16K99/0028 , F16K99/0034 , F16K99/0044 , F16K2099/0084 , Y10T137/4238
摘要： Provided are a bubble-based microvalve and a microfluidic chip using the microvalve. Also provided are methods of using the microvalve for manipulating fluid in a microfluidic channel by changing the volume and/or location of the gas in the microvalve.
摘要翻译：提供了基于气泡的微型阀和使用微型阀的微流控芯片。还提供了通过改变微型阀中的气体的体积和/或位置来使用微型阀来在微流体通道中操纵流体的方法。

10. 发明授权

US07939035B2 Sample preparation device for extracting drug residue 有权
标题翻译：用于提取药物残留物的样品制备装置
公开(公告)号：US07939035B2
公开(公告)日：2011-05-10
申请号：US11661019
申请日：2004-11-22
申请人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
发明人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
IPC分类号： B01D21/00 , B01L99/00
CPC分类号： G01N1/40 , G01N2001/2866
摘要： The present invention provides a sample preparation device for extracting drug residue. It comprises a case, in which a water bath, a vortex mixer, and a homogenizer are integrated. The case also has on it an integrated control panel for controlling heating temperature of the water bath and homogenization time of the homogenizer.
摘要翻译：本发明提供了用于提取药物残留物的样品制备装置。它包括其中集成了水浴，涡流混合器和均化器的壳体。该情况还具有用于控制水浴的加热温度和均化器的均化时间的集成控制面板。

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