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1. 发明授权

US06984516B2 Multilayered microfluidic DNA analysis system and method 失效
公开(公告)号：US06984516B2
公开(公告)日：2006-01-10
申请号：US10340057
申请日：2003-01-10
申请人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Robert Marrero , Jeremy W. Burdon , Rong-Fong Huang
发明人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Robert Marrero , Jeremy W. Burdon , Rong-Fong Huang
IPC分类号： C12M1/34 , C12P19/34 , B01J19/08
CPC分类号： G01N30/6069 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00966 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1822 , B01L2400/0415 , B01L2400/0439 , B32B18/00 , B32B2038/042 , B32B2311/06 , B32B2311/08 , B32B2315/02 , B81B2201/058 , B81C1/00119 , B81C2201/019 , C04B2235/6562 , C04B2237/341 , C04B2237/343 , C04B2237/348 , C04B2237/50 , C04B2237/62 , C04B2237/68 , C04B2237/704 , C40B60/14 , F04B19/006 , F28D9/00 , F28D2021/0029 , F28F13/00 , F28F2260/02 , G01N30/60 , G01N30/6004 , G01N30/6095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237 , H05K1/0272 , H05K1/0306 , H05K3/4611 , H05K3/4629
摘要： A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.

2. 发明授权

US06648999B2 Low pressure laminated ceramic devices and method 失效
标题翻译：低压层压陶瓷器件及方法
公开(公告)号：US06648999B2
公开(公告)日：2003-11-18
申请号：US09940291
申请日：2001-08-27
申请人： Jeremy W. Burdon , Rong Fong Huang
发明人： Jeremy W. Burdon , Rong Fong Huang
IPC分类号： H01G400
CPC分类号： C04B35/10 , B32B18/00 , B32B37/04 , B32B2309/022 , C04B35/632 , C04B35/63444 , C04B35/638 , C04B35/645 , C04B35/653 , C04B2235/36 , C04B2235/656 , C04B2235/9615 , C04B2237/343 , C04B2237/525 , C04B2237/62
摘要： An intermediate low-pressure laminated ceramic device is formed from a plurality of layers of unfired ceramic material each including ceramic particles in an organic binder. A polymer interfacial layer having a glass transition temperature such that it flows at a temperature below a temperature required for the unfired ceramic layers to substantially deform, is deposited on one surface of each of the unfired ceramic layers. The unfired ceramic layers are stacked with an interfacial layer positioned between adjacent unfired ceramic layers in the stack. The stack is heated to a temperature greater than the glass transition temperature of the interfacial layers and a pressure is applied to the heated stack below approximately 1200 psi to fixedly bond the plurality of layers in the stack together.
摘要翻译：中间低压层压陶瓷装置由多层未焙烧陶瓷材料形成，每层包含有机粘合剂中的陶瓷颗粒。具有玻璃化转变温度的聚合物界面层被沉积在每个未煅烧的陶瓷层的一个表面上，所述聚合物界面层在低于未焙烧陶瓷层所需温度的温度基本上变形的温度下流动。未焙烧的陶瓷层层叠有位于堆叠中的相邻未烧结陶瓷层之间的界面层。堆叠被加热到大于界面层的玻璃化转变温度的温度，并且将压力施加到低于约1200psi的加热堆叠，以将堆叠中的多个层固定地结合在一起。

3. 发明授权

US06572830B1 Integrated multilayered microfludic devices and methods for making the same 有权
标题翻译：集成多层微流体装置及其制造方法
公开(公告)号：US06572830B1
公开(公告)日：2003-06-03
申请号：US09337086
申请日：1999-06-21
申请人： Jeremy W. Burdon , Rong-Fong Huang , David Wilcox , Nicholas J. Naclerio , Cynthia Ann Gorsuch Briscoe , Piotr Grodzinski , Huinan Yu , Robert Marrero , Sean Ross Gallagher , Yuk-Tong Chan , Barbara McNeil Foley , Xunhu Dai
发明人： Jeremy W. Burdon , Rong-Fong Huang , David Wilcox , Nicholas J. Naclerio , Cynthia Ann Gorsuch Briscoe , Piotr Grodzinski , Huinan Yu , Robert Marrero , Sean Ross Gallagher , Yuk-Tong Chan , Barbara McNeil Foley , Xunhu Dai
IPC分类号： B01J1000
CPC分类号： G01N30/6069 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00966 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1822 , B01L2400/0415 , B01L2400/0439 , B32B18/00 , B32B2038/042 , B32B2311/06 , B32B2311/08 , B32B2315/02 , B81B2201/058 , B81C1/00119 , B81C2201/019 , C04B2235/6562 , C04B2237/341 , C04B2237/343 , C04B2237/348 , C04B2237/50 , C04B2237/62 , C04B2237/68 , C04B2237/704 , C40B60/14 , F04B19/006 , F28D9/00 , F28D2021/0029 , F28F13/00 , F28F2260/02 , G01N30/60 , G01N30/6004 , G01N30/6095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237 , H05K1/0272 , H05K1/0306 , H05K3/4611 , H05K3/4629
摘要： A multilayered microfluidic device having a substantially monolithic structure is formed by sintering together a plurality of green-sheet layers. The substantially monolithic structure has an inlet port for receiving fluid, an outlet port for releasing fluid, and an interconnection between the inlet port and the outlet port. The substantially monolithic structure may also include a variety of components to enable useful interaction with the fluid, such as electrically conductive pathways, heaters, fluid sensors, fluid motion transducers, and optically transmissive portions. The components are preferably fabricated using thick-film or green-sheet technology and are preferably co-fired with and sintered to the green-sheet layers to become integral with the substantially monolithic structure.
摘要翻译：具有基本上整体结构的多层微流体装置通过将多个绿色层层烧结在一起而形成。基本上单片结构具有用于接收流体的入口端口，用于释放流体的出口以及入口和出口之间的互连。基本上单片结构还可以包括各种部件以使得能够与诸如导电通路，加热器，流体传感器，流体运动换能器和光学透射部分之类的流体有用的相互作用。这些组分优选使用厚膜或生片技术制造，并且优选与生片层共烧并烧结成与基本上整体的结构一体。

4. 发明授权

US06527890B1 Multilayered ceramic micro-gas chromatograph and method for making the same 有权
标题翻译：多层陶瓷微气相色谱仪及其制作方法
公开(公告)号：US06527890B1
公开(公告)日：2003-03-04
申请号：US09460283
申请日：1999-12-09
申请人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Rong-Fong Huang , Jeremy W. Burdon
发明人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Rong-Fong Huang , Jeremy W. Burdon
IPC分类号： B32B3126
CPC分类号： G01N30/6069 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00966 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1822 , B01L2400/0415 , B01L2400/0439 , B32B18/00 , B32B2038/042 , B32B2311/06 , B32B2311/08 , B32B2315/02 , B81B2201/058 , B81C1/00119 , B81C2201/019 , C04B2235/6562 , C04B2237/341 , C04B2237/343 , C04B2237/348 , C04B2237/50 , C04B2237/62 , C04B2237/68 , C04B2237/704 , C40B60/14 , F04B19/006 , F28D9/00 , F28D2021/0029 , F28F13/00 , F28F2260/02 , G01N30/60 , G01N30/6004 , G01N30/6095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237 , H05K1/0272 , H05K1/0306 , H05K3/4611 , H05K3/4629
摘要： A micro-gas chromatograph column is formed by texturing a channel into a plurality of green-sheet layers, which are then sintered together to form a substantially monolithic structure. A thick-film paste may be added to the channel textured in the green-sheet layers to provide a porous plug sintered in the micro-gas chromatograph column in the substantially monolithic. A thermal conductivity detector is formed in the substantially monolithic structure by depositing a conductive thick-film paste on the surface of one of the green-sheet layers to define a resistor in an exit channel of the micro-gas chromatograph column.
摘要翻译：通过将通道纹理化成多个生片层来形成微气相色谱柱，然后将其烧结在一起形成基本上整体的结构。可以在生片层中纹理化的通道中加入厚膜膏，以提供在微气相色谱柱中烧结的基本上整体的多孔塞。通过在其中一个生片层的表面上沉积导电厚膜膏以在微气相色谱柱的出口通道中限定电阻，在基本上整体的结构中形成导热性检测器。

5. 发明申请

US20110197655A1 MULTI-LAYERED CERAMIC MICRO-GAS CHROMATOGRAPH AND METHOD FOR MAKING THE SAME 审中-公开
标题翻译：多层陶瓷微气体色谱及其制备方法
公开(公告)号：US20110197655A1
公开(公告)日：2011-08-18
申请号：US12962376
申请日：2010-12-07
申请人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Rong-Fong Huang , Jeremy W. Burdon , Nicholas J. Naclerio , David Wilcox
发明人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Rong-Fong Huang , Jeremy W. Burdon , Nicholas J. Naclerio , David Wilcox
IPC分类号： G01N30/02
CPC分类号： G01N30/6095 , C04B37/008 , C04B2235/604 , C04B2235/9615 , C04B2237/343 , C04B2237/365 , C04B2237/366 , C04B2237/368
摘要： A micro-gas chromatograph column is formed by texturing a channel into a plurality of green-sheet layers, which are then sintered together to form a substantially monolithic structure. A thick-film paste may be added to the channel textured in the green-sheet layers to provide a porous plug sintered in the micro-gas chromatograph column in the substantially monolithic. A thermal conductivity detector is formed in the substantially monolithic structure by depositing a conductive thick-film paste on the surface of one of the green-sheet layers to define a resistor in an exit channel of the micro-gas chromatograph column.
摘要翻译：通过将通道纹理化成多个生片层来形成微气相色谱柱，然后将其烧结在一起形成基本上整体的结构。可以在生片层中纹理化的通道中加入厚膜膏，以提供在微气相色谱柱中烧结的基本上整体的多孔塞。通过在其中一个生片层的表面上沉积导电厚膜膏以在微气相色谱柱的出口通道中限定电阻，在基本上整体的结构中形成导热性检测器。

6. 发明授权

US06732567B2 Multilayered ceramic micro-gas chromatograph and method for making the same 有权
标题翻译：多层陶瓷微气相色谱仪及其制作方法
公开(公告)号：US06732567B2
公开(公告)日：2004-05-11
申请号：US10310378
申请日：2002-12-05
申请人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Rong-Fong Huang , Jeremy W. Burdon
发明人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Rong-Fong Huang , Jeremy W. Burdon
IPC分类号： G01N3002
CPC分类号： G01N30/6069 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00966 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1822 , B01L2400/0415 , B01L2400/0439 , B32B18/00 , B32B2038/042 , B32B2311/06 , B32B2311/08 , B32B2315/02 , B81B2201/058 , B81C1/00119 , B81C2201/019 , C04B2235/6562 , C04B2237/341 , C04B2237/343 , C04B2237/348 , C04B2237/50 , C04B2237/62 , C04B2237/68 , C04B2237/704 , C40B60/14 , F04B19/006 , F28D9/00 , F28D2021/0029 , F28F13/00 , F28F2260/02 , G01N30/60 , G01N30/6004 , G01N30/6095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237 , H05K1/0272 , H05K1/0306 , H05K3/4611 , H05K3/4629
摘要： A micro-gas chromatograph column is formed by texturing a channel into a plurality of green-sheet layers, which are then sintered together to form a substantially monolithic structure. A thick-film paste may be added to the channel textured in the green-sheet layers to provide a porous plug sintered in the micro-gas chromatograph column in the substantially monolithic. A thermal conductivity detector is formed in the substantially monolithic structure by depositing a conductive thick-film paste on the surface of one of the green-sheet layers to define a resistor in an exit channel of the micro-gas chromatograph column.
摘要翻译：通过将通道纹理化成多个生片层来形成微气相色谱柱，然后将其烧结在一起形成基本上整体的结构。可以在生片层中纹理化的通道中加入厚膜膏，以提供在微气相色谱柱中烧结的基本上整体的多孔塞。通过在其中一个生片层的表面上沉积导电厚膜膏以在微气相色谱柱的出口通道中限定电阻，在基本上整体的结构中形成导热性检测器。

7. 发明授权

US06592696B1 Method for fabricating a multilayered structure and the structures formed by the method 有权
标题翻译：制造多层结构的方法和通过该方法形成的结构
公开(公告)号：US06592696B1
公开(公告)日：2003-07-15
申请号：US09235081
申请日：1999-01-21
申请人： Jeremy W. Burdon , Rong-Fong Huang , David Wilcox , Nicholas J. Naclerio
发明人： Jeremy W. Burdon , Rong-Fong Huang , David Wilcox , Nicholas J. Naclerio
IPC分类号： B32B3112
CPC分类号： B01J19/0093 , B01J2219/00835 , B01L3/502707 , B01L7/52 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/18 , B01L2300/1822 , B01L2400/0415 , B01L2400/0439 , B32B18/00 , B32B2038/042 , B32B2311/06 , B32B2311/08 , B32B2315/02 , C04B2237/343 , C04B2237/348 , C04B2237/62 , C04B2237/68 , C04B2237/704 , F04B19/006 , F28D9/00 , F28D2021/0029 , F28F13/00 , F28F2260/02 , G01N30/6004 , G01N2030/528 , H05K1/0272 , H05K1/0306 , H05K3/4611 , H05K3/4629 , Y10T156/1039
摘要： A method for fabricating a multilayered structure out of sheets of green-tape without the application of high pressures includes the step of applying an adhesive to the sheets of green-tape. Selection of an adhesive with a polymer that decomposes at a higher temperature than the binder present in the green-tape promotes stability of the interfaces during the firing process and promotes void-free sintering within the interfacial regions. A multilayered structure with internal electrical conduction pathways and with internal vias, channels, and cavities may be fabricated by this method
摘要翻译：在不施加高压的情况下，从生片纸制造多层结构的方法包括将粘合剂施加到生胶带片的步骤。使用在比生坯中存在的粘合剂更高的温度下分解的聚合物的粘合剂的选择促进了烧结过程中界面的稳定性并且促进界面区域内的无空隙烧结。可以通过该方法制造具有内部导电路径并具有内部通孔，通道和空腔的多层结构

8. 发明授权

US06544734B1 Multilayered microfluidic DNA analysis system and method 失效
标题翻译：多层微流体DNA分析系统及方法
公开(公告)号：US06544734B1
公开(公告)日：2003-04-08
申请号：US09460281
申请日：1999-12-09
申请人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Robert Marrero , Jeremy W. Burdon , Rong-Fong Huang
发明人： Cynthia G. Briscoe , Huinan Yu , Piotr Grodzinski , Robert Marrero , Jeremy W. Burdon , Rong-Fong Huang
IPC分类号： C12Q168
CPC分类号： G01N30/6069 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00495 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00966 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , B01L2300/1822 , B01L2400/0415 , B01L2400/0439 , B32B18/00 , B32B2038/042 , B32B2311/06 , B32B2311/08 , B32B2315/02 , B81B2201/058 , B81C1/00119 , B81C2201/019 , C04B2235/6562 , C04B2237/341 , C04B2237/343 , C04B2237/348 , C04B2237/50 , C04B2237/62 , C04B2237/68 , C04B2237/704 , C40B60/14 , F04B19/006 , F28D9/00 , F28D2021/0029 , F28F13/00 , F28F2260/02 , G01N30/60 , G01N30/6004 , G01N30/6095 , G01N2030/025 , G01N2030/528 , G01N2035/00158 , G01N2035/00237 , H05K1/0272 , H05K1/0306 , H05K3/4611 , H05K3/4629
摘要： A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.
摘要翻译：多层微流体DNA分析系统包括细胞裂解室，DNA分离室，DNA扩增室和DNA检测系统。多层微流体DNA分析系统被提供为由多个烧结在一起的生片层组成的基本上整体的结构。基本上整体的结构在其中限定了用于加热DNA扩增室的装置和用于冷却DNA扩增室的装置。用于加热的装置和用于冷却的装置用于循环DNA扩增室的温度，以进行DNA扩增过程如PCR所需。

9. 发明授权

US06586885B2 MHCD and microfluidic apparatus and method 有权
标题翻译： MHCD和微流体装置及方法
公开(公告)号：US06586885B2
公开(公告)日：2003-07-01
申请号：US09932913
申请日：2001-08-20
申请人： Bernard F. Coll , Frederic Zenhausern , Jeremy W. Burdon , Chowdary R. Koripella
发明人： Bernard F. Coll , Frederic Zenhausern , Jeremy W. Burdon , Chowdary R. Koripella
IPC分类号： H05B3126
CPC分类号： G01N21/31 , G01N21/05 , G01N2021/0112 , G01N2021/0346
摘要： A microhollow cathode discharge (MHCD) cavity and microfluidic channel are combined for interrogation of samples. The apparatus includes a dielectric body and layers of conductive material defining a MHCD cavity containing an environment for carrying a gas discharge within the MHCD cavity. The gas discharge generates gas based electromagnetic waves. Electrical connections apply a cathode discharge potential to the layers of conductive material. A microfluidic channel is integrated on the substrate, and a path extends from the MHCD cavity laterally through a portion of the microfluidic channel. A detector, which may be integrated on the common substrate, is positioned to receive electromagnetic waves from the path and electronic circuitry is coupled to the detector for acquiring and processing data.
摘要翻译：将微气体阴极放电（MHCD）腔和微流体通道组合用于询问样品。该装置包括绝缘体和导电材料层，其限定了包含用于在MHCD腔内承载气体放电的环境的MHCD空腔。气体放电产生基于气体的电磁波。电连接将阴极放电电位施加到导电材料层。微流体通道集成在衬底上，并且路径从MHCD空腔横向延伸穿过微流体通道的一部分。可以集成在公共基板上的检测器被定位成从路径接收电磁波，并且电子电路耦合到检测器以获取和处理数据。

10. 发明授权

US07164572B1 Multi-path, mono-polar co-fired hermetic electrical feedthroughs and methods of fabrication therfor 有权
标题翻译：多路，单极联合密封电馈电及其制造方法
公开(公告)号：US07164572B1
公开(公告)日：2007-01-16
申请号：US11227523
申请日：2005-09-15
申请人： Jeremy W. Burdon , Joyce K. Yamamoto
发明人： Jeremy W. Burdon , Joyce K. Yamamoto
IPC分类号： H01G4/35
CPC分类号： A61N1/3754 , H01G9/008
摘要： An electrical feedthrough assembly according to the invention can be used as a component of an implantable medical device (IMD) and/or or electrochemical cell. An IMD includes implantable pulse generators, cardioverter-defibrillators, physiologic sensors, drug-delivery systems, etc. Such assemblies require biocompatibility and resistance to degradation under applied bias current or voltage. In some forms of the invention, such assemblies are fabricated by using electrically common, multiply-interconnected electrical pathways including metallized vias and interlayer structures of conductive metallic material within bores and between ceramic layers. The layers are stacked together and sintered to form a substantially monolithic dielectric structure with at least one electrically common embedded metallization pathway extending through the structure. The metallization pathway reliably conducts electrical signals even when exposed to body fluids and tissue and providing electrical communication between internal IMD circuitry and active electrical components and/or circuitry coupled to the exterior of an IMD.
摘要翻译：根据本发明的电馈通组件可以用作可植入医疗装置（IMD）和/或电化学电池的组件。 IMD包括植入式脉冲发生器，心律转复除颤器，生理传感器，药物递送系统等。这些组件在施加的偏置电流或电压下需要生物相容性和抗降解性。在本发明的某些形式中，通过使用电通常的，多重互连的电路径制造这种组件，所述电路径包括在孔内和陶瓷层之间的导电金属材料的金属化通孔和层间结构。这些层堆叠在一起并烧结以形成具有延伸穿过该结构的至少一个电通常的嵌入金属化通路的基本上单片电介质结构。金属化路径即使暴露于体液和组织也可靠地传导电信号，并提供内部IMD电路与耦合到IMD外部的有源电气部件和/或电路之间的电气通信。

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