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1. 发明申请

US20090325275A1 CELL MANIPULATION AND CULTIVATION EQUIPMENTS FOR THE PRODUCTION OF CELL THERAPY PRODUCTS 审中-公开
标题翻译：用于生产细胞治疗产品的细胞操作和培养设备
公开(公告)号：US20090325275A1
公开(公告)日：2009-12-31
申请号：US12309868
申请日：2007-02-15
申请人： Jeong-Yong Choi , Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Hyang-Soon Chang , Jin-Wook Chung , Cheong-Ho Chang
发明人： Jeong-Yong Choi , Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Hyang-Soon Chang , Jin-Wook Chung , Cheong-Ho Chang
IPC分类号： C12M1/18
CPC分类号： C12M37/00 , B01L1/04 , F24F3/1607
摘要： Cell manipulation and cultivation equipment for the production of cell therapy products has developed for preventing contamination of cells and improving the utility of a space. The equipment includes a room for the production and testing of cell therapy products, the room having an inner space enclosed in all sides and an outer entrance/exit door provided at any one side thereof, an L-shaped partition installed in a position of the room for the production and testing of cell therapy products, the partition having an inner entrance/exit door provided at any one side thereof, and a clean bench device placed inside the partition, the clean bench device including first, second, and third clean benches for preventing contamination of cells and increasing the utility of a space to the maximum extent. The operating of the clean room and clean bench has advantages to prevent contamination and improving the quality and reliability of cell therapy products.
摘要翻译：用于生产细胞治疗产品的细胞操作和培养设备已经开发用于防止细胞污染和改善空间的效用。该设备包括用于生产和测试细胞治疗产品的房间，房间具有封闭在其内侧的内部空间和设置在其任一侧的外部入口/出口门，L形分隔件安装在用于生产和测试细胞治疗产品的空间，所述隔板具有设置在其任一侧的内入口/出口门，以及放置在隔板内的洁净工作台装置，所述清洁台装置包括第一，第二和第三清洁台用于防止细胞的污染和最大程度地增加空间的效用。无尘室和洁净台的运行具有防止污染，提高细胞治疗产品质量和可靠性的优点。

2. 发明申请

US20090126285A1 Facility Module for Production and Storage of Cell Therapy Product 审中-公开
标题翻译：细胞治疗产品生产和储存设施模块
公开(公告)号：US20090126285A1
公开(公告)日：2009-05-21
申请号：US12224855
申请日：2006-03-16
申请人： Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Sung-Jun Koh , Eun-Young Lee , Soo-Jin Jung , Dong-il Chang , Jun-Keun Lee , Hyun-Gi Yoon , Hyang-Soon Chang , Yong-Hyun Yoo , Jin-Wook Chung , Cheong-Ho Chang
发明人： Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Sung-Jun Koh , Eun-Young Lee , Soo-Jin Jung , Dong-il Chang , Jun-Keun Lee , Hyun-Gi Yoon , Hyang-Soon Chang , Yong-Hyun Yoo , Jin-Wook Chung , Cheong-Ho Chang
IPC分类号： E04H5/00 , C12M3/00
CPC分类号： F24F3/0442 , C12M23/44 , C12M37/00 , C12M37/06 , C12M41/14 , C12M45/22 , F24F3/161
摘要： A facility module is provided for producing and storing a cell therapy product comprising: a Cell Therapy (CT) module one including separately prefabricated units having specific functions and separate entrances and exits so as to minimize contamination, and being capable of producing the cell therapy product, and a Banking of Cell and Tissue (BC) module Two including prefabricated units having specific functions and separate entrances and exits so as to minimize contamination, and being capable of appropriately storing hematopoietic stem cells, bone marrow cells and other cells for a prolonged period. It enables easy and low cost production of the cell therapy product, with sufficient quality to be transplanted into patients, within a short period, and permits clinical application to patients expeditiously. The present invention enables convenient installation and use of such a facility module anywhere adequate space is available, by providing the facility in a prefabricated module composed of specialized units according to function.
摘要翻译：提供了用于生产和储存细胞治疗产品的设施模块，包括：细胞治疗（CT）模块，其包括具有特定功能的单独预制单元和分开的入口和出口，以使污染最小化，并且能够产生细胞治疗产品，以及细胞和组织（BC）模块二，包括具有特定功能的预制单元和单独的入口和出口，以最小化污染，并且能够长时间适当地储存造血干细胞，骨髓细胞和其他细胞。它能够在短时间内容易且低成本地生产细胞治疗产品，具有足够的质量移植到患者体内，并允许临床快速应用于患者。本发明通过在根据功能的专用单元组成的预制模块中提供设备，可以方便地将这种设施模块安装和使用在足够的空间。

3. 发明申请

US20090018868A1 Method for Utilizing Cell Therapy Product Facility and Network-Based Business Model Using the Same 审中-公开
标题翻译：使用细胞疗法产品设施和基于网络的商业模式的使用方法
公开(公告)号：US20090018868A1
公开(公告)日：2009-01-15
申请号：US12224949
申请日：2006-03-16
申请人： Jae-Deog Chang , Cheong-Ho Chang , Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Hee-Chul Ko , Sae-Bom Lee
发明人： Jae-Deog Chang , Cheong-Ho Chang , Dong-Sam Suh , Chang-Kwon Ko , Seung-Ju Ryu , Hee-Chul Ko , Sae-Bom Lee
IPC分类号： G06Q50/00 , C12N5/00 , G06Q30/00
CPC分类号： G06Q50/22
摘要： A method is provided for utilizing a cell therapy product facility and an internet franchise market business comprising: producing a cell therapy product by a CT (Cell Therapy)-module (1) of prefabricated units having specific functions, and; storing of hematopoietic stem cells, bone marrow cells and other cells, by a BC (Banking of Cell and Tissue)-module (2) of prefabricated units having specific functions. Both modules eliminate contamination and maximize efficiency. It provides an operating method and a use method and business method for the above cell therapy product facility. The invention enables easy, low cost production of a product having sufficient quality to be transplanted into patients and put into clinical application within a short period of time. The facility module of the invention can be installed and used wherever adequate space is available. The invention provides improved quality and reliability of cell therapy products.
摘要翻译：提供了一种利用细胞疗法产品设备和网络营销市场业务的方法，包括：通过具有特定功能的预制单元的CT（Cell Therapy）模块（1）产生细胞治疗产品; 通过具有特定功能的预制单元的BC（Cell of Cell and Tissue）模块（2）存储造血干细胞，骨髓细胞和其它细胞。两个模块都能消除污染并最大限度地提高效率。它提供了上述细胞治疗产品设施的操作方法和使用方法和商业方法。本发明能够容易，低成本地生产具有足够质量的产品移植到患者中并在短时间内投入临床应用。本发明的设施模块可以在有足够空间的地方安装和使用。本发明提供了改善细胞治疗产品的质量和可靠性。

4. 发明申请

US20070087032A1 Composition of cartilage therapeutic agents and its application 审中-公开
标题翻译：软骨治疗剂的组成及其应用
公开(公告)号：US20070087032A1
公开(公告)日：2007-04-19
申请号：US10578719
申请日：2004-12-07
申请人： Cheong-Ho Chang , Chang-Kwon Ko , Jae-Deog Jang , Eun-Young Lee , Jeong-Yong Choi
发明人： Cheong-Ho Chang , Chang-Kwon Ko , Jae-Deog Jang , Eun-Young Lee , Jeong-Yong Choi
IPC分类号： A61F2/00
CPC分类号： A61K35/32 , A61F2/30756 , A61K35/36 , A61K35/39 , A61L27/225 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61K2300/00
摘要： A cartilage therapeutic composition is developed for clinical transplantation into articulatio genu (knee joints) or ankle joints. It has clinical significance for symptomatic cartilage defects of the femoral condyle (medial, lateral, or trochlear) and bone cartilage defects of the talus (anklebone) in human or animal hosts, The cartilage therapeutic composition comprises a mixture of components of chondrocytes isolated and expanded or differentiated from a host such as a human or animal, and thrombin and a fibrinogen matrix containing fibrinogen. An application of the cartilage therapeutic composition is that a mixture of thrombin, chondrocyte components and a fibrinogen matrix is injected into a cartilage defect region followed by solidification therein. It provides rapid healing and effective regeneration of cartilage without surgical operation. It has the merits of safety and simplicity by allowing the use of an arthroscope for transplantation.
摘要翻译：软骨治疗组合物被开发用于临床移植到关节（膝关节）或踝关节。对于人或动物宿主中的距骨（踝骨）的股骨髁（内侧，外侧或滑车）和骨软骨缺损的症状性软骨缺损具有临床意义。软骨治疗组合物包含分离和扩大的软骨细胞成分的混合物或与宿主如人或动物分化，以及含有纤维蛋白原的凝血酶和纤维蛋白原基质。软骨治疗组合物的应用是将凝血酶，软骨细胞成分和纤维蛋白原基质的混合物注射到软骨缺损区域中，随后在其中固化。它可以快速愈合，有效地再生软骨，无需外科手术。通过允许使用关节镜进行移植，具有安全和简单的优点。

5. 发明申请

US20090254065A1 Simple method of transplanting injectable chordrocyte for autologous chondrocyte transplantation 审中-公开
标题翻译：移植注射性软骨细胞用于自体软骨细胞移植的简单方法
公开(公告)号：US20090254065A1
公开(公告)日：2009-10-08
申请号：US11988924
申请日：2005-09-23
申请人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
发明人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
IPC分类号： A61M37/00
CPC分类号： A61K38/363 , A61K38/39 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L2430/06 , A61K2300/00
摘要： A method of transplanting an injectable chondrocyte is developed for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, which are the main ingredients of animal cartilage, and injecting the resulting mixture into a damaged cartilage region. One 1 ml syringe is prepared by mixing 1 ml of a chondrocyte culture with white or light-yellow lyophilized powder (fibrinogen). A second 1 ml syringe is prepared by mixing 1 ml of chondrocyte culture with white lyophilized powder (thrombin), adding 0.1 cc of that mixture to the entire contents of two vials containing chondrocyte suspension, and mixing well. The two syringes are then mounted on a syringe stand, and a mixing tip is mounted to their tips. The contents are mixed in the mixing tip while injecting the resulting mixture into a damaged cartilage region of an animal.
摘要翻译：开发了用于自体软骨细胞移植的移植注射软骨细胞的方法，包括混合作为动物软骨的主要成分的纤维蛋白，透明质酸和胶原的基质，并将所得混合物注入损伤的软骨区域。通过将1ml软骨细胞培养物与白色或浅黄色冻干粉末（纤维蛋白原）混合来制备1ml注射器。通过将1ml软骨细胞培养物与白色冻干粉末（凝血酶）混合，将0.1cc该混合物加入到含有软骨细胞悬液的两个小瓶的全部内容物中并混合，制备第二个1ml注射器。然后将两个注射器安装在注射器支架上，并将混合头安装到其尖端。将内容物混合在混合尖端中，同时将所得混合物注入动物的损伤的软骨区域。

6. 发明申请

US20090311220A1 Bone forming compound composed of a mixture of osteoblast and biomatrix and method for producing the same 审中-公开
标题翻译：由成骨细胞和生物基质的混合物组成的骨形成化合物及其制造方法
公开(公告)号：US20090311220A1
公开(公告)日：2009-12-17
申请号：US11921217
申请日：2005-06-27
申请人： Jae-Deog Jang , Hyun-Shin Park , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
发明人： Jae-Deog Jang , Hyun-Shin Park , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
IPC分类号： A61K35/32 , A61P19/00
CPC分类号： A61K35/32 , A61K35/12 , A61K38/4833 , A61L27/3821 , A61L27/3847 , A61L27/3895 , A61L2430/02 , C12N5/0654 , C12N2533/56
摘要： A compound for bone forming and a method for producing the same are provided using a mixture of an osteoblast and a bio-matrix. The method comprises: isolating osteoblasts from bone tissue and culturing the isolated osteoblasts to prepare an osteoblast suspension; and mixing the resulting osteoblast suspension with a bio-matrix to prepare an osteoblast therapeutic agent. A bone formation method is provided that results in no clinical graft rejection, and is capable of achieving effective and rapid bone formation via injection of a compound which has been pre-shaped to a certain extent, so as to alleviate problems associated with bone tissue formation in unwanted regions resulting from escape of injected osteoblasts from the targeted site for bone formation and then propagation thereof to other sites via the blood stream, which are caused by injection of an osteoblast suspension.
摘要翻译：使用成骨细胞和生物基质的混合物提供骨形成用化合物及其制造方法。该方法包括：从骨组织中分离成骨细胞并培养分离的成骨细胞以制备成骨细胞悬液; 并将所得的成骨细胞悬浮液与生物基质混合以制备成骨细胞治疗剂。提供了一种骨形成方法，其导致没有临床移植物排斥反应，并且能够通过注射预先形成一定程度的化合物来实现有效和快速的骨形成，以便减轻与骨组织形成相关的问题在由注射的成骨细胞从目标部位排出骨形成而导致的不需要的区域中，然后通过注射成骨细胞悬浮液引起的血流将其传播到其它部位。

7. 发明申请

US20080213229A1 Fibrin Contained Semi-Solid Osteoblast Composition for Curing Bone Fracture and Method for Producing the Same 审中-公开
标题翻译：用于固化骨折的纤维蛋白含有半固体成骨细胞组合物及其制备方法
公开(公告)号：US20080213229A1
公开(公告)日：2008-09-04
申请号：US11885943
申请日：2005-08-03
申请人： Hyun-Shin Park , Jae-Deog Jang , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
发明人： Hyun-Shin Park , Jae-Deog Jang , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
IPC分类号： A61K35/12
CPC分类号： A61K35/32 , A61K38/363 , A61K38/4833 , A61K2300/00
摘要： A method for producing the fibrin contained semi-solid osteoblast composition has developed for treating the bone fracture. The method is comprised of: isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in Dulbecco's Modified Eagle's Medium (DMEM) or Minimum Essential Medium, Alpha Modification (α-MEM) to prepare an osteoblast suspension. Then, mixing the resulting osteoblast suspension with a coagulation factor to prepare an osteoblast therapeutic agent. Accordingly, the fibrin contained semi-solid osteoblast composition of the present invention has capability to achieve the bone grafting for performing bone union without the clinical graft rejection. It is possible to uniformly distribute the fibrin mixed semi-solid osteoblast composition into the affected area of the bone fracture via injection. Therefore, the fibrin contained semi-solid osteoblast composition is effectively and rapidly cure the bone fracture via constant injection of into the affected area.
摘要翻译：已经开发了用于生产含有纤维蛋白的半固体成骨细胞组合物的方法用于治疗骨折。该方法包括：从骨组织中分离成骨细胞并在Dulbecco's Modified Eagle's Medium（DMEM）或Minimum Essential Medium，Alpha Modification（α-MEM））中培养/增殖分离的成骨细胞以制备成骨细胞悬浮液。然后，将得到的成骨细胞悬浮液与凝血因子混合，制备成骨细胞治疗剂。因此，本发明的纤维蛋白含有半固体成骨细胞组合物具有实现骨移植以进行骨结合而没有临床移植排斥的能力。可以通过注射将纤维蛋白混合的半固体成骨细胞组合物均匀地分布到骨折的受影响区域中。因此，含有纤维蛋白的半固体成骨细胞组合物通过持续注射进入受影响的区域，有效快速地治愈了骨折。

8. 发明授权

US07781158B2 Method of separating collagen from the various animal tissues for producing collagen solution and product using the same 失效
标题翻译：从各种动物组织分离胶原蛋白以产生胶原蛋白溶液的方法和使用其的产品的方法
公开(公告)号：US07781158B2
公开(公告)日：2010-08-24
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： A01N1/00 , C12P21/04 , C12P21/06 , A61K38/00 , A61K38/39 , C07K14/00
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸以进行酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

9. 发明申请

US20080118947A1 Method of Separating Collagen From the Various Animal Tissues for Producing Collagen Solution and Product Using the Same 失效
标题翻译：从各种动物组织分离胶原蛋白的方法，用于生产胶原蛋白溶液和使用其的产品
公开(公告)号：US20080118947A1
公开(公告)日：2008-05-22
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： C12P21/06 , C07K14/78 , A61K38/40
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸用于酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织以通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

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