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1. 发明申请

US20090311220A1 Bone forming compound composed of a mixture of osteoblast and biomatrix and method for producing the same 审中-公开
标题翻译：由成骨细胞和生物基质的混合物组成的骨形成化合物及其制造方法
公开(公告)号：US20090311220A1
公开(公告)日：2009-12-17
申请号：US11921217
申请日：2005-06-27
申请人： Jae-Deog Jang , Hyun-Shin Park , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
发明人： Jae-Deog Jang , Hyun-Shin Park , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
IPC分类号： A61K35/32 , A61P19/00
CPC分类号： A61K35/32 , A61K35/12 , A61K38/4833 , A61L27/3821 , A61L27/3847 , A61L27/3895 , A61L2430/02 , C12N5/0654 , C12N2533/56
摘要： A compound for bone forming and a method for producing the same are provided using a mixture of an osteoblast and a bio-matrix. The method comprises: isolating osteoblasts from bone tissue and culturing the isolated osteoblasts to prepare an osteoblast suspension; and mixing the resulting osteoblast suspension with a bio-matrix to prepare an osteoblast therapeutic agent. A bone formation method is provided that results in no clinical graft rejection, and is capable of achieving effective and rapid bone formation via injection of a compound which has been pre-shaped to a certain extent, so as to alleviate problems associated with bone tissue formation in unwanted regions resulting from escape of injected osteoblasts from the targeted site for bone formation and then propagation thereof to other sites via the blood stream, which are caused by injection of an osteoblast suspension.
摘要翻译：使用成骨细胞和生物基质的混合物提供骨形成用化合物及其制造方法。该方法包括：从骨组织中分离成骨细胞并培养分离的成骨细胞以制备成骨细胞悬液; 并将所得的成骨细胞悬浮液与生物基质混合以制备成骨细胞治疗剂。提供了一种骨形成方法，其导致没有临床移植物排斥反应，并且能够通过注射预先形成一定程度的化合物来实现有效和快速的骨形成，以便减轻与骨组织形成相关的问题在由注射的成骨细胞从目标部位排出骨形成而导致的不需要的区域中，然后通过注射成骨细胞悬浮液引起的血流将其传播到其它部位。

2. 发明申请

US20080213229A1 Fibrin Contained Semi-Solid Osteoblast Composition for Curing Bone Fracture and Method for Producing the Same 审中-公开
标题翻译：用于固化骨折的纤维蛋白含有半固体成骨细胞组合物及其制备方法
公开(公告)号：US20080213229A1
公开(公告)日：2008-09-04
申请号：US11885943
申请日：2005-08-03
申请人： Hyun-Shin Park , Jae-Deog Jang , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
发明人： Hyun-Shin Park , Jae-Deog Jang , Cheong-Ho Chang , Soo-Jin Jung , Sae-Bom Lee , Chang-Kwon Ko
IPC分类号： A61K35/12
CPC分类号： A61K35/32 , A61K38/363 , A61K38/4833 , A61K2300/00
摘要： A method for producing the fibrin contained semi-solid osteoblast composition has developed for treating the bone fracture. The method is comprised of: isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in Dulbecco's Modified Eagle's Medium (DMEM) or Minimum Essential Medium, Alpha Modification (α-MEM) to prepare an osteoblast suspension. Then, mixing the resulting osteoblast suspension with a coagulation factor to prepare an osteoblast therapeutic agent. Accordingly, the fibrin contained semi-solid osteoblast composition of the present invention has capability to achieve the bone grafting for performing bone union without the clinical graft rejection. It is possible to uniformly distribute the fibrin mixed semi-solid osteoblast composition into the affected area of the bone fracture via injection. Therefore, the fibrin contained semi-solid osteoblast composition is effectively and rapidly cure the bone fracture via constant injection of into the affected area.
摘要翻译：已经开发了用于生产含有纤维蛋白的半固体成骨细胞组合物的方法用于治疗骨折。该方法包括：从骨组织中分离成骨细胞并在Dulbecco's Modified Eagle's Medium（DMEM）或Minimum Essential Medium，Alpha Modification（α-MEM））中培养/增殖分离的成骨细胞以制备成骨细胞悬浮液。然后，将得到的成骨细胞悬浮液与凝血因子混合，制备成骨细胞治疗剂。因此，本发明的纤维蛋白含有半固体成骨细胞组合物具有实现骨移植以进行骨结合而没有临床移植排斥的能力。可以通过注射将纤维蛋白混合的半固体成骨细胞组合物均匀地分布到骨折的受影响区域中。因此，含有纤维蛋白的半固体成骨细胞组合物通过持续注射进入受影响的区域，有效快速地治愈了骨折。

3. 发明授权

US07781158B2 Method of separating collagen from the various animal tissues for producing collagen solution and product using the same 失效
标题翻译：从各种动物组织分离胶原蛋白以产生胶原蛋白溶液的方法和使用其的产品的方法
公开(公告)号：US07781158B2
公开(公告)日：2010-08-24
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： A01N1/00 , C12P21/04 , C12P21/06 , A61K38/00 , A61K38/39 , C07K14/00
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸以进行酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

4. 发明申请

US20080118947A1 Method of Separating Collagen From the Various Animal Tissues for Producing Collagen Solution and Product Using the Same 失效
标题翻译：从各种动物组织分离胶原蛋白的方法，用于生产胶原蛋白溶液和使用其的产品
公开(公告)号：US20080118947A1
公开(公告)日：2008-05-22
申请号：US11885386
申请日：2006-03-09
申请人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
发明人： Ji-Chul Yu , Jae-Deog Jang , Cheong-Ho Chang , Sae-Bom Lee , Se-Geun Yeo , Chang-Kwon Ko
IPC分类号： C12P21/06 , C07K14/78 , A61K38/40
CPC分类号： C07K14/78
摘要： A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.; concentrating collagen by centrifugation; and dissolving the thus-concentrated collagen in refrigerated weakly-acidic solvent or phosphate buffered saline (PBS), thereby preparing collagen having a concentration of 1 to 5 mg/mL.
摘要翻译：公开了从各种动物组织分离胶原蛋白的方法，用于制备胶原蛋白溶液和使用其的产品。将猪组织加工成具有适当的形式和尺寸用于酸处理。用胃蛋白酶重复酸处理以分离I型或II型胶原蛋白。分离的胶原蛋白进行盐分处理以进行分级和乙醇处理，从初始组织重量获得5〜10％的胶原蛋白。处理所制备的组织以通过胶原分离过程分离胶原。处理分离的胶原蛋白以制备产品。制备产品的方法包括：在低温下在中性条件下处理具有预定浓度的胶原溶液，然后在30至35℃的温度下进行过夜处理; 通过离心浓缩胶原蛋白; 将如此浓缩的胶原蛋白溶解在冷冻的弱酸性溶剂或磷酸盐缓冲盐水（PBS）中，由此制备浓度为1〜5mg / mL的胶原。

5. 发明授权

US09408975B2 Apparatus for operating syringe piston 有权
标题翻译：用于操作注射器活塞的装置
公开(公告)号：US09408975B2
公开(公告)日：2016-08-09
申请号：US14019657
申请日：2013-09-06
申请人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
发明人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
IPC分类号： A61M5/31 , A61M5/315 , A61M5/48 , A61M5/20
CPC分类号： A61M5/31511 , A61M5/20 , A61M5/31 , A61M5/31565 , A61M5/484 , A61M2005/2026
摘要： An apparatus for operating a syringe has developed comprising: an upper semi-cylindrical tube section, semi-circular shaped locking groove and lower semi-cylindrical tube section. The upper semi-cylindrical tube section is integrally formed an upper head part with a threaded hole for axial movement. The lower semi-cylindrical tube section forms a top portion, intermediate portion and end portion. A diameter (Dc) at the intermediate portion larger than the diameter (Dtip) at end portion is gradually reduced from intermediate to end portion. The length of the tapered portion is same as that portion of the constant diameter. A tip portion has formed an opened semi-circular shape to simply overlap the syringe over the cartridge for easily snapping-in and out. The syringe piston moves downward with no reverse action when the piston press-unit is rotated, thus it is possible to inject the precise amount of medicine to a patient with constant pressure.
摘要翻译：已经开发了一种用于操作注射器的装置，其包括：上半圆筒管部分，半圆形锁定槽和下半圆筒管部分。上部半圆柱形管部分一体地形成有具有用于轴向移动的螺纹孔的上部头部。下半圆柱形管部分形成顶部，中间部分和端部。在中间部分处的直径（Dc）大于端部部分处的直径（Dtip）的直径（Dc）从中间部分逐渐减小。锥形部分的长度与恒定直径的那部分相同。尖端部分形成为开放的半圆形形状，以使得注射器在盒上简单地重叠，以便容易地进入和退出。当活塞压力单元旋转时，注射器活塞向下移动而没有反向作用，因此可以将恒定压力的精确量的药剂注射到患者身上。

6. 发明申请

US20090137965A1 Apparatus for Operating Syringe Piston 审中-公开
标题翻译：用于操作注射器活塞的装置
公开(公告)号：US20090137965A1
公开(公告)日：2009-05-28
申请号：US12226316
申请日：2006-06-02
申请人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
发明人： Seok-Jung Kim , Cheong-Ho Chang , Jae-Deog Jang , Hyun-Shin Park , Sae-Bom Lee , Kyoung-Phil Byun
IPC分类号： A61M5/315
CPC分类号： A61B17/8822 , A61M5/315
摘要： An apparatus for operating a syringe piston is developed, which is comprised of: a syringe mounting section for fixedly holding a syringe, a thread hole formed at an upper head part of the syringe mounting section, and a piston press unit having a threaded rod, which is inserted into the thread hole so that the syringe piston press unit can move up and down along the thread hole, a locking slot for fixedly inserting and retaining the medicine filled syringe, a semi-cylindrical tube to assemble with the syringe mounting section. The syringe filled with medical cement is attached to the syringe mounting section and the syringe piston is moved downward with no reverse movement when the piston press unit is rotated, so the medical cement contained in the syringe is injected with a constant pressure, so that a predetermined amount of medical cement is precisely injected into a patient's body.
摘要翻译：开发了一种用于操作注射器活塞的装置，其包括：用于固定地保持注射器的注射器安装部分，形成在注射器安装部分的上头部的螺纹孔和具有螺杆的活塞压力单元，其插入到螺纹孔中，使得注射器活塞压力单元可以沿着螺纹孔上下移动，用于固定地插入和保持药液填充的注射器的锁定槽，与注射器安装部分组装的半圆柱形管。填充有医用水泥的注射器被安装在注射器安装部上，当活塞压力单元旋转时，注射器活塞不会反向移动，所以注射器中所含的医用胶水被注入一定的压力，将预定量的医用水泥精确地注入患者体内。

7. 发明申请

US20090111087A1 Separation method of Nucleated Cells Derived from Bone Marrow for Bone Formation 审中-公开
标题翻译：来自骨髓的成骨细胞分离方法用于骨形成
公开(公告)号：US20090111087A1
公开(公告)日：2009-04-30
申请号：US12226472
申请日：2006-06-23
申请人： Hyun-Shin Park , Jae-Deog Jang , Sae-Bom Lee , Cheong-Ho Chang
发明人： Hyun-Shin Park , Jae-Deog Jang , Sae-Bom Lee , Cheong-Ho Chang
IPC分类号： A01N1/02
CPC分类号： C12N5/0654 , A61K35/28
摘要： The present invention relates to a method for separating bone marrow-derived nucleated cells for bone formation. The method comprises: the steps of: washing bone marrow; lysing red blood cells in the bone marrow; neutralizing the bone marrow lysate; purifying nucleated cells from the neutralized bone marrow; and mixing the nucleated cells with a maintenance buffer for bone formation. According to the invention, bone marrow-derived nucleated cells, which can be grafted into a site in need of bone formation or bone defect treatment, can be separated in a rapid and convenient manner. As a result, bone formation in emergency patients or patients, who require repeated surgical operations, can be effectively achieved by separating the nucleated cells for bone formation in surgical locations in a convenient and rapid manner and injecting the separated cells into the patients.
摘要翻译：本发明涉及用于分离用于骨形成的骨髓衍生的有核细胞的方法。该方法包括：洗涤骨髓; 裂解骨髓中的红细胞; 中和骨髓裂解物; 从中和骨髓中纯化有核细胞; 并将有核细胞与用于骨形成的维持缓冲液混合。根据本发明，可以以快速方便的方式分离可以移植到需要骨形成或骨缺损处理的部位的骨髓衍生的有核细胞。结果，需要重复外科手术的急诊患者或患者的骨形成可以通过以方便和快速的方式分离外科手术位置中的骨形成核细胞并将分离的细胞注射入患者中来有效地实现。

8. 发明授权

US09011929B2 Composition for inducing tissue regeneration by activating platelet-rich plasma (PRP) 有权
标题翻译：通过激活富血小板血浆（PRP）诱导组织再生的组合物
公开(公告)号：US09011929B2
公开(公告)日：2015-04-21
申请号：US13502116
申请日：2009-11-17
申请人： Hyun-Shin Park , Ji-Chul Yu , Ju-Hee Park , Jang-Hoon Kim , Hun Kim , Sae-Bom Lee , Jae-Deog Jang , Cheong-Ho Jang
发明人： Hyun-Shin Park , Ji-Chul Yu , Ju-Hee Park , Jang-Hoon Kim , Hun Kim , Sae-Bom Lee , Jae-Deog Jang , Cheong-Ho Jang
IPC分类号： A61K35/16 , A61K38/39 , A61L27/36 , A61L27/24 , A61L27/38
CPC分类号： A61L27/3616 , A61K35/16 , A61K38/39 , A61L27/24 , A61L27/38 , A61K2300/00
摘要： The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.
摘要翻译：本发明涉及一种用于软骨组织修复的组合物及其制备方法。本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便使损伤的软骨组织被修复到允许移植到组织上的状态，从而可以有效地再生，减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

9. 发明申请

US20120207736A1 COMPOSITION FOR CARTILAGINOUS TISSUE REPAIR AND A PRODUCTION METHOD THEREFOR 审中-公开
标题翻译：用于组织织物修复的组合物及其生产方法
公开(公告)号：US20120207736A1
公开(公告)日：2012-08-16
申请号：US13503228
申请日：2009-12-03
申请人： Cheong-Ho Jang , Ji-Chul Yu , Sae-Bom Lee , Hyun-Shin Park , Hyun-Jo Kim , Jae-Deog Jang , Se-Ken Yeo , Ju-Hee Park , Seok-Jung Kim
发明人： Cheong-Ho Jang , Ji-Chul Yu , Sae-Bom Lee , Hyun-Shin Park , Hyun-Jo Kim , Jae-Deog Jang , Se-Ken Yeo , Ju-Hee Park , Seok-Jung Kim
IPC分类号： A61K38/48 , A61P19/00
CPC分类号： A61L27/26 , A61F2002/30766 , A61L2400/06 , A61L2430/06 , C08L89/06
摘要： The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.
摘要翻译：本发明涉及一种用于软骨组织修复的组合物及其制备方法。本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便将损伤的软骨组织修复到允许移植到组织上的状态，从而可以有效地再生，减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

10. 发明申请

US20120201897A1 COMPOSITION FOR INDUCING TISSUE REGENERATION BY ACTIVATING PLATELET-RICH PLASMA (PRP), AND METHOD FOR MANUFACTURING SAME 有权
标题翻译：用于通过激活血浆PLSMA（PRP）诱导组织再生的组合物及其制造方法
公开(公告)号：US20120201897A1
公开(公告)日：2012-08-09
申请号：US13502116
申请日：2009-11-17
申请人： Hyun-Shin Park , Ji-Chul Yu , Ju-Hee Park , Jang-Hoon Kim , Hun Kim , Sae-Bom Lee , Jae-Deog Jang , Cheong-Ho Jang
发明人： Hyun-Shin Park , Ji-Chul Yu , Ju-Hee Park , Jang-Hoon Kim , Hun Kim , Sae-Bom Lee , Jae-Deog Jang , Cheong-Ho Jang
IPC分类号： A61K35/16 , A61P43/00
CPC分类号： A61L27/3616 , A61K35/16 , A61K38/39 , A61L27/24 , A61L27/38 , A61K2300/00
摘要： The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.
摘要翻译：本发明涉及一种用于软骨组织修复的组合物及其制备方法。本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便使损伤的软骨组织被修复到允许移植到组织上的状态，从而可以有效地再生，减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

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