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1. 发明授权

US06562011B1 Medication delivery device 失效
标题翻译：药物输送装置
公开(公告)号：US06562011B1
公开(公告)日：2003-05-13
申请号：US09348536
申请日：1999-07-07
申请人： Thomas Buch-Rasmussen , Benny Munk , Jens Ulrik Poulsen , Henrik Ljungreen , Peter Møller Jensen , Jens Møller Jensen
发明人： Thomas Buch-Rasmussen , Benny Munk , Jens Ulrik Poulsen , Henrik Ljungreen , Peter Møller Jensen , Jens Møller Jensen
IPC分类号： A61M500
CPC分类号： A61M5/24 , A61M5/31525 , A61M5/31535 , A61M5/31566 , A61M5/31578 , A61M2005/2407 , A61M2005/2488 , A61M2005/2492
摘要： The present invention relates to a medication delivery device comprising a cartridge assembly, a dosing assembly and optionally a needle assembly. The cartridge assembly comprises a cartridge having a stopper adapted to receive a plunger means. Furthermore, the cartridge assembly has one end sealed with a pierceable sealing, said end comprising coupling means for engaging a needle assembly, and another end comprising coupling means for engaging the dosing assembly. At least one of the coupling means of the cartridge assembly is unitarily moulded with the cartridge. The dosing assembly comprises a plunger means and has coupling means for engaging the cartridge assembly. The cartridge assembly and the dosing assembly are coupled together for delivering selected doses of medication. The cartridge is preferably moulded from a plastic material, such as a transparent material, and may be housed in a cartridge housing for protection of the cartridge. The coupling means may be selected from threaded locks, snap locks, hinged locks, or bajonet locks. The medication delivery device is especially suitable for delivering insulin, growth hormone or other medicines.
摘要翻译：本发明涉及药物输送装置，其包括药筒组件，剂量组合件和任选的针组件。盒组件包括具有适于容纳柱塞装置的止动件的盒。此外，盒组件具有用可刺破密封件密封的一端，所述端部包括用于接合针组件的联接装置，以及包括用于接合给药组件的联接装置的另一端。盒组件的联接装置中的至少一个与盒一体地模制。配料组件包括柱塞装置并具有用于接合盒组件的联接装置。药筒组件和剂量组合件联接在一起以递送选定剂量的药物。盒优选地由诸如透明材料的塑料材料成型，并且可以容纳在盒壳体中以保护盒。联接装置可以选自螺纹锁，卡扣锁，铰链锁或双面胶锁。药物输送装置特别适用于输送胰岛素，生长激素或其他药物。

2. 发明授权

US06582408B1 Medical device 失效
标题翻译：医疗装置
公开(公告)号：US06582408B1
公开(公告)日：2003-06-24
申请号：US09349748
申请日：1999-07-08
申请人： Thomas Buch-Rasmussen , Benny Munk , Jens Ulrik Poulsen , Henrik Ljungreen , Peter Møller Jensen , Jens Møller Jensen
发明人： Thomas Buch-Rasmussen , Benny Munk , Jens Ulrik Poulsen , Henrik Ljungreen , Peter Møller Jensen , Jens Møller Jensen
IPC分类号： A61M500
CPC分类号： A61M5/315 , A61M5/24 , A61M5/3129 , A61M5/31525 , A61M5/31535 , A61M5/31566 , A61M5/31578 , A61M2005/2407 , A61M2005/2488 , A61M2005/2492
摘要： The present invention relates to a medication delivery device comprising a cartridge assembly, a dosing assembly and optionally a needle assembly. The cartridge assembly comprises a cartridge having a stopper adapted to receive a plunger. Furthermore, the cartridge assembly has one end sealed with a pierce able sealing, said end comprising coupling device for engaging a needle assembly, and another end comprising coupling device for engaging the dosing assembly. The dosing assembly comprises a plunger and has coupling device for engaging the cartridge assembly. The cartridge assembly and the dosing assembly are coupled together for delivering selected doses of medication. The device further comprises mechanism for securing that the plunger abuts on the stopper during use of the device, in particular when the dosing assembly is releasable coupled to the cartridge assembly. The securing mechanism is preferably a mechanism for preventing the cartridge assembly from being inadvertently released from the dosing assembly. The cartridge is preferably molded from a plastic material, such as a transparent material, and may be housed in a cartridge housing for protection of the cartridge. The medication delivery device is especially suitable for delivering insulin, growth hormone or the like medicines.
摘要翻译：本发明涉及药物输送装置，其包括药筒组件，剂量组合件和任选的针组件。盒组件包括具有适于容纳柱塞的止动件的盒。此外，盒组件具有用可刺穿密封件密封的一端，所述端部包括用于接合针组件的联接装置，以及包括用于接合给药组件的联接装置的另一端。配料组件包括柱塞并具有用于接合盒组件的联接装置。药筒组件和剂量组合件联接在一起以递送选定剂量的药物。该装置还包括用于在使用装置期间固定柱塞抵靠止动件的机构，特别是当定量给料组件可释放地联接到药筒组件时。固定机构优选地是用于防止盒组件被无意地从定量给料组件释放的机构。盒优选地由诸如透明材料的塑料材料模制，并且可以容纳在盒壳体中以保护盒。药物输送装置特别适用于输送胰岛素，生长激素等药物。

3. 发明授权

US06312413B1 Cylinder ampoule 失效
标题翻译：气瓶安瓿
公开(公告)号：US06312413B1
公开(公告)日：2001-11-06
申请号：US09176581
申请日：1998-10-21
申请人： Jens Møller Jensen , Thomas Buch-Rasmussen , Jens Ulrik Poulsen
发明人： Jens Møller Jensen , Thomas Buch-Rasmussen , Jens Ulrik Poulsen
IPC分类号： A61M500
CPC分类号： A61M5/31511 , A61M5/284 , A61M5/288 , A61M5/3129 , A61M5/31551 , A61M5/31561 , A61M5/31563 , A61M2005/3103
摘要： A cylinder ampoule (1) having a first end sealed by a closure through which an injection unit can communicate with a medicament in the ampoule and a second end closed by a piston (3) which can be forced into the ampoule (1) to press out a dose of a medicament stored in the ampoule between the closure and the piston (3) through said injection unit, which cylinder ampoule (1) has a non-circular inner cross section and which piston (3) has a non-circular cross section corresponding to the inner cross section of the ampoule (1). A piston rod (4) has a pressure foot (5) which has a cross section corresponding to the inner cross section of the ampoule (1) and is non-rotatably connected to the piston rod (4).
摘要翻译：一种气瓶安瓿（1），其具有由封闭件密封的第一端，注射单元可以通过该封闭件与安瓿中的药物连通，以及由活塞（3）封闭的第二端，所述活塞可以被迫进入安瓿（1）以按压通过所述注射单元排出存储在封闭件和活塞（3）之间的安瓿中的药物的剂量，该气瓶安瓿（1）具有非圆形的内部横截面，并且该活塞（3）具有非圆形横截面对应于安瓿（1）的内部横截面的截面。活塞杆（4）具有压力脚（5），其具有与安瓿（1）的内横截面对应的横截面，并且不可旋转地连接到活塞杆（4）。

4. 发明授权

US06755810B1 Medicament transferring device 失效
标题翻译：药物转运装置
公开(公告)号：US06755810B1
公开(公告)日：2004-06-29
申请号：US09856258
申请日：2001-09-20
申请人： Thomas Buch-Rasmussen , Jens-Ulrik Poulsen , Henrik Ljunggreen
发明人： Thomas Buch-Rasmussen , Jens-Ulrik Poulsen , Henrik Ljunggreen
IPC分类号： A61M532
CPC分类号： A61J1/2096 , A61J1/201 , A61M5/1782 , A61M5/31511
摘要： The present invention relates to a transfer device for transferring medicament from a medicament container to a syringe with a needle. The transfer device is arranged for transferring accurate dosages of insulin, growth hormone or other medicaments. The accuracy is ensured by the device comprising means for mounting a syringe to the device, the needle piercing a sealing of the device. Opposite the sealing a piston is arranged, said piston being non-releasable engaged with the piston driver during transfer of the medicament. Thereby the piston is not erroneously drawn from the piston driver, which would otherwise lead to incorrect dosing. Furthermore, the device comprises dosing means including the piston driver.
摘要翻译：本发明涉及一种用于将药物从药物容器转移到具有针的注射器的转移装置。转移装置被设置用于转移精确剂量的胰岛素，生长激素或其他药物。通过装置确保精度，该装置包括用于将注射器安装到装置的装置，针刺穿装置的密封。在密封件相对的位置布置有活塞，所述活塞在药物转移期间不可释放地与活塞驱动器接合。因此，活塞不会从活塞驱动器错误地抽出，否则会导致不正确的配量。此外，该装置包括包括活塞驱动器的计量装置。

5. 发明授权

US6010485A Working cylinder 失效
标题翻译：工作缸
公开(公告)号：US6010485A
公开(公告)日：2000-01-04
申请号：US932354
申请日：1997-09-17
申请人： Thomas Buch-Rasmussen , Jens Ulrik Poulsen , Henrik Ljunggreen , Jens M.o slashed.ller Jensen
发明人： Thomas Buch-Rasmussen , Jens Ulrik Poulsen , Henrik Ljunggreen , Jens M.o slashed.ller Jensen
IPC分类号： A61M5/31 , A61M5/178 , A61M5/20 , A61M5/315 , A61M39/00 , A61M5/00
CPC分类号： A61M5/31525 , A61M5/204 , A61M5/31595 , A61M5/31555 , A61M5/31561 , A61M5/3158
摘要： The present invention relates to a drug delivery system, comprising a reservoir from which set doses are apportioned, a dose setting mechanism by which the relative position of two elements is changed by a distance proportional to a set dose, and a push button by activation of which an element is moved a distance corresponding to the distance proportional to the set dose, further comprises a working cylinder having an open end into which a plunger fits, and a closed end at which an inlet and an outlet port connect the space beneath the plunger with an inlet communicating with the reservoir and an outlet communicating with a drug delivery member, respectively. Valves means at the inlet and outlet control the passages from the reservoir to the working cylinder and from the working cylinder to the drug delivery member, respectively. The cylinder with the plunger, and the injection member are independently exchangeable, disposable parts.
摘要翻译：本发明涉及一种药物递送系统，其包括分配设定剂量的储存器，剂量设定机构，通过该剂量设定机构将两个元件的相对位置改变与设定剂量成比例的距离，以及按钮，通过激活元件被移动到与设定剂量成比例的距离处的距离，还包括具有开口端的柱塞配合的工作缸和入口和出口连接柱塞下方的空间的封闭端其中入口与储存器连通并且分别与药物递送构件连通。阀门在入口和出口处分别控制从储存器到工作缸以及从工作缸到药物传送构件的通道。具有柱塞的气缸和注射构件可独立地更换，一次性部件。

6. 发明授权

US06485453B1 Cassette for storing and insertion of solid medicine 有权
标题翻译：用于储存和插入固体药物的盒子
公开(公告)号：US06485453B1
公开(公告)日：2002-11-26
申请号：US09548957
申请日：2000-04-13
申请人： Thomas Buch-Rasmussen , Søren Aasmul , James M. Flink , Philip Hansen , Claus Juul-Mortensen , Jens Ulrik Poulsen
发明人： Thomas Buch-Rasmussen , Søren Aasmul , James M. Flink , Philip Hansen , Claus Juul-Mortensen , Jens Ulrik Poulsen
IPC分类号： A61M3100
CPC分类号： A61M37/0069 , A61M31/007 , A61M2205/123
摘要： A cassette for storing and insertion of a solid medicine peg appears as a unit having a first bore (2) which accommodates the medicine peg (3) and has a diameter corresponding to the diameter of this peg (3), a second bore (4) in coaxial extension of the first bore (2) and having a diameter larger than the diameter of the first bore (2), an inserter having a shaft (5) fitting into the first bore (2) and a guiding head (6) in coaxial extension of the shaft (5) fitting into the second bore. The inserter shaft (5) has one end adjacent to the peg (3) and the other connected to the guiding head (6) which projects from the cassette. The head (6) fits into the second bore with a fitting providing a diffusion tight sealing and the distal end of the unit is closed by a membrane diffusion tightly sealing this distal end.
摘要翻译：用于存放和插入固体药物栓钉的盒子出现为具有容纳药物钉（3）的第一孔（2）的单元，并且具有对应于该栓钉（3）的直径的直径，第二孔（4）），其具有大于所述第一孔（2）的直径的直径，所述插入器具有装配到所述第一孔（2）中的轴（5）和引导头（6）在轴（5）的同轴延伸中装配到第二孔中。插入器轴（5）具有与钉（3）相邻的一端，另一端连接到从盒突出的引导头（6）。头部（6）通过具有扩散密封的配件装配到第二孔中，并且单元的远端通过密封该远端的膜扩散来封闭。

7. 发明授权

US06660197B1 Method for producing an elongated drug formation 有权
标题翻译：用于生产细长药物组合物的方法
公开(公告)号：US06660197B1
公开(公告)日：2003-12-09
申请号：US09689189
申请日：2000-10-12
申请人： Thomas Buch-Rasmussen , Søren Aasmul , James M. Flink , Philip Hansen , Claus Juul-Mortensen , Jens-Ulrik Poulsen
发明人： Thomas Buch-Rasmussen , Søren Aasmul , James M. Flink , Philip Hansen , Claus Juul-Mortensen , Jens-Ulrik Poulsen
IPC分类号： B29B1112
CPC分类号： A61J3/06 , A61J2200/20 , B30B11/16
摘要： The present invention relates to a method and a system for producing an elongated drug formulation being suitable for being injected through the skin of a patient with-out the use of a needle or a cannula. The drug formulation is produced by compressing a drug granulate in cavity of a system comprising a roller and a surface, wherein the roller roles over the surface thereby comprising the granulate to the formulation.
摘要翻译：本发明涉及用于生产细长药物制剂的方法和系统，该方法和系统适用于通过使用针或套管而通过患者的皮肤注射。药物制剂通过在包含辊子和表面的系统的腔体中压缩药物颗粒而制备，其中辊子在表面上的角色，由此包含制剂的颗粒。

8. 发明申请

US20080255440A1 Method of Forming a Sterilized Sensor Package and a Sterilized Sensor Package 审中-公开
标题翻译：形成灭菌传感器封装和灭菌传感器封装的方法
公开(公告)号：US20080255440A1
公开(公告)日：2008-10-16
申请号：US11660035
申请日：2005-07-13
申请人： Michael Eilersen , Thomas Buch-Rasmussen , Kristian Glejbol
发明人： Michael Eilersen , Thomas Buch-Rasmussen , Kristian Glejbol
IPC分类号： A61B5/00 , B65B55/08
CPC分类号： A61B5/14865 , A61B5/076 , A61B5/14532 , A61B5/6849 , A61B2560/063 , A61B2562/125 , A61B2562/242 , A61L2/087 , A61N1/05 , A61N1/08 , A61N1/375
摘要： A sensor package is provided comprising an implantable sensor having an electrode area and an electric contact area, the package comprising a shielding packaging enclosing at least the electrode area of the sensor while exposing the electric contact area. The sensor package fascilitates handling of the implantable sensor and provides for the possibility of sterilising the electric contact area leaving the electrode area protected.
摘要翻译：提供了包括具有电极区域和电接触区域的可植入传感器的传感器封装，所述封装包括在暴露所述电接触区域的同时封闭所述传感器的电极区域的屏蔽封装。传感器组件可以处理植入式传感器的处理，并提供对电气接触区域进行灭菌的可能性，使电极区域受到保护。

9. 发明授权

US06461334B1 Medical article with coated surfaces exhibiting low friction and protein adsorption 失效
标题翻译：具有低摩擦和蛋白质吸附的涂层表面的医疗制品
公开(公告)号：US06461334B1
公开(公告)日：2002-10-08
申请号：US09260758
申请日：1999-03-02
申请人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni
发明人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni
IPC分类号： A61M5315
CPC分类号： A61M5/31513 , A61J1/062 , A61M5/2448 , A61M2005/3131
摘要： The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating in ternal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.
摘要翻译：本发明涉及一种用于容纳含有至少第一组分和第二组分的药物蛋白质制剂的医疗制品，其具有至少一个涂覆有涂层的表面以减少两种组分之间的摩擦并减少蛋白质吸附至涂层。涂层是一种亲水性涂层，其中通过水接触角测量的涂层表面的亲水性低于90°，第一和第二组分之间的长期静摩擦力低于14N。根据本发明特别适用于在装有用于贮存和给药液体蛋白制剂例如胰岛素制剂的塞子的容器的三元表面中永久地涂覆。涂层优选为含硅涂层，例如聚（二烷基硅氧烷）油或共聚物。本发明还涉及如上所述涂敷的医疗用品的成分的制造方法，其特征在于，在成型前将所述涂料添加到所述成分材料中，从所述混合物中随后成型所述成分，或者从所述成分材料成型所述成分，随后将涂层材料施加到部件的至少一个表面，并且在模制之前或模制之后使涂层材料亲水化。本发明还涉及如上所述的具有至少第一组分和第二组分的制品的涂层。

10. 发明授权

US5945187A Medicament container of polymer of linear olefin for storing a liquid medicament 失效
标题翻译：用于储存液体药物的线性烯烃聚合物的药物容器
公开(公告)号：US5945187A
公开(公告)日：1999-08-31
申请号：US991518
申请日：1997-12-16
申请人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne J.o slashed.rgensen
发明人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne J.o slashed.rgensen
IPC分类号： A61J1/00 , A61J1/05 , A61J1/06 , C08K3/40 , C08L23/04 , C08L23/10 , C08L23/12 , C08L45/00 , C08L23/00
CPC分类号： A61J1/062 , A61J1/10 , C08L23/04 , C08L23/10 , C08L23/12 , Y10T428/1352 , Y10T428/1397
摘要： A medicaments, container for storing a liquid medicament comprising one or more active medicaments, water and at least one preservative has a preferably cylindrical wall defining an interior space for such liquid medicament. The wall includes at least two opposed portions composed of a polymer material with a thickness of between 0.3 mm and 3 mm, a light transmission at 400 nm of 25% or more measured through the opposed container wall portions when the container is filled with water, using a standard spectrophotometer and air as reference. The polymer wall portions are of a material comprising at least 70% by weight of a linear optionally branched polyolefin material, the olefin monomer being selected from ethylene, propylene, butylene or a mixture thereof The polyolefin material has a crystallinity above 35% by weight, measured by differential scanning calorimetry, by cutting pieces from the container walls and heating them in an aluminum pan from 10.degree. C. to 270.degree. C. at the scanning rate of 10.degree. C./min, recording and integrating the melting endotherms, and using the value of 209 J/g for 100% crystalline polypropylene as a reference.
摘要翻译：药物，用于储存包含一种或多种活性药物，水和至少一种防腐剂的液体药物的容器具有限定用于这种液体药物的内部空间的优选圆柱形壁。所述壁包括至少两个相对部分，所述至少两个相对部分由厚度在0.3mm至3mm之间的聚合物材料组成，当容器充满水时通过相对的容器壁部分测量的400nm的透光率为25％或更高，使用标准分光光度计和空气作为参考。聚合物壁部分是包含至少70重量％的线性任意支化聚烯烃材料的材料，烯烃单体选自乙烯，丙烯，丁烯或其混合物。聚烯烃材料的结晶度高于35重量％通过差示扫描量热法测量，通过从容器壁切割并将其在10℃至270℃的铝盘中以10℃/分钟的扫描速率加热，记录并整合熔融吸热温度，使用209J / g的值作为100％结晶聚丙烯的参考。

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