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1. 发明授权

US06482509B2 Coating system providing low friction 有权
标题翻译：涂层系统提供低摩擦
公开(公告)号：US06482509B2
公开(公告)日：2002-11-19
申请号：US09260757
申请日：1999-03-02
申请人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni , Nils Berg Madsen
发明人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni , Nils Berg Madsen
IPC分类号： B32B1706
CPC分类号： C08J7/047 , A61J1/062 , A61M5/3129 , A61M5/31513 , A61M2005/3131 , C08J2483/00 , Y10T428/265 , Y10T428/31612 , Y10T428/31663 , Y10T428/31667
摘要： The present invention relates to a coating system, in particular to a coating system for articles where plastic materials slide against flexible rubber materials. The coating system is a silicone oil based coating having a viscosity of at least 200,000 centistokes, i.e. a high viscosity coating. The coating comprises in a preferred embodiment a silicone oil based block or graft copolymer, or segmented copolymer. Further the invention relates to a process of producing a component of an article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, as well as an article coated with a silicone oil based coating as defined above. Such an article is preferably a medical article, such as a container or an injection cylinder and a stopper. The coatings according to the present invention are especially suited to use for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations. The coatings providing low friction between the two components, such as a container wall and a rubber stopper, result in high-precision dosing. The described coatings are particularly useful for coating containers for storage and administration of liquid protein solutions, such as insulin formulations.
摘要翻译：本发明涉及一种涂覆系统，特别涉及一种用于制品的涂层系统，其中塑料材料滑动抵靠柔性橡胶材料。该涂层系统是一种硅油基涂层，其粘度至少为20万厘沲，即高粘度涂层。该涂层在优选的实施方案中包括基于硅油的嵌段或接枝共聚物或分段的共聚物。此外，本发明涉及一种制造如上所述涂覆的制品的组分的方法，包括在模制之前将涂料添加到组分材料中，随后从混合物中模制组分，或者将组分从组分材料中模制，随后将涂层材料施加到部件的至少一个表面上，以及涂覆有如上所述的硅油基涂层的制品。这样的制品优选为医疗用品，例如容器，注射筒和塞子。根据本发明的涂层特别适用于永久地涂覆装有用于储存和施用液体蛋白制剂的塞子的容器的内表面。在两个部件之间提供低摩擦的涂层，例如容器壁和橡胶塞，导致高精度计量。所描述的涂层对于包衣容器特别有用，用于储存和施用液体蛋白质溶液，例如胰岛素制剂。

2. 发明授权

US06461334B1 Medical article with coated surfaces exhibiting low friction and protein adsorption 失效
标题翻译：具有低摩擦和蛋白质吸附的涂层表面的医疗制品
公开(公告)号：US06461334B1
公开(公告)日：2002-10-08
申请号：US09260758
申请日：1999-03-02
申请人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni
发明人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni
IPC分类号： A61M5315
CPC分类号： A61M5/31513 , A61J1/062 , A61M5/2448 , A61M2005/3131
摘要： The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating in ternal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.
摘要翻译：本发明涉及一种用于容纳含有至少第一组分和第二组分的药物蛋白质制剂的医疗制品，其具有至少一个涂覆有涂层的表面以减少两种组分之间的摩擦并减少蛋白质吸附至涂层。涂层是一种亲水性涂层，其中通过水接触角测量的涂层表面的亲水性低于90°，第一和第二组分之间的长期静摩擦力低于14N。根据本发明特别适用于在装有用于贮存和给药液体蛋白制剂例如胰岛素制剂的塞子的容器的三元表面中永久地涂覆。涂层优选为含硅涂层，例如聚（二烷基硅氧烷）油或共聚物。本发明还涉及如上所述涂敷的医疗用品的成分的制造方法，其特征在于，在成型前将所述涂料添加到所述成分材料中，从所述混合物中随后成型所述成分，或者从所述成分材料成型所述成分，随后将涂层材料施加到部件的至少一个表面，并且在模制之前或模制之后使涂层材料亲水化。本发明还涉及如上所述的具有至少第一组分和第二组分的制品的涂层。

3. 发明授权

US06680091B2 Medicament container of polymer of cyclic hydrocarbon for storing a liquid medicament 失效
标题翻译：用于储存液体药物的环状烃聚合物的药物容器
公开(公告)号：US06680091B2
公开(公告)日：2004-01-20
申请号：US08991519
申请日：1997-12-16
申请人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen
发明人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen
IPC分类号： B29D2200
CPC分类号： A61J1/062 , A61J1/10 , C08L23/04 , C08L23/10 , C08L23/12 , Y10T428/1352 , Y10T428/1397
摘要： A medicament container for storing a liquid medicament, such as insulin, comprises a wall with at least two opposite portions made of a polymer material having a light transmission at 400 nm of at least 25%, a glass transition temperature above 50° C., and a density of 0.95 g/cm3 or more. The polymer material comprises at least 70% by weight of a copolymer material composed of aliphatic cyclic or bicyclic hydrocarbons with 5 to 7 membered ring or rings and ethylene or propylene. The container is substantially inert to the medicament and, because it is either transparent or at least includes at least two opposed transparent portions, it is possible visually to inspect the contents of the container to make sure that the medicament has not crystalized or polymerized. The walls of the container provide a good barrier against m-cresol/phenol/benzyl alcohol preservatives and water.
摘要翻译：用于储存诸如胰岛素的液体药物的药物容器包括具有至少两个相对部分的壁，所述至少两个相对部分由聚合物材料制成，所述聚合物材料在400nm处的透光率至少为25％，玻璃化转变温度高于50℃，且密度为0.95g / cm 3以上。聚合物材料包含至少70重量％的由具有5至7元环或环的脂族环或双环烃和乙烯或丙烯组成的共聚物材料。容器对药物基本上是惰性的，并且由于其是透明的或至少包括至少两个相对的透明部分，所以可以在目视上检查容器的内容物以确保药物未结晶化或聚合。容器壁提供了对间甲酚/苯酚/苯甲醇防腐剂和水的良好屏障。

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