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1. 发明申请

US20110186165A1 THREE-DIMENSIONAL MICROFLUIDIC PLATFORMS AND METHODS OF USE AND MANUFACTURE THEREOF 审中-公开
标题翻译：三维微流平台及其使用和制造方法
公开(公告)号：US20110186165A1
公开(公告)日：2011-08-04
申请号：US12898307
申请日：2010-10-05
申请人： Jeffrey T. Borenstein , Joseph L. Charest , Jessie Sungyun Jeon , Roger D. Kamm , Seok Chung , Ioannis Zervantonakis , Vernella Vickerman
发明人： Jeffrey T. Borenstein , Joseph L. Charest , Jessie Sungyun Jeon , Roger D. Kamm , Seok Chung , Ioannis Zervantonakis , Vernella Vickerman
IPC分类号： F15C1/06 , B29C59/02
CPC分类号： C12M23/16 , B01L3/502707 , C12M25/14 , Y10T137/2224 , Y10T156/1002
摘要： Microfluidic devices may be fabricated from thermoplastics using, for example, hot embossing techniques. In some embodiments, the devices feature non-uniform surface modifications.
摘要翻译：微流体装置可以使用例如热压花技术由热塑性塑料制成。在一些实施例中，装置具有不均匀的表面修改。

2. 发明授权

US09121847B2 Three-dimensional microfluidic platforms and methods of use thereof 有权
标题翻译：三维微流体平台及其使用方法
公开(公告)号：US09121847B2
公开(公告)日：2015-09-01
申请号：US12936954
申请日：2009-04-03
申请人： Roger D. Kamm , Seok Chung , Vernella V. Vickerman-Kelley
发明人： Roger D. Kamm , Seok Chung , Vernella V. Vickerman-Kelley
IPC分类号： C12M1/34 , G01N33/50 , C12Q1/02 , B01L3/00
CPC分类号： G01N33/5029 , B01L3/5027 , C12M23/16 , C12M25/14 , C12M41/46 , C12Q1/02 , G01N33/5082 , G01N2333/515
摘要： Provided are methods and devices for formation and study of three-dimensional biological systems, including prokaryotic and eukaryotic cell migration, proliferation, and differentiation.
摘要翻译：提供用于形成和研究三维生物系统的方法和装置，包括原核和真核细胞迁移，增殖和分化。

3. 发明申请

US20110159522A1 Three-Dimensional Microfluidic Platforms and Methods of Use Thereof 有权
标题翻译：三维微流控平台及其使用方法
公开(公告)号：US20110159522A1
公开(公告)日：2011-06-30
申请号：US12936954
申请日：2009-04-03
申请人： Roger D. Kamm , Seok Chung , Vernella V. Vickerman-Kelley
发明人： Roger D. Kamm , Seok Chung , Vernella V. Vickerman-Kelley
IPC分类号： C12Q1/02 , C12M1/34 , G01N33/53
CPC分类号： G01N33/5029 , B01L3/5027 , C12M23/16 , C12M25/14 , C12M41/46 , C12Q1/02 , G01N33/5082 , G01N2333/515
摘要： Provided are methods and devices for formation and study of three-dimensional biological systems, including prokaryotic and eukaryotic cell migration, proliferation, and differentiation.
摘要翻译：提供用于形成和研究三维生物系统的方法和装置，包括原核和真核细胞迁移，增殖和分化。

4. 发明申请

US20160097027A1 Engineering Of A Novel Breast Tumor Microenvironment On A Microfluidic Chip 有权
标题翻译：微流控芯片上的新型乳腺肿瘤微环境工程
公开(公告)号：US20160097027A1
公开(公告)日：2016-04-07
申请号：US14872920
申请日：2015-10-01
申请人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
发明人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
IPC分类号： C12M3/06 , C12M1/00 , C12M1/12
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L2300/0816 , B01L2300/12 , C12M25/14 , G01N33/5011
摘要： A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may further comprise one or more endothelial cells, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, and a second three dimensional scaffold comprising one or more stromal cells, at least a portion of which is interposed between the one or more microfluidic channels and the first three dimensional scaffold. The second three dimensional scaffold is in fluid communication with both the first three dimensional scaffold and the one or more microfluidic channels. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.
摘要翻译：公开了一种用于更准确地模拟发生癌症的体外环境的微流体装置。该装置包括限定一个或多个微流体通道的表面，其可以进一步包含一个或多个内皮细胞，第一三维支架，其包含一个或多个在空间上与一个或多个微流体通道分离的癌细胞，以及第二三维支架其包含一个或多个基质细胞，其至少一部分介于所述一个或多个微流体通道和所述第一三维支架之间。第二三维支架与第一三维支架和一个或多个微流体通道流体连通。该装置可用于测定抗癌剂，或用作对癌细胞的生长，行为或转移和肿瘤形成进行建模的系统。

5. 发明授权

US06605053B1 Conduit designs and related methods for optimal flow control 失效
标题翻译：管道设计和相关方法，以实现最佳流量控制
公开(公告)号：US06605053B1
公开(公告)日：2003-08-12
申请号：US09657567
申请日：2000-09-08
申请人： Roger D. Kamm , Eun Bo Shim
发明人： Roger D. Kamm , Eun Bo Shim
IPC分类号： A61M500
CPC分类号： A61F2/06 , A61B2017/00252 , A61F2/2493 , G06F19/00 , G16H50/50
摘要： A bypass conduit and related methods include implanting a bypass in the heart between a heart chamber and an at least partially occluded artery to directly flow blood from the chamber to the artery. The bypass conduit is configured to have a higher resistance to blood flow in a first direction than in a second direction without any active flow control mechanism. The bypass conduit may have a first end defining a first opening and a second end defining a second opening and a wall extending between the two ends that defines a lumen extending between the two openings. The ends and the wall of the conduit are configured to have a higher resistance to blood flow in a first direction than in a second direction. A method of bypassing an at least partially occluded artery includes determining a resistance to blood flow of the artery at a location of an at least partial occlusion and selecting a conduit having a configuration based on the resistance to blood flow of the artery at the location of the at least partial occlusion. The method further includes implanting the conduit in a heart wall between the heart chamber and the artery downstream of the at least partial occlusion to directly flow blood between the chamber and the artery.
摘要翻译：旁路管道和相关方法包括在心脏室和至少部分闭塞的动脉之间的心脏植入旁路以将血液从腔室直接流动到动脉。旁通管被构造成在没有任何主动流量控制机构的情况下具有比在第二方向上在第一方向上更高的血流阻力。旁路导管可以具有限定第一开口的第一端和限定第二开口的第二端和在两个端部之间延伸的壁，其限定在两个开口之间延伸的内腔。导管的端部和壁被构造成在第一方向上具有比在第二方向上更高的血流阻力。旁路至少部分闭塞的动脉的方法包括确定在至少部分闭塞的位置处的动脉血流阻力，并且选择具有基于在所述位置处的动脉血流阻力的构型的导管至少部分闭塞。该方法还包括将导管植入心室和至少部分闭塞下游的动脉之间的心壁，以直接在腔室和动脉之间流动血液。

6. 发明授权

US06949080B2 Left ventricular conduits to coronary arteries and methods for coronary bypass 失效
标题翻译：冠状动脉左心室导管和冠状动脉搭桥方法
公开(公告)号：US06949080B2
公开(公告)日：2005-09-27
申请号：US10218916
申请日：2002-08-15
申请人： Scott J. Wolf , Greg R. Furnish , Todd A. Hall , David Y. Phelps , Peter J. Wilk , Nancy Briefs , William Santamore , Daniel Burkhoff , Simon Furnish , Stephen Evans , Roger D. Kamm , Richard Renati , Gerald Melsky , Eun Bo Shim
发明人： Scott J. Wolf , Greg R. Furnish , Todd A. Hall , David Y. Phelps , Peter J. Wilk , Nancy Briefs , William Santamore , Daniel Burkhoff , Simon Furnish , Stephen Evans , Roger D. Kamm , Richard Renati , Gerald Melsky , Eun Bo Shim
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/026 , A61B17/00 , A61B17/08 , A61B17/11 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/94 , A61F11/00 , A61F13/00 , A61M20060101 , A61M5/00 , A61M25/00 , A61M27/00 , A61M37/00
CPC分类号： A61F2/2493 , A61B5/0031 , A61B5/0215 , A61B5/026 , A61B5/6862 , A61B5/6876 , A61B17/0057 , A61B17/11 , A61B17/3468 , A61B2017/00247 , A61B2017/00252 , A61B2017/00637 , A61B2017/00654 , A61B2017/1107 , A61B2017/1135 , A61B2018/00392 , A61F2/06 , A61F2/064 , A61F2/915 , A61F2/94 , A61F2002/8486 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2220/0008 , A61F2220/0016 , A61F2250/0002 , A61F2250/0039 , A61F2250/0067 , A61M27/002
摘要： A stent suitable for implantation in myocardial tissue to enhance perfusion therein may include a tubular member having first and second ends and a lumen. The first end of the stent may be configured to pierce myocardial tissue and the lumen may be configured to be placed in flow communication with a coronary vessel. The stent may further include a means for retaining the tubular member within the myocardial tissue. A method for implanting the stent may include positioning the first end of the stent at a desired implantation site and applying force to the second end of the stent to implant the stent within the myocardial tissue. The method may further include engaging the means for retaining with the myocardial tissue to retain the stent in position.
摘要翻译：适于植入心肌组织以增强其中灌注的支架可包括具有第一和第二末端和内腔的管状构件。支架的第一端可以被配置成刺穿心肌组织，并且内腔可被配置成与冠状血管流动连通。支架还可以包括用于将管状构件保持在心肌组织内的装置。用于植入支架的方法可以包括将支架的第一端定位在期望的植入部位并且将力施加到支架的第二端以将支架植入心肌组织内。该方法还可以包括将用于保持心肌组织的装置接合以将支架保持在适当的位置。

7. 发明授权

US10017724B2 Engineering of a novel breast tumor microenvironment on a microfluidic chip 有权
公开(公告)号：US10017724B2
公开(公告)日：2018-07-10
申请号：US14872920
申请日：2015-10-01
申请人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
发明人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
IPC分类号： B01L3/00 , G01N33/50 , C12M3/00 , C12M1/00 , C12M1/12 , C12M3/06
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L2300/0816 , B01L2300/12 , C12M25/14 , G01N33/5011
摘要： A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may further comprise one or more endothelial cells, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, and a second three dimensional scaffold comprising one or more stromal cells, at least a portion of which is interposed between the one or more microfluidic channels and the first three dimensional scaffold. The second three dimensional scaffold is in fluid communication with both the first three dimensional scaffold and the one or more microfluidic channels. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.

8. 发明授权

US6117087A Method and apparatus for noninvasive assessment of a subject's cardiovascular system 失效
标题翻译：无创性评估受试者心血管系统的方法和装置
公开(公告)号：US6117087A
公开(公告)日：2000-09-12
申请号：US53369
申请日：1998-04-01
申请人： Roger D. Kamm , Edwin Tomoya Ozawa
发明人： Roger D. Kamm , Edwin Tomoya Ozawa
IPC分类号： A61B5/021 , A61B5/00
CPC分类号： A61B5/021
摘要： A method and apparatus for deriving a physiological description and clinically-useful data reboarding the cardiovascular system of an individual subject. The method includes obtaining a measurement sample associated with cardiovascular flow and utilizing a model, which may be distributed and/or non-linear to derive a description and data. The model generates and uses functions of source parameters and may, in an embodiment, match measurement samples against a library of stored predicted samples. A best-matching, predicted sample may then be associated with a measurement sample. An apparatus is provided which, according to an embodiment, includes an input for obtaining a measurement sample, a processor to derive the description and data, and an output. The apparatus may also include a digital storage medium to store a library of predicted samples.
摘要翻译：一种用于导出生理描述和临床上有用的数据的方法和装置，其重新登记个体受试者的心血管系统。该方法包括获得与心血管流量相关联的测量样本并利用可以被分布和/或非线性地导出描述和数据的模型。该模型生成和使用源参数的功能，并且在一个实施例中，可以将测量样本与存储的预测样本库相匹配。然后可以将最佳匹配的预测样本与测量样本相关联。根据实施例，提供了一种装置，其包括用于获得测量样本的输入，用于导出描述和数据的处理器以及输出。该装置还可以包括用于存储预测样本库的数字存储介质。

9. 发明授权

US4627448A Tobacco smoke article holder and method therefor 失效
标题翻译：烟草烟制品架及其方法
公开(公告)号：US4627448A
公开(公告)日：1986-12-09
申请号：US705160
申请日：1985-02-25
申请人： Roger D. Kamm , Louis Fine
发明人： Roger D. Kamm , Louis Fine
IPC分类号： A24C5/34 , G01N1/24 , A24F13/02 , A24F13/08
CPC分类号： A24C5/3418 , G01N1/24
摘要： A tobacco smoke article holder for a testing machine and a method of mounting a tobacco smoke article in the holder to simulate the human smoking process including an inflatably lined flow-through conduit having a depth substantially equal to the average width of a human lip and a cross-section in liner-relaxed state approximating the cross-section of the tobacco smoke article to accommodate normal insertion depth of the tobacco smoke article.
摘要翻译：一种用于测试机器的烟草制品保持器和一种将烟草烟制品安装在保持器中以模拟人体吸烟过程的方法，其包括具有基本上等于人唇部的平均宽度的深度的可膨胀衬里的流通导管，以及线性放松状态的横截面近似于烟草烟制品的横截面，以适应烟草烟制品的正常插入深度。

10. 发明授权

US4446747A Method and apparatus for testing lip pressure applied to a smoking article and for calibrating the pressure testing apparatus 失效
标题翻译：用于测试施加到吸烟制品上的唇压并用于校准压力测试装置的方法和装置
公开(公告)号：US4446747A
公开(公告)日：1984-05-08
申请号：US356979
申请日：1982-03-11
申请人： Roger D. Kamm
发明人： Roger D. Kamm
IPC分类号： A24C5/34 , G01L1/02 , G01L5/00
CPC分类号： A24C5/34 , G01L1/02 , G01L5/00
摘要： A method and apparatus for testing pressure applied to a smoking article is provided and is particularly useful in testing lip pressure applied to cigarettes. The system includes a pressure sensor adapted to be positioned on a predetermined portion of the smoking article that is to be subjected to external pressure. A pressure transducer is connected to the sensor. The output of the transducer responsive to the pressure applied to the smoking article and sensed by the sensor is displayed. Additionally, a method and apparatus for calibrating the pressure sensor is included. The calibration system includes a rigid enclosure and an elastomeric tube positioned in a recess in the enclosure and connected to a pressure regulator. The enclosure includes a recess conforming to the configuration of the smoking article with a pressure sensor mounted thereon and positioned so that the smoking article in the recess is in communication with the elastomeric tube so that when the tube is pressurized it exerts a measured contact stress on the smoking article and pressure sensor. Thus, the calibration can take place over a range of anticipated pressures.
摘要翻译：提供了一种用于测试施加到吸烟制品上的压力的方法和装置，并且特别适用于测试施加于香烟的唇部压力。该系统包括适于定位在要经受外部压力的吸烟物品的预定部分上的压力传感器。压力传感器连接到传感器。显示响应于施加到吸烟制品并由传感器感测的压力的换能器的输出。此外，还包括用于校准压力传感器的方法和装置。校准系统包括刚性外壳和位于外壳中的凹部中并连接到压力调节器的弹性体管。外壳包括符合吸烟制品的构造的凹部，其上安装有压力传感器并定位成使得凹部中的吸烟物品与弹性管连通，使得当管被加压时，其将测量的接触应力施加到吸烟物品和压力传感器。因此，校准可以在一定范围的预期压力下进行。

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