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1. 发明申请

US20090215998A1 DEVICES AND METHODS FOR HIGH-PRESSURE REFOLDING OF PROTEINS 审中-公开
标题翻译：蛋白质高压重建的装置和方法
公开(公告)号：US20090215998A1
公开(公告)日：2009-08-27
申请号：US12094398
申请日：2006-11-21
申请人： Jeffrey D. Antman , Ryan L. Crisman , Lyndal K. Hesterberg , Robert Nelson , Theodore W. Randolph , Matthew B. Seefeldt
发明人： Jeffrey D. Antman , Ryan L. Crisman , Lyndal K. Hesterberg , Robert Nelson , Theodore W. Randolph , Matthew B. Seefeldt
IPC分类号： C07K1/00 , B01L3/00
CPC分类号： B01L3/50825 , B01L3/50853 , B01L2200/0684 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/14 , B01L2400/0605
摘要： Disclosed are devices for holding samples, particularly liquid samples, during high-pressure treatment. The devices enable a variety of functions, such as high-throughput screening of samples in multi-compartment device embodiments, and adjustment of solution conditions during high-pressure treatment. The devices are designed to maintain integrity during the high-pressure conditions, and are optionally substantially impermeable to oxygen.
摘要翻译：公开了用于在高压处理期间保持样品，特别是液体样品的装置。这些装置能够实现多种功能，例如在多隔室装置实施例中的样品的高通量筛选，以及在高压处理期间调节溶液条件。设备被设计成在高压条件下保持完整性，并且任选地基本上不透氧。

2. 发明申请

US20120245329A1 HIGH PRESSURE REFOLDING OF MONOCLONAL ANTIBODY AGGREGATES 有权
标题翻译：单克隆抗体聚合物的高压重建
公开(公告)号：US20120245329A1
公开(公告)日：2012-09-27
申请号：US13405573
申请日：2012-02-27
申请人： Matthew B. Seefeldt , Robert Nelson , Theodore W. Randolph , Lyndal K. Hesterberg
发明人： Matthew B. Seefeldt , Robert Nelson , Theodore W. Randolph , Lyndal K. Hesterberg
IPC分类号： C07K1/00 , C07K19/00
CPC分类号： C07K16/2827 , C07K1/113 , C07K1/1136 , C07K14/70521 , C07K2319/30 , C07K2319/33
摘要： Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.
摘要翻译：提供了通过使抗体制剂进行高静水压力从聚合和/或变性制剂中重新折叠抗体，特别是单克隆抗体的方法。还提供了通过本文所述方法产生的抗体的重折叠制剂。

3. 发明申请

US20090076247A1 HIGH PRESSURE REFOLDING OF MONOCLONAL ANTIBODY AGGREGATES 审中-公开
标题翻译：单克隆抗体聚合物的高压重建
公开(公告)号：US20090076247A1
公开(公告)日：2009-03-19
申请号：US12208193
申请日：2008-09-10
申请人： Matthew B. Seefeldt , Robert Nelson , Theodore W. Randolph , Lyndal K. Hesterberg
发明人： Matthew B. Seefeldt , Robert Nelson , Theodore W. Randolph , Lyndal K. Hesterberg
IPC分类号： C07K16/00 , G01N33/536 , C07K19/00 , G01T1/10 , G01N21/00 , G01J3/00 , G01V3/00
CPC分类号： C07K16/2827 , C07K1/113 , C07K1/1136 , C07K14/70521 , C07K2319/30 , C07K2319/33
摘要： Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.
摘要翻译：提供了通过使抗体制剂进行高静水压力从聚合和/或变性制剂中重新折叠抗体，特别是单克隆抗体的方法。还提供了通过本文所述方法产生的抗体的重折叠制剂。

4. 发明授权

US08802828B2 High pressure refolding of monoclonal antibody aggregates 有权
标题翻译：单克隆抗体聚集体的高压重折叠
公开(公告)号：US08802828B2
公开(公告)日：2014-08-12
申请号：US13405573
申请日：2012-02-27
申请人： Matthew B. Seefeldt , Robert Nelson , Theodore W. Randolph , Lyndal K. Hesterberg
发明人： Matthew B. Seefeldt , Robert Nelson , Theodore W. Randolph , Lyndal K. Hesterberg
IPC分类号： C07K17/00
CPC分类号： C07K16/2827 , C07K1/113 , C07K1/1136 , C07K14/70521 , C07K2319/30 , C07K2319/33
摘要： Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.
摘要翻译：提供了通过使抗体制剂进行高静水压力从聚合和/或变性制剂中重新折叠抗体，特别是单克隆抗体的方法。还提供了通过本文所述方法产生的抗体的重折叠制剂。

5. 发明授权

US08838393B2 Systems and methods for topographic analysis 有权
标题翻译：用于地形分析的系统和方法
公开(公告)号：US08838393B2
公开(公告)日：2014-09-16
申请号：US13437759
申请日：2012-04-02
申请人： Ananya Sen Gupta , Christopher M. Reddy , Robert Nelson
发明人： Ananya Sen Gupta , Christopher M. Reddy , Robert Nelson
IPC分类号： G01N33/48 , G01N30/86 , G06F19/00 , G01N30/46
CPC分类号： G01N30/8686 , G01N30/463 , G06F19/703 , G06F19/707
摘要： The systems and methods described herein provide a scientific and analytical basis for the following: (a) collective interpretation of the entire spectrum of chromatographic data, e.g., GC×GC two-dimensional data, with capability of operating at multi-resolution over bigger or smaller sub-regions of the two-dimensional data, (b) given two or more samples that are from the same source, and some samples from clearly different sources, quantitatively estimate where the fingerprint of the source lies, (c) given a source signature template, an unknown sample can be compared to decide whether it is related to, and if so, to what degree, to this source, and (d) given two source signature templates, the templates can be compared to determine how related is one source to the other.
摘要翻译：本文所述的系统和方法为以下内容提供了科学和分析依据：（a）对色谱数据的整个谱图的集体解释，例如GC×GC二维数据，具有在更大或更大分辨率下操作的能力二维数据的较小子区域，（b）给出来自相同源的两个或更多个样本，以及来自清晰不同源的一些样本，定量估计源的指纹位置，（c）给定源签名模板，一个未知的样本可以进行比较，以决定是否与之相关，如果是这样，在何种程度上，对这个来源，和（d）给定两个源签名模板，可以比较模板来确定如何相关是一个来源到另一个。

6. 发明申请

US20120065343A1 Silicone Composition for Producing Transparent Silicone Materials and Optical Devices 审中-公开
标题翻译：用于生产透明硅酮材料和光学器件的硅胶组合物
公开(公告)号：US20120065343A1
公开(公告)日：2012-03-15
申请号：US13257659
申请日：2010-02-25
申请人： Maneesh Bahadur , Robert Nelson , Michael Strong
发明人： Maneesh Bahadur , Robert Nelson , Michael Strong
IPC分类号： C08L83/07
CPC分类号： H01L23/296 , C08G77/12 , C08G77/20 , C08L83/04 , H01L2224/48091 , H01L2224/48247 , H01L2224/8592 , H01L2924/181 , C08L83/00 , H01L2924/00014 , H01L2924/00012
摘要： A hydrosilylation curable composition contains a combination of high and low viscosity polyorganosiloxanes, a silicone resin, a crosslinker, and a catalyst. The composition, and the cured product thereof, is useful in optical devices such as charged coupled devices (CCDs), light emitting diodes (LEDs), lightguides, optical cameras, photo-couplers, and waveguides. Processes for fabricating the optical devices include various molding techniques, including overmolding.
摘要翻译：氢化硅烷化固化性组合物包含高粘度和低粘度聚有机硅氧烷，硅树脂，交联剂和催化剂的组合。组合物及其固化产物可用于诸如带电耦合器件（CCD），发光二极管（LED），光导，光学照相机，光耦合器和波导的光器件中。用于制造光学器件的工艺包括各种成型技术，包括包覆成型。

7. 发明授权

US07757765B2 Downhole preparation and use of thixotropic cement slurries 失效
标题翻译：井底准备和使用触变胶泥
公开(公告)号：US07757765B2
公开(公告)日：2010-07-20
申请号：US11946958
申请日：2007-11-29
申请人： Nathan Hilleary , Robert Nelson , Robert Bucher
发明人： Nathan Hilleary , Robert Nelson , Robert Bucher
IPC分类号： E21B33/13
CPC分类号： C09K8/467 , C04B28/02 , C09K8/426 , Y02W30/94 , Y02W30/96 , C04B40/0028 , C04B2103/44 , C04B14/042 , C04B14/102 , C04B14/104 , C04B14/106 , C04B18/146 , C04B18/20 , C04B24/2611 , C04B24/287 , C04B24/425
摘要： A method for use within a subterranean formation penetrated by a wellbore includes introducing a thixotropic agent into the well and introducing a cement slurry into the well. The method includes forming a thixotropic cement slurry downhole, including mixing the cement slurry and the thixotropic agent downhole.
摘要翻译：在井眼穿透的地下地层中使用的方法包括将触变剂引入井中并将水泥浆引入井中。该方法包括在井下形成触变性水泥浆料，包括将水泥浆和触变剂在井下混合。

8. 发明申请

US20100015407A1 Airbag and Process for its Assembly 失效
标题翻译：安全气囊及其装配流程
公开(公告)号：US20100015407A1
公开(公告)日：2010-01-21
申请号：US12515427
申请日：2007-09-27
申请人： Anh Be , William Blackwood , Loren Dale Lower , Robert Nelson , Todd Starke
发明人： Anh Be , William Blackwood , Loren Dale Lower , Robert Nelson , Todd Starke
IPC分类号： B32B7/14 , B32B37/12
CPC分类号： B60R21/235 , B60R2021/2358 , Y10T428/24793
摘要： A process for assembling an airbag for use in vehicle applications is disclosed. The airbag has a seam made from two or more different materials (102, 104). The combination of the materials and the process for assembling the airbag minimize the need for sewn seams.
摘要翻译：公开了一种组装用于车辆应用的气囊的方法。气囊具有由两种或更多种不同材料（102,104）制成的接缝。材料的组合和组装气囊的过程最大限度地减少了对缝合缝的需要。

9. 发明申请

US20080105032A1 HIGH ACCURACY CONTAMINATION ESTIMATION IN HYDROCARBON SAMPLES USING GC X GC 有权
标题翻译：使用GC X GC的油气样品中的高精度污染估算
公开(公告)号：US20080105032A1
公开(公告)日：2008-05-08
申请号：US11876185
申请日：2007-10-22
申请人： Christopher Reddy , Oliver Mullins , Bhavani Raghuraman , Robert Nelson
发明人： Christopher Reddy , Oliver Mullins , Bhavani Raghuraman , Robert Nelson
IPC分类号： G01N30/02
CPC分类号： G01N30/463 , E21B49/08 , G01N33/2823 , G01N33/2835 , G01N2030/025
摘要： A method of estimating contamination of oil based mud filtrate in a hydrocarbon sample. The method comprising the steps of obtaining a hydrocarbon sample contaminated with oil based mud filtrate, then analyzing the contaminated hydrocarbon sample using two-dimensional gas chromatography (GC×GC). The method further comprises identifying one or more unique component or tracer in the oil based mud filtrate in the contaminated hydrocarbon sample. Finally, the method comprises of summing the peak volumes of the one or more unique component or tracer, relative to the peak volumes of a clean hydrocarbon sample.
摘要翻译：一种估算烃样品中油基泥浆滤液污染的方法。该方法包括以下步骤：获得被油基泥浆滤液污染的烃样品，然后使用二维气相色谱（GCxGC）分析污染的烃样品。该方法还包括鉴定污染的烃样品中的油基泥浆滤液中的一种或多种独特组分或示踪剂。最后，该方法包括相对于清洁烃样品的峰值体积求和一种或多种独特组分或示踪剂的峰体积。

10. 发明申请

US20070123558A1 IMMUNE RESPONSE MODIFIER FORMULATIONS CONTAINING OLEIC ACID AND METHODS 有权
标题翻译：含有油酸的免疫反应调节剂配方及方法
公开(公告)号：US20070123558A1
公开(公告)日：2007-05-31
申请号：US11276324
申请日：2006-02-24
申请人： Alexis Statham , Robert Nelson
发明人： Alexis Statham , Robert Nelson
IPC分类号： A61K31/4745 , A61K31/202
CPC分类号： A61K31/202 , A61K9/0014 , A61K9/06 , A61K31/4745 , A61K47/12
摘要： Pharmaceutical formulations and methods including an immune response modifier (IRM) compound and an oleic acid component are provided where stability is improved by using oleic acid have low polar impurities such as peroxides.
摘要翻译：提供包括免疫应答调节剂（IRM）化合物和油酸组分的药物制剂和方法，其中通过使用具有低极性杂质如过氧化物的油酸来改善稳定性。

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