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    • 2. 发明申请
    • Package for products to be sterlised with a high-temperature sterilising fluid
    • 用高温灭菌液灭菌的产品包装
    • US20050103666A1
    • 2005-05-19
    • US10485930
    • 2001-11-16
    • Jean-Pierre GrimardJean-Claude Thibault
    • Jean-Pierre GrimardJean-Claude Thibault
    • B65D77/26A61J1/14A61L2/26B65D53/04B65D81/20A61L15/00
    • A61L2/183A61L2/26A61L2202/181A61L2202/24A61M5/008
    • The invention concerns a plastic package, having a content capable of being sterilised at high temperature, said package comprising at least a fluid communication member (16) between the inside and the outside of said package consisting of at least a frame circumscribing an opening and an inner seal (18) closing the opening, and whereof the peripheral edge (18a, 22a) is continuously linked to said frame, said inner seal including, a selectively sealing material sheet whereof the cutoff threshold from outside inwards, stops contaminating particles and allows through the thermal sterilising fluid, said selectively sealing material being deformable in the plane of said sheet at said high temperature. The invention is characterised in that it comprises means compensating the planar deformation of the selectively sealing material sheet, when said inner seal (18) is in contact with the thermal sterilising fluid, said compensating means being designed to release at least part of the load in the direction opening the fluid communication member (16) applied on the frame as a result of said deformation.
    • 本发明涉及一种塑料包装,其具有能够在高温下灭菌的内容物,所述包装至少包括在所述包装的内部和外部之间的流体连通构件(16),该流体连通构件至少包括围绕开口的框架和 封闭开口的内部密封件(18),并且周边边缘(18a,22a)连续地连接到所述框架,所述内部密封件包括选择性地密封材料片,其中从外侧进入的截止阈值停止污染颗粒, 允许通过热灭菌流体,所述选择性密封材料可在所述高温下在所述片材的平面中变形。 本发明的特征在于,当所述内部密封件(18)与热灭菌流体接触时,其包括补偿选择性密封材料片材的平面变形的装置,所述补偿装置设计成将至少部分负载释放 作为所述变形的结果,打开施加在框架上的流体连通构件(16)的方向。
    • 3. 发明授权
    • Package for products to be sterilized with a high-temperature sterilizing fluid
    • 用高温灭菌液灭菌的产品包装
    • US07100768B2
    • 2006-09-05
    • US10485930
    • 2001-11-16
    • Jean-Pierre GrimardJean-Claude Thibault
    • Jean-Pierre GrimardJean-Claude Thibault
    • A61B17/06
    • A61L2/183A61L2/26A61L2202/181A61L2202/24A61M5/008
    • The invention concerns a plastic package, having a content capable of being sterilised at high temperature, said package comprising at least a fluid communication member (16) between the inside and the outside of said package consisting of at least a frame circumscribing an opening and an inner seal (18) closing the opening, and whereof the peripheral edge (18a, 22a) continuously linked to said frame, said inner seal including, a selectively sealing material sheet whereof the cutoff threshold from outside inwards, stops contaminating particles and allows through the thermal sterilising fluid, said selectively sealing material being deformable in the plane of said sheet at said high temperature. The invention is characterised in that it comprises means compensating the planar deformation of the selectively sealing material sheet, when said inner seal (18) is in contact with the thermal sterilising fluid, said compensating means being designed to release at least part of the load in the direction opening the fluid communication member (16) applied on the frame as a result of said deformation.
    • 本发明涉及一种塑料包装,其具有能够在高温下灭菌的内容物,所述包装至少包括在所述包装的内部和外部之间的流体连通构件(16),该流体连通构件至少包括围绕开口的框架和 封闭开口的内密封件(18),以及与所述框架连续连接的周边边缘(18a,22a),所述内密封件包括选择性密封材料片,其中从外侧进入的截止阈值停止污染颗粒,并允许 通过热灭菌流体,所述选择性密封材料可在所述高温下在所述片材的平面中变形。 本发明的特征在于,当所述内部密封件(18)与热灭菌流体接触时,其包括补偿选择性密封材料片材的平面变形的装置,所述补偿装置设计成将至少部分负载释放 作为所述变形的结果,打开施加在框架上的流体连通构件(16)的方向。
    • 4. 发明授权
    • Pre-fillable syringe and stopper assembly therefor
    • 预填充注射器和止动器组件
    • US5607400A
    • 1997-03-04
    • US445130
    • 1995-05-19
    • Jean-Claude ThibaultJean-Pierre GrimardCatherine F. Faure
    • Jean-Claude ThibaultJean-Pierre GrimardCatherine F. Faure
    • A61M5/178A61M5/31A61M5/315A61M5/32
    • A61M5/31513A61M2005/3121A61M2005/3131A61M2205/0222A61M2205/0238A61M5/3202
    • A pre-fillable hypodermic syringe is provided. The hypodermic syringe includes a syringe barrel having opposed proximal and distal ends and a drug-receiving chamber therebetween. The distal end of the syringe receives a needle cannula that is sealingly and protectively covered by a cap. The proximal end of the syringe is sealed by a stopper assembly. The stopper assembly includes a distal stopper that is positioned adjacent the drug pre-filled into the syringe barrel. The distal stopper is formed to exhibit acceptably low sliding forces without the presence of lubricants deleterious to the drug. The stopper assembly further includes a proximal stopper formed from a material that exhibits acceptable microbiological sealing. Because the proximal stopper is separated from the drug by the distal stopper the proximal stopper may be treated with any convenient lubricant, such as silicone oil. The distal stopper functions as a barrier between the drug and the lubricant such as silicone oil that is on or near the proximal stopper. The proximal stopper, on the other hand, provides the required microbiological sealing.
    • 提供预先填充的皮下注射器。 皮下注射器包括具有相对的近端和远端的注射器筒和其间的药物接收室。 注射器的远端接收密封地且由帽盖保护性地覆盖的针插管。 注射器的近端由止动器组件密封。 止动器组件包括远端止动器,该远端止动件邻近预先填充到注射器筒内的药物定位。 远端止动器形成为显示可接受的低滑动力,而不存在对药物有害的润滑剂。 止动器组件还包括由表现出可接受的微生物密封的材料形成的近端塞。 由于近侧止动器通过远端止动件与药物分开,所以近端止动器可以用任何方便的润滑剂例如硅油处理。 远侧止血器用作药物和润滑剂之间的屏障,例如在近端塞上或附近的硅油。 另一方面,近端塞子提供所需的微生物密封。
    • 5. 发明授权
    • Vial with resealable connector assembly having a membrane and a
multi-configuration fluid access device
    • 具有可重复密封的连接器组件的样品瓶,其具有膜和多配置流体存取装置
    • US6003702A
    • 1999-12-21
    • US534519
    • 1995-09-27
    • Jean-Pierre GrimardJean-Claude Thibault
    • Jean-Pierre GrimardJean-Claude Thibault
    • B65D51/18A61J1/00A61J1/20B65D47/24B65D47/30B65B1/06B65D39/00B65D45/30
    • A61J1/2089B65D47/248A61J1/201A61J1/2037A61J1/2055A61J1/2072Y10S215/03
    • A resealable vial featuring a fluid access device having a membrane for selectively opening or sealing a fluid passageway between the bottle and the fluid access device. The vial includes a body disposed on said bottle. The fluid access device can be configured as a spike assembly, a needle assembly, or a luer lock assembly, and features a hollowed rod in sliding, fluid-tight relation to an orifice defined by the body. A membrane, preferably formed from an elastomeric material, is secured across both the orifice and the open top of the bottle, and may be retained between the top surface of the bottle and the body. The membrane preferably includes a central area sealing the orifice from the open top of the bottle, with one or more fluid passages defined on a portion of the membrane outside of the central area. A force exerted upon the hollowed rod deflects the membrane towards the interior of the vial, urging the membrane and fluid openings away from the body to open the fluid path between the bottle and the orifice. A sealing rib may be provided around the portion of the periphery of the recess for sealing contact between the central area of the membrane and the orifice.
    • 一种可重新密封的小瓶,其特征在于具有用于选择性地打开或密封瓶与流体存取装置之间的流体通道的膜的流体进入装置。 小瓶包括设置在所述瓶子上的主体。 流体通道装置可以被配置为尖钉组件,针组件或路厄锁定组件,并且具有与由主体限定的孔隙滑动,流体密封的中空杆。 优选由弹性体材料形成的膜跨过瓶口的孔口和开口顶部固定,并且可以保持在瓶子的顶部表面和主体之间。 膜优选地包括从孔的开口顶部密封孔口的中心区域,其中一个或多个流体通道限定在中心区域外部的膜的一部分上。 施加在中空杆上的力使膜朝向小瓶的内部偏转,从而使膜和流体开口远离本体以打开瓶和孔之间的流体路径。 密封肋可以围绕凹部的周边部分设置,用于密封膜的中心区域和孔口之间的接触。
    • 6. 发明申请
    • Injection set and injection assistance device
    • 注射器和注射辅助装置
    • US20090318864A1
    • 2009-12-24
    • US11912270
    • 2006-04-20
    • Franck CarrelFrederic PerotJean-Pierre Grimard
    • Franck CarrelFrederic PerotJean-Pierre Grimard
    • A61M5/46
    • A61M5/46A61M5/326A61M5/3272A61M5/3287A61M2005/3247A61M2005/3267
    • The present invention relates to an injection assistance device (1) for an injection device (3) comprising one body (2) one needle (7) one piston plunger (26), characterized in that it comprises: a hollow sleeve (4) receiving the body (2), coupling means (10) for moving the piston plunger (26) from an end-of-insertion position to an end of injection position said coupling means being maintained in a passive state until said end-of-insertion position, spacer means (8) to maintain the piston plunger (26) and said body (2) in an initial position, disengaging means (22, 14, 15, 16) linked with the spacer means (8), said spacer means (8) and/or disengaging means (22, 14, 15, 16; 25, 31) being arranged in order not to free the distal displacement of said piston plunger (26) before the one of said body (2).
    • 本发明涉及一种用于注射装置(3)的注射辅助装置(1),其包括一个主体(2)一个针(7),一个活塞柱塞(26),其特征在于,其包括:中空套筒(4) 主体(2),用于将活塞柱塞(26)从插入位置移动到注射位置的端部的联接装置(10),所述联接装置保持处于被动状态,直到所述插入位置 ,用于将活塞柱塞(26)和所述主体(2)保持在初始位置的间隔装置(8),与隔离装置(8)连接的分离装置(22,14,15,16),所述间隔装置(8) )和/或分离装置(22,14,15,16,25,31),以便在所述主体(2)之一之前不释放所述活塞柱塞(26)的远侧位移。
    • 7. 发明授权
    • Packaging for sterile objects or objects to be sterilized
    • 无菌物品或灭菌物品的包装
    • US07303073B2
    • 2007-12-04
    • US10511579
    • 2003-04-18
    • Claire Raynal-OliveJean-Pierre Grimard
    • Claire Raynal-OliveJean-Pierre Grimard
    • A61B17/06A61L2/20A65B55/02
    • A61L2/208A61L2/26A61L2202/182A61M5/001A61M5/002
    • A package for transporting objects which are sterile or which are to be sterilized. The package has a box for accommodating objects, and a covering sheet made of a leak tight material which is fastened to the box so as to seal the box in a leak tight manner. The package has a layer of a material forming a screen which is at least partial with respect to a decontamination gas and/or able to absorb a decontamination gas. The layer is sized to be placed in the box along the covering sheet such that the layer lies above the objects. A plate or grill is provided with projections and is shaped, depending on the position of the package, to allow unrestricted diffusion of the sterilization gas over the objects, and to restrict or prevent diffusion of the decontamination gas over these same objects.
    • 用于运输无菌或要灭菌的物品的包装。 该包装具有用于容纳物品的盒子和由密封材料制成的覆盖片材,该覆盖片材紧固到盒子上以便以密封方式密封盒子。 该包装具有形成屏幕的材料层,其相对于净化气体至少部分和/或能够吸收去污气体。 该层的尺寸设置成沿着覆盖片放置在盒中,使得层位于物体上方。 板或格栅设置有突起,并且根据包装的位置成形,以允许灭菌气体不受限制地扩散在物体上,并且限制或防止净化气体在这些相同物体上的扩散。
    • 10. 发明授权
    • Sterile closure assembly for sealing a medicament container
    • 用于密封药物容器的无菌封闭组件
    • US5803284A
    • 1998-09-08
    • US722292
    • 1996-09-27
    • Jean-Pierre Grimard
    • Jean-Pierre Grimard
    • B65D81/20A61J1/00A61J1/05A61J1/14B65D51/00B65D51/24B65D39/00
    • A61J1/1406B65D51/002B65D51/241Y10S215/03
    • A sterile closure assembly for a container or vial includes an elastomeric closure for sealing the open top of a medicament container. The elastomeric closure features a plug for sealing the open top of the container and a top surface facing away from the open top of the container. A washer is secured in surface contact with the top surface of the closure. The washer defines an opening that delimits an access area on the top surface of the closure for access by a fluid delivery device such as a syringe. A membrane is removably secured over the washer and hermetically encloses the access area of the elastomeric closure. The sterile closure assembly can be provided pre-assembled in a sterile state to assure the sterility of the top surface of the closure, obviating the need to sterilize the top surface of the closure, such as with an alcohol solution, prior to use of the vial.
    • 用于容器或小瓶的无菌封闭组件包括用于密封药物容器的开口顶部的弹性闭合件。 弹性体闭合件具有用于密封容器的敞开顶部的塞子和背离容器开口顶部的顶表面。 垫圈固定在与盖子的顶面表面接触。 垫圈限定了一个开口,其限定了封闭件的顶表面上的进入区域,以便通过诸如注射器之类的流体输送装置进入。 膜可移除地固定在垫圈上并且密封地包围弹性闭合件的进入区域。 无菌封闭组件可以预先组装成无菌状态,以确保封盖顶表面的无菌性,从而避免了在使用前将封闭物的顶部表面(例如用醇溶液)灭菌的需要, 小瓶。