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1. 发明授权

US5049322A Process for the preparaton of dispersible colloidal systems of a substance in the form of nanocapsules 失效
标题翻译：制备纳米胶囊形式的物质的可分散胶体体系的方法
公开(公告)号：US5049322A
公开(公告)日：1991-09-17
申请号：US140246
申请日：1987-12-31
申请人： Jean-Philippe Devissaguet , Hatem Fessi , Francis Puisieux
发明人： Jean-Philippe Devissaguet , Hatem Fessi , Francis Puisieux
IPC分类号： A61K9/50 , A61K9/10 , A61K9/51 , B01J13/00 , B01J13/12
CPC分类号： A61K9/5138 , A61K9/5153 , A61K9/5192 , Y10S514/963 , Y10T428/2984
摘要： The process according to the invention comprises:(1) the preparation of a liquid phase consisting essentially of a solution of a substance A in a solvent or in a mixture of solvents, and containing the substance B in solution or as a dispersion,(2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substances A and B, and supplemented with one or more surfactants, the solvent or mixture of solvents of the first phase being miscible in all proportions with the non-solvent or mixture of non-solvents of the second phase,(3) the addition of the first phase to the second phase with moderate agitation so as to produce a colloidal suspension of nanocapsules, the wall of which is constituted by the substance A and the core by the substance B,(4) if desired, the removal of all or part of the solvent or the mixture of solvents and of the non-solvent or the mixture of non-solvents so as to produce a colloidal suspension of nanocapsules of the desired concentration or to produce a powder of nanocapsules following the addition of stabilizing substances.
摘要翻译：根据本发明的方法包括：（1）制备基本上由物质A在溶剂或溶剂混合物中的溶液组成并在溶液或分散体中含有物质B的液相（2 ）制备基本上由物质A和B的非溶剂或非溶剂混合物组成的第二液相，并补充有一种或多种表面活性剂，第一相的溶剂或溶剂混合物可溶于所有比例与第二相的非溶剂或非溶剂混合物，（3）在适度搅拌下将第一相加入到第二相中，以产生其壁构成的纳米胶囊的胶态悬浮液通过物质A和物质B的核心，（4）如果需要，去除全部或部分溶剂或溶剂混合物，非溶剂或非溶剂混合物，以产生纳米胶体悬浮液所需浓度的眼睛或在加入稳定物质后产生纳米胶囊的粉末。

2. 发明授权

US5718905A Preparation and use of novel cyclodextrin-based dispersible colloidal systems in the form of nanospheres 失效
标题翻译：以纳米球形式制备和使用新型基于环糊精的可分散胶体体系
公开(公告)号：US5718905A
公开(公告)日：1998-02-17
申请号：US356167
申请日：1995-03-08
申请人： Mohamed Skiba , Denis Wouessidjewe , Antony Coleman , Hatem Fessi , Jean-Philippe Devissaguet , Dominique Duchene , Francis Puisieux
发明人： Mohamed Skiba , Denis Wouessidjewe , Antony Coleman , Hatem Fessi , Jean-Philippe Devissaguet , Dominique Duchene , Francis Puisieux
IPC分类号： A61J3/07 , A61K8/04 , A61K8/73 , A61K9/51 , A61K47/40 , A61Q19/00 , B01J13/00 , B01J13/04 , B01J13/08
CPC分类号： B01J13/08 , A61K8/0279 , A61K8/738 , A61K9/5161 , A61K9/5192 , A61Q19/00 , B82Y5/00 , A61K2800/413 , A61K2800/56 , Y10T428/1405 , Y10T428/2989
摘要： A nanoparticulate system prepared by: 1) preparing a liquid phase essentially consisting of a solution of cyclodextrin modified by acyl groups in an organic solvent or solvent mixture, an active molecule being optionally added thereto; 2) preparing a second liquid phase essentially consisting of water or an aqueous mixture optionally containing one or more surfactants, and optionally having an active molecule added thereto; and 3) gently stirring one of the liquid phases resulting from 1) or 2) into the other in order to obtain, almost instantaneously, a colloidal solution of modified cyclodextrin nanospheres. If required, all or part of the solvent and all or part of the water may be removed. The system may be used as a carrier for pharmaceuticals, cosmetics, chemicals, etc.
摘要翻译： PCT No.PCT / FR93 / 00594 Sec。 371日期：1995年3月8日 102（e）日期1995年3月8日PCT提交1993年6月16日PCT公布。公开号WO93 / 25195 日期：1993年12月23日A纳米颗粒体系通过以下步骤制备：1）制备基本由在有机溶剂或溶剂混合物中被酰基改性的环糊精溶液组成的液相，任选地加入活性分子; 2）制备基本由水或任选含有一种或多种表面活性剂的水性混合物组成的第二液相，并任选地加入其中的活性分子; 和3）将由1）或2）得到的液相之一轻轻地搅拌到另一个中，以便几乎瞬间地获得改性环糊精纳米球的胶体溶液。如果需要，可以除去全部或部分溶剂和全部或部分水。该系统可用作药物，化妆品，化学品等的载体。

3. 发明授权

US5174930A Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions 失效
标题翻译：制备亚微米尺寸的寡糖脂质体形式的两亲性脂质的可分散胶体体系的方法
公开(公告)号：US5174930A
公开(公告)日：1992-12-29
申请号：US666469
申请日：1991-03-06
申请人： Serge Stainmesse , Hatem Fessi , Jean-Philippe Devissaguet , Francis Puisieux
发明人： Serge Stainmesse , Hatem Fessi , Jean-Philippe Devissaguet , Francis Puisieux
IPC分类号： A61K9/127 , A61K9/51
CPC分类号： A61K9/1277 , Y10T428/2984
摘要： Dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions are prepared by combining a first liquid phase consisting essentially of a solution of the lipids with a greater amount of a second liquid phase consisting essentially of water. The solvent for the first liquid phase is miscible in all proportions with water. If desired, the first liquid phase may also contain a substance A in solution therewith, such as cholesterol. An additional substance B, which is a biologically active substance, may be present in the first phase if it is lipophilic, and in the second phase if it is hydrophilic.
摘要翻译：通过将基本上由脂质溶液组成的第一液相与基本上由水组成的更大量的第二液相组合，制备亚微米尺寸的寡胶体脂质体形式的两亲性脂质的可分散胶体体系。用于第一液相的溶剂可与水以所有比例混溶。如果需要，第一液相也可以含有其溶液中的物质A，例如胆固醇。如果另外一种生物活性物质B可以存在于第一相中，如果它是亲脂性的，并且在第二相中，如果它是亲水的。

4. 发明授权

US5133908A Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles 失效
标题翻译：用于制备纳米颗粒形式的物质的可分散胶体体系的方法
公开(公告)号：US5133908A
公开(公告)日：1992-07-28
申请号：US374246
申请日：1989-06-30
申请人： Serge Stainmesse , Hatem Fessi , Jean-Phillppe Devissaguet , Francis Puisieux , Curt Theis
发明人： Serge Stainmesse , Hatem Fessi , Jean-Phillppe Devissaguet , Francis Puisieux , Curt Theis
IPC分类号： A61K8/04 , A61K8/64 , A61K8/65 , A61K9/51 , A61Q19/00 , C08J3/14
CPC分类号： A61K9/5169 , A61K8/0241 , A61K8/64 , A61K8/65 , A61K9/5192 , A61Q19/00 , B82Y5/00 , C08J3/14 , A61K2800/413 , A61K2800/56 , Y10S514/965 , Y10S977/773 , Y10S977/786 , Y10S977/84
摘要： The Process according to the invention comprises:(1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants,(2) the preparation of a second liquid phase consisting essentially of a non-solvent of a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance,(3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance and,(4) if desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to produce a powder of nanoparticles. Said substance may be a protein.Field of use: chemistry, biochemistry, pharmacy, medicine, cosmetics.
摘要翻译：根据本发明的方法包括：（1）制备基本上由物质在溶剂或溶剂混合物中的溶液组成的液相，其中可加入一种或多种表面活性剂，（2）制备基本上由物质的非溶剂混合物的非溶剂组成的第二液相，其可以加入一种或多种表面活性剂，所述物质的非溶剂或非溶剂的混合物在所有物质中是可混溶的与物质的溶剂或溶剂混合物的比例，（3）在适当搅拌下将（1）或（2）中制备的一种液相加入到另一种液相中以产生纳米颗粒的胶态悬浮液物质和（4）如果需要，去除物质和非溶剂的全部或部分溶剂或溶剂混合物或非溶剂的混合物，以产生物质的胶体悬浮液纳米颗粒有效浓度或产生纳米颗粒粉末。所述物质可以是蛋白质。使用领域：化学，生物化学，制药，医药，化妆品。

5. 发明授权

US5118528A Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles 失效
标题翻译：制备纳米粒子中物质的不同胶体系统的方法
公开(公告)号：US5118528A
公开(公告)日：1992-06-02
申请号：US593522
申请日：1990-10-04
申请人： Curt Fessi , Jean-Philippe Devissaguet , Francis Puisieux , Curt Thies
发明人： Curt Fessi , Jean-Philippe Devissaguet , Francis Puisieux , Curt Thies
IPC分类号： A61K9/14 , A01N25/04 , A01N25/12 , A61K9/10 , A61K9/107 , A61K9/19 , A61K9/50 , A61K9/51 , B01J13/00 , C08J3/14 , D21H19/00 , D21H19/10 , D21H19/44
CPC分类号： A61K9/5138 , A61K9/5153 , A61K9/5192 , C08J3/14 , Y10S514/965 , Y10S977/775 , Y10S977/875 , Y10S977/895 , Y10T428/2984 , Y10T428/2985
摘要： The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance, (3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance, and (4) is desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to produce a powder of nanoparticles.
摘要翻译：根据本发明的方法包括：（1）基本上由物质在溶剂或溶剂混合物中的溶液组成的液相的制备，其中可加入一种或多种表面活性剂，（2）制备基本上由物质的非溶剂或非溶剂混合物组成的第二液相，可以加入一种或多种表面活性剂，所述物质的非溶剂或非溶剂混合物在所有物质中是可混溶的与物质的溶剂或溶剂混合物的比例，（3）在适当搅拌下将（1）或（2）中制备的一种液相加入到另一种液相中以产生纳米颗粒的胶态悬浮液物质和（4），需要除去物质和非溶剂的全部或部分溶剂或溶剂的混合物或非溶剂的混合物，以产生该物质的胶体悬浮液纳米颗粒有效浓度或产生纳米颗粒粉末。

6. 发明授权

US4666641A Preparation of biodegradable microcapsules based on serum albumin 失效
标题翻译：基于血清白蛋白的可生物降解微胶囊的制备
公开(公告)号：US4666641A
公开(公告)日：1987-05-19
申请号：US741190
申请日：1985-06-04
申请人： Rene Fickat , Simon Benita , Francis Puisieux
发明人： Rene Fickat , Simon Benita , Francis Puisieux
IPC分类号： A61K9/64 , A61K9/16 , A61K9/50 , A61K9/52 , B01J13/02
CPC分类号： A61K9/5052 , A61K9/1658 , Y10S514/963 , Y10T428/2984
摘要： The present invention relates to biodegradable microcapsules based on serum albumin, the preparation thereof and the application thereof to the release of drugs in situ.A feature of the microcapsules according to the present invention is that their wall consists of serum albumin, a portion of which is crosslinked by interfacial polymerization with the aid of an acylating bifunctional reagent, and the other, non-crosslinked portion of which is denatured by means of an alcohol.
摘要翻译：本发明涉及基于血清白蛋白的生物可降解微胶囊，其制备方法及其在原位释放药物中的应用。根据本发明的微胶囊的特征在于它们的壁由血清白蛋白组成，其一部分借助于酰化双功能试剂通过界面聚合而交联，另一部分非交联部分被酒精的手段

7. 发明授权

US5714154A Process for the production of multiple w/o/w emulsions 失效
标题翻译：用于生产多重w / o / w乳液的方法
公开(公告)号：US5714154A
公开(公告)日：1998-02-03
申请号：US532836
申请日：1995-12-20
申请人： Catherine Le Hen-Ferrenbach , Isabelle Terrisse , Armelle Magnet , Monique Seiller , Francis Puisieux , Jean-Louis Grossiord
发明人： Catherine Le Hen-Ferrenbach , Isabelle Terrisse , Armelle Magnet , Monique Seiller , Francis Puisieux , Jean-Louis Grossiord
IPC分类号： A61K9/107 , A61K8/06 , A61K8/23 , A61K8/31 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/92 , A61K9/113 , A61Q19/00 , B01F17/00 , B01J13/00
CPC分类号： A61Q19/00 , A61K8/066 , A61K9/113 , B01F17/0092 , A61Q19/10 , A61Q5/02
摘要： A process for the production of multiple w/o/w emulsions in which a) a mixture of an oil and a lipophilic emulsifier I comprising glycerol and/or oligoglycerol or polyglycerol fatty acid esters is initially processed with intensive shearing to form a w/o pre-emulsion A, and b) the w/o pre-emulsion A is then further treated with an aqueous emulsifier II comprising adducts of ethylene oxide with fatty alcohols and/or sterols and, optionally, fatty alcohols, wherein the treatment is accompanied by gentle shearing; and to the resulting multiple w/o/w emulsions and their use in the preparation of cosmetic and pharmaceutical products.
摘要翻译： PCT No.PCT / EP94 / 00996 Sec。 371 1995年12月20日第 102（e）日期1995年12月20日PCT 1994年3月30日PCT PCT。公开号WO94 / 22414 PCT 日期1994年10月13日一种生产多重w / o / w乳液的方法，其中a）油和包含甘油和/或低聚甘油或聚甘油脂肪酸酯的亲脂性乳化剂I的混合物最初是用强力剪切加工形成aw / o预乳液A，和b）然后用包含环氧乙烷与脂肪醇和/或甾醇和任选的脂肪醇的加合物的水性乳化剂II进一步处理w / o预乳液A，其中治疗伴随着温和的剪切; 和所得的多重w / o / w乳液及其在制备化妆品和药物产品中的用途。

8. 发明授权

US5290563A Method for combining a mixture of heterogeneous substances with liposomes 失效
标题翻译：将异质物质混合物与脂质体组合的方法
公开(公告)号：US5290563A
公开(公告)日：1994-03-01
申请号：US797151
申请日：1991-11-26
申请人： Isabelle Millet-Genin , Francis Puisieux , Tran X. Thao , Liliane Roblot-Treupel
发明人： Isabelle Millet-Genin , Francis Puisieux , Tran X. Thao , Liliane Roblot-Treupel
IPC分类号： A61K9/127 , A61K39/35 , A61K37/22
CPC分类号： A61K39/35 , A61K9/127 , Y10S424/812 , Y10S436/829
摘要： In the method for combining with liposomes heterogeneous substances contained in a mixture, in particular, allergenic substances such as allergens and/or allergenic extracts, contained in an allergenic preparation, by adsorption on the surface of, and/or incorporation in, liposomes which comprise cholesterol, a phospholipid and/or at least one ionic lipid which gives the liposome a positive or negative charge, the liposome or its constituents are combined with the mixture of heterogeneous substances, the pH of the entire combination being higher or lower than the isoelectric point ip of the substances contained in the mixture, depending on whether the ionic lipid is charged positively or negatively respectively.
摘要翻译：在与包含在过敏原制剂中的过敏原和/或变应原提取物，通过吸附表面上和/或并入脂质体中的混合物中的脂质体异构物质，特别是过敏原和/或变应原提取物组合的方法中，所述方法包括胆固醇，磷脂和/或至少一种使脂质体成为正电荷或负电荷的离子脂质，脂质体或其成分与异质物质的混合物组合，整个组合的pH高于或低于等电点的混合物中所含的物质，这取决于离子脂质是分别带正电荷还是负电荷。

9. 发明授权

US4765987A Artificial surfactants, pharmaceutical compositions containing them and use thereof 失效
标题翻译：人造表面活性剂，含有它们的药物组合物及其用途
公开(公告)号：US4765987A
公开(公告)日：1988-08-23
申请号：US899656
申请日：1986-08-25
申请人： Frederic Bonte , Michel Dehan , Alain Le Ridant , Francis Puisieux , Christiane C. Taupin
发明人： Frederic Bonte , Michel Dehan , Alain Le Ridant , Francis Puisieux , Christiane C. Taupin
IPC分类号： A61K31/685 , A61K9/00 , A61K9/127 , A61P11/00 , B01F17/14 , C11D1/88 , A61K37/22 , A61K9/42 , B01J13/02 , C07F9/10
CPC分类号： C11D1/886 , A61K31/685 , A61K9/0082 , A61K9/127 , Y10S436/829 , Y10S516/06 , Y10T428/2984
摘要： New artificial surfactants composed of dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine and soya lecithin and pharmaceutical compositions containing them, which can be used to replace deficient endogenous pulmonary surfactant.
摘要翻译：由二棕榈酰磷脂酰胆碱，二硬脂酰磷脂酰胆碱和大豆卵磷脂组成的新型人造表面活性剂和含有它们的药物组合物，可用于代替缺乏内源性肺表面活性剂。

10. 发明授权

US06881421B1 Nanoparticles comprising at least one polymer and at least one compound able to complex one or more active ingredients 有权
标题翻译：纳米颗粒包含至少一种聚合物和至少一种能够络合一种或多种活性成分的化合物
公开(公告)号：US06881421B1
公开(公告)日：2005-04-19
申请号：US09648304
申请日：2000-08-25
申请人： Airton Monza da Silveira , Gilles Ponchel , Dominique Duchene , Patrick Couvreur , Francis Puisieux
发明人： Airton Monza da Silveira , Gilles Ponchel , Dominique Duchene , Patrick Couvreur , Francis Puisieux
IPC分类号： A61K9/51 , A61K47/48 , A61K9/14 , A61K9/50
CPC分类号： A61K9/5138 , A61K9/5161 , A61K47/6951 , B82Y5/00
摘要： Nanoparticles containing at least one active ingredient including at least one polymer, preferably a poly(alkylcyanoacrylate), in which the alkyl group, linear or branched, contains from 1 to 12 carbon atoms, and of at least one compound able to complex said active ingredient. The invention also concerns the method for preparing these nanoparticles.
摘要翻译：含有至少一种活性成分的纳米颗粒包括至少一种聚合物，优选聚（烷基氰基丙烯酸酯），其中直链或支链的烷基含有1至12个碳原子，以及至少一种能够使所述活性成分复合的化合物。本发明还涉及制备这些纳米颗粒的方法。

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