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1. 发明申请

US20080021339A1 Anesthesia monitor, capacitance nanosensors and dynamic sensor sampling method 审中-公开
标题翻译：麻醉监护仪，电容式纳米传感器和动态传感器取样方法
公开(公告)号：US20080021339A1
公开(公告)日：2008-01-24
申请号：US11588845
申请日：2006-10-26
申请人： Jean-Christophe Gabriel , Vikram Joshi , John Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
发明人： Jean-Christophe Gabriel , Vikram Joshi , John Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
IPC分类号： A61B5/08 , G01N31/22
CPC分类号： A61B5/0833 , A61B5/097 , A61B5/4821 , A61B5/6819 , A61B2562/0285 , B82Y30/00
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such as anesthesia gases, CO2 and the like in human breath. An integrated monitor system and disposable sensor unit is described which permits a number of different anesthetic agents to be identified and monitored, as well as concurrent monitoring of other breath species, such as CO2. The sensor unit may be configured to be compact, light weight, and inexpensive. Wireless embodiments provide such enhancements as remote monitoring. A simulator system for modeling the contents and conditions of human inhalation and exhalation with a selected mixture of a treatment agent is also described, particularly suited to the testing of sensors to be used in airway sampling.
摘要翻译：描述了纳米电子传感器的实施例，包括用于在人呼吸中检测分析物例如麻醉气体，CO 2等的传感器。描述了一种集成监视器系统和一次性传感器单元，其允许识别和监视多个不同的麻醉剂，以及对其它呼吸物质（例如CO 2）的并发监测。传感器单元可以被配置为紧凑，重量轻并且便宜。无线实施例提供诸如远程监视的增强。还描述了一种用于用选定的处理剂混合物对人吸入和呼出的内容物和条件进行建模的模拟器系统，特别适合于用于气道取样的传感器的测试。

2. 发明申请

US20060055392A1 Remotely communicating, battery-powered nanostructure sensor devices 有权
公开(公告)号：US20060055392A1
公开(公告)日：2006-03-16
申请号：US11111121
申请日：2005-04-20
申请人： John Passmore , Jean-Christophe Gabriel , Alexander Star , Vikram Joshi , Sergei Skarupo
发明人： John Passmore , Jean-Christophe Gabriel , Alexander Star , Vikram Joshi , Sergei Skarupo
IPC分类号： G01N27/00
CPC分类号： G01N27/4146 , B82Y15/00 , G01N27/4141
摘要： A portable sensor device incorporates a low-power, nanostructure sensor coupled to a wireless transmitter. The sensor uses a nanostructure conducting channel, such as a nanotube network, that is functionalized to respond to a selected analyte. A measurement circuit connected to the sensor determines a change in the electrical characteristic of the sensor, from which information concerning the present or absence of the analyte may be determined. The portable sensor device may include a portable power source, such as a battery. It may further include a transmitter for wirelessly transmitting data to a base station.

3. 发明申请

US20070048181A1 Carbon dioxide nanosensor, and respiratory CO2 monitors 审中-公开
标题翻译：二氧化碳纳米传感器和呼吸二氧化碳监测仪
公开(公告)号：US20070048181A1
公开(公告)日：2007-03-01
申请号：US11488456
申请日：2006-07-18
申请人： Daniel Chang , Ying-Lan Chang , Jean-Christophe Gabriel , Vikram Joshi , William Mickelson , Joseph Niemann , John Passmore , Alexander Star , Christian Valcke
发明人： Daniel Chang , Ying-Lan Chang , Jean-Christophe Gabriel , Vikram Joshi , William Mickelson , Joseph Niemann , John Passmore , Alexander Star , Christian Valcke
IPC分类号： G01N31/22
CPC分类号： G01N27/4146 , B82Y15/00 , B82Y30/00 , G01N33/004 , G01N33/497
摘要： An electronic system and method for detecting analytes, such as carbon dioxide, is provided, using an improved nanostructure sensor (CO2 sensor). The CO2 sensor may comprise a substrate and a nanostructure, such as a one or more carbon nanotubes disposed over the substrate (e.g., as a network). One or more conductive elements may electrically communicate with the nanostructure. A counter or gate electrode may be positioned adjacent the nanostructure. A functionalization material reactive with carbon dioxide may be included, either disposed in contact with the nanostructure or isolated by a dielectric. The sensor may be connected to a circuit responsive to changes in CO2 concentration in the environment. Embodiments are described of medical sensing systems including one or more CO2 sensors. One embodiment comprises a breath sampling cannula which is connected to a sensor unit. In an alternative, the cannula permits supplemental oxygen to be administered, while recovering and measuring analytes in breath samples. The cannula may connect to a portable processor-display unit for monitoring one or more analytes, such as CO2. Another embodiment includes a cannula configured for the monitoring of sleep disorders, such as apnea, comprising one or more sensors disposed adjacent a breath sampling channel, optionally including flow rate or other sensors. The sensors may be connected by wired or wireless links for to a processor/input/display unit. Any of the embodiments may include filters, selectively permeable membranes, absorbents, and the like to precondition the breath sample, may be configured to include complementary chemistry measurements.
摘要翻译：提供了一种用于检测分析物（如二氧化碳）的电子系统和方法，使用改进的纳米结构传感器（CO2传感器）。 CO 2传感器可以包括衬底和纳米结构，例如设置在衬底上的一个或多个碳纳米管（例如，作为网络）。一个或多个导电元件可以与纳米结构电连通。计数器或栅电极可以邻近纳米结构定位。可以包括与二氧化碳反应的官能化材料，其被设置为与纳米结构接触或通过电介质隔离。传感器可以响应于环境中二氧化碳浓度的变化而连接到电路。描述了包括一个或多个CO 2传感器的医学感测系统的实施例。一个实施例包括连接到传感器单元的呼吸取样套管。在替代方案中，套管允许补充氧气，同时在呼吸样本中回收和测量分析物。套管可以连接到便携式处理器显示单元，用于监测一个或多个分析物，例如CO 2。另一个实施例包括配置用于监测睡眠障碍（例如呼吸暂停）的插管，其包括邻近呼吸采样通道设置的一个或多个传感器，可选地包括流速或其它传感器。传感器可以通过有线或无线链路连接到处理器/输入/显示单元。任何实施方案可以包括过滤器，选择性渗透膜，吸收剂等以预处理呼吸样品，可以被配置为包括互补的化学测量。

4. 发明申请

US20100085067A1 ANESTHESIA MONITOR, CAPACITANCE NANOSENSORS AND DYNAMIC SENSOR SAMPLING METHOD 审中-公开
标题翻译：麻醉监护仪，电容式纳米传感器和动态传感器采样方法
公开(公告)号：US20100085067A1
公开(公告)日：2010-04-08
申请号：US12560316
申请日：2009-09-15
申请人： Jean-Christophe P. Gabriel , Vikram Joshi , John Loren Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
发明人： Jean-Christophe P. Gabriel , Vikram Joshi , John Loren Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
IPC分类号： G01N33/497 , G01N27/22 , A61B5/08 , A61B5/05
CPC分类号： A61B5/0833 , A61B5/097 , A61B5/4821 , A61B5/6819 , A61B2562/0285 , B82Y30/00
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such as anesthesia gases, CO2 and the like in human breath. An integrated monitor system and disposable sensor unit is described which permits a number of different anesthetic agents to be identified and monitored, as well as concurrent monitoring of other breath species, such as CO2. The sensor unit may be configured to be compact, light weight, and inexpensive. Wireless embodiments provide such enhancements as remote monitoring. A simulator system for modeling the contents and conditions of human inhalation and exhalation with a selected mixture of a treatment agent is also described, particularly suited to the testing of sensors to be used in airway sampling.
摘要翻译：描述了纳米电子传感器的实施例，包括用于在人呼吸中检测分析物例如麻醉气体，CO 2等的传感器。描述了一种集成监视器系统和一次性传感器单元，其允许识别和监视多个不同的麻醉剂，以及对其它呼吸物质（例如CO 2）的并发监测。传感器单元可以被配置为紧凑，重量轻并且便宜。无线实施例提供诸如远程监视的增强。还描述了一种用于用选定的处理剂混合物对人吸入和呼出的内容物和条件进行建模的模拟器系统，特别适合于用于气道取样的传感器的测试。

5. 发明申请

US20070048180A1 Nanoelectronic breath analyzer and asthma monitor 审中-公开
标题翻译：纳米电子呼吸分析仪和哮喘监测仪
公开(公告)号：US20070048180A1
公开(公告)日：2007-03-01
申请号：US11437275
申请日：2006-05-18
申请人： Jean-Christophe Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , David Thomas , Christian Valcke
发明人： Jean-Christophe Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , David Thomas , Christian Valcke
IPC分类号： G01N31/22
CPC分类号： G01N33/497 , B82Y15/00
摘要： Nanoelectronic sensors, including sensors for detecting analytes such as CO2, NO, anesthesia gases, and the like in human breath. An integrated multivalent monitor system is described which permits two or more analytes to be measured in breath, for example to monitor pulmonary conditions such as asthma. The monitor system may be configured to be compact, light weight, inexpensive, and to include a microprocessor capable of both analyzing measurements to determine patient status, and storing measurement history. Wireless embodiments provide such enhancements as remote monitoring.
摘要翻译：纳米电子传感器，包括用于在人呼吸中检测诸如CO 2，NO，麻醉气体等分析物的传感器。描述了一种综合多价监测系统，其允许在呼吸中测量两种或更多种分析物，例如监测肺部疾病如哮喘。监视器系统可以被配置为紧凑，重量轻，便宜，并且包括能够分析测量以确定患者状态并存储测量历史的微处理器。无线实施例提供诸如远程监视的增强。

6. 发明申请

US20100323925A1 Nanosensor array for electronic olfaction 审中-公开
标题翻译：用于电子嗅觉的纳米传感器阵列
公开(公告)号：US20100323925A1
公开(公告)日：2010-12-23
申请号：US11541794
申请日：2006-10-02
申请人： Jean-Christophe P. Gabriel , Vikram Joshi , Sergei Skarupo , Alexander Star , David Thomas
发明人： Jean-Christophe P. Gabriel , Vikram Joshi , Sergei Skarupo , Alexander Star , David Thomas
IPC分类号： C40B60/12
CPC分类号： B82Y30/00 , B82Y15/00 , G01N27/4146
摘要： A detector system is described including arrays having a plurality of nanoelectronic sensors comprising a channel including a nanostructured element disposed on a substrate, the nanostructured element functionalized by one or more materials disposed on or adjacent to the nanostructured element so as to operatively influence one or more sensor electrical properties. In certain embodiments, the nanostructured element comprise one or more nanotubes, and the functionalization material may include nanoparticles composed of one or more metals, metal oxides, salts, or other inorganic or organic materials or composites of these.In one exemplary embodiment, an array includes plurality of sensors which are configured as field effect transistors, the nanostructured element comprising a randomly dispersed interconnecting network of single-walled carbon nanotubes (SWNTs) having semiconducting properties, and functionalized by deposition of metallic nanoparticles comprising one or more metallic elements. The deposition of nanoparticles may be controlled to preserve semiconductive properties of the nanotubes. Novel methods of electrodeposition of such nanoparticles are described.The detector system may be configured to distinguish and detect a range of different analyte species by measurement of the responses of a plurality of sensors of the array, and analyzing the measurements using principal component analysis, pattern-recognition analysis tools, and the like. Example analytes may comprise a plurality of organic and inorganic gases, such as are relevant to medical, industrial, environmental and security detection.
摘要翻译：描述了一种检测器系统，其包括具有多个纳米电子传感器的阵列，该多个纳米电子传感器包括通道，该通道包括设置在基底上的纳米结构元件，该纳米结构元件由设置在纳米结构元件上或其上的一种或多种材料功能化，以便可操作地影响一个或多个传感器电气特性。在某些实施方案中，纳米结构元件包含一个或多个纳米管，并且官能化材料可以包括由一种或多种金属，金属氧化物，盐或其它无机或有机材料或这些的复合材料组成的纳米颗粒。在一个示例性实施例中，阵列包括配置为场效应晶体管的多个传感器，纳米结构元件包括具有半导体性质的单壁碳纳米管（SWNT）的随机分散的互连网络，并且通过沉积包含一个或更多的金属元素。可以控制纳米颗粒的沉积以保持纳米管的半导体性质。描述了这种纳米颗粒的电沉积的新方法。检测器系统可以被配置为通过测量阵列的多个传感器的响应并且使用主成分分析，模式识别分析工具等分析测量来区分和检测不同分析物种的范围。示例性分析物可以包括多种有机和无机气体，例如与医疗，工业，环境和安全性检测相关的。

7. 发明授权

US07522040B2 Remotely communicating, battery-powered nanostructure sensor devices 有权
标题翻译：远程通信，电池供电的纳米结构传感器设备
公开(公告)号：US07522040B2
公开(公告)日：2009-04-21
申请号：US11111121
申请日：2005-04-20
申请人： John Loren Passmore , Jean-Christophe P. Gabriel , Alexander Star , Vikram Joshi , Sergei Skarupo
发明人： John Loren Passmore , Jean-Christophe P. Gabriel , Alexander Star , Vikram Joshi , Sergei Skarupo
IPC分类号： G08B21/00
CPC分类号： G01N27/4146 , B82Y15/00 , G01N27/4141
摘要： A portable sensor device incorporates a low-power, nanostructure sensor coupled to a wireless transmitter. The sensor uses a nanostructure conducting channel, such as a nanotube network, that is functionalized to respond to a selected analyte. A measurement circuit connected to the sensor determines a change in the electrical characteristic of the sensor, from which information concerning the present or absence of the analyte may be determined. The portable sensor device may include a portable power source, such as a battery. It may further include a transmitter for wirelessly transmitting data to a base station.
摘要翻译：便携式传感器装置包括耦合到无线发射器的低功率纳米结构传感器。传感器使用纳米结构导电通道，例如纳米管网络，其被功能化以响应于所选择的分析物。连接到传感器的测量电路确定传感器的电特性的变化，从该信号可以确定与分析物的存在或不存在有关的信息。便携式传感器装置可以包括诸如电池的便携式电源。它还可以包括用于向基站无线发送数据的发射机。

8. 发明申请

US20050157445A1 Nanostructures with electrodeposited nanoparticles 有权
标题翻译：具有电沉积纳米粒子的纳米结构
公开(公告)号：US20050157445A1
公开(公告)日：2005-07-21
申请号：US10945803
申请日：2004-09-20
申请人： Keith Bradley , Alona Davis , Jean-Christophe Gabriel , Tzong-Ru Han , Vikram Joshi , Alexander Star
发明人： Keith Bradley , Alona Davis , Jean-Christophe Gabriel , Tzong-Ru Han , Vikram Joshi , Alexander Star
IPC分类号： G01N27/00 , G01N27/414 , G01N33/00 , H02H1/00
CPC分类号： B82Y30/00 , G01N27/4146 , G01N33/005 , Y10S977/72
摘要： A nanoelectronic device includes a nanostructure, such as a nanotube or network of nanotubes, disposed on a substrate. Nanoparticles are disposed on or adjacent to the nanostructure so as to operatively effect the electrical properties of the nanostructure. The nanoparticles may be composed of metals, metal oxides, or salts, and nanoparticles composed of different materials may be present. The amount of nanoparticles may be controlled to preserve semiconductive properties of the nanostructure, and the substrate immediately adjacent to the nanostructure may remain substantially free of nanoparticles. A method for fabricating the device includes electrodeposition of the nanoparticles using one or more solutions of dissolved ions while providing an electric current to the nanostructures but not to the surrounding substrate.
摘要翻译：纳米电子器件包括设置在衬底上的纳米结构，例如纳米管或纳米管网络。将纳米颗粒设置在纳米结构上或与纳米结构相邻，以便有效地影响纳米结构的电性能。纳米颗粒可以由金属，金属氧化物或盐组成，并且可以存在由不同材料组成的纳米颗粒。可以控制纳米颗粒的量以保持纳米结构的半导体性质，并且紧邻纳米结构的衬底可以基本上不含纳米颗粒。制造该器件的方法包括使用一种或多种溶解离子的溶液电沉积纳米颗粒，同时向纳米结构提供电流，而不向周围的衬底提供电流。

9. 发明授权

US07714398B2 Nanoelectronic measurement system for physiologic gases and improved nanosensor for carbon dioxide 有权
标题翻译：用于生理气体的纳米电子测量系统和改进的二氧化碳纳米传感器
公开(公告)号：US07714398B2
公开(公告)日：2010-05-11
申请号：US11390493
申请日：2006-03-27
申请人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
发明人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
IPC分类号： G01N27/414
CPC分类号： G01N33/5438 , A61B5/073 , A61B2562/0285 , B82Y10/00 , B82Y15/00 , B82Y20/00 , H01L51/0048 , H01L51/0052 , H01L51/0545
摘要： A system for measuring an analyte of interest, particularly carbon dioxide, dissolved in a fluid media of a patient including a nanoelectronic sensor and a measurement instrument in communication with the sensor and configured to receive at least a signal from the sensor indicative of a response of the sensor to at least the analyte of interest.
摘要翻译：一种用于测量感兴趣的分析物，特别是二氧化碳的系统，其溶解在患者的流体介质中，包括与所述传感器通信的纳米电子传感器和测量仪器，并且被配置为从所述传感器接收表示响应的信号传感器至少是所关注的分析物。

10. 发明申请

US20100056892A1 NANOELECTRONIC MEASUREMENT SYSTEM FOR PHYSIOLOGIC GASES AND IMPROVED NANOSENSOR FOR CARBON DIOXIDE 有权
标题翻译：用于生物气体的纳米电子测量系统和改进的二氧化碳纳米传感器
公开(公告)号：US20100056892A1
公开(公告)日：2010-03-04
申请号：US11390493
申请日：2006-03-27
申请人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
发明人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
IPC分类号： A61B5/05 , A61N1/36
CPC分类号： G01N33/5438 , A61B5/073 , A61B2562/0285 , B82Y10/00 , B82Y15/00 , B82Y20/00 , H01L51/0048 , H01L51/0052 , H01L51/0545
摘要： A system for measuring an analyte of interest, particularly carbon dioxide, dissolved in a fluid media of a patient including a nanoelectronic sensor and a measurement instrument in communication with the sensor and configured to receive at least a signal from the sensor indicative of a response of the sensor to at least the analyte of interest.
摘要翻译：一种用于测量感兴趣的分析物，特别是二氧化碳的系统，其溶解在患者的流体介质中，包括与所述传感器通信的纳米电子传感器和测量仪器，并且被配置为从所述传感器接收表示响应的信号传感器至少是所关注的分析物。

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