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1. 发明授权

US07332353B2 Method for detecting analyte(s) using magnetic colloidal particles 有权
标题翻译：使用磁性胶体颗粒检测分析物的方法
公开(公告)号：US07332353B2
公开(公告)日：2008-02-19
申请号：US10496114
申请日：2002-11-20
申请人： Jean Baudry , Jérôme Bibette , Alain Rousseau
发明人： Jean Baudry , Jérôme Bibette , Alain Rousseau
IPC分类号： G01N33/553
CPC分类号： G01N33/5434
摘要： The invention concerns a method for detecting and/or quantifying at least an analyte in a liquid medium, characterized in that it consists in using magnetic colloidal particles functionalized at the surface with at least a ligand specific of the analyte to be detected and/or assayed and in that it comprises: contacting said particles with said medium to be analyzed; applying a magnetic field to said medium, at an intensity sufficient to cause said magnetic particles to be structured in the form of chains; maintaining said magnetic field for a sufficient time interval to enable coupling or combination of the analyte concerned with at least two specific ligands present respectively on two neighbouring particles of a chain; cancelling the magnetic field, and determining the presence and/or absence of said analyte and, as the case may be, its concentration via the presence and/or the absence of said permanent chains of magnetic particles.
摘要翻译：本发明涉及用于检测和/或定量液体介质中的至少一种分析物的方法，其特征在于它使用在表面官能化的至少一种被检测和/或分析的分析物的配体特异性的磁性胶体颗粒并且其包括：使所述颗粒与待分析的介质接触; 以足以使所述磁性颗粒以链的形式构造的强度向所述介质施加磁场; 保持所述磁场足够的时间间隔，以使所述分析物与分别存在于链的两个相邻颗粒上的至少两种特异性配体相耦合或组合; 消除磁场，并且通过所述永久磁性颗粒的存在和/或不存在来确定所述分析物的存在和/或不存在以及视情况而定的浓度。

2. 发明申请

US20050048673A1 Method for detecting analyte(s) using magnetic colloidal particles 有权
标题翻译：使用磁性胶体颗粒检测分析物的方法
公开(公告)号：US20050048673A1
公开(公告)日：2005-03-03
申请号：US10496114
申请日：2002-11-20
申请人： Jean Baudry , Jerome Bibette , Alain Rousseau
发明人： Jean Baudry , Jerome Bibette , Alain Rousseau
IPC分类号： G01N33/553 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/569
CPC分类号： G01N33/5434
摘要： The invention concerns a method for detecting and/or quantifying at least an analyte in a liquid medium, characterized in that it consists in using magnetic colloidal particles functionalized at the surface with at least a ligand specific of the analyte to be detected and/or assayed and in that it comprises: contacting said particles with said medium to be analyzed; applying a magnetic field to said medium, at an intensity sufficient to cause said magnetic particles to be structured in the form of chains; maintaining said magnetic field for a sufficient time interval to enable coupling or combination of the analyte concerned with at least two specific ligands present respectively on two neighbouring particles of a chain; cancelling the magnetic field, and determining the presence and/or absence of said analyte and, as the case may be, its concentration via the presence and/or the absence of said permanent chains of magnetic particles.
摘要翻译：本发明涉及用于检测和/或定量液体介质中的至少一种分析物的方法，其特征在于它使用在表面官能化的至少一种被检测和/或分析的分析物的配体特异性的磁性胶体颗粒并且其包括：使所述颗粒与待分析的介质接触; 以足以使所述磁性颗粒以链的形式构造的强度向所述介质施加磁场; 保持所述磁场足够的时间间隔，以使所述分析物与分别存在于链的两个相邻颗粒上的至少两种特异性配体相耦合或组合; 消除磁场，并且通过所述永久磁性颗粒的存在和/或不存在来确定所述分析物的存在和/或不存在以及视情况而定的浓度。

3. 发明授权

US07959878B2 Unit cuvette for analyzing a biological fluid, automatic device for in vitro analysis 有权
标题翻译：用于分析生物液体的单位比色皿，用于体外分析的自动装置
公开(公告)号：US07959878B2
公开(公告)日：2011-06-14
申请号：US12087492
申请日：2007-01-17
申请人： Alain Rousseau
发明人： Alain Rousseau
IPC分类号： B01L3/00
CPC分类号： B01L3/50855 , B01L2200/025 , G01N21/03 , G01N35/025 , G01N2035/041 , G01N2035/0465
摘要： The bottom of the cuvette comprises a curved raceway placed so as to guide the oscillating movement of a ball inserted into the cuvette. In addition, the cuvette comprises means of attachment, in two perpendicular directions, to adjacent unit cuvettes. The cuvettes can thus be stored as plates in a feed magazine of an analytical device. The analytical device comprises several stations placed around a rotary ring. Only where it is desired to determine the clotting time of the blood contained in the cuvette a ball is introduced into the latter, at a ball distribution post. The cuvette equipped in this way is then brought to a station where the test is carried out. The major advantage of the invention is the polyvalence of the cuvette and of the analytical device.
摘要翻译：比色皿的底部包括弯曲的滚道，以便引导插入比色杯中的球的摆动运动。此外，试管包括在两个垂直方向上连接到相邻的单位比色皿的装置。因此，反应杯可以作为板储存在分析装置的进料仓中。分析装置包括围绕旋转环放置的若干台。只有在需要确定包含在比色杯中的血液的凝血时间的情况下，在球分配柱处将球引入后者。以这种方式装备的比色杯然后被带到进行测试的工位。本发明的主要优点是比色皿和分析装置的多价性。

4. 发明申请

US20100247385A1 Multidisciplinary automatic analyzer for in vitro diagnosis 有权
标题翻译：用于体外诊断的多学科自动分析仪
公开(公告)号：US20100247385A1
公开(公告)日：2010-09-30
申请号：US12662738
申请日：2010-04-30
申请人： Alain Rousseau
发明人： Alain Rousseau
IPC分类号： G01N21/03
CPC分类号： G01N35/025 , B01L3/50855 , B01L2300/0858 , G01N2035/00356 , G01N2035/0465 , G01N2035/047 , Y10T436/113332
摘要： The device comprises reaction unit cuvettes for different types of tests, a vertial axis rotor which is associated with a rotation drive means and provided with a horizontal gear-teeth crown delimiting radially outwardly open cavities for receiving the reaction unit cuvettes, a device for supplying the gear-teeth crown with the reaction unit cuvettes, a device for supplying cuvettes with analysable biological liquid samples, stations arranged around the crown for carrying out measurements and/or analysis and an automation for managing the sequences of a desired process for each cuvette.
摘要翻译：该装置包括用于不同类型测试的反应单元比色皿，与旋转驱动装置相关联并设置有水平齿轮齿冠的横向轴转子，其限定径向向外敞开的空腔，用于接收反应单元比色皿，具有反应单元比色皿的齿轮齿冠，用于向比色皿提供可分析的生物液体样品的装置，围绕冠部设置的用于进行测量和/或分析的台站以及用于管理每个比色皿所需工艺序列的自动化。

5. 发明授权

US07507377B2 Device for automatic analysis of a liquid sample 有权
标题翻译：用于液体样品自动分析的装置
公开(公告)号：US07507377B2
公开(公告)日：2009-03-24
申请号：US10503239
申请日：2003-01-28
申请人： Alain Rousseau , Khaled Abou-Saleh , Patrick Perin , Philippe Poutrel
发明人： Alain Rousseau , Khaled Abou-Saleh , Patrick Perin , Philippe Poutrel
IPC分类号： G01N35/02 , G01N35/04
CPC分类号： G01N35/026 , G01N35/04 , Y10T436/11 , Y10T436/113332 , Y10T436/114998
摘要： This invention relates to a device usable in an automatical apparatus for the determination of the rate of change of the physical state of a medium. This device has a series of cuvettes having two opposites shoulders which extend in the plane of the opening of the cuvette and a flexible film which is fixed on the shoulders. This film is provided with a series of oblong opening respectively arranged above the cuvette openings. An optical detection station is provided which has a light source generating a light beam which illuminates the upper face of the cuvette bowls and an optoeleclectronic detector placed below the bottom of the bowls.
摘要翻译：本发明涉及可用于确定介质的物理状态变化率的自动装置中的装置。该装置具有一系列比色皿，其具有在比色皿开口平面上延伸的两个相对的肩部和固定在肩上的柔性膜。该膜具有分别布置在比色皿开口上方的一系列长圆形开口。提供了一种光学检测站，其具有产生照明比色皿碗的上表面的光束的光源和放置在碗的底部下方的光电检测器。

6. 发明申请

US20050175502A1 Device for automatic analysis of a liquid sample 有权
标题翻译：用于液体样品自动分析的装置
公开(公告)号：US20050175502A1
公开(公告)日：2005-08-11
申请号：US10503239
申请日：2003-01-28
申请人： Alain Rousseau , Khaled Abou-Saleh , Patrick Perin , Philippe Poutrel
发明人： Alain Rousseau , Khaled Abou-Saleh , Patrick Perin , Philippe Poutrel
IPC分类号： G01N33/49 , G01N1/00 , G01N35/02 , G01N35/04 , G01N35/00
CPC分类号： G01N35/026 , G01N35/04 , Y10T436/11 , Y10T436/113332 , Y10T436/114998
摘要： The invention relates to a device comprising a series of single-use cuvettes (C), each with a base, an upper face opposite said base with an opening and two opposing flanges (R 1 , R 2 ) which each extend from the cuvette essentially in the plane of the opening. Said cuvettes are arranged side by side and fixed to each other by means of a flexible film (3) fixed to said flanges (R 1 , R 2 ) and at least partially covering the openings of said cuvettes (C). Said film is provided with a series of openings (4) respectively arranged to the right of said openings on said cuvettes. The above finds application in an automatic analytical apparatus, particularly for the determination of the rate of change of the physical state of a medium.
摘要翻译：本发明涉及一种装置，其包括一系列单次使用的比色杯（C），每个比色皿具有基座，与基座相对的上表面具有开口和两个相对的凸缘（R s1>，R < > 2 ），其基本上在开口的平面中从比色杯延伸。所述比色皿被并排布置并且通过固定到所述凸缘（R s 1，R b 2>）的柔性膜（3）彼此固定并且至少部分地覆盖所述比色皿（C）的开口。所述膜设置有分别布置在所述比色杯上的所述开口右侧的一系列开口（4）。以上发现在自动分析装置中的应用，特别是用于确定介质的物理状态的变化率。

7. 发明授权

US06767511B1 Automatic analysis apparatus used for timing blood coagulation 有权
标题翻译：自动分析装置用于定时凝血
公开(公告)号：US06767511B1
公开(公告)日：2004-07-27
申请号：US09719091
申请日：2001-04-16
申请人： Alain Rousseau
发明人： Alain Rousseau
IPC分类号： G01N3348
CPC分类号： G01N35/021 , G01N11/16 , G01N33/4905 , Y10T436/11
摘要： The invention concerns an automatic analysis apparatus wherein the liquid sample to be analysed is arranged in a cup (C) containing a ferromagnetic ball (BE) driven in a periodic motion under the effect of a magnetic field. In order to detect the ball (BE) movements representing the physical state of the sample, an electronic camera (CM1 to CM3) is oriented towards the cup (C) while a processor (P) determines, from the cup (C) image, the modifications in the ball (BE) movements. The invention is useful for producing small-size and medium-size automatic appliances.
摘要翻译：本发明涉及一种自动分析装置，其中待分析的液体样品被布置在包含在磁场作用下以周期运动驱动的铁磁球（BE）的杯（C）中。为了检测代表样品的物理状态的球（BE）运动，电子照相机（CM1至CM3）朝向杯子（C）定向，而处理器（P）从杯（C）图像确定，球（BE）运动中的修改。本发明对于生产小尺寸和中型自动电器是有用的。

8. 发明授权

US06428893B1 Graded index plastics optical fiber and a method of continuously fabricating a graded index plastics optical fiber 失效
标题翻译：渐变折射率塑料光纤和连续制造渐变折射率塑料光纤的方法
公开(公告)号：US06428893B1
公开(公告)日：2002-08-06
申请号：US09409341
申请日：1999-09-30
申请人： Jean-Yves Barraud , Dominique Morichere , Alain Pastouret , Bernard Boutevin , Alain Rousseau
发明人： Jean-Yves Barraud , Dominique Morichere , Alain Pastouret , Bernard Boutevin , Alain Rousseau
IPC分类号： B32B900
CPC分类号： G02B6/02038 , D01F8/10 , Y10T428/2933 , Y10T428/2964
摘要： A method of continuous application of a graded index plastics optical fiber in which the refractive index is highest in the center and decreases progressively towards the periphery, said fiber having a plurality of layers of resin deposited concentrically, the method comprising making a plurality of mixtures, each mixture comprising at least one polymer P and a reactive diluting agent including at least two monomers, then depositing said mixtures in the form of coaxial layers, allowing interdiffusing to take place between the layers, and finally crosslinking the polymer P and/or the reactive diluting agent.
摘要翻译：一种连续应用渐变折射率塑料光纤的方法，其中中心的折射率最高并且朝向周边逐渐减小，所述纤维具有多个同心沉积的树脂层，该方法包括制备多种混合物，每个混合物包含至少一种聚合物P和包含至少两种单体的活性稀释剂，然后以同轴层的形式沉积所述混合物，允许相互扩散在层之间发生，最后交联聚合物P和/或反应性稀释剂。

9. 发明授权

US06255101B1 Seal for reagent flask usable by a blood analyzer 失效
标题翻译：用于通过血液分析仪可用的试剂瓶的密封
公开(公告)号：US06255101B1
公开(公告)日：2001-07-03
申请号：US09341953
申请日：1999-07-21
申请人： Alain Rousseau , Jean-François Gelin
发明人： Alain Rousseau , Jean-François Gelin
IPC分类号： C12M134
CPC分类号： A61J1/2096 , A61J1/2041 , B65D25/085 , B65D51/002 , B65D2231/005 , G01N35/1002
摘要： The invention concerns a seal for closing the neck of a flask. The seal comprises a stopper with a central coaxial channel for passage of an injection and/or sampling needle, this channel being sealed by at least one ball with a diameter slightly greater than that of the channel. This seal is suitable for a reagent flask used by a blood analyzer.
摘要翻译：本发明涉及用于封闭烧瓶颈部的密封件。密封件包括具有用于通过注射和/或采样针的中心同轴通道的止动件，该通道被直径略大于通道直径的至少一个球密封。该密封适用于血液分析仪使用的试剂瓶。

10. 发明授权

US6020150A Gelled system and method for detecting microorganisms by separation and culture on gelled system 失效
标题翻译：凝胶体系和通过分离和培养在凝胶体系上检测微生物的方法
公开(公告)号：US6020150A
公开(公告)日：2000-02-01
申请号：US913757
申请日：1997-09-22
申请人： Genevieve Contant-Pussard , Fran.cedilla.oise Boisard-Beaupere , Jean-Luc Martinoli , Alain Rousseau
发明人： Genevieve Contant-Pussard , Fran.cedilla.oise Boisard-Beaupere , Jean-Luc Martinoli , Alain Rousseau
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/02 , C12Q1/04 , C12Q1/24 , C12N1/02 , C12Q1/06 , C12Q1/08
CPC分类号： C12Q1/04 , C12Q1/24 , Y10S435/975
摘要： A method for detecting the presence or absence of microorganisms belonging to the group which consists of bacteria and yeasts in a liquid sample (5) of a biological material. The method comprises placing the liquid sample (5) in a centrifuge tube (6a, 6b) above a gelled system (10) comprising at least (a) a first so-called development phase (1), i.e. a gel comprising a microorganism culture medium and a reagent for inducing a detectable optical measurement change in the presence of microorganisms, said gel being an intimate mixture of water and water-absorbing polymeric particles that have swelled in such a way that, in said intimate mixture, said polymeric particles have (.alpha.) a dry weight concentration of 0.05-0.2 g/ml, and (.beta.) a swollen-state diameter of 90-320 .mu.m, the water in the intimate mixture being at least partially provided by said culture medium; centrifuging; and revealing the presence or absence of microorganisms in said liquid sample (5) at said first phase (1) of the gelled system (10) by means of said reagent inducing a detectable optical measurement change.
摘要翻译： PCT No.PCT / FR96 / 00419 Sec。 371日期：1997年9月22日 102（e）日期1997年9月22日PCT提交1996年3月20日PCT公布。公开号WO96 / 29427 日期1996年9月26日在生物材料的液体样品（5）中检测属于由细菌和酵母组成的组的微生物的存在或不存在的方法。该方法包括将液体样品（5）放置在凝胶系统（10）上方的离心管（6a，6b）中，所述凝胶系统（10）至少包含（a）第一所谓的显影相（1），即包含微生物培养物介质和用于在微生物存在下诱导可检测的光学测量变化的试剂，所述凝胶是水和吸水聚合物颗粒的紧密混合物，其以这样的方式溶胀，使得在所述紧密混合物中所述聚合物颗粒具有 α）0.05-0.2g / ml的干重浓度，和（β）90-320μm的膨胀状态直径，紧密混合物中的水至少部分地由所述培养基提供; 离心; 并且通过所述试剂在凝胶系统（10）的所述第一阶段（1）处揭示所述液体样品（5）中存在或不存在微生物，从而引起可检测的光学测量变化。

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