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1. 发明授权

US09631115B2 Coating composition, and a process for producing the same 有权
公开(公告)号：US09631115B2
公开(公告)日：2017-04-25
申请号：US14009634
申请日：2011-04-08
申请人： Jane E. Weier , Charles S. Kan , John A. Roper, III , Rebecca S. Ortiz , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
发明人： Jane E. Weier , Charles S. Kan , John A. Roper, III , Rebecca S. Ortiz , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
IPC分类号： C09D167/00 , C09D167/08 , C09D123/00 , C09D163/00
CPC分类号： C09D167/00 , C09D123/00 , C09D163/00 , C09D167/08 , C08L23/00 , C08L75/04 , C08L67/00 , C08L63/00
摘要： The present invention provides a coating composition, a process for producing the same, one or more coating layers derived therefrom, and articles comprising one or more such coating layers. The coating composition according to the present invention comprises: (a) from 10 to 90 percent by weight of an aqueous, high-solid, solvent-free alkyd dispersion comprising: (i) from 40 to 70 percent by weight of one or more alkyds based on the total weight of the dispersion, wherein each said one or more alkyds has an acid value of less than 20 and a molecular weight (Mn) in the range of greater than 1000 Dalton; (ii) from less than 10 percent by weight of one or more surfactants, based on the total weight of the dispersion; and (iii) from 30 to 55 percent by weight of water, based on the total weight of the dispersion; wherein said aqueous, high-solid, solvent-free alkyd dispersion has an average particle size diameter in the range of from 0.05 to 5 μm; (b) from 10 to 90 one or more second dispersions, one or more second emulsions, or combinations thereof; wherein said coating composition has a solid content of in the range of from 25 to 65 percent by weight of solid content, based on the total weight of the coating composition, and the coating composition has a pH in the range of from 7 to 11, and wherein the coating composition has a volume average particle size in the range of from 0.03 to 5 μm, and wherein the coating composition has a viscosity in the range of from 100 to 10,000 cP.

2. 发明申请

US20110207850A1 COATING COMPOSITION, AND A PROCESS FOR PRODUCING THE SAME 有权
标题翻译：涂料组合物及其制造方法
公开(公告)号：US20110207850A1
公开(公告)日：2011-08-25
申请号：US13083078
申请日：2011-04-08
申请人： Charles S. Kan , Rebecca S. Ortiz , John A. Roper, III , Jane E. Weier , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
发明人： Charles S. Kan , Rebecca S. Ortiz , John A. Roper, III , Jane E. Weier , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
IPC分类号： C09D167/00 , C09D163/00 , C09D133/08 , C09D131/04
CPC分类号： C09D167/08 , C08J3/03 , C08J3/05 , C08J2367/08 , C09D5/022 , Y10T428/31786 , Y10T428/31938
摘要： The present invention provides a coating composition, a process for producing the same, one or more coating layers derived therefrom, and articles comprising one or more such coating layers. The coating composition according to the present invention comprises: (a) from 10 to 90 percent by weight of an aqueous, high-solid, solvent-free alkyd dispersion comprising: (i) from 40 to 70 percent by weight of one or more alkyds based on the total weight of the dispersion, wherein each said one or more alkyds has an acid value of less than 20 and a molecular weight (Mn) in the range of greater than 1000 Dalton; (ii) from less than 10 percent by weight of one or more surfactants, based on the total weight of the dispersion; and (iii) from 30 to 55 percent by weight of water, based on the total weight of the dispersion; wherein said aqueous, high-solid, solvent-free alkyd dispersion has an average particle size diameter in the range of from 0.05 to 5 μm; (b) from 10 to 90 one or more second dispersions, one or more second emulsions, or combinations thereof; wherein said coating composition has a solid content of in the range of from 25 to 65 percent by weight of solid content, based on the total weight of the coating composition, and the coating composition has a pH in the range of from 7 to 11, and wherein the coating composition has a volume average particle size in the range of from 0.03 to 5 μm, and wherein the coating composition has a viscosity in the range of from 100 to 10,000 cP.
摘要翻译：本发明提供一种涂料组合物，其制备方法，由其衍生的一种或多种涂层，以及包含一种或多种这样的涂层的制品。根据本发明的涂料组合物包含：（a）10至90重量％的水性，高固体，无溶剂的醇酸树脂分散体，其包含：（i）40至70重量％的一种或多种醇酸树脂基于分散体的总重量，其中每个所述一种或多种醇酸树脂的酸值小于20，分子量（Mn）在大于1000道尔顿范围内; （ii）基于分散体的总重量，少于10重量％的一种或多种表面活性剂; 和（iii）基于分散体的总重量的30至55重量％的水; 其中所述水性，高固体，无溶剂的醇酸树脂分散体的平均粒度直径在0.05至5μm的范围内; （b）10至90个一种或多种第二分散体，一种或多种第二乳液或其组合; 其中所述涂料组合物的固体含量为固体含量的25至65重量％，基于涂料组合物的总重量，并且涂料组合物的pH为7至11，并且其中所述涂料组合物的体积平均粒径在0.03至5μm的范围内，并且其中所述涂料组合物的粘度在100至10000cP的范围内。

3. 发明授权

US08709607B2 Coating composition, and a process for producing the same 有权
标题翻译：涂料组合物及其制备方法
公开(公告)号：US08709607B2
公开(公告)日：2014-04-29
申请号：US13083078
申请日：2011-04-08
申请人： Charles S. Kan , Rebecca S. Ortiz , John A. Roper, III , Jane E. Weier , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
发明人： Charles S. Kan , Rebecca S. Ortiz , John A. Roper, III , Jane E. Weier , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
IPC分类号： B32B27/36 , B32B27/32 , C09D5/02 , C09D167/08 , C09D125/02
CPC分类号： C09D167/08 , C08J3/03 , C08J3/05 , C08J2367/08 , C09D5/022 , Y10T428/31786 , Y10T428/31938
摘要： The present invention provides a coating composition, a process for producing the same, one or more coating layers derived therefrom, and articles comprising one or more such coating layers. The coating composition according to the present invention comprises: (a) from 10 to 90 percent by weight of an aqueous, high-solid, solvent-free alkyd dispersion comprising: (i) from 40 to 70 percent by weight of one or more alkyds based on the total weight of the dispersion, wherein each said one or more alkyds has an acid value of less than 20 and a molecular weight (Mn) in the range of greater than 1000 Dalton; (ii) from less than 10 percent by weight of one or more surfactants, based on the total weight of the dispersion; and (iii) from 30 to 55 percent by weight of water, based on the total weight of the dispersion; wherein said aqueous, high-solid, solvent-free alkyd dispersion has an average particle size diameter in the range of from 0.05 to 5 μm; (b) from 10 to 90 one or more second dispersions, one or more second emulsions, or combinations thereof; wherein said coating composition has a solid content of in the range of from 25 to 65 percent by weight of solid content, based on the total weight of the coating composition, and the coating composition has a pH in the range of from 7 to 11, and wherein the coating composition has a volume average particle size in the range of from 0.03 to 5 μm, and wherein the coating composition has a viscosity in the range of from 100 to 10,000 cP.
摘要翻译：本发明提供一种涂料组合物，其制备方法，由其衍生的一种或多种涂层，以及包含一种或多种这样的涂层的制品。根据本发明的涂料组合物包含：（a）10至90重量％的水性，高固体，无溶剂的醇酸树脂分散体，其包含：（i）40至70重量％的一种或多种醇酸树脂基于分散体的总重量，其中每个所述一种或多种醇酸树脂的酸值小于20，分子量（Mn）在大于1000道尔顿范围内; （ii）基于分散体的总重量，少于10重量％的一种或多种表面活性剂; 和（iii）基于分散体的总重量的30至55重量％的水; 其中所述水性，高固体，无溶剂的醇酸树脂分散体的平均粒度直径在0.05至5μm的范围内; （b）10至90个一种或多种第二分散体，一种或多种第二乳液或其组合; 其中所述涂料组合物的固体含量为固体含量的25至65重量％，基于涂料组合物的总重量，并且涂料组合物的pH为7至11，并且其中所述涂料组合物的体积平均粒径在0.03至5μm的范围内，并且其中所述涂料组合物的粘度在100至10000cP的范围内。

4. 发明申请

US20140024742A1 COATING COMPOSITION, AND A PROCESS FOR PRODUCING THE SAME 有权
标题翻译：涂料组合物及其制造方法
公开(公告)号：US20140024742A1
公开(公告)日：2014-01-23
申请号：US14009634
申请日：2011-04-08
申请人： Charles S. Kan , Rebecca S. Ortiz , John A. Roper, III , Jane Elizabeth Weier , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
发明人： Charles S. Kan , Rebecca S. Ortiz , John A. Roper, III , Jane Elizabeth Weier , Timothy J. Young , Gary E. Spilman , Ray E. Drumright
IPC分类号： C09D167/00 , C09D163/00
CPC分类号： C09D167/00 , C09D123/00 , C09D163/00 , C09D167/08 , C08L23/00 , C08L75/04 , C08L67/00 , C08L63/00
摘要： The present invention provides a coating composition, a process for producing the same, one or more coating layers derived therefrom, and articles comprising one or more such coating layers. The coating composition according to the present invention comprises: (a) from 10 to 90 percent by weight of an aqueous, high-solid, solvent-free alkyd dispersion comprising: (i) from 40 to 70 percent by weight of one or more alkyds based on the total weight of the dispersion, wherein each said one or more alkyds has an acid value of less than 20 and a molecular weight (Mn) in the range of greater than 1000 Dalton; (ii) from less than 10 percent by weight of one or more surfactants, based on the total weight of the dispersion; and (iii) from 30 to 55 percent by weight of water, based on the total weight of the dispersion; wherein said aqueous, high-solid, solvent-free alkyd dispersion has an average particle size diameter in the range of from 0.05 to 5 μm; (b) from 10 to 90 one or more second dispersions, one or more second emulsions, or combinations thereof; wherein said coating composition has a solid content of in the range of from 25 to 65 percent by weight of solid content, based on the total weight of the coating composition, and the coating composition has a pH in the range of from 7 to 11, and wherein the coating composition has a volume average particle size in the range of from 0.03 to 5 μm, and wherein the coating composition has a viscosity in the range of from 100 to 10,000 cP.
摘要翻译：本发明提供一种涂料组合物，其制备方法，由其衍生的一种或多种涂层，以及包含一种或多种这样的涂层的制品。根据本发明的涂料组合物包含：（a）10至90重量％的水性，高固体，无溶剂的醇酸树脂分散体，其包含：（i）40至70重量％的一种或多种醇酸树脂基于分散体的总重量，其中每个所述一种或多种醇酸树脂的酸值小于20，分子量（Mn）在大于1000道尔顿范围内; （ii）基于分散体的总重量，少于10重量％的一种或多种表面活性剂; 和（iii）基于分散体的总重量的30至55重量％的水; 其中所述水性，高固体，无溶剂的醇酸树脂分散体的平均粒度直径为0.05-5μm; （b）10至90个一种或多种第二分散体，一种或多种第二乳液或其组合; 其中所述涂料组合物的固体含量为固体含量的25至65重量％，基于涂料组合物的总重量，并且涂料组合物的pH为7至11，并且其中所述涂料组合物的体积平均粒度在0.03至5μm的范围内，并且其中所述涂料组合物具有在100至10,000cP范围内的粘度。

5. 发明授权

US09200177B2 Alkyd dispersion, and a process for producing the same 有权
标题翻译：醇酸分散体及其制造方法
公开(公告)号：US09200177B2
公开(公告)日：2015-12-01
申请号：US13498264
申请日：2010-11-01
申请人： Timothy J. Young , Gary E. Spilman , Suresh Subramonian , Ray E. Drumright , David D. Mall , Rosemarie Lauer , Andrea Greyson , Robert Sandoval , Ahmad Madkour
发明人： Timothy J. Young , Gary E. Spilman , Suresh Subramonian , Ray E. Drumright , David D. Mall , Rosemarie Lauer , Andrea Greyson , Robert Sandoval , Ahmad Madkour
IPC分类号： B05D7/24 , C09D191/00 , C09D167/08 , C08J3/03 , C08J3/05 , C09D5/02
CPC分类号： C09D167/08 , C08J3/03 , C08J3/05 , C08J2367/08 , C09D5/022 , Y10T428/31786 , Y10T428/31938
摘要： The instant invention provides a high-solid, solvent-free alkyd dispersion, and a continuous process for producing the same. The aqueous alkyd dispersion, according to the present invention comprises (a) from 40 to 70 percent by weight of one or more alkyds based on the total weight of the dispersion, wherein each one or more alkyds has an acid value of less than 20 and a molecular weight (Mn) in the range of greater than 1000 Dalton; (b) from less than 10 percent by weight of one or more surfactants, based on the total weight of the dispersion; and (c) from 30 to 55 percent by weight of water, based on the total weight of the dispersion; and the dispersion has an average particle size diameter in the range of 0.05 to 5 μm.
摘要翻译：本发明提供了一种高固体，无溶剂的醇酸树脂分散体及其生产方法。根据本发明的醇酸水性分散体包含（a）基于分散体总重量的40-70重量％的一种或多种醇酸树脂，其中每一种或多种醇酸树酯的酸值小于20，在大于1000道尔顿范围内的分子量（Mn）; （b）基于分散体的总重量，少于10重量％的一种或多种表面活性剂; 和（c）30-55重量％的水，基于分散体的总重量; 分散体的平均粒径为0.05〜5μm的范围。

6. 发明申请

US20120244288A1 ALKYD DISPERSION, AND A PROCESS FOR PRODUCING THE SAME 有权
标题翻译： ALKYD分散剂及其生产方法
公开(公告)号：US20120244288A1
公开(公告)日：2012-09-27
申请号：US13498264
申请日：2010-11-01
申请人： Timothy J. Young , Gary E. Spilman , Suresh Subramonian , Ray E. Drumright , David D. Mall , Rosemarie Lauer , Andrea Greyson , Robert Sandoval , Ahmad Madkour
发明人： Timothy J. Young , Gary E. Spilman , Suresh Subramonian , Ray E. Drumright , David D. Mall , Rosemarie Lauer , Andrea Greyson , Robert Sandoval , Ahmad Madkour
IPC分类号： C09D191/00 , C08K5/42 , C08K5/13 , B05D7/24 , C08K5/06
CPC分类号： C09D167/08 , C08J3/03 , C08J3/05 , C08J2367/08 , C09D5/022 , Y10T428/31786 , Y10T428/31938
摘要： The instant invention provides a high-solid, solvent-free alkyd dispersion, and a continuous process for producing the same. The aqueous alkyd dispersion, according to the present invention comprises (a) from 40 to 70 percent by weight of one or more alkyds based on the total weight of the dispersion, wherein each one or more alkyds has an acid value of less than 20 and a molecular weight (Mn) in the range of greater than 1000 Dalton; (b) from less than 10 percent by weight of one or more surfactants, based on the total weight of the dispersion; and (c) from 30 to 55 percent by weight of water, based on the total weight of the dispersion; and the dispersion has an average particle size diameter in the range of 0.05 to 5 μm.
摘要翻译：本发明提供了一种高固体，无溶剂的醇酸树脂分散体及其生产方法。根据本发明的醇酸水性分散体包含（a）基于分散体总重量的40-70重量％的一种或多种醇酸树脂，其中每一种或多种醇酸树酯的酸值小于20，在大于1000道尔顿范围内的分子量（Mn）; （b）基于分散体的总重量，少于10重量％的一种或多种表面活性剂; 和（c）30-55重量％的水，基于分散体的总重量; 分散体的平均粒径为0.05〜5μm的范围。

7. 发明授权

US09080059B2 Coating compositions 有权
标题翻译：涂料组合物
公开(公告)号：US09080059B2
公开(公告)日：2015-07-14
申请号：US13817015
申请日：2011-09-13
申请人： Xin Jin , Ray E. Drumright , Bernhard Kainz , Jerry E. White , Robert E. Hefner, Jr.
发明人： Xin Jin , Ray E. Drumright , Bernhard Kainz , Jerry E. White , Robert E. Hefner, Jr.
IPC分类号： B32B15/092 , B32B27/38 , C09D163/00 , C08G59/24 , B05D3/02 , C09D5/00 , C08G59/06
CPC分类号： C09D5/00 , C08G59/066 , C08L2205/05 , C09D163/00 , C08L33/02 , C08L67/00
摘要： A coating composition comprising an advanced epoxy resin polymeric composition having the following chemical structure:(formula) I where n is a number from 1 to about 3000; each m independently has a value of 0 or 1; each R0 is independently —H or —CH3; each R1 is independently —H or a C1 to C6 alkylene radical (saturated divalent aliphatic hydrocarbon radical); R′1-R′4 are independently hydrogen, an alkyl, cycloalkyl, an aryl or an aralkyl group or other substituent, for example, a nitro, an isocyanate, or an alkyloxy group; additionally, any two of R′1-R′4 may form fused ring independently; and X is cycloalkylene group, including substituted cycloalkylene group, where the substituent groups include an alkyl, cycloalkyl, an aryl or an aralkyl group or other substituent group, for example, a halide, a cyano, a nitro, a blocked isocyanate, or an alkyloxy group; the combination of cycloalkylene and alkylene groups and the combination of alkylene and cycloalkylene group with a bridging moiety in between.
摘要翻译：一种涂料组合物，其包含具有以下化学结构的高级环氧树脂聚合物组合物：（式）I，其中n为1至约3000的数; 每个m独立地具有0或1的值; 每个R 0独立地是-H或-CH 3; 每个R 1独立地为-H或C 1至C 6亚烷基（饱和二价脂族烃基）; R'1-R'4独立地为氢，烷基，环烷基，芳基或芳烷基或其它取代基，例如硝基，异氰酸酯基或烷氧基; 此外，R'1-R'4中的任何两个可以独立地形成稠环; 并且X是亚环烷基，包括取代的亚环烷基，其中取代基包括烷基，环烷基，芳基或芳烷基或其它取代基，例如卤素，氰基，硝基，封端异氰酸酯或烷氧基亚环烷基和亚烷基的组合以及亚烷基和亚环烷基之间的桥连部分的组合。

8. 发明授权

US06277916B1 Process for preparing thermoplastic vulcanizates 失效
标题翻译：制备热塑性硫化胶的方法
公开(公告)号：US06277916B1
公开(公告)日：2001-08-21
申请号：US09257771
申请日：1999-02-25
申请人： Robert H. Terbrueggen , Ray E. Drumright , Thoi H. Ho
发明人： Robert H. Terbrueggen , Ray E. Drumright , Thoi H. Ho
IPC分类号： C08L5300
CPC分类号： C08K5/43 , C08F8/34 , C08F2800/20 , C08F2810/20 , C08F210/02 , C08F212/08 , C08F297/04 , C08F297/046 , C08F8/04 , C08F210/18
摘要： This invention includes a process for forming a thermoplastic vulcanizate comprising: (a) admixing a C—H insertion curing agent with at least one elastomeric phase polymer to form a first admixture; (b) admixing at least one non-elastomeric polyolefin with the first admixture to form a second admixture; and (c) heating the second admixture to a temperature at least the decomposition temperature of the curing agent to crosslink the elastomeric phase while mixing the admixture to an extent sufficient to result in the formation of a thermoplastic material, hereinafter referred to as a thermoplastic vulcanizate, and optionally including an additional step (d) of shaping the resulting thermoplastic vulcanizate, especially by heating and foaming or molding the TPV. The C—H insertion curing agent is preferably selected from alkyl and aryl azides (R—N3), acyl azides (R—C(O)N3), azidoformates (R—O—C(O)—N3), sulfonyl azides (R—SO2—N3), phosphoryl azides ((RO)2—(PO)—N3), phosphinic azides (R2—P(O)—N3) and silyl azides (R3—Si—N3), with poly(sulfonyl azide) most preferred. Additionally, the invention includes a thermoplastic vulcanizate comprising a blend of: (1) an elastomeric phase crosslinked using a C—H insertion curing agent dispersed in; (2) at least one non-elastomeric thermoplastic polyolefin. The invention also includes a foamable composition comprising (1) an elastomeric phase crosslinked using a C—H insertion curing agent dispersed in; (2) at least one non-elastomeric thermoplastic polyolefin; and (3) from about 0.1 to about 25 percent by weight based on the combined weight of components (1) and (2) of at least one foaming agent as well as a fabricated part, cable jacket, cable insulation, or foam comprising the thermoplastic vulcanizate or the invention or resulting from the process of the invention.
摘要翻译：本发明包括形成热塑性硫化橡胶的方法，其包括：（a）将C-H嵌入固化剂与至少一种弹性体相聚合物混合以形成第一混合物; （b）将至少一种非弹性体聚烯烃与第一混合物混合以形成第二混合物; 和（c）将第二混合物加热到至少固化剂的分解温度的温度以交联弹性体相，同时将该混合物混合到足以导致形成热塑性材料的程度，以下称为热塑性硫化橡胶并且任选地包括使得到的热塑性硫化橡胶成型的附加步骤（d），特别是通过加热和发泡或模制TPV。 CH插入固化剂优选选自烷基和芳基叠氮化物（R-N 3），酰基叠氮化物（RC（O）N 3），叠氮基甲酸酯（ROC（O）-N 3），磺酰基叠氮化物（R-SO 2 -N 3）叠氮化物（（RO）2-（PO）-N3），次膦酸叠氮化物（R2-P（O）-N3）和甲硅烷基叠氮化物（R3-Si-N3），最优选为聚（磺酰基叠氮化物）。另外，本发明包括热塑性硫化橡胶，其包含以下共混物：（1）使用分散在其中的C-H嵌入固化剂交联的弹性体相; （2）至少一种非弹性体热塑性聚烯烃。本发明还包括可发泡组合物，其包含（1）使用分散在其中的C-H插入固化剂交联的弹性体相; （2）至少一种非弹性热塑性聚烯烃; 和（3）约0.1至约25重量％，基于至少一种发泡剂的组分（1）和（2）的组合重量，以及制造的部件，电缆护套，电缆绝缘或泡沫，其包含热塑性硫化橡胶或本发明，或由本发明的方法得到。

9. 发明授权

US5807962A Aromatic sulfonated diester monomer, process to synthesize, polymer derived therefrom and method to prepare said polymer 失效
标题翻译：芳族磺化二酯单体，合成方法，由其衍生的聚合物和制备所述聚合物的方法
公开(公告)号：US5807962A
公开(公告)日：1998-09-15
申请号：US915364
申请日：1997-08-20
申请人： Ray E. Drumright , Michael J. Mullins , William B. Marshall , Edvins L. Daiga
发明人： Ray E. Drumright , Michael J. Mullins , William B. Marshall , Edvins L. Daiga
IPC分类号： C08G63/688 , C08G64/08 , C08G64/30 , C08G64/40 , C08G63/68 , C08K3/24 , C08L67/02
CPC分类号： C08G64/307 , C08G63/6886 , C08G64/081 , C08G64/40
摘要： A sulfonated dicarboxylic acid and a diaromatic carbonate are reacted by a solution process to form a sulfonated aromatic diester such as diphenyl sodium 5-sulfoisophthalate. The sulfonated aromatic diester is reacted with an aromatic polymer precursor mixture such as bisphenol A and diphenyl carbonate, polymer or combination thereof, at a temperature above the melting point of the polymer or a member of the aromatic polymer precursor to form a randomly positioned sulfonated aromatic moiety in a polymer chain of a thermoplastic non-crosslinked aromatic polymer such as a linear polycarbonate.
摘要翻译：通过溶液方法使磺化二羧酸和二芳族碳酸酯反应形成磺化芳族二酯，例如5-磺基间苯二甲酸二苯基钠。将磺化芳族二酯与芳族聚合物前体混合物如双酚A和碳酸二苯酯，聚合物或其组合在高于聚合物或芳族聚合物前体的熔点的温度下反应，形成无规定位的磺化芳族化合物部分在热塑性非交联芳族聚合物如线性聚碳酸酯的聚合物链中。

10. 发明授权

US5728874A Anti-HIV achiral polyurea oligomers, a process for creating them, formulations using them, and their use in the treatment of AIDS 失效
标题翻译：抗艾滋病毒非手性聚脲低聚物，创造它们的方法，使用它们的配方，以及它们在治疗艾滋病中的应用
公开(公告)号：US5728874A
公开(公告)日：1998-03-17
申请号：US174597
申请日：1993-12-27
申请人： Michael J. Mullins , Ray E. Drumright , Alan D. Cardin , Norton P. Peet
发明人： Michael J. Mullins , Ray E. Drumright , Alan D. Cardin , Norton P. Peet
IPC分类号： C08G71/02 , A61K20060101 , A61K31/185 , A61K31/74 , A61K31/765 , A61K31/785 , A61K31/795 , A61K49/00 , A61P31/12 , A61P31/18 , C07C309/42 , C07C309/51 , C08G18/00 , C08G18/32 , C08G18/76 , C08G63/02 , C08G63/06 , C08G63/18 , C08G63/19 , C08G63/688 , C08G63/692 , C08G64/00 , C08G64/04 , C08G64/06 , C08G64/08 , C08G64/12 , C08G69/00 , C08G69/26 , C08G69/32 , C08L67/00 , C08L67/02 , C08L69/00 , C07C273/00 , A61K31/17
CPC分类号： A61K31/185 , A61K31/785 , A61K31/795 , C07C309/42 , C07C309/51 , C08G63/19 , C08G63/6884 , C08G63/6924 , C08G64/06 , C08G64/081 , C08G64/083 , C08G69/26 , C08G69/32 , C08G71/02 , Y10S514/885
摘要： The present invention relates to achiral polyurea oligomers, their uses and formulations as anti-HIV pharmaceuticals and to a process for the preparation of narrow mono- and polydispersed oligomers as an emodiment of the invention. The achiral oligomers are derived from repeating units of the monomer 4,4'-diamino-biphenyl-3,3'-disulfonic acid and are water soluble, have a rigid backbone, possess ordered anionic spacing and have a number average molecular weight of
摘要翻译：本发明涉及非手性聚脲低聚物，其用途和制剂作为抗HIV药物，以及制备作为本发明实施例的窄单分散和多分散低聚物的方法。非手性低聚物衍生自单体4,4'-二氨基 - 联苯-3,3'-二磺酸的重复单元并且是水溶性的，具有刚性主链，具有有序的阴离子间隔并且具有数均分子量< 20,000。该方法涉及窄聚和单 - 二极低聚物的合成，其包括以下步骤：1）将粗分散的阴离子低聚物混合物限制为窄的多分散阴离子低聚物混合物至窄的多分散阴离子低聚物混合物; 和/或2）分离单分散的阴离子低聚物; 和3）任选地将窄的多分散或单分散的阴离子低聚物盐从步骤1或2转化为所需的药学上可接受的盐，特别是溶胶或钾盐。可以执行处理步骤，从而单独进行步骤1或2，每个步骤与步骤3组合，或者完成所有三个步骤。

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