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1. 发明授权

US5728874A Anti-HIV achiral polyurea oligomers, a process for creating them, formulations using them, and their use in the treatment of AIDS 失效
标题翻译：抗艾滋病毒非手性聚脲低聚物，创造它们的方法，使用它们的配方，以及它们在治疗艾滋病中的应用
公开(公告)号：US5728874A
公开(公告)日：1998-03-17
申请号：US174597
申请日：1993-12-27
申请人： Michael J. Mullins , Ray E. Drumright , Alan D. Cardin , Norton P. Peet
发明人： Michael J. Mullins , Ray E. Drumright , Alan D. Cardin , Norton P. Peet
IPC分类号： C08G71/02 , A61K20060101 , A61K31/185 , A61K31/74 , A61K31/765 , A61K31/785 , A61K31/795 , A61K49/00 , A61P31/12 , A61P31/18 , C07C309/42 , C07C309/51 , C08G18/00 , C08G18/32 , C08G18/76 , C08G63/02 , C08G63/06 , C08G63/18 , C08G63/19 , C08G63/688 , C08G63/692 , C08G64/00 , C08G64/04 , C08G64/06 , C08G64/08 , C08G64/12 , C08G69/00 , C08G69/26 , C08G69/32 , C08L67/00 , C08L67/02 , C08L69/00 , C07C273/00 , A61K31/17
CPC分类号： A61K31/185 , A61K31/785 , A61K31/795 , C07C309/42 , C07C309/51 , C08G63/19 , C08G63/6884 , C08G63/6924 , C08G64/06 , C08G64/081 , C08G64/083 , C08G69/26 , C08G69/32 , C08G71/02 , Y10S514/885
摘要： The present invention relates to achiral polyurea oligomers, their uses and formulations as anti-HIV pharmaceuticals and to a process for the preparation of narrow mono- and polydispersed oligomers as an emodiment of the invention. The achiral oligomers are derived from repeating units of the monomer 4,4'-diamino-biphenyl-3,3'-disulfonic acid and are water soluble, have a rigid backbone, possess ordered anionic spacing and have a number average molecular weight of
摘要翻译：本发明涉及非手性聚脲低聚物，其用途和制剂作为抗HIV药物，以及制备作为本发明实施例的窄单分散和多分散低聚物的方法。非手性低聚物衍生自单体4,4'-二氨基 - 联苯-3,3'-二磺酸的重复单元并且是水溶性的，具有刚性主链，具有有序的阴离子间隔并且具有数均分子量< 20,000。该方法涉及窄聚和单 - 二极低聚物的合成，其包括以下步骤：1）将粗分散的阴离子低聚物混合物限制为窄的多分散阴离子低聚物混合物至窄的多分散阴离子低聚物混合物; 和/或2）分离单分散的阴离子低聚物; 和3）任选地将窄的多分散或单分散的阴离子低聚物盐从步骤1或2转化为所需的药学上可接受的盐，特别是溶胶或钾盐。可以执行处理步骤，从而单独进行步骤1或2，每个步骤与步骤3组合，或者完成所有三个步骤。

2. 发明授权

US6086864A Pharmaceutical formulations comprising polythiourea and methods of use thereof 失效
标题翻译：包含聚硫脲的药物制剂及其使用方法
公开(公告)号：US6086864A
公开(公告)日：2000-07-11
申请号：US979031
申请日：1997-11-26
申请人： Michael J. Mullins , William A. Fordyce , William J. Kruper , Norton P. Peet , Alan D. Cardin
发明人： Michael J. Mullins , William A. Fordyce , William J. Kruper , Norton P. Peet , Alan D. Cardin
IPC分类号： A61K31/795 , A61F6/04 , A61P31/12 , A61P31/18 , C07C335/06 , C07C335/16 , C07C335/20 , C07F9/09 , C07F9/24 , C08G18/32 , C08G18/38 , C08G18/71 , C08G18/00
CPC分类号： C07C335/16 , C07C335/20
摘要： The oligomers of the present invention are polythioureas having 3 to 50 recurring units derived from aromatic diamines substituted with anionic groups, and having a number average molecular weight of less than 10,000. These oligomers are water-soluble, preferably have a rigid backbone, and are pharmaceutically-acceptable. The oligomers are useful for the treatment and/or diagnosis of AIDS.
摘要翻译：本发明的低聚物是具有3至50个由阴离子基团取代的芳族二胺衍生的重复单元，数均分子量小于10,000的聚硫脲。这些低聚物是水溶性的，优选具有刚性主链，并且是药学上可接受的。寡聚物可用于治疗和/或诊断艾滋病。

3. 发明授权

US5807962A Aromatic sulfonated diester monomer, process to synthesize, polymer derived therefrom and method to prepare said polymer 失效
标题翻译：芳族磺化二酯单体，合成方法，由其衍生的聚合物和制备所述聚合物的方法
公开(公告)号：US5807962A
公开(公告)日：1998-09-15
申请号：US915364
申请日：1997-08-20
申请人： Ray E. Drumright , Michael J. Mullins , William B. Marshall , Edvins L. Daiga
发明人： Ray E. Drumright , Michael J. Mullins , William B. Marshall , Edvins L. Daiga
IPC分类号： C08G63/688 , C08G64/08 , C08G64/30 , C08G64/40 , C08G63/68 , C08K3/24 , C08L67/02
CPC分类号： C08G64/307 , C08G63/6886 , C08G64/081 , C08G64/40
摘要： A sulfonated dicarboxylic acid and a diaromatic carbonate are reacted by a solution process to form a sulfonated aromatic diester such as diphenyl sodium 5-sulfoisophthalate. The sulfonated aromatic diester is reacted with an aromatic polymer precursor mixture such as bisphenol A and diphenyl carbonate, polymer or combination thereof, at a temperature above the melting point of the polymer or a member of the aromatic polymer precursor to form a randomly positioned sulfonated aromatic moiety in a polymer chain of a thermoplastic non-crosslinked aromatic polymer such as a linear polycarbonate.
摘要翻译：通过溶液方法使磺化二羧酸和二芳族碳酸酯反应形成磺化芳族二酯，例如5-磺基间苯二甲酸二苯基钠。将磺化芳族二酯与芳族聚合物前体混合物如双酚A和碳酸二苯酯，聚合物或其组合在高于聚合物或芳族聚合物前体的熔点的温度下反应，形成无规定位的磺化芳族化合物部分在热塑性非交联芳族聚合物如线性聚碳酸酯的聚合物链中。

4. 发明授权

US5674968A Aromatic sulfonated diester monomer, process to synthesize, polymer derived therefrom and method to prepare said polymer 失效
标题翻译：芳族磺化二酯单体，合成方法，由其衍生的聚合物和制备所述聚合物的方法
公开(公告)号：US5674968A
公开(公告)日：1997-10-07
申请号：US519374
申请日：1995-08-25
申请人： Ray E. Drumright , Michael J. Mullins , William B. Marshall , Edvins L. Daiga
发明人： Ray E. Drumright , Michael J. Mullins , William B. Marshall , Edvins L. Daiga
IPC分类号： C08G63/688 , C08G64/08 , C08G64/30 , C08G64/40 , C08G63/68 , C08K3/24 , C08L67/02
CPC分类号： C08G64/307 , C08G63/6886 , C08G64/081 , C08G64/40
摘要： A sulfonated dicarboxylic acid and a diaromatic carbonate are reacted by a solution process to form a sulfonated aromatic diester such as dipbenyl sodium 5-sulfoisophthalate. The sulfonated aromatic diester is reacted with an aromatic polymer precursor mixture such as bisphenol A and diphenyl carbonate, polymer or combination thereof, at a temperature above the melting point of the polymer or a member of the aromatic polymer precursor to form a randomly positioned sulfonated aromatic moiety in a polymer chain of a thermoplastic non-crosslinked aromatic polymer such as a linear polycarbonate.
摘要翻译：通过溶液法使磺化二羧酸和二芳族碳酸酯反应形成磺化芳族二酯，例如5-磺基间苯二甲酸二苯基酯。将磺化芳族二酯与芳族聚合物前体混合物如双酚A和碳酸二苯酯，聚合物或其组合在高于聚合物或芳族聚合物前体的熔点的温度下反应，形成无规定位的磺化芳族化合物热塑性非交联芳族聚合物如线性聚碳酸酯的聚合物链中的部分。

5. 发明授权

US5644017A Polycarbonate terminated by an ionic sulfonated aromatic moiety and preparation thereof 失效
标题翻译：由离子磺化芳族部分封端的聚碳酸酯及其制备
公开(公告)号：US5644017A
公开(公告)日：1997-07-01
申请号：US519853
申请日：1995-08-25
申请人： Ray E. Drumright , Michael J. Mullins , Stephen E. Bales
发明人： Ray E. Drumright , Michael J. Mullins , Stephen E. Bales
IPC分类号： C08G64/08 , C08G64/14 , C08G64/42 , C08G63/02
CPC分类号： C08G64/081 , C08G64/14 , C08G64/42
摘要： An aromatic polycarbonate is terminated by an ionic sulfonated aromatic moiety bonded to the polycarbonate by a carbonate or ester linkage. The aromatic polycarbonate can be terminated by reacting a sulfonated aromatic compound such as a sulfonated phenol, sulfonated benzoic acid, phenyl ester of a sulfonated aromatic carboxylic acid and sulfonated diphenyl carbonate with an aromatic polycarbonate, an aromatic dihydroxy compound and a carbonate precursor, or a combination thereof. The reaction can be performed in a nonaqueous solution or a melt transesterification process. The aromatic sulfonated terminated polycarbonate can be thermally molded and displays non-newtonian melt rheology and improved solvent resistance.
摘要翻译：芳族聚碳酸酯由通过碳酸酯或酯键与聚碳酸酯键合的离子磺化芳族部分封端。芳香族聚碳酸酯可以通过使磺化苯酚，磺化苯甲酸，磺化芳香族羧酸的苯基酯和磺化碳酸二苯酯的磺化芳香族化合物与芳香族聚碳酸酯，芳香族二羟基化合物和碳酸酯前体，或的组合。反应可以在非水溶液或熔融酯交换法中进行。芳族磺化封端的聚碳酸酯可以热模塑并显示非牛顿熔体流变性和改善的耐溶剂性。

6. 发明授权

US06211302B1 Rheology modification of interpolymers of alpha-olefins and vinylidene aromatic monomers 失效
标题翻译： α-烯烃和亚乙烯基芳族单体互聚物的流变改性
公开(公告)号：US06211302B1
公开(公告)日：2001-04-03
申请号：US09129155
申请日：1998-08-05
申请人： Thoi H. Ho , Ray E. Drumright , Robert H. Terbrueggen , Clark H. Cummins , Michael J. Mullins , H. Craig Silvis
发明人： Thoi H. Ho , Ray E. Drumright , Robert H. Terbrueggen , Clark H. Cummins , Michael J. Mullins , H. Craig Silvis
IPC分类号： C08F830
CPC分类号： C08L23/02 , C08G81/02 , C08K5/43 , C08L23/04 , C08L23/06 , C08L23/08 , C08L23/0815 , C08L23/0838 , C08L23/0853 , C08L23/16 , C08L2205/22 , C08L2312/00 , C08L2314/06 , Y10T428/1334 , Y10T428/1352 , Y10T428/1386 , Y10T428/139 , Y10T428/31913 , Y10T428/31917 , C08L2666/04
摘要： The invention includes a process of preparing a coupled polymer comprising heating an admixture containing (1) at least one interpolymer of an alpha olefin and vinyl aromatic monomer and (2) a coupling amount of at least one poly(sulfonyl azide) to at least the decomposition temperature of the poly(sulfonyl azide) for a period sufficient for decomposition of at least about 80 weight percent of the poly(sulfonyl azide) and sufficient to result in a coupled polymer. The polymer preferably. comprises ethylene, and a vinyl aromatic monomer, preferably styrene. The amount of poly(sulfonyl azide) is preferably from about 0.01 to about 1 weight percent of the interpolymer and the reaction preferably takes place at a temperature greater than about 150° C., more preferably 185° C. The process optionally and in one preferred embodiment additionally comprises steps (b) fabricating an article from the coupled polymer and (c) crosslinking the fabricated coupled polymer. The invention additionally includes any composition produced by a process of the invention and any article made from the composition, preferably articles formed from a melt of the composition, more preferably by blow molding, blowing a film, foaming, or profile extruding, most preferably to form a coating for wire or cable, a tube, a gasket, a seal, roofing, or fiber. The article is optionally calendared. Additionally, the invention includes the use of compositions of the invention as starting materials for forming processes in which the composition is melted and especially in blow molding, blowing a film, foaming, or profile extruding, most preferably to form a coating for wire or cable, a tube, a gasket, a seal, roofing, or fiber.
摘要翻译：本发明包括制备偶联聚合物的方法，其包括加热含有（1）至少一种α-烯烃和乙烯基芳族单体的共聚物的混合物和（2）至少一种聚（磺酰基叠氮化物）的偶联量至少至少聚（磺酰基叠氮化物）的分解温度足以分解至少约80重量％的聚（磺酰基叠氮化物）并足以产生偶联聚合物。优选聚合物。包括乙烯和乙烯基芳族单体，优选苯乙烯。聚（磺酰基叠氮化物）的量优选为互聚物的约0.01至约1重量％，并且反应优选在大于约150℃，更优选185℃的温度下进行。该方法任选地和一个优选实施方案另外包括步骤（b）从偶联的聚合物制备制品和（c）交联制备的偶联聚合物。本发明还包括通过本发明的方法制备的任何组合物和由组合物制成的任何制品，优选由组合物的熔体形成的制品，更优选通过吹塑，吹膜，发泡或型材挤出，最优选形成电线或电缆的涂层，管，垫圈，密封件，屋顶或纤维。该文章是可选的日历。此外，本发明包括使用本发明的组合物作为其中组合物熔融的方法的起始原料，特别是在吹塑，吹塑膜，发泡或型材挤出中，最优选形成电线或电缆涂层管，垫圈，密封件，屋顶或纤维。

7. 发明授权

US6013251A Narrow poly-and-mono-dispersed anionic oligomers, and their uses, formulations and processes 失效
标题翻译：窄聚单分散阴离子低聚物及其用途，配方和工艺
公开(公告)号：US6013251A
公开(公告)日：2000-01-11
申请号：US834699
申请日：1997-04-01
申请人： Alan D. Cardin , William A. Fordyce , Michael J. Mullins , Thomas A. Chamberlin , Michael J. Fazio
发明人： Alan D. Cardin , William A. Fordyce , Michael J. Mullins , Thomas A. Chamberlin , Michael J. Fazio
IPC分类号： A61K31/655 , A61K31/17 , A61K31/185 , A61K31/216 , A61K31/235 , A61K31/245 , A61K31/66 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61P31/12 , A61P31/18 , C07C69/82 , C07C69/86 , C07C69/96 , C07C309/42 , C07C309/51 , C08G63/16 , C08G63/685 , C08G63/688 , C08G63/692 , C08G64/00 , C08G64/06 , C08G64/08 , C08G69/02 , C08G69/08 , C08G69/10 , C08G69/26 , C08G69/32 , C08G71/02 , A61K31/765
CPC分类号： C08G69/08 , A61K31/185 , A61K31/216 , A61K31/235 , A61K31/785 , A61K31/795 , C07C309/51 , C08G63/6856 , C08G63/6886 , C08G63/6926 , C08G64/08 , C08G69/02 , C08G69/10 , C08G69/26 , C08G71/02 , Y10S514/885
摘要： The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.
摘要翻译：本发明的窄聚或单分散低聚物是具有3-50个重复单元的聚脲，聚碳酸酯，聚酯或聚酰胺。这些低聚物是水溶性的，优选具有刚性主链，具有通过羰基连接的重复单元具有阴离子基团的连接部分显示出主要的线性几何形状，使得阴离子基团之间的规则间隔存在于水性介质中，并且是药学上可接受的。窄的聚合或单分散的低聚物可用于治疗和/或诊断AIDS和/或ARC或HSV。

8. 发明授权

US5986044A Narrow poly- and mono-dispersed anionic oligomers 失效
标题翻译：窄聚和单分散阴离子低聚物
公开(公告)号：US5986044A
公开(公告)日：1999-11-16
申请号：US979085
申请日：1997-11-26
申请人： Alan D. Cardin , Michael J. Mullins , William A. Fordyce , Thomas A. Chamberlin , Michael J. Fazio
发明人： Alan D. Cardin , Michael J. Mullins , William A. Fordyce , Thomas A. Chamberlin , Michael J. Fazio
IPC分类号： A61K31/655 , A61K31/17 , A61K31/185 , A61K31/216 , A61K31/235 , A61K31/245 , A61K31/66 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61P31/12 , A61P31/18 , C07C69/82 , C07C69/86 , C07C69/96 , C07C309/42 , C07C309/51 , C08G63/16 , C08G63/685 , C08G63/688 , C08G63/692 , C08G64/00 , C08G64/06 , C08G64/08 , C08G69/02 , C08G69/08 , C08G69/10 , C08G69/26 , C08G69/32 , C08G71/02 , A01N33/00
CPC分类号： C08G69/08 , A61K31/185 , A61K31/216 , A61K31/235 , A61K31/785 , A61K31/795 , C07C309/51 , C08G63/6856 , C08G63/6886 , C08G63/6926 , C08G64/08 , C08G69/02 , C08G69/10 , C08G69/26 , C08G71/02 , Y10S514/885
摘要： The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.
摘要翻译：本发明的窄聚或单分散低聚物是具有3-50个重复单元的聚脲，聚碳酸酯，聚酯或聚酰胺。这些低聚物是水溶性的，优选具有刚性主链，具有通过羰基连接的重复单元具有阴离子基团的连接部分显示出主要的线性几何形状，使得阴离子基团之间的规则间隔存在于水性介质中，并且是药学上可接受的。窄的聚合或单分散的低聚物可用于治疗和/或诊断AIDS和/或ARC或HSV。

9. 发明授权

US5670143A Anti-HIV pharmaceutical formulations 失效
标题翻译：抗HIV药物制剂
公开(公告)号：US5670143A
公开(公告)日：1997-09-23
申请号：US445192
申请日：1995-05-19
申请人： Alan D. Cardin , Richard L. Jackson , Michael J. Mullins
发明人： Alan D. Cardin , Richard L. Jackson , Michael J. Mullins
IPC分类号： C08G71/02 , A61K20060101 , A61K31/185 , A61K31/74 , A61K31/765 , A61K31/785 , A61K31/795 , A61K49/00 , A61P31/12 , A61P31/18 , C07C309/42 , C07C309/51 , C08G18/00 , C08G18/32 , C08G18/76 , C08G63/02 , C08G63/06 , C08G63/18 , C08G63/19 , C08G63/688 , C08G63/692 , C08G64/00 , C08G64/04 , C08G64/06 , C08G64/08 , C08G64/12 , C08G69/00 , C08G69/26 , C08G69/32 , C08L67/00 , C08L67/02 , C08L69/00
CPC分类号： A61K31/185 , A61K31/785 , A61K31/795 , C07C309/42 , C07C309/51 , C08G63/19 , C08G63/6884 , C08G63/6924 , C08G64/06 , C08G64/081 , C08G64/083 , C08G69/26 , C08G69/32 , C08G71/02 , Y10S514/885
摘要： The preferred oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a number average molecular weight of
摘要翻译：本发明优选的低聚物是数均分子量<10,000的聚脲，聚碳酸酯，聚酯或聚酰胺。这些低聚物是水溶性的，具有刚性主链，具有通过具有阴离子基团的羰基连接部分偶联的重复单元，主要显示出线性几何形式，使得阴离子基团之间的规则间隔存在于水性介质中，并且是药学上可接受的。低聚物可用于治疗和/或诊断AIDS和ARC。

10. 发明授权

US5571505A Anti-HIV oligomers 失效
标题翻译：抗HIV寡聚体
公开(公告)号：US5571505A
公开(公告)日：1996-11-05
申请号：US445158
申请日：1995-05-19
申请人： Alan D. Cardin , Richard L. Jackson , Michael J. Mullins
发明人： Alan D. Cardin , Richard L. Jackson , Michael J. Mullins
IPC分类号： C08G71/02 , A61K20060101 , A61K31/185 , A61K31/74 , A61K31/765 , A61K31/785 , A61K31/795 , A61K49/00 , A61P31/12 , A61P31/18 , C07C309/42 , C07C309/51 , C08G18/00 , C08G18/32 , C08G18/76 , C08G63/02 , C08G63/06 , C08G63/18 , C08G63/19 , C08G63/688 , C08G63/692 , C08G64/00 , C08G64/04 , C08G64/06 , C08G64/08 , C08G64/12 , C08G69/00 , C08G69/26 , C08G69/32 , C08L67/00 , C08L67/02 , C08L69/00
CPC分类号： A61K31/185 , A61K31/785 , A61K31/795 , C07C309/42 , C07C309/51 , C08G63/19 , C08G63/6884 , C08G63/6924 , C08G64/06 , C08G64/081 , C08G64/083 , C08G69/26 , C08G69/32 , C08G71/02 , Y10S514/885
摘要： The preferred oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a number average molecular weight of
摘要翻译：本发明优选的低聚物是数均分子量<10,000的聚脲，聚碳酸酯，聚酯或聚酰胺。这些低聚物是水溶性的，具有刚性主链，具有通过具有阴离子基团的羰基连接部分偶联的重复单元，主要显示出线性几何形式，使得阴离子基团之间的规则间隔存在于水性介质中，并且是药学上可接受的。低聚物可用于治疗和/或诊断AIDS和ARC。

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