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1. 发明授权

US4637894A Activator of peroxo compounds 失效
标题翻译：过氧化合物的活化剂
公开(公告)号：US4637894A
公开(公告)日：1987-01-20
申请号：US706511
申请日：1985-02-28
申请人： Jan Smidrkal , Jaroslav Simunek , Jiri Tolman , Jiri Soucek , Alois Novacek , Jan Novak , Vaclav Krob , Pavel Kovar , Miroslav Klofec , Bohumir Vondracek
发明人： Jan Smidrkal , Jaroslav Simunek , Jiri Tolman , Jiri Soucek , Alois Novacek , Jan Novak , Vaclav Krob , Pavel Kovar , Miroslav Klofec , Bohumir Vondracek
IPC分类号： C11D7/54 , C11D3/39 , C01B15/00
CPC分类号： C11D3/3935 , C11D3/3907
摘要： The present invention relates to an activator of peroxo compounds, its method of manufacture, and its method of use. The activator is useful as an additive to textile cleansing and disinfecting agents that contain peroxo compounds. The invention permits the bleaching and disinfecting of textiles at temperatures between 25.degree. C. and 60.degree. C.The activator comprises a combination of the following compounds, by weight: (a) phthalic anhydride (4-98%); (b) N-acetylphthalimide (2-96%); (c) phthalimide (0.1-28%); (d) stabilizer (0.2-25%) and/or (e) soluble polymer (0.2-12%); wherein the stabilizer is an aliphatic carboxylic acid having from 12-22 carbon atoms, the polymer is soluble in water or in organic solvents, and the particle size of the final activator composition is from 0.1 to 3.5 mm.The activator component mixture is converted into particles spraying the molten liquid through a nozzle or atomizer in a cooling tower, or by solidification in a fluid bed, or by grinding of the melt after solidification on cooling rollers.
摘要翻译：本发明涉及过氧化合物的活化剂，其制备方法及其使用方法。活化剂可用作含有过氧化合物的织物清洁和消毒剂的添加剂。本发明允许纺织品在25℃至60℃的温度下进行漂白和消毒。活化剂包含以下化合物的组合，重量比：（a）邻苯二甲酸酐（4-98％）; （b）N-乙酰邻苯二甲酰亚胺（2-96％）; （c）邻苯二甲酰亚胺（0.1-28％）; （d）稳定剂（0.2-25％）和/或（e）可溶性聚合物（0.2-12％）; 其中所述稳定剂是具有12-22个碳原子的脂族羧酸，所述聚合物可溶于水或有机溶剂，并且最终活化剂组合物的粒径为0.1-3.5mm。将活化剂组分混合物转化成通过冷却塔中的喷嘴或雾化器喷射熔融液体，或者通过在流化床中固化，或者在冷却辊上固化之后研磨熔体。

2. 发明授权

US3989634A Detergent containing a tenside with activating power 失效
标题翻译：洗涤剂含有具有活化能力的表面活性剂
公开(公告)号：US3989634A
公开(公告)日：1976-11-02
申请号：US496548
申请日：1974-08-12
申请人： Karel Prochazka , Jan Novak , Jaroslav Simunek , Vlastimil Peterka , Vaclav Krob
发明人： Karel Prochazka , Jan Novak , Jaroslav Simunek , Vlastimil Peterka , Vaclav Krob
IPC分类号： C11D1/00 , C11D1/02 , C11D1/10 , C11D1/34 , C11D1/38 , C11D1/40 , C11D1/42 , C11D1/44 , C11D1/52 , C11D3/00 , C11D3/30 , C11D3/32 , C11D3/34 , C11D3/36 , C11D3/08 , C11D7/18 , C11D9/08
CPC分类号： C11D3/364 , C11D1/002 , C11D1/02 , C11D1/10 , C11D1/342 , C11D1/347 , C11D1/385 , C11D1/40 , C11D1/42 , C11D1/44 , C11D1/52 , C11D3/30 , C11D3/32 , C11D3/349 , C11D3/3454 , C11D3/3472
摘要： This invention relates to a detergent containing a tenside which evidences an activating power which is distinct from the common properties of surface-active agents. More particularly, the present invention relates to a detergent containing a tenside which manifests the ability to form complex compounds with metal cations.
摘要翻译：本发明涉及一种含有表面活性剂的表面活性剂的表面活性剂的表面活性剂。更具体地说，本发明涉及一种含有表面活性剂的洗涤剂，其表现出与金属阳离子形成络合物的能力。

3. 发明申请

US20120266260A1 DIAGNOSING AND TREATING IGA NEPHROPATHY 审中-公开
标题翻译：诊断和治疗IGA NEPHROPATHY
公开(公告)号：US20120266260A1
公开(公告)日：2012-10-18
申请号：US13321025
申请日：2010-05-26
申请人： Hitoshi Suzuki , Run Fan , Bruce A. Julian , Jan Novak , Zina Moldoveanu , Zhixin Zhang , Milan Tomana , Jiri Mestecky , Robert J. Wyatt , Yasuhiko Tomino , Yusuke Suzuki , Stephen Olson
发明人： Hitoshi Suzuki , Run Fan , Bruce A. Julian , Jan Novak , Zina Moldoveanu , Zhixin Zhang , Milan Tomana , Jiri Mestecky , Robert J. Wyatt , Yasuhiko Tomino , Yusuke Suzuki , Stephen Olson
IPC分类号： A61K39/395 , G01N33/566 , C12Q1/68 , G01N21/76 , C07K16/00 , C07K16/42 , A01K67/00 , A61K35/16 , A61P13/12 , G01N21/78 , C40B30/04
CPC分类号： A61K39/39541 , C07K16/4283 , C07K2317/41 , C07K2317/55 , C07K2317/565 , G01N33/6854 , G01N33/6893 , G01N2800/347
摘要： Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the IgG binds to a galactose-deficient IgA1. Optionally, the methods comprise providing a biological sample from the subject and detecting in the sample a mutation in a IGH gene, wherein the mutation is in a nucleotide sequence encoding a complementarity determining region 3 (CDR3) of a IGH variable region. Optionally, the methods comprise determining a level of IgG specific for a galactose-deficient IgA1 in the subject. Also provided are methods of treating or reducing the risk of developing IgA nephropathy in a subject.
摘要翻译：提供了诊断受试者中IgA肾病的方法。任选地，所述方法包括从受试者中分离IgG并确定IgG是否结合到半乳糖缺乏型IgA1。任选地，所述方法包括提供来自受试者的生物样品，并在样品中检测IGH基因中的突变，其中突变位于编码IGH可变区的互补决定区3（CDR3）的核苷酸序列中。任选地，所述方法包括测定受试者中对半乳糖缺乏型IgA1具有特异性的IgG水平。还提供了治疗或降低受试者中发生IgA肾病风险的方法。

4. 发明授权

US06521596B1 Lanthionine antibiotic compositions and method 失效
标题翻译：羊抗坏血酸组成及方法
公开(公告)号：US06521596B1
公开(公告)日：2003-02-18
申请号：US09151203
申请日：1998-09-10
申请人： Page W. Caufield , Jan Novak
发明人： Page W. Caufield , Jan Novak
IPC分类号： A61K3800
CPC分类号： C07K14/315 , C12N15/52 , C12N15/746
摘要： Certain bacteria indigenous to humans produce antimicrobial substances called bacteriocins which inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and &bgr;-methyllanthionine. Also provided are methods of making and using the purified polypeptide.
摘要翻译：人类本身的某些细菌产生称为细菌素的抗微生物物质，其抑制其他细菌，包括其自身物种的成员。 Mutacins是由变形链球菌制成的一类抗生素物质。公开了来自变形链球菌的新型含有羊水苷的mutacin肽的纯化和生物化学表征。纯化的肽是pH-和温度稳定的，其氨基酸组成表明存在羊血硫酸和β-甲基青蒿素。还提供了制备和使用纯化的多肽的方法。

5. 发明授权

US5650320A Lanthionine antibiotic compositions and methods 失效
标题翻译：羊抗坏血酸组成和方法
公开(公告)号：US5650320A
公开(公告)日：1997-07-22
申请号：US230473
申请日：1994-04-20
申请人： Page W. Caufield , Jan Novak
发明人： Page W. Caufield , Jan Novak
IPC分类号： C07K14/315 , C12N1/15 , C12N1/21 , C12N15/52 , C12N15/74 , C07H21/04 , C12N15/63
CPC分类号： C12N15/52 , C07K14/315 , C12N15/746
摘要： Certain bacteria indigenous to humans produce antimicrobial substances called bacteriocins which inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and .beta.-methyllanthionine. Also provided are methods of making and using the purified polypeptide.
摘要翻译：人类本身的某些细菌产生称为细菌素的抗微生物物质，其抑制其他细菌，包括其自身物种的成员。 Mutacins是由变形链球菌制成的一类抗生素物质。公开了来自变形链球菌的新型含有羊水苷的mutacin肽的纯化和生物化学表征。纯化的肽是pH-和温度稳定的，其氨基酸组成表明存在羊血硫酸和β-甲基牛磺酸。还提供了制备和使用纯化的多肽的方法。

6. 发明授权

US4326966A Agent for textile livening with an antistatic effect and favorable dermatologic properties 失效
标题翻译：用于纺织品的抗菌剂具有抗静电效果和良好的皮肤病学特性
公开(公告)号：US4326966A
公开(公告)日：1982-04-27
申请号：US158692
申请日：1980-06-12
申请人： Jan Novak , Miloslav Sorm , Karel Ulbert , Stanislav Nespurek , Dagmar Mikulcova , Jiri Cmolik
发明人： Jan Novak , Miloslav Sorm , Karel Ulbert , Stanislav Nespurek , Dagmar Mikulcova , Jiri Cmolik
IPC分类号： D06M13/368 , D06M13/38
CPC分类号： D06M13/368
摘要： The invention pertains to the textile livening agent with the antistatic effect and favorable dermatologic properties which contains softening, stabilizing, whitening, coloring, scenting and dermatologic components, anionactive, nonionogenic and cationactive tensides and other additives and 2-50 (preferably 4-25) wt. % of 3-(hydroxyalkylamino)-2-hydroxypropyl esters of fatty acids of the general formula RCOOCH.sub.2 CH(OH)CH.sub.2 N(R.sub.1 R.sub.2), where R are the C.sub.16 -C.sub.22 alkyls or alkenyls, R.sub.1 is H, CH.sub.2 CH.sub.2 OH, CH.sub.2 CH.sub.2 CH.sub.2 OH, CH.sub.3 CHCH.sub.2 OH, CH.sub.2 CH(OH)CH.sub.3, CH.sub.3 CH.sub.2 CHCH.sub.2 OH, CH.sub.3 CHCH.sub.2 CH.sub.2 OH, CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OH, or CH.sub.3 CHCH(OH)CH.sub.3, and R.sub.2 is the same substituent as R.sub.1 except for H. The agent serves for the repeated regeneration of antistatic and other properties of fabrics made of synthetic fibers and is applied to washed and rinsed fabrics by a short-termed soaking, moderate squeeze and drying. The surface electric resistivity of the fabrics is effectively reduced even at the low humidity of environment already by a very small amount of the agent. The said agent is not toxic and its effect is not reduced even by certain amounts of anion-active detergents retained by fabric after incomplete rinsing.
摘要翻译：本发明涉及具有抗静电效果和有利的皮肤病学特性的纺织活性剂，其含有软化，稳定，增白，着色，香味和皮肤病学成分，阴离子活性，非离子和阳离子表面活性剂和其它添加剂，并且2-50（优选4-25）重量％的通式为RCOOCH 2 CH（OH）CH 2 N（R 1 R 2）的脂肪酸的3-（羟基烷基氨基）-2-羟丙基酯，其中R是C16-C22烷基或烯基，R1是H，CH2CH2OH，CH2CH2CH2OH，CH3CHCH2OH，CH2CH （OH）CH 3，CH 3 CH 2 CHCH 2 OH，CH 3 CHCH 2 CH 2 OH，CH 2 CH 2 CH 2 CH 2 OH或CH 3 CHCH（OH）CH 3，并且R 2除了H外，与R 1相同。取代基用于反复再生由合成纤维制成的织物的抗静电和其它性能，通过短期浸泡，中等挤压和干燥将其施加到洗涤和漂洗的织物上。即使在环境的低湿度下，织物的表面电阻率也可以通过极少量的试剂有效降低。所述试剂无毒，即使在不完全冲洗后由织物保留的某些量的阴离子活性洗涤剂也不会降低其效果。

7. 发明授权

US4489588A Apparatus for manufacturing screw workpieces of a tube semi-product 失效
标题翻译：用于制造管半产品的螺丝工件的装置
公开(公告)号：US4489588A
公开(公告)日：1984-12-25
申请号：US480463
申请日：1983-03-30
申请人： Josef Svercl , Jan Novak , Stepan Zampach
发明人： Josef Svercl , Jan Novak , Stepan Zampach
IPC分类号： B29D1/00 , B21C37/15 , B21D11/06 , B21D11/14 , B21D15/04 , B21D15/12 , B21K1/12 , B21K21/16 , B29C33/00 , B29C61/00 , B29C65/00
CPC分类号： B21K21/16 , B21C37/15 , B21D11/14 , B21D15/04 , B21K1/12 , B21K1/305
摘要： Forming die for manufacturing screw workpieces of a tube semi-product, e.g. rotors of single-spindle pumps. The function cavity of the forming dies consists of a guide part, a forming part, and a calibrating part. The guide part of the function cavity is formed by the intersection of a cylindrical surface and a helix, the forming part is formed by the intersection of a conical surface and a helix, and the calibrating part is of the shape of the helix of the final product. A minimum length of the guide part of the function cavity is equal to the diameter of the cylindrical surface, but the minimum length of the forming part as well as the length of the calibrating part of the function cavity is equal to one lead of the helix. The ratio of the diameter of the cylindrical surface of the guide part to the diameter of the helix is at least 1.1:1.
摘要翻译：用于制造管半产品的螺丝工件的成形模具，例如单轴泵转子。成形模具的功能腔由导向部件，成形部件和校准部件组成。功能腔的引导部分由圆柱形表面和螺旋线组成，形成部分由圆锥形表面和螺旋线形成，校准部分为最终螺旋形的形状产品。功能腔的引导部分的最小长度等于圆柱形表面的直径，但是成形部件的最小长度以及功能腔的校准部件的长度等于螺旋线的一个引线。引导部分的圆柱形表面的直径与螺旋直径之比至少为1.1:1。

8. 发明授权

US4434645A Apparatus for the radial shaping of tubular articles 失效
标题翻译：用于管状物品的径向成形的装置
公开(公告)号：US4434645A
公开(公告)日：1984-03-06
申请号：US288167
申请日：1981-07-29
申请人： Josef Svercl , Jan Novak , Zdenek Kalab
发明人： Josef Svercl , Jan Novak , Zdenek Kalab
IPC分类号： B21D11/06 , B21D11/10 , B21D15/12 , B21J7/14 , B21K1/12 , B21D41/00
CPC分类号： B21D11/10 , B21D11/06 , B21D15/12 , B21J7/145 , B21K1/12
摘要： Apparatus for radial shaping of rotors, stators, crankshafts, spindles and the like from an elongate seamless tube where a supporting ring performing a reciprocating motion according to an adjustable stroke of a connecting rod causes by way of rollers and guiding segments a reduction and increase of the radial distance of sliding shoes with forming jaws with respect to the formed object.
摘要翻译：用于从细长无缝管径向成形转子，定子，曲轴，主轴等的装置，其中根据连杆的可调节行程执行往复运动的支承环通过滚子和引导段导致减小和增加具有成形夹爪的滑动鞋相对于成形物体的径向距离。

9. 发明授权

US5872001A Lanthionine antibiotic compositions and methods 失效
标题翻译：羊抗坏血酸组成和方法
公开(公告)号：US5872001A
公开(公告)日：1999-02-16
申请号：US736334
申请日：1996-10-23
申请人： Page W. Caufield , Jan Novak
发明人： Page W. Caufield , Jan Novak
IPC分类号： C12N15/09 , A61K8/00 , A61K8/99 , A61K38/00 , A61P1/02 , A61P31/04 , A61Q11/00 , C07K1/30 , C07K14/315 , C12N1/15 , C12N1/21 , C12N15/52 , C12N15/74 , C07H21/04 , C12N15/63
CPC分类号： C07K14/315 , C12N15/52 , C12N15/746
摘要： Certain bacteria indigenous to humans produce antimicrobial substances called bacteriocins which inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and .beta.-methyllanthionine. Also provided are methods of making and using the purified polypeptide.
摘要翻译：人类本身的某些细菌产生称为细菌素的抗微生物物质，其抑制其他细菌，包括其自身物种的成员。 Mutacins是由变形链球菌制成的一类抗生素物质。公开了来自变形链球菌的新型含有羊水苷的mutacin肽的纯化和生物化学表征。纯化的肽是pH-和温度稳定的，其氨基酸组成表明存在羊血硫酸和β-甲基牛磺酸。还提供了制备和使用纯化的多肽的方法。

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