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1. 发明授权

US08113834B2 Arrangement of two or more implants provided with growth-stimulating substance(s) 有权
标题翻译：提供有生长刺激物质的两个或多个植入物的布置
公开(公告)号：US08113834B2
公开(公告)日：2012-02-14
申请号：US12126542
申请日：2008-05-23
申请人： Jan Hall
发明人： Jan Hall
IPC分类号： A61C8/00
CPC分类号： A61L27/227 , A61C8/0006 , A61F2/2803 , A61F2/2846 , A61F2002/2817 , A61F2002/2835 , A61L2430/02
摘要： Two or more implants (8, 9, 10) are arranged in succession in the jaw bone (1) and bear or comprise growth-stimulating substances (25), here called GSS, which, as a function of secretion of body fluid at the implants, are intended to be released and form new bone (11-15) around the implants. The implants are designed to work with a release process for GSS, permitting a leveling-out effect along the extent of the jaw bone in the horizontal and/or vertical direction and/or a level-raising effect in the vertical direction. In this way it is possible to achieve optimum positions for the implants without the risk of reduced stability and/or compromised esthetics.
摘要翻译：两个或更多个植入物（8,9,10）被连续排列在颚骨（1）中，并且承载或包含生长刺激物质（25），这里称为GSS，其作为在体外液体分泌的功能植入物，旨在被释放并在植入物周围形成新的骨骼（11-15）。植入物设计用于GSS的释放过程，允许沿着颚骨在水平和/或垂直方向上的程度的平移效应和/或垂直方向上的升高效果。以这种方式，可以实现植入物的最佳位置，而不会降低稳定性和/或损害美学的风险。

2. 发明申请

US20100112519A1 IMPLANT, METHOD FOR PRODUCING THE IMPLANT, AND USE OF THE IMPLANT 有权
标题翻译：植入物，植入物的制造方法和植入物的使用
公开(公告)号：US20100112519A1
公开(公告)日：2010-05-06
申请号：US12684591
申请日：2010-01-08
申请人： Jan Hall , Jukka Lausmaa
发明人： Jan Hall , Jukka Lausmaa
IPC分类号： A61C13/08
CPC分类号： A61F2/30767 , A61C8/0006 , A61C8/0012 , A61C8/0015 , A61F2/2803 , A61F2/3094 , A61F2002/30011 , A61F2002/30036 , A61F2002/3085 , A61F2002/30927 , A61F2250/0023 , A61F2250/0035 , A61F2310/00023 , A61F2310/00616 , A61F2310/00976 , A61L27/06 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/602
摘要： An implant comprises titanium and has one or more surfaces which can be applied in or on a bone growth area. One or more of the surfaces are arranged with a depot for bone-growth-initiating or bone-growth-stimulating substance, in which the depot is formed by a pore arrangement in a relatively thick oxide layer on the titanium. The substance is acted on, for a considerable period of time, by one or more release functions for the substance which permit a controlled or optimized release of substance to the surrounding tissue or bone growth area.
摘要翻译：植入物包括钛并且具有一个或多个可以施加在骨生长区域中或骨生长区域上的表面。一个或多个表面布置有用于骨生长起始或骨生长刺激物质的贮库，其中通过在钛上相对厚的氧化物层中的孔排列形成贮库。该物质在相当长的一段时间内通过物质的一种或多种释放功能起作用，所述功能允许将物质控制或优化地释放到周围组织或骨生长区域。

3. 发明申请

US20070275350A1 Arrangement of an Implant and/or a Unit Belonging to Said Implant, and Method for Production of the Implant and/or Unit 审中-公开
标题翻译：植入物和/或属于所述植入物的单元的安排以及植入物和/或单元的生产方法
公开(公告)号：US20070275350A1
公开(公告)日：2007-11-29
申请号：US10582468
申请日：2004-12-06
申请人： Jan Hall
发明人： Jan Hall
IPC分类号： A61C8/00
CPC分类号： A61C13/0012 , A61C8/0012 , A61C8/0013 , A61C8/0015 , A61K6/0235 , A61L27/06 , A61L27/50 , C25D11/022 , C25D11/26
摘要： An implant (5, 13) and/or a unit (9), e.g. spacer sleeve, belonging to said implant is/are intended to extend through a hole (4′) formed in a jaw bone (2) and through soft tissue (3) belonging to the jaw bone and to comprise one or more outer layers of principally titanium dioxide. Each layer consists of crystalline titanium dioxide which largely or completely assumes the anatase phase. The invention also relates to a method for production of such a dental implant (5, 13) and/or of a unit (9) belonging to it, which has one or more outer layers of titanium dioxide. The method is an anodic oxidation method in which the part or parts bearing the outer layer(s) is/are applied to electrolyte under voltage, e.g. comprising sulfuric acid and phosphoric acid, and the voltage (U) and the dwell time of the part or parts in the electrolyte are chosen such that titanium dioxide, largely or completely assuming the crystalline anatase phase, is formed. Excellent bone guidance and soft tissue integration can be achieved in this way.
摘要翻译：植入物（5,13）和/或单元（9），例如，属于所述植入物的间隔套筒旨在延伸通过形成在颚骨（2）中的孔（4'）和通过属于颚骨的软组织（3）延伸并且包括一个或多个外层二氧化钛。每层由结晶二氧化钛组成，其大部分或完全呈现锐钛矿相。本发明还涉及一种用于生产这种牙植入物（5,13）和/或属于其的单元（9）的方法，该方法具有一个或多个外层二氧化钛。该方法是阳极氧化方法，其中承载外层的部分或部分被施加到电压下的电解质，例如，包括硫酸和磷酸，并且选择电解质中部分或部分的电压（U）和停留时间，使得形成大部分或完全呈现结晶锐钛矿相的二氧化钛。以这种方式可以实现良好的骨骼指导和软组织整合。

4. 发明申请

US20060091033A1 Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product 审中-公开
标题翻译：用于保持植入物产品的生长刺激物质的新骨形成效果的布置和方法
公开(公告)号：US20060091033A1
公开(公告)日：2006-05-04
申请号：US10520009
申请日：2003-06-18
申请人： Jan Hall
发明人： Jan Hall
IPC分类号： A61B19/02 , B65B31/02
CPC分类号： A61C8/0087 , A61C8/0006 , A61F2/0095 , A61F2002/2817
摘要： In an arrangement and method, use is made of a container for preserving, even for a long time, the new-bone-forming effect of growth-stimulating substances (GS) applied to one or more implant products. The container is arranged so as, dependent on being acted upon, to allow accessibility of the product concerned with applied GS as the time of its use. The container is arranged to enclose the product or the products with applied GS in an environment which is essentially free from air, water and moisture. The container functions as a vacuum container, and the storage times for GS can be extended considerably in relation to previously used arrangements and methods.
摘要翻译：在一种布置和方法中，使用容器，甚至长期保存施用于一种或多种植入物产品的生长刺激物质（GS）的新骨形成效应。集装箱的安排是依赖于采取的行动，以便使用与使用GS相关的产品的可及性。容器被布置成将产品或产品与施用的GS包围在基本上不含空气，水和水分的环境中。容器用作真空容器，并且与以前使用的布置和方法相比，可以大大延长GS的储存时间。

5. 发明申请

US20060003291A1 Implant arrangement 有权
标题翻译：种植体安排
公开(公告)号：US20060003291A1
公开(公告)日：2006-01-05
申请号：US11169189
申请日：2005-06-28
申请人： Jan Hall
发明人： Jan Hall
IPC分类号： A61C8/00
CPC分类号： A61C8/0022
摘要： An implant is arranged with a thread which can be exposed to a jaw bone and which has a first extent in the longitudinal direction of the implant. Thread flanks are assigned second extents between the inner and outer peripheries of the thread. Along all or most of the first extent, the thread flanks are arranged with one or more grooves that can extend in the peripheral direction and can be situated on the second extents. The groove or grooves are arranged to participate in the process by which the implant fuses with the jaw bone (2).
摘要翻译：植入物布置有可以暴露于颚骨并且在植入物的纵向方向上具有第一程度的线。螺纹侧面被分配在螺纹的内周和外周之间的第二范围。沿着所有或大部分的第一程度，螺纹牙齿被设置有一个或多个凹槽，该凹槽可在圆周方向上延伸并且可以位于第二范围上。凹槽或凹槽布置成参与植入物与颚骨（2）融合的过程。

6. 发明授权

US06918766B1 Method, arrangement and use of an implant for ensuring delivery of bioactive substance to the bone and/or tissue surrounding the implant 有权
标题翻译：用于确保将生物活性物质递送到植入物周围的骨和/或组织的植入物的方法，布置和使用
公开(公告)号：US06918766B1
公开(公告)日：2005-07-19
申请号：US09980009
申请日：2000-05-23
申请人： Jan Hall , Lennart Lööf
发明人： Jan Hall , Lennart Lööf
IPC分类号： A61C8/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61L27/24 , A61L27/54 , A61F13/00
CPC分类号： A61C8/00 , A61F2/2803 , A61F2002/2817 , A61F2002/2889 , A61F2002/30062 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/54 , A61L2300/414 , A61L2300/602
摘要： In connection with implants for bone or tissue, delivery of bioactive substances to the bone or tissue is ensured. The implant is designed with an internal space, and one or more bodies comprising the bioactive substance are designed to cooperate with the bone and/or tissue structure surrounding the implant and to release the bioactive substance to the said structure. The said body or bodies is/are applied in the space in order thereby to be exposed to the surrounding structure and deliver the bioactive substrate or substances to the latter.
摘要翻译：关于骨或组织的植入物，确保将生物活性物质递送至骨骼或组织。植入物设计有内部空间，并且包括生物活性物质的一个或多个主体被设计成与围绕植入物的骨和/或组织结构配合并将生物活性物质释放到所述结构。所述身体或物体被施加在空间中，从而暴露于周围结构并将生物活性基质或物质递送到后者。

7. 发明授权

US08657601B2 Implant for example dental implant 有权
标题翻译：植入物例如牙种植体
公开(公告)号：US08657601B2
公开(公告)日：2014-02-25
申请号：US10482736
申请日：2002-06-26
申请人： Jan Hall
发明人： Jan Hall
IPC分类号： A61L27/54
CPC分类号： A61L27/54 , A61C8/0012 , A61C8/0013 , A61C2008/0046 , A61F2/30767 , A61F2/3094 , A61F2002/30797 , A61F2002/30866 , A61F2002/30924 , A61F2002/30925 , A61F2002/30929 , A61F2002/3097 , A61F2310/00023 , A61F2310/00976 , A61L27/50 , A61L2300/252 , A61L2300/606
摘要： An implant (10) has one or more surfaces (10a, 10b) with a basic or starting surface structure (1a) derived from mechanical working. A topographic modification of the surface structures is arranged on said surface structure or surface structures. The topographic modification can be formed, for example, by means of shot-peening, etching, plasma spraying, chemical action, etc. The topographically modified surface structures support bone-growth-stimulating agent. In a method for producing the implant, three subsidiary methods are used for carrying out the mechanical working, the topographical modification, and the application of the bone-growth-stimulating agent. An important niche in the demand which exists in the field of implants is thus covered in an advantageous manner.
摘要翻译：植入物（10）具有一个或多个来自机械加工的具有基础或起始表面结构（1a）的表面（10a，10b）。在所述表面结构或表面结构上布置表面结构的形貌变化。地形修改可以例如通过喷丸，蚀刻，等离子体喷涂，化学作用等形成。表面改性的表面结构支持骨生长刺激剂。在用于生产植入物的方法中，使用三种辅助方法进行机械加工，形貌修饰和骨生长刺激剂的应用。因此，在植入物领域中存在的需求中的重要利基被以有利的方式覆盖。

8. 发明授权

US08439919B2 Implant provided with attachment and hole-insert parts, and a method for producing such an implant 有权
公开(公告)号：US08439919B2
公开(公告)日：2013-05-14
申请号：US12634466
申请日：2009-12-09
申请人： Jan Hall
发明人： Jan Hall
IPC分类号： A61B17/56 , A61B17/58 , A61F2/30
CPC分类号： A61C8/0022 , A61C2008/0046 , A61F2002/30011 , A61F2002/30321 , A61F2002/30859 , A61F2002/30871 , A61F2002/30874 , A61F2002/30927 , A61F2250/0023 , A61F2250/0025
摘要： An implant (4) is provided with attachment and hole-insert parts (2, 3) with surfaces which have different degrees of finishing and/or degrees of roughness and/or porosities (2f, 2g). Arranged on the surfaces there is at least one dozen (A-B) in which the degree of finishing and/or the degree of roughness and/or the porosity is continuously changed. The changes in porosity in said zones can mirror continuous or discontinuous changes in the bone in question, for example the jaw bone or tooth bone. The continuously changed zones can be obtained with the aid of electrolyte (15) and, connected to the latter, an anode and cathode arrangement (13, 14). When establishing the porosity, it is possible to mask different portions of the respective implant and to control the temperature of the implant.

9. 发明授权

US08167618B2 Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose 有权
标题翻译：使用骨诱导或生物活性材料诱导骨骼和/或增加颌骨植入物的稳定性的装置和用于该目的的植入物
公开(公告)号：US08167618B2
公开(公告)日：2012-05-01
申请号：US12210899
申请日：2008-09-15
申请人： Jan Hall
发明人： Jan Hall
IPC分类号： A61C8/00
CPC分类号： A61L27/54 , A61C8/0009 , A61C8/0012 , A61L2300/414
摘要： The stability of an implant (5) which is fitted in a jaw bone hole created by tooth root extraction is increased using osteoinductive material. Bone formation in the space between the implant and the bone wall is also stimulated. In an initial stage, the implant is anchored or fitted in the hole. With its outer parts (5a) the implant extends into a part (4a) of the hole which has a cross-sectional area exceeding the crossectional area of the outer parts (5a) of the implant. The soft tissue of the jaw bone, with possible periosteum, covers the implant and the space to form a closed space (4a). The bioactive material consists of growth-stimulating substances (GSS) arranged on the implant. In a stage of incorporation, GSS passes outward into body fluid which has penetrated into the closed space and interacts with cells present in the fluid so that new bone is formed around the outer pats (5a) of the implant. The invention also relates to a use and to an implant. The invention also simplifies the handling of implants.
摘要翻译：使用骨诱导材料增加了通过牙根提取产生的装配在颚骨孔中的植入物（5）的稳定性。在植入物和骨壁之间的空间中的骨形成也被刺激。在初始阶段，植入物被锚固或装配在孔中。通过其外部部分（5a），植入物延伸到孔的部分（4a）中，该部分的横截面积超过植入物的外部部分（5a）的横截面面积。具有可能的骨膜的颚骨的软组织覆盖植入物和空间以形成封闭空间（4a）。生物活性物质由植入物上的生长刺激物质（GSS）组成。在并入阶段，GSS向外通入已经渗透到封闭空间中并与存在于流体中的细胞相互作用的体液，使得在植入物的外部片（5a）周围形成新骨。本发明还涉及一种用途和植入物。本发明还简化了植入物的处理。

10. 发明授权

US07713307B1 Layer arranged on implant for bone or tissue structure 有权
标题翻译：层布置在植入物上用于骨或组织结构
公开(公告)号：US07713307B1
公开(公告)日：2010-05-11
申请号：US09980006
申请日：2000-05-23
申请人： Jan Hall , Jukka Lausmaa
发明人： Jan Hall , Jukka Lausmaa
IPC分类号： A61F2/28
CPC分类号： A61C8/0012 , A61C8/0015 , A61L27/306 , A61L27/56
摘要： A layer (2∝″) is arranged on an implant (1″) for bone or tissue structure (5). The layer constitutes a boundary or a barrier between the actual or unoxidized body of the implant (1″) and the structure for the purpose of increasing retention and has in this context, a substantial thickness (T′). The layer (2′″) is designed with a channel network (6) which gives the layer a substantial porosity. The channel network (6) is designed with mouths (3′,4′) which face towards the structure (5) and whose respective cross-sectional diameters (D), at the surface (2a′) of the layer (2′″) facing towards the structure (5), are substantially less than the respective extents (e.g., H) of the channels in and down into the layer (2′″) as seen from the said surface (2a′).
摘要翻译：在用于骨或组织结构（5）的植入物（1“）上布置有层（2α”）。该层构成植入物（1“）的实际或未氧化体与用于增加保留性的结构之间的边界或屏障，并且在本文中具有相当大的厚度（T'）。层（2“”）被设计成具有通道网络（6），其使层具有显着的孔隙率。通道网络（6）设计有朝向结构（5）的口（3'，4'），并且在层（2“）的表面（2a'）处具有各自的横截面直径（D））基本上小于从所述表面（2a'）看到的在层（2“”）内和向下的通道的相应范围（例如，H）。

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