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1. 发明授权

US07604981B1 Excitable target marker detection 失效
标题翻译：可兴奋的靶标检测
公开(公告)号：US07604981B1
公开(公告)日：2009-10-20
申请号：US10384166
申请日：2003-03-07
申请人： James S. Harris, Jr. , Stephen J. Smith , Evan P. Thrush , Ofer Levi
发明人： James S. Harris, Jr. , Stephen J. Smith , Evan P. Thrush , Ofer Levi
IPC分类号： C12M1/34 , C12M3/00 , G01N21/64 , G01N33/53 , G01N21/00
CPC分类号： G01N21/6454 , G01N21/6408
摘要： A variety of types of molecules are detected and/or analyzed using an integrated micro-circuit arrangement. According to an example embodiment of the present invention, a micro-circuit arrangement detects excitable target markers in response to an excitation source. The excitation source emits a first electromagnetic radiation to excite one or more target markers into emitting a second electromagnetic radiation. The excitation source and detector combination can be optimized to detect a specific characteristic of a biological specimen. In this manner, an excitation source can be combined with several optical-detectors or detection channels, where each optical-detector is measuring or sensing the same or different characteristic of the biological specimen.
摘要翻译：使用集成微电路装置检测和/或分析各种类型的分子。根据本发明的示例性实施例，微电路装置响应于激发源检测可激发的目标标记。激发源发射第一电磁辐射以激发一个或多个目标标记物发射第二电磁辐射。可以优化激发源和检测器组合以检测生物样品的特定特征。以这种方式，激发源可以与几个光学检测器或检测通道组合，其中每个光学检测器正在测量或感测生物样本的相同或不同的特性。

2. 发明授权

US08306607B1 Implantable sensing arrangement and approach 失效
标题翻译：植入式感应装置和方法
公开(公告)号：US08306607B1
公开(公告)日：2012-11-06
申请号：US10979091
申请日：2004-11-01
申请人： Ofer Levi , Evan P. Thrush , James S. Harris , Stepehn J. Smith , Krishna V. Shenoy
发明人： Ofer Levi , Evan P. Thrush , James S. Harris , Stepehn J. Smith , Krishna V. Shenoy
IPC分类号： A61B5/00
CPC分类号： A61B5/0086 , A61B5/0031 , A61B5/0071 , A61B5/4064 , A61B2562/046
摘要： Characteristics of biological substances, such as cerebral cortex matter, are sensed. According to an example embodiment, the present invention is directed to a negligibly-intrusive, multi-layer integrated circuit arrangement for monitoring activity of an area of a cerebral cortex that would normally be covered by an anatomical layer. The multi-layer integrated circuit arrangement includes an optics layer located outside the cerebral cortex area that includes an emitter and a detector. The optics layer is adapted for implantation in the anatomical layer and for sensing at least one brain-activity parameter. The multi-layered integrated circuit arrangement also includes a data-processing layer that includes a digital-processing circuit that is adapted for assimilating neural data in response to the optics layer sensing at least one brain-activity parameter.
摘要翻译：感觉到生物物质如大脑皮层物质的特征。根据示例性实施例，本发明涉及一种用于监测通常被解剖层覆盖的大脑皮质区域的活动的可忽略不计的多层集成电路装置。多层集成电路装置包括位于大脑皮质区域外部的光学层，该光学层包括发射器和检测器。光学层适于植入解剖层并用于感测至少一个脑活动参数。多层集成电路装置还包括数据处理层，其包括数字处理电路，该数字处理电路适于响应于感测至少一个脑活动参数的光学层而吸收神经数据。

3. 发明授权

US11189363B2 Generation of nuclear magnetic resonance multidimensional T1(spin-matrix)-T2(spin-spin) energy relaxation maps and uses thereof 有权
公开(公告)号：US11189363B2
公开(公告)日：2021-11-30
申请号：US16562847
申请日：2019-09-06
申请人： Ze'ev Wiesman , Charles Linder , Ofer Levi
发明人： Ze'ev Wiesman , Charles Linder , Ofer Levi , Michael Saunders
IPC分类号： G16C20/20 , G01N24/08 , G01R33/30 , G01R33/44 , G01R33/46 , G01R33/465 , G01R33/50 , G01V3/32
摘要： A method of characterizing chemical and/or morphological features of a material, comprising acquiring energy relaxation data from 1H low field nuclear magnetic resonance (1H LF-NMR) measurements of said material, converting the relaxation signals into a multidimensional distribution of longitudinal and transverse relaxation times by solving an inverse problem under both L1 and L2 regularizations and further imposing a non-negativity constraint, and identifying one or more characteristics of said material with the aid of said multidimensional T1-T2 distribution. The method is useful, inter alia, in monitoring chemical processes, screening of additives and quality control.

4. 发明授权

US09253419B2 System and method for optical imaging with vertical cavity surface emitting lasers 有权
标题翻译：具有垂直腔表面发射激光器的光学成像系统和方法
公开(公告)号：US09253419B2
公开(公告)日：2016-02-02
申请号：US13357070
申请日：2012-01-24
申请人： Elizabeth Alice Munro , Ofer Levi
发明人： Elizabeth Alice Munro , Ofer Levi
IPC分类号： H04N5/232 , H04N5/33 , H04N5/225
CPC分类号： H04N5/332 , H04N5/2256
摘要： The present invention uses vertical-cavity surface-emitting lasers (VCSELs) as illumination source for simultaneous imaging of blood flow and tissue oxygenation dynamics in vivo, or a means to monitor neural activity in brain slices ex vivo. The speckle pattern on the brain tissue due to a VCSEL's coherence properties is the main challenge to producing low-noise high-brightness illumination, required for evaluating tissue oxygenation. Moreover, using oxide-confined VCSELs we show a fast switching from a single-mode operation scheme to a special multi-modal, multi-wavelength rapid sweep scheme. The multi-modal, multi-wavelength rapid sweep scheme reduces noise values to within a factor of 40% compared to non-coherent LED illumination, enabling high-brightness VCSELs to act as efficient miniature light sources for various brain imaging modalities and other imaging applications. These VCSELs are promising for long-term portable continuous monitoring of brain dynamics in freely moving animals.
摘要翻译：本发明使用垂直腔表面发射激光器（VCSEL）作为用于体内血流和组织氧合动力学的同时成像的照明源，或者是用于监测体外脑切片神经活动的方法。由于VCSEL的相干性质，脑组织上的斑点图案是产生评估组织氧合所需的低噪声高亮度照明的主要挑战。此外，使用氧化物限制的VCSEL，我们显示从单模式操作方案到特殊的多模式，多波长快速扫描方案的快速切换。多模式，多波长快速扫描方案将噪声值与非相干LED照明相比降低到40％的比例，使高亮度VCSEL能够用作各种脑成像模式和其他成像应用的高效微型光源。这些VCSELs可以长期便携式连续监测自由移动的动物的脑动力学。

5. 发明申请

US20120188354A1 SYSTEM AND METHOD FOR OPTICAL IMAGING WITH VERTICAL CAVITY SURFACE EMITTING LASERS 有权
标题翻译：用垂直孔表面发射激光进行光学成像的系统和方法
公开(公告)号：US20120188354A1
公开(公告)日：2012-07-26
申请号：US13357070
申请日：2012-01-24
申请人： Elizabeth Alice Munro , Ofer Levi
发明人： Elizabeth Alice Munro , Ofer Levi
IPC分类号： H04N7/18 , H04N5/232
CPC分类号： H04N5/332 , H04N5/2256
摘要： The present invention uses vertical-cavity surface-emitting lasers (VCSELs) as illumination source for simultaneous imaging of blood flow and tissue oxygenation dynamics in vivo, or a means to monitor neural activity in brain slices ex vivo. The speckle pattern on the brain tissue due to a VCSEL's coherence properties is the main challenge to producing low-noise high-brightness illumination, required for evaluating tissue oxygenation. Moreover, using oxide-confined VCSELs we show a fast switching from a single-mode operation scheme to a special multi-modal, multi-wavelength rapid sweep scheme. The multi-modal, multi-wavelength rapid sweep scheme reduces noise values to within a factor of 40% compared to non-coherent LED illumination, enabling high-brightness VCSELs to act as efficient miniature light sources for various brain imaging modalities and other imaging applications. These VCSELs are promising for long-term portable continuous monitoring of brain dynamics in freely moving animals.
摘要翻译：本发明使用垂直腔表面发射激光器（VCSEL）作为用于体内血流和组织氧合动力学的同时成像的照明源，或者是用于监测体外脑切片神经活动的方法。由于VCSEL的相干性质，脑组织上的斑点图案是产生评估组织氧合所需的低噪声高亮度照明的主要挑战。此外，使用氧化物限制的VCSEL，我们显示从单模式操作方案到特殊的多模式，多波长快速扫描方案的快速切换。多模式，多波长快速扫描方案将噪声值与非相干LED照明相比降低到40％的比例，使高亮度VCSEL能够用作各种脑成像模式和其他成像应用的高效微型光源。这些VCSELs可以长期便携式连续监测自由移动的动物的脑动力学。

6. 发明授权

US08381263B1 System, method, and computer program for allowing a non-chargeable event based on an authorization thereof 有权
标题翻译：系统，方法和计算机程序，用于允许基于其授权的不可收费事件
公开(公告)号：US08381263B1
公开(公告)日：2013-02-19
申请号：US12140786
申请日：2008-06-17
申请人： Dalia Zipor , Adi Lachman , Ofer Levi , Ilan Buganim , Felix Margulis
发明人： Dalia Zipor , Adi Lachman , Ofer Levi , Ilan Buganim , Felix Margulis
IPC分类号： H04L29/06
CPC分类号： H04M15/83 , H04L12/1485 , H04L63/10 , H04M15/80 , H04M15/85 , H04M15/852 , H04M15/881
摘要： A system, method, and computer program product are provided for allowing a non-chargeable event based on an authorization thereof. In use, an instruction to authorize events is received from an event threshold module based on a determination that an event threshold has been met. Additionally, in response to the instruction, a request is sent to an event processor to authorize an event, where the authorization is based on a determination of whether the event is chargeable or non-chargeable. Further, the event is allowed if the event is authorized by the event processor.
摘要翻译：提供了一种系统，方法和计算机程序产品，用于基于其授权允许不可收费的事件。在使用中，基于已经满足事件阈值的确定从事件阈值模块接收到授权事件的指令。此外，响应于该指令，将请求发送到事件处理器以授权事件，其中授权基于该事件是可计费还是不可收费的确定。此外，如果事件被事件处理器授权，则允许该事件。

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