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1. 发明授权

US06226553B1 Endothelium preserving microwave treatment for atherosclerois 有权
标题翻译：内皮保护微波治疗动脉粥样硬化
公开(公告)号：US06226553B1
公开(公告)日：2001-05-01
申请号：US09501150
申请日：2000-02-09
申请人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
发明人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
IPC分类号： A61F200
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1492 , A61B18/1815 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861 , A61N1/06
摘要： Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof. Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial layer and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount about 20° C., within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed, directable or focussed heating preserves healthy sectors of the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed beam. A computer simulation predicts isothermic temperature profiles for the given conditions and may be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.
摘要翻译：提供了治疗动脉粥样硬化的方法和装置，其中动脉通过扩张动脉而部分闭合，同时保留其重要且敏感的内皮层。具有频率从3GHz到300GHz的微波能量传播到动脉壁中以在组织深度处产生期望的温度曲线，其组织深度足以热破坏结缔组织和软化脂肪和蜡状斑块，同时限制包括内皮层的周围组织的加热和 /或其他健康的组织，器官和血液。在动脉粥样硬化病变期间将温度升高约20℃的潜在期望量的加热期可以小于约1秒。在本发明的一个实施例中，使用自旋斜面波导天线以25GHz或30GHz至约300GHz的频率传送微波能量，并且朝着动脉的特定径向扇区聚焦。由于动脉粥样硬化病变通常不对称地布置，可直接或聚焦的加热保留了动脉的健康部分，并且比非定向束更快地将能量施加到不对称定位的病变处。计算机模拟预测给定条件下的等温温度曲线，并且可用于选择功率，脉冲持续时间，波束宽度和操作频率以最大限度地增加能量沉积并控制动脉粥样硬化病变中的热上升而不伤害健康组织或敏感的内皮细胞。

2. 发明授权

US06223086B1 Endothelium preserving microwave treatment for atherosclerosis 有权
标题翻译：内皮保护微波治疗动脉粥样硬化
公开(公告)号：US06223086B1
公开(公告)日：2001-04-24
申请号：US09504768
申请日：2000-02-09
申请人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
发明人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
IPC分类号： A61F200
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1492 , A61B18/1815 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861 , A61N1/06
摘要： Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof. Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial layer and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20° C. within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed directable or focussed heating preserves healthy sectors of the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed beam. A computer simulation predicts isothermic temperature profiles for the given conditions and may be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.
摘要翻译：提供了治疗动脉粥样硬化的方法和装置，其中动脉通过扩张动脉而部分闭合，同时保留其重要且敏感的内皮层。具有频率从3GHz到300GHz的微波能量传播到动脉壁中以在组织深度处产生期望的温度曲线，其组织深度足以热破坏结缔组织和软化脂肪和蜡状斑块，同时限制包括内皮层的周围组织的加热和 /或其他健康的组织，器官和血液。在动脉粥样硬化病变期间将温度提高至约20℃的潜在期望量的加热期可以小于约1秒。在本发明的一个实施例中，使用自旋斜面波导天线以25GHz或30GHz至约300GHz的频率传送微波能量，并且朝着动脉的特定径向扇区聚焦。由于动脉粥样硬化病变通常是不对称地布置的可直接或聚焦的加热保留了动脉的健康部分，并且比非定向的束更快地将能量施加到不对称定位的病变处。计算机模拟预测给定条件下的等温温度曲线，并且可用于选择功率，脉冲持续时间，波束宽度和操作频率以最大限度地增加能量沉积并控制动脉粥样硬化病变中的热上升而不伤害健康组织或敏感的内皮细胞。

3. 发明授权

US06496736B1 Endothelium preserving microwave treatment for atherosclerosis 有权
标题翻译：内皮保护微波治疗动脉粥样硬化
公开(公告)号：US06496736B1
公开(公告)日：2002-12-17
申请号：US09500538
申请日：2000-02-09
申请人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
发明人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
IPC分类号： A61F200
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1492 , A61B18/1815 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861 , A61N1/06
摘要： Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof. Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial layer and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20° C. within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed, directable or focussed heating preserves healthy sectors or the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed bean. A computer simulation predicts isothermic temperature profiles for the given conditions and may be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells
摘要翻译：提供了治疗动脉粥样硬化的方法和装置，其中动脉通过扩张动脉而部分闭合，同时保留其重要且敏感的内皮层。具有频率从3GHz到300GHz的微波能量传播到动脉壁中以在组织深度处产生期望的温度曲线，其组织深度足以热破坏结缔组织和软化脂肪和蜡状斑块，同时限制包括内皮层的周围组织的加热和 /或其他健康的组织，器官和血液。在动脉粥样硬化病变期间将温度提高至约20℃的潜在期望量的加热期可以小于约1秒。在本发明的一个实施例中，使用自旋斜面波导天线以25GHz或30GHz至约300GHz的频率传送微波能量，并且朝着动脉的特定径向扇区聚焦。由于动脉粥样硬化病变通常不对称地布置，可直接或聚焦的加热保留健康部门或动脉，并且比非定向的豆更快地将能量施加到不对称定位的病变处。计算机模拟预测给定条件下的等温温度曲线，并且可用于选择功率，脉冲持续时间，波束宽度和操作频率以最大化能量沉积并控制动脉粥样硬化病变中的热升高而不伤害健康组织或敏感内皮细胞

4. 发明授权

US6047216A Endothelium preserving microwave treatment for atherosclerosis 有权
标题翻译：内皮保护微波治疗动脉粥样硬化
公开(公告)号：US6047216A
公开(公告)日：2000-04-04
申请号：US129832
申请日：1998-08-05
申请人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
发明人： James R. Carl , G. Dickey Arndt , Patrick W. Fink , N. Reginald Beer , Phillip D. Henry , Antonio Pacifico , George W. Raffoul
IPC分类号： A61B18/14 , A61B18/18 , A61N1/06 , A61F2/00
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61N1/06 , A61B18/1206 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861
摘要： Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial laser and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20.degree. C., within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed, directable or focussed heating preserves healthy sectors of the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed beam. A computer simulation predicts isothermic temperature profiles for the given conditions and man be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.
摘要翻译：提供了治疗动脉粥样硬化的方法和装置，其中动脉通过扩张动脉而部分闭合，同时保留其重要且敏感的内皮层。具有3GHz至300GHz频率的微波能量传播到动脉壁中以产生所需温度曲线其中组织深度足以热破坏结缔组织并软化脂肪和蜡状斑块，同时限制包括内皮激光和/或其它健康组织，器官和血液在内的周围组织的加热。在动脉粥样硬化病变期间将温度升高约20℃的可能期望量的加热时间可以小于约1秒。在本发明的一个实施例中，使用自旋斜面波导天线以25GHz或30GHz至约300GHz的频率传送微波能量，并且朝着动脉的特定径向扇区聚焦。由于动脉粥样硬化病变通常不对称地布置，可直接或聚焦的加热保留了动脉的健康部分，并且比非定向束更快地将能量施加到不对称定位的病变处。计算机模拟预测给定条件下的等温温度曲线，人们可以用于选择功率，脉冲持续时间，波束宽度和操作频率，以最大限度地提高能量沉积并控制动脉粥样硬化病变中的热升高，而不会伤害健康组织或敏感内皮细胞。

5. 发明授权

US06175768B1 In vivo simulator for microwave treatment 失效
标题翻译：用于微波处理的体内模拟器
公开(公告)号：US06175768B1
公开(公告)日：2001-01-16
申请号：US09154622
申请日：1998-09-16
申请人： G. Dickey Arndt , James R. Carl , George W. Raffoul , Vincent G. Karasack , Antonio Pacifico , Carl F. Pieper
发明人： G. Dickey Arndt , James R. Carl , George W. Raffoul , Vincent G. Karasack , Antonio Pacifico , Carl F. Pieper
IPC分类号： A61F200
CPC分类号： A61F2/00 , A61B18/1206 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861 , A61N1/06
摘要： Method and apparatus are provided for propagating microwave energy into heart tissues to produce a desired temperature profile therein at tissue depths sufficient for thermally ablating arrhythmogenic cardiac tissue to treat ventricular tachycardia and other arrhythmias while preventing excessive heating of surrounding tissues, organs, and blood. A wide bandwidth double-disk antenna (700) is effective for this purpose over a bandwidth of about six gigahertz. A computer simulation provides initial screening capabilities for an antenna such as antenna, frequency, power level, and power application duration. The simulation also allows optimization of techniques for specific patients or conditions. In operation, microwave energy between about 1 Gigahertz and 12 Gigahertz is applied to monopole microwave radiator (600) having a surface wave limiter (606). A test setup provides physical testing of microwave radiators (854) to determine the temperature profile created in actual heart tissue or ersatz heart tissue (841). Saline solution (872) pumped over the heart tissue (841) with a peristaltic pump (862) simulates blood flow. Optical temperature sensors (838) disposed at various tissue depths within the heart tissue (841) detect the temperature profile without creating any electromagnetic interference. The method may be used to produce a desired temperature profile in other body tissues reachable by catheter (510) such as tumors and the like.
摘要翻译：提供的方法和装置用于将微波能量传播到心脏组织中以在组织深度处产生期望的温度曲线，该组织深度足以热消融致心律失常性心脏组织以治疗室性心动过速和其他心律不齐，同时防止周围组织，器官和血液的过度加热。宽带宽双盘天线（700）在大约六千兆赫的带宽上对此有效。计算机模拟提供天线的初始屏蔽能力，例如天线，频率，功率电平和功率应用持续时间。该模拟还允许优化特定患者或病症的技术。在操作中，在具有表面波限制器（606）的单极微波辐射器（600）上施加约1吉赫兹与12千赫兹之间的微波能量。测试设置提供微波辐射器（854）的物理测试，以确定在实际心脏组织或ersatz心脏组织中产生的温度曲线（841）。用蠕动泵（862）泵送在心脏组织（841）上的盐水溶液（872）模拟血流量。设置在心脏组织（841）内的各种组织深度处的光学温度传感器（838）检测温度曲线，而不产生任何电磁干扰。该方法可以用于在由诸如肿瘤等的导管（510）可到达的其他身体组织中产生期望的温度分布。

6. 发明授权

US5904709A Microwave treatment for cardiac arrhythmias 失效
标题翻译：微波治疗心律失常
公开(公告)号：US5904709A
公开(公告)日：1999-05-18
申请号：US641045
申请日：1996-04-17
申请人： G. Dickey Arndt , James R. Carl , George W. Raffoul , Antonio Pacifico
发明人： G. Dickey Arndt , James R. Carl , George W. Raffoul , Antonio Pacifico
IPC分类号： A61B18/14 , A61B18/18 , A61N1/06 , A61F2/00
CPC分类号： A61N1/06 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/1206 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861
摘要： Method and apparatus are provided for propagating microwave energy into heart tissues to produce a desired temperature profile therein at tissue depths sufficient for thermally ablating arrhythmogenic cardiac tissue to treat ventricular tachycardia and other arrhythmias while preventing excessive heating of surrounding tissues, organs, and blood. A wide bandwidth double-disk antenna (700) is effective for this purpose over a bandwidth of about six gigahertz. A computer simulation provides initial screening capabilities for an antenna such as antenna, frequency, power level, and power application duration. The simulation also allows optimization of techniques for specific patients or conditions. In operation, microwave energy between about 1 Gigahertz and 12 Gigahertz is applied to monopole microwave radiator (600) having a surface wave limiter (606). A test setup provides physical testing of microwave radiators (854) to determine the temperature profile created in actual heart tissue or ersatz heart tissue (841). Saline solution (872) pumped over the heart tissue (841) with a peristaltic pump (862) simulates blood flow. Optical temperature sensors (838) disposed at various tissue depths within the heart tissue (841) detect the temperature profile without creating any electromagnetic interference. The method may be used to produce a desired temperature profile in other body tissues reachable by catheter (510) such as tumors and the like.
摘要翻译：提供的方法和装置用于将微波能量传播到心脏组织中以在组织深度处产生期望的温度曲线，该组织深度足以热消融致心律失常性心脏组织以治疗室性心动过速和其他心律不齐，同时防止周围组织，器官和血液的过度加热。宽带宽双盘天线（700）在大约六千兆赫的带宽上对此有效。计算机模拟提供天线的初始屏蔽能力，例如天线，频率，功率电平和功率应用持续时间。该模拟还允许优化特定患者或病症的技术。在操作中，在具有表面波限制器（606）的单极微波辐射器（600）上施加约1吉赫兹与12千赫兹之间的微波能量。测试设置提供微波辐射器（854）的物理测试，以确定在实际心脏组织或ersatz心脏组织中产生的温度曲线（841）。用蠕动泵（862）泵送在心脏组织（841）上的盐水溶液（872）模拟血流量。设置在心脏组织（841）内的各种组织深度处的光学温度传感器（838）检测温度曲线，而不产生任何电磁干扰。该方法可以用于在由诸如肿瘤等的导管（510）可到达的其他身体组织中产生期望的温度分布。

7. 发明授权

US6134476A Transcatheter antenna for microwave treatment 失效
标题翻译：用于微波处理的导管天线
公开(公告)号：US6134476A
公开(公告)日：2000-10-17
申请号：US154989
申请日：1998-09-17
申请人： G. Dickey Arndt , James R. Carl , George W. Raffoul , Vincent G. Karasack , Antonio Pacifico , Carl F. Pieper
发明人： G. Dickey Arndt , James R. Carl , George W. Raffoul , Vincent G. Karasack , Antonio Pacifico , Carl F. Pieper
IPC分类号： A61B18/14 , A61B18/18 , A61N1/06 , A61F2/00
CPC分类号： A61N1/06 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/1206 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861
摘要： Method and apparatus are provided for propagating microwave energy into heart tissues to produce a desired temperature profile therein at tissue depths sufficient for thermally ablating arrhythmogenic cardiac tissue to treat ventricular tachycardia and other arrhythmias while preventing excessive heating of surrounding tissues, organs, and blood. A wide bandwidth double-disk antenna (700) is effective for this purpose over a bandwidth of about six gigahertz. A computer simulation provides initial screening capabilities for an antenna such as antenna, frequency, power level, and power application duration. The simulation also allows optimization of techniques for specific patients or conditions. In operation, microwave energy between about 1 Gigahertz and 12 Gigahertz is applied to monopole microwave radiator (600) having a surface wave limiter (606). A test setup provides physical testing of microwave radiators (854) to determine the temperature profile created in actual heart tissue or ersatz heart tissue (841). Saline solution (872) pumped over the heart tissue (841) with a peristaltic pump (862) simulates blood flow. Optical temperature sensors (838) disposed at various tissue depths within the heart tissue (841) detect the temperature profile without creating any electromagnetic interference. The method may be used to produce a desired temperature profile in other body tissues reachable by catheter (510) such as tumors and the like.
摘要翻译：提供的方法和装置用于将微波能量传播到心脏组织中以在组织深度处产生期望的温度曲线，该组织深度足以热消融致心律失常性心脏组织以治疗室性心动过速和其他心律不齐，同时防止周围组织，器官和血液的过度加热。宽带宽双盘天线（700）在大约六千兆赫的带宽上对此有效。计算机模拟提供天线的初始屏蔽能力，例如天线，频率，功率电平和功率应用持续时间。该模拟还允许优化特定患者或病症的技术。在操作中，在具有表面波限制器（606）的单极微波辐射器（600）上施加约1吉赫兹与12千赫兹之间的微波能量。测试设置提供微波辐射器（854）的物理测试，以确定在实际心脏组织或ersatz心脏组织中产生的温度曲线（841）。用蠕动泵（862）泵送在心脏组织（841）上的盐水溶液（872）模拟血流量。设置在心脏组织（841）内的各种组织深度处的光学温度传感器（838）检测温度曲线，而不产生任何电磁干扰。该方法可以用于在由诸如肿瘤等的导管（510）可到达的其他身体组织中产生期望的温度分布。

8. 发明授权

US06995572B2 Sensor and method for detecting a superstrate 失效
公开(公告)号：US06995572B2
公开(公告)日：2006-02-07
申请号：US09803613
申请日：2001-03-05
申请人： G. Dickey Arndt , James R. Carl , Phong H. Ngo , Patrick W. Fink , James D. Siekierski
发明人： G. Dickey Arndt , James R. Carl , Phong H. Ngo , Patrick W. Fink , James D. Siekierski
IPC分类号： G01R27/04 , G01R27/32
CPC分类号： G08B19/02
摘要： Method and apparatus are provided for determining a superstrate on or near a sensor, e.g., for detecting the presence of an ice superstrate on an airplane wing or a road. In one preferred embodiment, multiple measurement cells are disposed along a transmission line. While the present invention is operable with different types of transmission lines, construction details for a presently preferred coplanar waveguide and a microstrip waveguide are disclosed. A computer simulation is provided as part of the invention for predicting results of a simulated superstrate detector system. The measurement cells may be physically partitioned, non-physically partitioned with software or firmware, or include a combination of different types of partitions. In one embodiment, a plurality of transmission lines are utilized wherein each transmission line includes a plurality of measurement cells. The plurality of transmission lines may be multiplexed with the signal from each transmission line being applied to the same phase detector. In one embodiment, an inverse problem method is applied to determine the superstrate dielectric for a transmission line with multiple measurement cells.

9. 发明授权

US06592579B2 Method for selective thermal ablation 失效
标题翻译：选择性热消融方法
公开(公告)号：US06592579B2
公开(公告)日：2003-07-15
申请号：US09746542
申请日：2000-12-18
申请人： G. Dickey Arndt , James Carl , Phong Ngo , George W. Raffoul
发明人： G. Dickey Arndt , James Carl , Phong Ngo , George W. Raffoul
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/18 , A61B18/1815 , A61B2018/00351 , A61B2018/00577 , A61B2018/00732 , A61B2018/00791 , A61B2018/1861 , A61N1/06
摘要： A method, simulation, and apparatus are provided that are highly suitable for treatment of benign prostatic hyperplasia (BPH). A catheter is disclosed that includes a small diameter disk loaded monopole antenna surrounded by fusion material having a high heat of fusion and a melting point preferably at or near body temperature. Microwaves from the antenna heat prostatic tissue to promote necrosing of the prostatic tissue that relieves the pressure of the prostatic tissue against the urethra as the body reabsorbs the necrosed or dead tissue. The fusion material keeps the urethra cool by means of the heat of fusion of the fusion material. This prevents damage to the urethra while the prostatic tissue is necrosed. A computer simulation is provided that can be used to predict the resulting temperature profile produced in the prostatic tissue. By changing the various control features of the catheter and method of applying microwave energy a temperature profile can be predicted and produced that is similar to the temperature profile desired for the particular patient.
摘要翻译：提供了一种非常适合治疗良性前列腺增生（BPH）的方法，模拟和装置。公开了一种导管，其包括由融化材料围绕的小直径盘加载的单极天线，该熔融材料具有高的熔化热和熔点，优选处于或接近体温。来自天线的微波加热前列腺组织以促进前列腺组织的坏死，当身体重新吸收坏死或死亡组织时，前列腺组织抵抗尿道的压力减轻。融合材料通过融合材料的熔化热使尿道冷却。这可以防止前列腺组织坏死时对尿道的损伤。提供了可用于预测在前列腺组织中产生的最终温度曲线的计算机模拟。通过改变导管的各种控制特征和施加微波能量的方法，可以预测和产生类似于特定患者期望的温度曲线的温度分布。

10. 发明授权

US07410485B1 Directional microwave applicator and methods 有权
标题翻译：定向微波施加器和方法
公开(公告)号：US07410485B1
公开(公告)日：2008-08-12
申请号：US11040613
申请日：2005-01-14
申请人： Patrick W. Fink , Greg Y. Lin , Andrew W. Chu , Justin A. Dobbins , G. Dickey Arndt , Phong H. Ngo
发明人： Patrick W. Fink , Greg Y. Lin , Andrew W. Chu , Justin A. Dobbins , G. Dickey Arndt , Phong H. Ngo
IPC分类号： A61B18/04 , A61N1/06
CPC分类号： A61B18/12 , A61B18/18 , A61B18/1815 , A61B2018/183
摘要： A miniature microwave antenna is disclosed which may be utilized for biomedical applications such as, for example, radiation induced hyperthermia through catheter systems. One feature of the antenna is that it possesses azimuthal directionality despite its small size. This directionality permits targeting of certain tissues while limiting thermal exposure of adjacent tissue. One embodiment has an outer diameter of about 0.095″ (2.4 mm) but the design permits for smaller diameters.
摘要翻译：公开了一种微型微波天线，其可用于生物医学应用，例如通过导管系统的辐射诱导的高热。天线的一个特点是尽管其尺寸小，但具有方位方向性。这种方向性允许靶向某些组织，同时限制相邻组织的热暴露。一个实施例具有约0.095“（2.4mm）的外径，但是设计允许更小的直径。

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