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1. 发明申请

US20090246785A1 NOVEL STEROID 5-ALPHA-REDUCTASE 有权
标题翻译：新型甾体5-ALPHA-REDUCTASE
公开(公告)号：US20090246785A1
公开(公告)日：2009-10-01
申请号：US12404590
申请日：2009-03-16
申请人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
发明人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
IPC分类号： C12Q1/68 , C12Q1/26
CPC分类号： C12Q1/26 , C07K2319/21 , C07K2319/40 , C12N9/001 , C12N2799/022 , G01N33/57434
摘要： The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
摘要翻译：本发明提供了一种分离的新型类固醇5α-还原酶，称为SRD5AIII。蛋白质具有37kDa的估计分子量，并且能够在约7.0的pH下将睾酮转化为二氢睾酮。还提供了通过使SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。该方法包括从个体获得前列腺活检，并确定相对于正常对照的SRD5AIII基因或蛋白质的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。

2. 发明授权

US08241845B2 Steroid 5α-reductase 有权
标题翻译：类固醇5α-还原酶
公开(公告)号：US08241845B2
公开(公告)日：2012-08-14
申请号：US12404590
申请日：2009-03-16
申请人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
发明人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
IPC分类号： C12Q1/68 , C12Q1/26 , C12N15/53 , C12N9/02
CPC分类号： C12Q1/26 , C07K2319/21 , C07K2319/40 , C12N9/001 , C12N2799/022 , G01N33/57434
摘要： The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
摘要翻译：本发明提供了一种分离的新型类固醇5α-还原酶，称为SRD5AIII。蛋白质具有37kDa的估计分子量，并且能够在约7.0的pH下将睾酮转化为二氢睾酮。还提供了通过使SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。该方法包括从个体获得前列腺活检，并确定相对于正常对照的SRD5AIII基因或蛋白质的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。

3. 发明申请

US20060275807A1 Novel steroid 5alpha-reductase 审中-公开
标题翻译：新型类固醇5α-还原酶
公开(公告)号：US20060275807A1
公开(公告)日：2006-12-07
申请号：US11432424
申请日：2006-05-10
申请人： James Mohler , Mark Titus , Olga Kozyreva , O. Ford , Elsbieta Kawinski , Yun Li
发明人： James Mohler , Mark Titus , Olga Kozyreva , O. Ford , Elsbieta Kawinski , Yun Li
IPC分类号： C12Q1/68 , G01N33/574 , C12N9/02 , C12N15/861
CPC分类号： C12Q1/26 , C07K2319/21 , C07K2319/40 , C12N9/001 , C12N2799/022 , G01N33/57434
摘要： The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
摘要翻译：本发明提供了一种分离的新型类固醇5α-还原酶，称为SRD5AIII。蛋白质具有37kDa的估计分子量，并且能够在约7.0的pH下将睾酮转化为二氢睾酮。还提供了通过使SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。该方法包括从个体获得前列腺活检，并确定相对于正常对照的SRD5AIII基因或蛋白质的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。

4. 外观设计

USD1036799S1 Clean water tank of vacuum cleaner 有权
公开(公告)号：USD1036799S1
公开(公告)日：2024-07-23
申请号：US29824876
申请日：2022-01-27
申请人： Yun Li
设计人： Yun Li
摘要： FIG. 1 is a front elevational view of a clean water tank of vacuum cleaner showing my new design;
FIG. 2 is a left side elevational view thereof;
FIG. 3 is a right side elevational view thereof;
FIG. 4 is a top plan view thereof;
FIG. 5 is a bottom plan view thereof;
FIG. 6 is a rear elevational view thereof;
FIG. 7 is a first perspective view thereof;
FIG. 8 is a second perspective view thereof; and,
FIG. 9 is a third perspective view thereof.
The broken lines shown in the drawings are for the purpose of illustrating portions of the article and form no part of the claimed design.

5. 发明授权

US08416682B2 Method and implementing apparatus for cooperative multi-hop routing in wireless network 有权
标题翻译：无线网络中协同多跳路由的方法与实现装置
公开(公告)号：US08416682B2
公开(公告)日：2013-04-09
申请号：US13472779
申请日：2012-05-16
申请人： Yun Li , Hongcheng Zhuang , Rui Wang
发明人： Yun Li , Hongcheng Zhuang , Rui Wang
IPC分类号： G01R31/08 , G06F11/00 , G08C15/00 , H04J1/16 , H04J3/14 , H04L1/00 , H04L12/26
CPC分类号： H04B7/155 , H04B7/022 , H04L45/24 , H04W84/18 , H04W88/04 , Y02D70/34
摘要： The present invention relates to a method and an implementing apparatus for cooperative multi-hop routing in a wireless network. According to the method the diversity gains and the interrupt probabilities in a cooperative communication manner between master nodes in the route are obtained, and the segmenting mode for sending packet data is determined accordingly, thus implementing cooperative communication in a multi-hop route, where signals having same information are sent through different paths, and multiple independently faded copies of data symbols may be obtained at a receiver end, thus obtaining higher reception reliability and higher transmission capacity, and improving performance of a communication process.
摘要翻译：本发明涉及无线网络中协同多跳路由的方法和实现装置。根据该方法，获得路由中的主节点之间的协作通信方式的分集增益和中断概率，并且相应地确定用于发送分组数据的分段模式，从而在多跳路由中实现协作通信，其中信号具有相同的信息通过不同的路径发送，并且可以在接收机端获得数据符号的多个独立褪色的副本，从而获得更高的接收可靠性和更高的传输容量，并且提高通信过程的性能。

6. 发明授权

US08042412B2 Turbomachinery system fiberoptic multi-parameter sensing system and method 有权
标题翻译：涡轮机械系统光纤多参数传感系统及方法
公开(公告)号：US08042412B2
公开(公告)日：2011-10-25
申请号：US12215094
申请日：2008-06-25
申请人： Hua Xia , Norman Arnold Turnquist , David So Keung Chan , Danian Zheng , Kevin Thomas McCarthy , Richard Joseph Gawrelski , Matthew Damian Pietrzykowski , Alexander Seth Ross , Yun Li , Juntao Wu
发明人： Hua Xia , Norman Arnold Turnquist , David So Keung Chan , Danian Zheng , Kevin Thomas McCarthy , Richard Joseph Gawrelski , Matthew Damian Pietrzykowski , Alexander Seth Ross , Yun Li , Juntao Wu
IPC分类号： G01D9/00 , G01L1/24 , G01L3/00
CPC分类号： G01L3/12 , G01H9/004 , G01L3/109 , G01M11/081
摘要： A fiberoptic multi-parameter sensing system for monitoring turbomachinery system shaft static and dynamic torques, vibration modes and associated operation status includes a multi-furcated fiber bundle based optical splitter configured to transmit light to a surface of at least one turbomachinery system shaft through a plurality of optical fiber bundles disposed at a plurality of locations in proximity to the surface of the at least one shaft, in which the plurality of locations together are arranged in a substantially axial direction between the ends of the at least one shaft. The system further includes an array of high-temperature bifurcated fiber bundle based reflectance probes to receive reflectance signals from the shaft surface and send to an array of photosensitive detectors, configured to detect dynamic light reflected from the at least one turbomachinery system shaft surface in response to the transmitted light during rotation of at least one turbomachinery system shaft and generate dynamic reflected light signals there from. A sensing mechanism is configured to determine a torque or vibration on at least one turbomachinery system shaft in response to the dynamic reflected light signal signatures based on time-domain and frequency-domain signal processes.
摘要翻译：用于监测涡轮机械系统轴静态和动态扭矩，振动模式和相关操作状态的光纤多参数感测系统包括多分叉光纤束分光镜，其被配置为通过多个透镜将光透射到至少一个涡轮机械系统轴的表面设置在所述至少一个轴的表面附近的多个位置的光纤束，其中所述多个位置一起在所述至少一个轴的端部之间沿大致轴向布置。该系统还包括一组高温分叉纤维束的反射探测器，用于接收来自轴表面的反射信号并发送到一组光敏检测器，该阵列被配置为响应于检测从至少一个涡轮机械系统轴表面反射的动态光在至少一个涡轮机械系统轴的旋转期间的透射光，并且从那里产生动态反射光信号。感测机构被配置为响应于基于时域和频域信号处理的动态反射光信号特征来确定至少一个涡轮机械系统轴上的扭矩或振动。

7. 发明授权

US07898176B2 Fluidic thermal management article and method 有权
标题翻译：流体热管理文章和方法
公开(公告)号：US07898176B2
公开(公告)日：2011-03-01
申请号：US11863722
申请日：2007-09-28
申请人： Yun Li , Mark Lewis Grabb , John Erik Hershey , Jian Zhang , Hua Xia , Gelu Comanescu
发明人： Yun Li , Mark Lewis Grabb , John Erik Hershey , Jian Zhang , Hua Xia , Gelu Comanescu
IPC分类号： H01J1/62 , H01J63/04
CPC分类号： H05K7/20981 , Y10T428/249953 , Y10T428/26 , Y10T428/31504
摘要： An article includes a display layer having an outward facing surface and an inward facing surface. The display layer includes a light-emitting device that generates heat and light during use. A thermal transport layer may be secured to the display layer. The thermal transport layer may include a microfluidic layer including a coolant that can transport heat generated by the light-emitting device away from the light-emitting device. An article includes a display structure having a height, a width, and a thickness that define a volume. The display structure can include components that emit light to generate a three-dimensional image within the volume. The display structure includes a stack. The display structure also includes a thermal dissipation layer in contact with the sheet or stack that can transport generated heat from the sheet or stack to a heat absorbing structure.
摘要翻译：一种物品包括具有向外表面和向内表面的显示层。显示层包括在使用期间产生热和光的发光装置。热传输层可以固定到显示层。热传输层可以包括微流体层，该微流体层包括可将由发光器件产生的热量远离发光器件的冷却剂。一种物品包括具有限定体积的高度，宽度和厚度的显示结构。显示结构可以包括发射光以在该体积内产生三维图像的组件。显示结构包括堆叠。显示结构还包括与板或堆叠接触的散热层，其可以将产生的热量从片材或堆叠传送到吸热结构。

8. 发明授权

US07521685B2 Structured scintillator and systems employing structured scintillators 有权
标题翻译：结构闪烁体和采用结构闪烁体的系统
公开(公告)号：US07521685B2
公开(公告)日：2009-04-21
申请号：US11334718
申请日：2006-01-18
申请人： William Hennessy , Jeffrey Shaw , Ching-Yeu Wei , Yun Li
发明人： William Hennessy , Jeffrey Shaw , Ching-Yeu Wei , Yun Li
IPC分类号： G01T1/20 , H01L27/148
CPC分类号： G01T1/2018
摘要： A structured scintillator and a detection system employing structured scintillators. More specifically, a structured scintillator comprising a scintillator material having a plurality of isolated structures is disclosed. The structures may be conical in shape. The structures may be formed on a substantially transparent material layer which has been patterned to form a plurality of isolated regions. The structures may be formed on top of the isolated regions to provide isolated scintillator structures having space therebetween. The isolated regions and scintillator structures may be aligned with underlying detection devices.
摘要翻译：结构化闪烁体和采用结构闪烁体的检测系统。更具体地，公开了一种包括具有多个隔离结构的闪烁体材料的结构闪烁体。结构可以是圆锥形的。该结构可以形成在基本上透明的材料层上，该层被图案化以形成多个隔离区域。可以在隔离区域的顶部上形成结构以提供在其间具有间隔的隔离的闪烁体结构。隔离区域和闪烁体结构可以与底层检测装置对准。

9. 发明申请

US20090085454A1 THERMAL MANGEMENT ARTICLE HAVING THERMAL WAVE GUIDE 有权
标题翻译：具有热波导的热电偶
公开(公告)号：US20090085454A1
公开(公告)日：2009-04-02
申请号：US11863690
申请日：2007-09-28
申请人： Yun Li , Mark Lewis Grabb , John Erik Hershey , Jian Zhang , Hua Xia
发明人： Yun Li , Mark Lewis Grabb , John Erik Hershey , Jian Zhang , Hua Xia
IPC分类号： H01K1/58
CPC分类号： H01L51/529 , H01L27/1225 , H01L27/3209 , H01L27/322 , H01L27/3232 , H01L29/7869 , Y10T428/249953
摘要： An article includes a stack of display layers including a display layer having a high-shear modulus that is sandwiched between two display layers having a low-shear modulus. The display layers include a light-emitting device that generates heat and light during use. The heat generated by the display layers may form localized heat-sources in the stack. The display layer with the high-shear modulus is a thermal transport layer through which the localized heat-sources-induced guided elastic waves propagate along an acoustic waveguide plane and can transport the heat generated by the light-emitting device away from the light-emitting device. Alternately, a display layer having a high refractive index may be sandwiched between two display layers having a low refractive index. The display layers with low shear modulus or low refractive index may be replaced with thermal transport layers having low shear modulus or low refractive index respectively.
摘要翻译：一种物品包括一叠显示层，包括具有高剪切模量的显示层，该显示层夹在两个具有低剪切模量的显示层之间。显示层包括在使用期间产生热和光的发光装置。由显示层产生的热量可能在堆叠中形成局部热源。具有高剪切模量的显示层是热传导层，局部热源引导的弹性波沿着声波导面传播，并且可以将由发光装置产生的热量远离发光设备。或者，具有高折射率的显示层可以夹在具有低折射率的两个显示层之间。具有低剪切模量或低折射率的显示层可以分别由具有低剪切模量或低折射率的热传输层代替。

10. 发明申请

US20080251780A1 LIGHT-EMITTING DEVICE AND ARTICLE 有权
标题翻译：发光装置和文章
公开(公告)号：US20080251780A1
公开(公告)日：2008-10-16
申请号：US11767153
申请日：2007-06-22
申请人： Yun Li , Jie Liu , Anping Zhang
发明人： Yun Li , Jie Liu , Anping Zhang
IPC分类号： H01L29/06
CPC分类号： H01L27/3209 , B82Y10/00 , H01L27/3232 , H01L27/3262 , H01L27/3274 , H01L51/0037 , H01L51/0048 , H01L51/5203 , H01L51/5287 , H01L2251/5323 , H01L2924/0002 , Y10S977/762 , H01L2924/00
摘要： A device comprising a light transmissive element, a nano-wire light-emitting device, and a light transmissive controller communicating with the nano-wire light-emitting device. The nano-wire light-emitting device, and the light transmissive controller, are supported by the light transmissive element. An article includes two or more of the devices.
摘要翻译：一种包括透光元件，纳米线发光器件和与纳米线发光器件连通的透光控制器的器件。纳米线发光器件和透光控制器由透光元件支撑。一篇文章包括两个或更多的设备。

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