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1. 发明申请

US20060275807A1 Novel steroid 5alpha-reductase 审中-公开
标题翻译：新型类固醇5α-还原酶
公开(公告)号：US20060275807A1
公开(公告)日：2006-12-07
申请号：US11432424
申请日：2006-05-10
申请人： James Mohler , Mark Titus , Olga Kozyreva , O. Ford , Elsbieta Kawinski , Yun Li
发明人： James Mohler , Mark Titus , Olga Kozyreva , O. Ford , Elsbieta Kawinski , Yun Li
IPC分类号： C12Q1/68 , G01N33/574 , C12N9/02 , C12N15/861
CPC分类号： C12Q1/26 , C07K2319/21 , C07K2319/40 , C12N9/001 , C12N2799/022 , G01N33/57434
摘要： The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
摘要翻译：本发明提供了一种分离的新型类固醇5α-还原酶，称为SRD5AIII。蛋白质具有37kDa的估计分子量，并且能够在约7.0的pH下将睾酮转化为二氢睾酮。还提供了通过使SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。该方法包括从个体获得前列腺活检，并确定相对于正常对照的SRD5AIII基因或蛋白质的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。

2. 发明申请

US20090246785A1 NOVEL STEROID 5-ALPHA-REDUCTASE 有权
标题翻译：新型甾体5-ALPHA-REDUCTASE
公开(公告)号：US20090246785A1
公开(公告)日：2009-10-01
申请号：US12404590
申请日：2009-03-16
申请人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
发明人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
IPC分类号： C12Q1/68 , C12Q1/26
CPC分类号： C12Q1/26 , C07K2319/21 , C07K2319/40 , C12N9/001 , C12N2799/022 , G01N33/57434
摘要： The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
摘要翻译：本发明提供了一种分离的新型类固醇5α-还原酶，称为SRD5AIII。蛋白质具有37kDa的估计分子量，并且能够在约7.0的pH下将睾酮转化为二氢睾酮。还提供了通过使SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。该方法包括从个体获得前列腺活检，并确定相对于正常对照的SRD5AIII基因或蛋白质的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。

3. 发明授权

US08241845B2 Steroid 5α-reductase 有权
标题翻译：类固醇5α-还原酶
公开(公告)号：US08241845B2
公开(公告)日：2012-08-14
申请号：US12404590
申请日：2009-03-16
申请人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
发明人： James L. Mohler , Mark Titus , Olga Kozyreva , O. Harris Ford, III , Elsbieta Kawinski , Yun Li
IPC分类号： C12Q1/68 , C12Q1/26 , C12N15/53 , C12N9/02
CPC分类号： C12Q1/26 , C07K2319/21 , C07K2319/40 , C12N9/001 , C12N2799/022 , G01N33/57434
摘要： The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
摘要翻译：本发明提供了一种分离的新型类固醇5α-还原酶，称为SRD5AIII。蛋白质具有37kDa的估计分子量，并且能够在约7.0的pH下将睾酮转化为二氢睾酮。还提供了通过使SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。该方法包括从个体获得前列腺活检，并确定相对于正常对照的SRD5AIII基因或蛋白质的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。

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