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    • 1. 发明申请
    • HIGHLY SCALABLE NETWORK ENVIRONMENT FOR MANAGING REMOTE DEVICES
    • 用于管理远程设备的高可扩展网络环境
    • US20090125627A1
    • 2009-05-14
    • US11937442
    • 2007-11-08
    • James O. Ford
    • James O. Ford
    • G06F15/16
    • H04L63/029H04L29/12066H04L29/12783H04L61/1511H04L61/35H04L63/166H04L67/025
    • A highly scalable primary server is provided to serve an increasing number of users and remote devices. Instead of communicating with a primary server using an expensive communication protocol, a remote device communicates with a secondary server using a less expensive protocol to determine whether the primary server desires to communicate control instructions to the remote device. When the primary server has a request to control the remote device, the primary server creates a table entry to the secondary server to notify the remote device of a request to communicate. Upon polling the secondary server and learning of the created table entry, the remote device establishes a communication connection with the primary server to receive the instructions for controlling the remote device. In this manner, the demand for resources needed for communication with the primary server is significantly reduced.
    • 提供高度可扩展的主服务器来服务越来越多的用户和远程设备。 远程设备不是使用昂贵的通信协议与主服务器进行通信,而是使用较便宜的协议与辅助服务器进行通信,以确定主服务器是否希望向远程设备传送控制指令。 当主服务器具有控制远程设备的请求时,主服务器创建到副服务器的表条目以向远程设备通知请求进行通信。 在轮询辅助服务器并学习创建的表条目时,远程设备建立与主服务器的通信连接,以接收用于控制远程设备的指令。 以这种方式,与主服务器通信所需的资源需求显着降低。
    • 3. 发明授权
    • Highly scalable network environment for managing remote devices
    • 高度可扩展的网络环境用于管理远程设备
    • US08316135B2
    • 2012-11-20
    • US11937442
    • 2007-11-08
    • James O. Ford
    • James O. Ford
    • G06F15/16
    • H04L63/029H04L29/12066H04L29/12783H04L61/1511H04L61/35H04L63/166H04L67/025
    • A highly scalable primary server is provided to serve an increasing number of users and remote devices. Instead of communicating with a primary server using an expensive communication protocol, a remote device communicates with a secondary server using a less expensive protocol to determine whether the primary server desires to communicate control instructions to the remote device. When the primary server has a request to control the remote device, the primary server creates a table entry to the secondary server to notify the remote device of a request to communicate. Upon polling the secondary server and learning of the created table entry, the remote device establishes a communication connection with the primary server to receive the instructions for controlling the remote device. In this manner, the demand for resources needed for communication with the primary server is significantly reduced.
    • 提供高度可扩展的主服务器来服务越来越多的用户和远程设备。 远程设备不是使用昂贵的通信协议与主服务器进行通信,而是使用较便宜的协议与辅助服务器进行通信,以确定主服务器是否希望向远程设备传送控制指令。 当主服务器具有控制远程设备的请求时,主服务器创建到副服务器的表条目以向远程设备通知请求进行通信。 在轮询辅助服务器并学习创建的表条目时,远程设备建立与主服务器的通信连接,以接收用于控制远程设备的指令。 以这种方式,与主服务器通信所需的资源需求显着降低。
    • 5. 发明申请
    • Novel steroid 5alpha-reductase
    • 新型类固醇5α-还原酶
    • US20060275807A1
    • 2006-12-07
    • US11432424
    • 2006-05-10
    • James MohlerMark TitusOlga KozyrevaO. FordElsbieta KawinskiYun Li
    • James MohlerMark TitusOlga KozyrevaO. FordElsbieta KawinskiYun Li
    • C12Q1/68G01N33/574C12N9/02C12N15/861
    • C12Q1/26C07K2319/21C07K2319/40C12N9/001C12N2799/022G01N33/57434
    • The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
    • 本发明提供了一种分离的新型类固醇5α-还原酶,称为SRD5AIII。 蛋白质具有37kDa的估计分子量,并且能够在约7.0的pH下将睾酮转化为二氢睾酮。 还提供了通过使SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。 相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。 还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。 该方法包括从个体获得前列腺活检,并确定相对于正常对照的SRD5AIII基因或蛋白质的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。