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1. 发明申请

US20130184559A1 Magnetic Resonance Imaging Compatible Positron Emission Tomography Detector 审中-公开
标题翻译：磁共振成像兼容的正电子发射断层成像检测器
公开(公告)号：US20130184559A1
公开(公告)日：2013-07-18
申请号：US13740364
申请日：2013-01-14
申请人： James L. Corbeil , Nan Zhang , Matthias J. Schmand
发明人： James L. Corbeil , Nan Zhang , Matthias J. Schmand
IPC分类号： A61B5/00
CPC分类号： A61B5/0035 , A61B5/055 , G01T1/1603
摘要： A compact magnetic resonance imaging compatible positron emission tomography detector. The detector has integrated mechanical and electrical subcomponents. The detector uses a cooling channel which does not interfere with magnetic resonance imaging. The layout and selection of electrical subcomponents of the detector, along with a magnetic resonance compatible cooling strategy, enables the detector to function in a magnetic resonance imaging environment.
摘要翻译：紧凑型磁共振成像兼容的正电子发射断层扫描检测器。检测器集成了机电和电子部件。检测器使用不干扰磁共振成像的冷却通道。检测器的电子部件的布局和选择以及磁共振兼容冷却策略使得检测器能够在磁共振成像环境中起作用。

2. 发明授权

US09091771B2 System and method for improving detection of gamma interactions in a positron emission tomography system 有权
标题翻译：用于改善正电子发射断层摄影系统中γ相互作用检测的系统和方法
公开(公告)号：US09091771B2
公开(公告)日：2015-07-28
申请号：US13539915
申请日：2012-07-02
申请人： Debora Henseler , Ronald Grazioso , Nan Zhang , Matthias J. Schmand , Sanghee Cho
发明人： Debora Henseler , Ronald Grazioso , Nan Zhang , Matthias J. Schmand , Sanghee Cho
IPC分类号： G01T1/29 , A61B6/03 , G01T1/00 , A61B6/00
CPC分类号： G01T1/2985 , A61B6/00 , A61B6/037 , G01T1/00
摘要： A system and method are provided for determining the onset of gamma interactions for positron emission tomography (PET) imaging more accurately than with existing techniques. The timing of a sequence of primary trigger events is obtained and used to determine a weighted combination, which mixes the timing information from the various primary trigger events to compute an overall event trigger timing with improved time resolution. Numerical simulations demonstrate that the invention improves time resolution by approximately 10% over state-of-the-art methods. This improved time resolution directly benefits the imaging performance of the PET scanner, especially in time-of-flight (TOF) mode, where a high time resolution directly translates to a reduction in image noise at the same dose—or, alternatively, a reduction of dose to the patient or scan time for the same image quality.
摘要翻译：提供了一种系统和方法，用于比现有技术更准确地确定正电子发射断层摄影（PET）成像的γ相互作用的发生。获得主要触发事件序列的定时并用于确定加权组合，其混合来自各种主要触发事件的定时信息以通过改进的时间分辨率计算总体事件触发时序。数值模拟表明，本发明使用最先进的方法将时间分辨率提高约10％。这种改进的时间分辨率直接有利于PET扫描仪的成像性能，特别是在飞行时间（TOF）模式下，其中高时间分辨率直接转换为以相同剂量降低图像噪声，或者替代地，减少给予患者剂量或扫描时间相同的图像质量。

3. 发明授权

US07495222B2 Signal polarity inverting multiplexing circuits for nuclear medical detectors 有权
标题翻译：用于核医学检测器的信号极性反转多路复用电路
公开(公告)号：US07495222B2
公开(公告)日：2009-02-24
申请号：US11751372
申请日：2007-05-21
申请人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi
发明人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , G01T1/1647
摘要： A system for multiplexing photodetector signals from a scintillation detector. The system includes a detector module having a number of scintillator blocks, each scintillator block having a number of photosensors, and a number of multiplexing circuits. Each multiplexing circuit includes a number of inputs, a signal polarity inverter and at least one differential output attached to the signal polarity inverter. The multiplexing system inverts the polarity of preselected signals from the photosensors and selectively combines signals of different polarities to calculate event positioning and total energy.
摘要翻译：一种用于复用来自闪烁检测器的光检测器信号的系统。该系统包括具有多个闪烁体块的检测器模块，每个闪烁体块具有多个光电传感器，以及多个复用电路。每个多路复用电路包括多个输入端，信号极性反相器和附加到信号极性反相器的至少一个差分输出。复用系统将来自光电传感器的预选信号的极性反转，并且选择性地组合不同极性的信号以计算事件定位和总能量。

4. 发明授权

US09606199B2 MR-compatible blood sampling system for PET imaging applications in combined PET/MR imaging system 有权
公开(公告)号：US09606199B2
公开(公告)日：2017-03-28
申请号：US12260966
申请日：2008-10-29
申请人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
发明人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
IPC分类号： G01R33/28 , A61B5/15 , G01R33/48 , G01T1/16
CPC分类号： G01R33/28 , A61B5/150992 , G01R33/481 , G01T1/1603
摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.

5. 发明授权

US09086492B2 Concurrent DC-coupled anode and dynode readout scheme for PET block detectors 有权
标题翻译：并联DC耦合阳极和用于PET块检测器的倍增电极读出方案
公开(公告)号：US09086492B2
公开(公告)日：2015-07-21
申请号：US11753067
申请日：2007-05-24
申请人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
发明人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
IPC分类号： G01T1/00 , G01T1/164
CPC分类号： G01T1/1642 , G01T1/208
摘要： A scintillation detector including one or more photomultiplier tubes, a scintillation block optically attached to the photomultiplier tubes, and a DC-coupled bleeder circuit combining outputs of dynodes of the photomultipliers to provide a DC-coupled dynode output together with a DC-coupled anode output of the photomultiplier tubes. The DC-coupled bleeder circuit includes a RF transformer. A positive high voltage supply also can be used together with a DC-coupled bleeder circuit for the anode outputs.
摘要翻译：闪烁检测器，包括一个或多个光电倍增管，与光电倍增管光学连接的闪烁块，以及组合光电倍增管的倍增电极输出的DC耦合泄放电路，以提供DC耦合的倍增电极输出以及直流耦合的阳极输出的光电倍增管。直流耦合放电电路包括RF变压器。阳极高压电源也可以与阳极输出的直流耦合泄放电路一起使用。

6. 发明申请

US20120112083A1 High Density, Proportional-Mode, APD Arrays for Individual Scintillator Readout in PET Applications 有权
标题翻译：高密度，比例模式，APD阵列用于PET应用中的单个闪烁读出
公开(公告)号：US20120112083A1
公开(公告)日：2012-05-10
申请号：US12943164
申请日：2010-11-10
申请人： Nan Zhang , Ronald Grazioso , Debora Henseler , Matthias J. Schmand
发明人： Nan Zhang , Ronald Grazioso , Debora Henseler , Matthias J. Schmand
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , A61B6/037
摘要： The present invention is a photodetector including improved photosensors configured of an array of small (sub-millimeter) high-density avalanche photodiode cells utilized to readout a single scintillator. Each photosensor comprises a plurality of avalanche photodiodes cells arranged in an (n×n) array of avalanche photodiode cells (where, n>1) that are coupled to a single scintillation crystal. The overall (n×n) array area as the photosensor is the same as the area of a face of the scintillator and each avalanche photodiode cell has a surface area that is not greater than one square millimeter. The photosensor is also configured to facilitate reading the output of each avalanche photodiode cell in the array. By reading out each small avalanche photodiode cell independently, the noise and capacitance are minimized and thereby provide a more accurate determination of energy and timing.
摘要翻译：本发明是一种光电检测器，其包括由用于读出单个闪烁体的小（亚毫米）高密度雪崩光电二极管阵列的阵列构成的改进的光电传感器。每个光传感器包括以与单个闪烁晶体耦合的雪崩光电二极管单元（其中，n> 1）的（n×n）阵列排列的多个雪崩光电二极管单元。作为光传感器的整体（n×n）阵列区域与闪烁体的面的面积相同，并且每个雪崩光电二极管单元的表面积不大于1平方毫米。光传感器还被配置为便于读取阵列中每个雪崩光电二极管单元的输出。通过独立地读出每个小雪崩光电二极管单元，噪声和电容被最小化，从而提供更准确的能量和时间的确定。

7. 发明授权

US09121893B2 Combined PET/MR imaging system and APD-based pet detector for use in simultaneous PET/MR imaging 有权
标题翻译：组合PET / MR成像系统和基于APD的宠物检测器，用于同时PET / MR成像
公开(公告)号：US09121893B2
公开(公告)日：2015-09-01
申请号：US11532665
申请日：2006-09-18
申请人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
发明人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
IPC分类号： G01T1/164 , G01T1/166 , G01R33/28 , G01R33/26 , G01R33/381 , G01R33/48 , G01T1/16 , G01T1/29 , A61B6/03 , A61B8/08
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译：提供基于APD的PET模块，用于组合PET / MR成像。每个模块包括多个独立的光隔离探测器。每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。模块位于MR扫描仪的通道中。基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

8. 发明申请

US20130009063A1 System and Method for Improving Detection of Gamma Interactions in a Positron Emission Tomography System 有权
标题翻译：用于改善正电子发射断层扫描系统中伽马相互作用检测的系统和方法
公开(公告)号：US20130009063A1
公开(公告)日：2013-01-10
申请号：US13539915
申请日：2012-07-02
申请人： Debora Henseler , Ronald Grazioso , Nan Zhang , Matthias J. Schmand , Sanghee Cho
发明人： Debora Henseler , Ronald Grazioso , Nan Zhang , Matthias J. Schmand , Sanghee Cho
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/00 , A61B6/037 , G01T1/00
摘要： A system and method are provided for determining the onset of gamma interactions for positron emission tomography (PET) imaging more accurately than with existing techniques. The timing of a sequence of primary trigger events is obtained and used to determine a weighted combination, which mixes the timing information from the various primary trigger events to compute an overall event trigger timing with improved time resolution. Numerical simulations demonstrate that the invention improves time resolution by approximately 10% over state-of-the-art methods. This improved time resolution directly benefits the imaging performance of the PET scanner, especially in time-of-flight (TOF) mode, where a high time resolution directly translates to a reduction in image noise at the same dose—or, alternatively, a reduction of dose to the patient or scan time for the same image quality.
摘要翻译：提供了一种系统和方法，用于比现有技术更准确地确定正电子发射断层摄影（PET）成像的γ相互作用的发生。获得主要触发事件序列的定时并用于确定加权组合，其混合来自各种主要触发事件的定时信息以通过改进的时间分辨率计算总体事件触发时序。数值模拟表明，本发明使用最先进的方法将时间分辨率提高约10％。这种改进的时间分辨率直接有利于PET扫描仪的成像性能，特别是在飞行时间（TOF）模式下，其中高时间分辨率直接转换为以相同剂量降低图像噪声，或者替代地，减少给予患者剂量或扫描时间相同的图像质量。

9. 发明授权

US07924079B2 Baseline restore based on diode star configuration and transformer coupling 失效
标题翻译：基于二极管星形配置和变压器耦合的基线恢复
公开(公告)号：US07924079B2
公开(公告)日：2011-04-12
申请号：US12558007
申请日：2009-09-11
申请人： Matthias J. Schmand , Nan Zhang
发明人： Matthias J. Schmand , Nan Zhang
IPC分类号： H03L5/00
CPC分类号： G01T1/248
摘要： A simple, low cost circuit with only passive components, and thus low power consumption, is provided for baseline restoration of an AC coupled signal. The circuit includes a passive network of diodes arranged in a star configuration and an RF-transformer. A differential signal strategy may be employed by including a differential amplifier at the input and output of the passive network.
摘要翻译：提供了一种简单的低成本电路，仅具有无源组件，因此具有低功耗，用于AC耦合信号的基线恢复。该电路包括以星形结构布置的二极管的无源网络和RF变压器。可以通过在无源网络的输入和输出处包括差分放大器来采用差分信号策略。

10. 发明申请

US20100074396A1 MEDICAL IMAGING WITH BLACK SILICON PHOTODETECTOR 审中-公开
标题翻译：用黑色硅胶片进行医学成像
公开(公告)号：US20100074396A1
公开(公告)日：2010-03-25
申请号：US12498101
申请日：2009-07-06
申请人： Matthias J. Schmand , Debora Henseler , Ronald Grazioso , Nan Zhang , Mark S. Andreaco
发明人： Matthias J. Schmand , Debora Henseler , Ronald Grazioso , Nan Zhang , Mark S. Andreaco
IPC分类号： A61B6/03 , G01T1/24 , G01T1/20
CPC分类号： G01T1/1644 , A61B6/032 , A61B6/037
摘要： Medical imaging may be accomplished with a high photoconductive gain at a relatively low operating voltage by employing a black silicon photodetector and integrating CMOS components with elements of the photodetector.
摘要翻译：通过采用黑硅光电检测器并将CMOS部件与光电检测器的元件集成，可以在相对低的工作电压下以高的光电导增益实现医学成像。

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