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1. 发明授权

US07883031B2 Ophthalmic drug delivery system 有权
标题翻译：眼科药物输送系统
公开(公告)号：US07883031B2
公开(公告)日：2011-02-08
申请号：US10851611
申请日：2004-05-20
申请人： James F. Collins, Jr. , Randal B. Chinnock , Jeffrey Melanson , Joseph Howard
发明人： James F. Collins, Jr. , Randal B. Chinnock , Jeffrey Melanson , Joseph Howard
IPC分类号： A61M11/06
CPC分类号： B05B17/0646 , A61F9/0008 , A61M11/005 , A61M11/041 , A61M11/042 , A61M11/065 , A61M2205/59 , A61M2210/0612 , B05B17/0623 , B05B17/0676
摘要： A fluid atomizer is disclosed. The fluid atomizer comprises a body having a proximal end and a distal end. A removable reservoir containing a fluid disposed therein is connected to the body. A discharge plate is disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough. An ultrasonic oscillator is disposed in the body for transmitting the fluid from the reservoir to the discharge plate and through the plurality of openings, wherein transmission of the fluid through the plurality of openings atomizes the fluid.
摘要翻译：公开了一种流体雾化器。流体雾化器包括具有近端和远端的主体。包含设置在其中的流体的可移除的储存器连接到主体。放电板设置在远端，其中放电板包括从其延伸穿过的多个开口。超声波振荡器设置在主体中，用于将流体从储存器传送到排放板并通过多个开口，其中通过多个开口的流体的传输使流体雾化。

2. 外观设计

USD533658S1 Misting device 失效
标题翻译：雾化装置
公开(公告)号：USD533658S1
公开(公告)日：2006-12-12
申请号：US29205953
申请日：2004-05-20
申请人： James F. Collins, Jr. , Randal B. Chinnock , Jeffrey Melanson , Joseph Howard
设计人： James F. Collins, Jr. , Randal B. Chinnock , Jeffrey Melanson , Joseph Howard

3. 发明授权

US08215774B2 Ocular surface interferometry (OSI) devices and systems for imaging and measuring ocular tear film layer thickness(es) 有权
标题翻译：用于成像和测量眼泪膜层厚度的眼表干涉测量（OSI）装置和系统
公开(公告)号：US08215774B2
公开(公告)日：2012-07-10
申请号：US12798324
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

5. 发明申请

US20110130632A1 Visualization Instrument 有权
公开(公告)号：US20110130632A1
公开(公告)日：2011-06-02
申请号：US12874035
申请日：2010-09-01
申请人： Thomas W. McGrail , Michael S. Pargett , David J. Miller , Yun Siung Tony Yeh , Randal B. Chinnock , George Grubner , Elizabeth Powell Goodrich , Richard L. Miller , Gary Vincent Palladino , Brian Hack
发明人： Thomas W. McGrail , Michael S. Pargett , David J. Miller , Yun Siung Tony Yeh , Randal B. Chinnock , George Grubner , Elizabeth Powell Goodrich , Richard L. Miller , Gary Vincent Palladino , Brian Hack
IPC分类号： A61B1/267
CPC分类号： A61B1/267 , A61B1/00016 , A61B1/00052 , A61B1/00103 , A61B1/00105 , A61B1/018 , A61B1/05 , G02B23/2423 , G02B23/2446
摘要： A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses.

6. 发明授权

US07187442B2 Polarized optical probes 有权
标题翻译：极化光学探针
公开(公告)号：US07187442B2
公开(公告)日：2007-03-06
申请号：US10835747
申请日：2004-04-30
申请人： Randal B. Chinnock , Jeffrey S. Melanson
发明人： Randal B. Chinnock , Jeffrey S. Melanson
IPC分类号： G01J4/00
CPC分类号： G01J4/04 , G01N21/21
摘要： A variably-polarizing optical probe assembly. The assembly includes an optical probe having one or more optical light delivery channels that emit incident light from the sample end of the probe toward a sample being investigated, and one or more optical light-receiving channels that receive incident light from the sample. A variably-polarizing substrate assembly is coupled to the sample end of the probe. The substrate assembly includes an optically transmitting substrate and one or more discrete polarizer areas on a face of the substrate, each such polarizer area defining a polarization orientation, with the polarizer areas together defining one or more different polarization orientations. The substrate assembly is arranged relative to the probe such that one polarizer area covers at least one light delivery channel and one polarizer area covers at least one light-receiving channel.
摘要翻译：可变偏振光学探针组件。组件包括具有一个或多个光学传输通道的光学探针，其将从探针的样品端朝向被研究的样品发射入射光，以及一个或多个接收来自样品的入射光的光接收通道。可变偏振衬底组件耦合到探针的样品端。衬底组件包括光学透射衬底和在衬底的表面上的一个或多个离散偏振器区域，每个这样的偏振器区域限定极化取向，偏振器区域一起限定一个或多个不同的偏振取向。衬底组件相对于探针布置，使得一个偏振器区域覆盖至少一个光输送通道，并且一个偏振器区域覆盖至少一个光接收通道。

7. 外观设计

USD453964S1 Sheath for cervical optical probe 失效
公开(公告)号：USD453964S1
公开(公告)日：2002-02-26
申请号：US29136964
申请日：2001-02-09
申请人： Richard M. Morrell , Stephen C. Parshley , Randal B. Chinnock
设计人： Richard M. Morrell , Stephen C. Parshley , Randal B. Chinnock

8. 发明授权

US5056902A Magnetically coupled lens actuator 失效
标题翻译：磁性耦合镜头执行器
公开(公告)号：US5056902A
公开(公告)日：1991-10-15
申请号：US514119
申请日：1990-04-25
申请人： Randal B. Chinnock , Norman J. Dionne
发明人： Randal B. Chinnock , Norman J. Dionne
IPC分类号： A61B1/00 , G02B7/04 , G02B7/08 , G02B23/24 , H02K33/00
CPC分类号： A61B1/00066 , A61B1/00188 , A61B34/73 , G02B7/08 , Y10S359/903
摘要： A lens surrounded by a protective chamber is focused by utilizing a magnetic field to adjust the position of the lens within the chamber. By using a magnetic field to adjust the lens position, it is not necessary to pass a mechanical device through the surface of the chamber, thereby allowing the chamber to be completely sealed to prevent contaminants from contacting the lens.

9. 发明授权

US08277468B2 Tissue reconfiguration 有权
标题翻译：组织重构
公开(公告)号：US08277468B2
公开(公告)日：2012-10-02
申请号：US12953625
申请日：2010-11-24
申请人： Michael D. Laufer , Jeffrey C. Cerier , Amos G. Cruz , Jonathan O'Keefe , Richard Andrews , Ram Chuttani , Vincent A. Piucci, Jr. , Michael Barenboym , Neal H. Marshall , Randal B. Chinnock
发明人： Michael D. Laufer , Jeffrey C. Cerier , Amos G. Cruz , Jonathan O'Keefe , Richard Andrews , Ram Chuttani , Vincent A. Piucci, Jr. , Michael Barenboym , Neal H. Marshall , Randal B. Chinnock
IPC分类号： A61B17/08
CPC分类号： A61B17/0686 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0401 , A61B17/0467 , A61B17/0482 , A61B17/0485 , A61B17/0643 , A61B17/068 , A61B17/1285 , A61B17/29 , A61B2017/00296 , A61B2017/00314 , A61B2017/00349 , A61B2017/00557 , A61B2017/00827 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0441 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , A61B2017/06052 , A61B2017/061 , A61B2017/2905 , A61B2017/2915 , A61B2017/2916 , A61B2017/2917 , A61B2017/2927 , A61B2017/2932 , A61B2017/308 , A61B2090/065 , A61M25/0147
摘要： A medical instrument for engaging tissue includes a flexible shaft, a tissue piercing coil at a distal portion of the shaft, and a tissue stabilizer positioned over the shaft and biased in a distal direction such that as the tissue piercing coil enters tissue, the tissue stabilizer is urged against a surface of the tissue. A medical instrument for reconfiguring tissue includes a flexible shaft defining a lumen housing actuating controls, and a distal actuating assembly with a sealing portion configured to substantially seal the shaft lumen from contact with bodily fluids. A cartridge assembly includes first and second members configured for releasable attachment to a medical instrument, and a holder configured to receive the first and second members and to be released from the first and second members upon action of the first and second members attaching to the medical instrument.
摘要翻译：用于接合组织的医疗器械包括柔性轴，在轴的远端部分处的组织穿刺线圈和定位在轴上并且在远侧方向偏置的组织稳定器，使得当组织穿刺线圈进入组织时，组织稳定器被推靠在组织的表面上。用于重构组织的医疗器械包括限定腔室壳体致动控制器的柔性轴和具有密封部分的远端致动组件，所述密封部分构造成基本上密封轴腔与身体液体的接触。盒组件包括构造成用于可释放地附接到医疗器械的第一和第二构件，以及保持器，构造成容纳第一和第二构件并且在第一和第二构件附接到医疗装置的作用下从第一构件和第二构件释放仪器。

10. 发明申请

US20100253907A1 Ocular surface interferometery (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权
标题翻译：用于成像，处理和/或显示眼泪膜的眼表干涉仪（OSI）装置和系统
公开(公告)号：US20100253907A1
公开(公告)日：2010-10-07
申请号：US12798275
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

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