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1. 发明授权

US4916214A Cationic complexes of technetium-99m 失效
标题翻译：锝99m阳离子配合物
公开(公告)号：US4916214A
公开(公告)日：1990-04-10
申请号：US254082
申请日：1988-10-06
申请人： Kwok W. Chiu , James D. Kelly , Ian A. Latham , David V. Griffiths , Peter G. Edwards
发明人： Kwok W. Chiu , James D. Kelly , Ian A. Latham , David V. Griffiths , Peter G. Edwards
IPC分类号： A61K51/00 , A61K51/04 , C07F9/50 , C07F9/655 , C07F9/68 , C07F9/72 , C07F13/00
CPC分类号： C07F9/6552 , A61K51/04 , C07F13/005 , C07F9/5027 , C07F9/723 , A61K2123/00
摘要： The invention concerns cationic complexes of Technetium-99m with bidentate ligands (L), including complexes having the formulae [Tc(NO) X L.sub.2 ].sup.+ and [Tc L.sub.3 ].sup.+, which are of interest as heart imaging agents. The ligands are characterized by having the formula Y.sub.2 QZQY.sub.2, where each Q is phosphorus or arsenic, Z is a 2 or 3 carbon atom linking group, and at least one of the groups Y and Z includes at least one --COC--ether group.

2. 发明授权

US5312904A Cationic complexes of technetium-99M 失效
标题翻译：锝-99M阳离子配合物
公开(公告)号：US5312904A
公开(公告)日：1994-05-17
申请号：US879098
申请日：1992-05-04
申请人： James D. Kelly , Kwok W. Chiu , David V. Griffiths , Jonathan R. Dilworth
发明人： James D. Kelly , Kwok W. Chiu , David V. Griffiths , Jonathan R. Dilworth
IPC分类号： A61K51/00 , A61K51/04 , C07F9/50 , C07F9/72 , C07F9/74 , C07F13/00 , A61K49/02
CPC分类号： C07F13/005 , A61K51/0478 , A61K2123/00
摘要： Tridentate mono-anionic ligands have the structureX-A-Y-Q-Zwhere each of X and Y is independently P, As or N,Z is phenol, thiophenol or thiol, andA and Q are hydrocarbon linking groups.The ligands from cationic complexes with Technetium-99m, e.g. [Tc.sup.III K.sub.2 ].sup.+ where K is the ligand, having useful imaging properties.
摘要翻译：三齿单阴离子配体具有结构X-A-Y-Q-Z，其中X和Y各自独立地为P，As或N，Z为苯酚，苯硫酚或硫醇，A和Q为烃连接基团。来自与锝-99m的阳离子络合物的配体，例如 [TcIIIK2] +其中K是配体，具有有用的成像性质。

3. 发明授权

US4810486A Bone-seeking complexes of technetium-99m 失效
标题翻译：锝-99m寻骨综合体
公开(公告)号：US4810486A
公开(公告)日：1989-03-07
申请号：US160605
申请日：1988-02-29
申请人： James D. Kelly , David V. Griffiths
发明人： James D. Kelly , David V. Griffiths
IPC分类号： A61K51/00 , A61K51/04 , C07F9/38 , A61K49/02
CPC分类号： C07F9/3865 , A61K51/0489 , A61K2123/00
摘要： A composition for use in the preparation of a bone-scanning agent comprises a mixture of a bis-phosphonic acid of formula (I), wherein R.sup.1 and R.sup.3 may be the same or different group selected from H, --SO.sub.3 H and a lower aliphatic group which may optionally contain one or more hetero atoms and which contains at least one --SO.sub.3 H group; R.sup.2 is a group selected from H, --OH, --NH.sub.2, --NHMe, --NMe.sub.2 and lower alkyl optionally substituted by one or more polar groups; R.sup.4 is a group selected from H, --OH, --NH.sub.2 --NHMe, --NMe.sub.2, --SO.sub.3 H and a lower alkyl optionally substituted by one or more polar groups; and n is 0 or 1; with the proviso that when n is 0, R.sup.1 is not H and that when n is 1, R.sup.1 and R.sup.3 cannot both be H; or a non-toxic salt thereof, together with a reducing agent for pertechnetate ions. Technetium-99m, as an aqueous solution of pertechnetate ions, is added to the composition to form a complex of Tc-99m, and the bisphosphonate. The complex is useful as a bone-scanning agent and is rapidly taken up in bone to give scans of high definition.
摘要翻译： PCT No.PCT / GB87 / 00456 Sec。 371日期1988年2月29日第 102（e）日期1988年2月29日PCT Filed 1987年6月29日PCT公布。第WO88 / 00061号公报 1988年1月14日。用于制备骨扫描剂的组合物包含式（I）的双膦酸的混合物，其中R 1和R 3可以相同或不同，选自H， -SO 3 H和可以任选地含有一个或多个杂原子并且含有至少一个-SO 3 H基团的低级脂族基团; R2是选自H，-OH，-NH2，-NHMe，-NMe2和任选被一个或多个极性基团取代的低级烷基的基团; R4是选自H，-OH，-NH2 + L，-NHMe，-NMe2，-SO3H和任选被一个或多个极性基团取代的低级烷基的基团; 并且n为0或1; 条件是当n为0时，R1不为H，当n为1时，R1和R3不能同时为H; 或其无毒盐，以及高锝酸盐离子的还原剂。将锝-99m作为高锝酸盐离子的水溶液加入到组合物中以形成Tc-99m和双膦酸盐的络合物。该复合物作为骨扫描剂是有用的，并且被快速地吸收在骨中以给出高清晰度的扫描。

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