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    • 3. 发明授权
    • Needle venting device for sealed containers
    • 用于密封容器的针通气装置
    • US07886779B2
    • 2011-02-15
    • US12154062
    • 2008-05-20
    • James C. Smith
    • James C. Smith
    • B65B1/04
    • B65D47/0842B01L3/50825B01L2200/026B01L2200/0615B01L2200/141B01L2300/043B65D2251/105Y10S215/03
    • An improved liquid handling needle device for use with the reconstitution of toxic drugs such as those used in chemotherapy and other applications. When diluent, in this example, is added through a septum into a sealed container, a positive pressure builds up. Aerosols containing the reconstituted drugs can be release through the punctured opening exposing personnel to potential contamination. This improved needle device provides a low-cost aerosol resistant vent channel between the outside diameter of the needle and the inside diameter of the tubular member holding it allowing gas diffusion from inside of the sealed container through the vent channel to the outside of the container when said needle device is inserted into the sealed container. This specifically engineered aerosol resistant vent channel prohibits the flow of the aerosol particles from flowing due to the frictional contact of the aerosol particles with either of the opposing walls forming the vent channel causing any aerosol particles to condense and be redirected back into the liquid receiving sealed container, thus providing sterile air venting for both the injecting and withdrawal of fluids.
    • 一种改进的液体处理针装置,用于重建有毒药物,如用于化疗和其他应用的药物。 当将本例中的稀释剂通过隔膜加入到密封容器中时,形成正压力。 含有重组药物的气溶胶可以通过穿刺开口释放,使人员潜在的污染。 该改进的针装置在针的外径和保持其的管状构件的内径之间提供了低成本的气溶胶防止排气通道,从而允许气体从密封容器的内部通过排气通道扩散到容器的外部, 所述针装置插入密封容器中。 这种专门设计的气溶胶防止通气通道阻止气溶胶颗粒流动,因为气溶胶颗粒与形成通气通道的相对壁之间的摩擦接触导致任何气溶胶颗粒冷凝并被重定向回到液体接收密封 容器,从而为流体的注入和抽出提供无菌空气排放。
    • 4. 发明申请
    • Needle venting device for sealed containers
    • 用于密封容器的针通气装置
    • US20080228163A1
    • 2008-09-18
    • US12154062
    • 2008-05-20
    • James C. Smith
    • James C. Smith
    • A61M5/32
    • B65D47/0842B01L3/50825B01L2200/026B01L2200/0615B01L2200/141B01L2300/043B65D2251/105Y10S215/03
    • An improved liquid handling needle device for use with the reconstitution of toxic drugs such as those used in chemotherapy and other applications. When diluent, in this example, is added through a septum into a sealed container, a positive pressure builds up. Aerosols containing the reconstituted drugs can be release through the punctured opening exposing personnel to potential contamination. This improved needle device provides a low-cost aerosol resistant vent channel between the outside diameter of the needle and the inside diameter of the tubular member holding it allowing gas diffusion from inside of the sealed container through the vent channel to the outside of the container when said needle device is inserted into the sealed container. This specifically engineered aerosol resistant vent channel prohibits the flow of the aerosol particles from flowing due to the frictional contact of the aerosol particles with either of the opposing walls forming the vent channel causing any aerosol particles to condense and be redirected back into the liquid receiving sealed container, thus providing sterile air venting for both the injecting and withdrawal of fluids.
    • 一种改进的液体处理针装置,用于重建有毒药物,如用于化疗和其他应用的药物。 当将本例中的稀释剂通过隔膜加入到密封容器中时,形成正压力。 含有重组药物的气溶胶可以通过穿刺开口释放,使人员潜在的污染。 该改进的针装置在针的外径和保持其的管状构件的内径之间提供了低成本的气溶胶防止排气通道,从而允许气体从密封容器的内部通过排气通道扩散到容器的外部, 所述针装置插入密封容器中。 这种专门设计的气溶胶防止通气通道阻止气溶胶颗粒流动,因为气溶胶颗粒与形成通气通道的相对壁之间的摩擦接触导致任何气溶胶颗粒冷凝并被重定向回到液体接收密封 容器,从而为流体的注入和抽出提供无菌空气排放。
    • 5. 发明授权
    • Lubricated ball bearings
    • 润滑球轴承
    • US07004635B1
    • 2006-02-28
    • US10150171
    • 2002-05-17
    • James C. SmithDerrick Arnold
    • James C. SmithDerrick Arnold
    • F16C33/32
    • H01J35/101F16C33/32H01J2235/1066Y10S384/913
    • A lubricated ball bearing for use in ball bearing sets is disclosed. The lubricated ball bearing features a lubricating coating applied to its outer surface. The lubricating coating preferably comprises silver, and enables the ball bearing to be utilized in bearing assemblies environments where other lubricants may not be acceptably used, such as in the high vacuum environment of an x-ray tube. The lubricating coating is attached to the ball bearing via an intermediate bonding layer that is interposed between the outer surface of the ball bearing core and the lubricating coating. The intermediate bonding layer, preferably comprising nickel, is chemically bonded to both the ball bearing core and the lubricating coating. This produces a lubricating coating having a high-strength adhesion to the ball bearing such that flaking or degrading of the coating will not occur in the high heat, high vacuum environment of the x-ray tube during x-ray production.
    • 公开了一种用于滚珠轴承组的润滑球轴承。 润滑的滚珠轴承具有施加到其外表面的润滑涂层。 润滑涂层优选地包含银,并且使得球轴承能够用于其它润滑剂可能不被可接受地使用的轴承组件环境中,例如在x射线管的高真空环境中。 润滑涂层通过介于滚珠轴承芯的外表面和润滑涂层之间的中间粘合层附接到球轴承。 优选包含镍的中间粘合层与球轴承芯和润滑涂层化学结合。 这产生了对球轴承具有高强度粘合性的润滑涂层,使得在X射线生产期间X射线管的高热,高真空环境中不会发生涂层的剥落或降解。
    • 6. 发明授权
    • Membrane filtered pipette tip
    • 膜过滤移液器吸头
    • US6117394A
    • 2000-09-12
    • US841971
    • 1997-04-08
    • James C. Smith
    • James C. Smith
    • B01L3/02G01N35/10
    • B01L3/0275G01N2035/1023G01N2035/1053Y10T436/119163Y10T436/255Y10T436/2575
    • An apparatus for a pipette tip having a membrane filter includes a pipette tip having an interior annulus for receiving an exterior perimeter of the membrane filter. A shear plate overlying the pipette tip defines an aperture having a dimension equal to the exterior perimeter of the membrane filter. A cylindrical punch has a path of motion for passing through the aperture in the shear plate to the interior annulus of the pipette tip. Membrane filter material is placed over the shear plate in the path of motion of the cylindrical punch. By the expedient of moving the cylindrical punch through the membrane filter material, the aperture in the shear plate, to the interior annulus of the pipette tip to place sheared filter material over the annulus of the pipette tip. Specific embodiments of pipette tips are illustrated including tips having a first filter for filtering material drawn into the pipette tip and second filters from preventing contamination of the pipette.
    • 用于具有膜过滤器的移液管尖端的装置包括具有用于接收膜过滤器的外周的内环的移液管尖端。 覆盖移液管尖端的剪切板限定具有等于膜过滤器外周的尺寸的孔。 圆柱形冲头具有用于穿过剪切板中的孔的移动路径到移液管尖端的内部环。 膜过滤材料放置在圆柱冲头运动路径上的剪切板上。 通过将圆柱形冲头穿过膜过滤材料(剪切板中的孔)移动到移液管尖端的内部空间以将剪切的过滤材料置于移液管尖端的环上。 示出了移液管尖端的具体实施例,其包括具有用于过滤吸入移液管末端的材料的第一过滤器的尖端和第二过滤器以防止吸移管的污染。
    • 7. 发明授权
    • Positive displacement liquid drawing and dispensing apparatus
    • 正排量液体抽取和分配装置
    • US5770160A
    • 1998-06-23
    • US906137
    • 1997-07-25
    • James C. SmithDonald H. DeVaughn
    • James C. SmithDonald H. DeVaughn
    • B01L3/02G01N35/10G01N1/14
    • B01L3/0217G01N2035/1018Y10T436/2575
    • A positive displacement liquid drawing and dispensing apparatus (21) having a tubular member (22) with an axially extending lumen (24) and a plunger (31) mounted for axial displacement in the lumen (24). The plunger (31) has a first seal (33) positioned proximate an end (34) of the plunger and a second seal (37) axially spaced from the first seal (33). The first and second seal each slidably and sealingly engage an interior surface (23) defining the lumen (24) as the plunger (31) is displaced in the lumen. The plunger further includes a recess (38) intermediate the first and second seals for receipt of trapped gas (40,41) which can be drawn in through an intake end (27) of the lumen during drawing of the liquid (36) into the tubular member (22). The plunger is formed for positioning of the first seal (33) beyond the intake opening (27) so that air will automatically be isolated between the first and second seals (33,37) as the plunger is withdrawn into a lumen. A substantially gas-free draw of liquid will result between the first seal (33) and the intake opening (27). A method of drawing the liquid in the apparatus which includes automatically isolating an uppermost portion of the liquid (36) and gas (41) from a lower portion of the volume drawn into the apparatus (21).
    • 一种具有轴向延伸的内腔(24)的管状构件(22)和安装成用于在管腔(24)中轴向移位的柱塞(31))的正位移液体抽取和分配装置(21)。 柱塞(31)具有靠近柱塞的端部(34)定位的第一密封件(33)和与第一密封件(33)轴向间隔开的第二密封件(37)。 所述第一和第二密封件当所述柱塞(31)在所述内腔中移位时,可滑动并密封地接合限定所述内腔(24)的内表面(23)。 所述柱塞还包括位于所述第一和第二密封件之间的凹部(38),用于接收被捕获的气体(40,41),所述被捕获的气体(40,41)可以在将所述液体(36)拉入所述内部空间的过程中通过所述内腔的进气端(27) 管状构件(22)。 柱塞被形成用于将第一密封件(33)定位在进气口(27)之外,使得当柱塞被抽出到内腔中时,空气将在第一和第二密封件(33,37)之间自动隔离。 在第一密封件(33)和进气口(27)之间将产生基本无气体的液体抽吸。 一种在设备中拉制液体的方法,其包括将液体(36)的最上部分和气体(41)从吸入设备(21)的体积的下部自动隔离。
    • 9. 发明授权
    • Aerosol and liquid transfer resistant pipette tip apparatus
    • 气溶胶和液体转移阻力移液管尖端装置
    • US5580529A
    • 1996-12-03
    • US489506
    • 1995-06-12
    • Donald H. DeVaughnJames C. Smith
    • Donald H. DeVaughnJames C. Smith
    • B01L3/02G01N35/10
    • B01L3/0275G01N2035/1023Y10T436/255Y10T436/2575
    • A baffle assembly (23) positioned between a pipetter assembly (10) and a disposable pipette tip (16) for substantially reducing transfer of aerosol and/or fluid specimens to the pipetter. The baffle assembly (23) includes a barrier structure (25) extending transversely across a receiving chamber (17) of the pipette tip (16) and defines at least one narrow passageway (26) extending generally in the direction of the longitudinal axis (27) through the barrier member (25) between an entrance (30) and an exit (31) thereof. The passageway (26) includes a first wall (32) extending generally transverse, and preferably perpendicular to, the longitudinal axis (27) of the pipette tip to define at least one elbow portion positioned between the entrance (30) and the exit (31) of the passageway. A filter membrane (55) preferably is secured across the passageway (26) to reduce aerosol transport through the passageway (26). A method for substantially reducing transfer of aerosol and/or fluid to the pipetter (10) is also provided, as is a method for securing the filter (55) to the baffle assembly (23).
    • 定位在移液器组件(10)和一次性移液器吸头(16)之间的挡板组件(23),用于基本上减少气溶胶和/或流体样品转移到移液器。 挡板组件(23)包括横向延伸穿过移液器吸头(16)的接收室(17)的阻挡结构(25),并且限定了至少一个沿着纵向轴线(27)的方向延伸的窄通道(26) )通过入口(30)和其出口(31)之间的阻挡构件(25)。 通道(26)包括大体横向延伸并且优选地垂直于移液管尖端的纵向轴线(27)延伸的第一壁(32),以限定位于入口(30)和出口(31)之间的至少一个肘部 )的通道。 过滤膜(55)优选地被固定在通道(26)上,以减少通过通道(26)的气溶胶输送。 还提供了用于将过滤器(55)固定到挡板组件(23)的方法,用于大大减少气溶胶和/或流体到移液管(10)的转移的方法。
    • 10. 发明授权
    • Method and apparatus for forming and dispensing single and multiple
phase coating material containing fluid diluent
    • 用于形成和分配含有流体稀释剂的单相和多相涂层材料的方法和装置
    • US5330783A
    • 1994-07-19
    • US953973
    • 1992-09-30
    • Laurence B. SaidmanTimothy E. WilsonStephen L. MerkelJames C. Smith
    • Laurence B. SaidmanTimothy E. WilsonStephen L. MerkelJames C. Smith
    • B05B7/24B05B7/32B05B12/08B05C11/10B05D1/02B05D1/26G05D11/13
    • B05B7/2486B05B12/085B05B12/1418B05B7/32B05D1/025G05D11/132B05D2401/90
    • A method and apparatus for forming and dispensing a coating material formulation or solution containing a liquid coating composition and a fluid diluent such as a supercritical fluid comprises a supply for the liquid coating composition, a supply for the fluid diluent, a mixer for combining the two components to form the coating material solution or formulation, and a control system for monitoring a parameter of the formulation which can be correlated to the fluid diluent content and/or liquid coating composition content of the formulation, and for monitoring the pressure of the formulation at selected locations within the system. The control system is effective to open or close the supply of fluid diluent and/or liquid coating composition in accordance with variations in the formulation parameter which is being sensed, and in response to pressure changes within the system, to maintain single or multiple phase coating material formulations, to account for changes in a parameter of the liquid coating composition and to ensure that the desired ratio of fluid diluent to liquid coating composition is maintained in the formulation which is supplied to coating dispensers for deposition onto a substrate.
    • 用于形成和分配包含液体涂料组合物和流体稀释剂例如超临界流体的涂料配方或溶液的方法和设备包括液体涂料组合物供应源,流体稀释剂供应源,混合器 用于形成涂料材料溶液或制剂的组分,以及用于监测制剂参数的控制系统,其可与制剂的流体稀释剂含量和/或液体涂料组合物含量相关,并且用于监测制剂的压力 选定的系统内的位置。 控制系统有效地根据正在检测的配方参数的变化以及响应于系统内的压力变化来打开或关闭流体稀释剂和/或液体涂料组合物的供应,以维持单相或多相涂层 材料配方,以解决液体涂料组合物参数的变化,并确保在供给到涂布分散器中用于沉积到基材上的制剂中保持流体稀释剂与液体涂料组合物的期望比例。