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1. 发明授权

US09005109B2 Cardiac disease treatment and device 有权
公开(公告)号：US09005109B2
公开(公告)日：2015-04-14
申请号：US13088133
申请日：2011-04-15
申请人： J. Edward Shapland , Robert G. Walsh , John David Dockter , John C. Vanden Hoek
发明人： J. Edward Shapland , Robert G. Walsh , John David Dockter , John C. Vanden Hoek
IPC分类号： A61F2/00 , A61L31/14 , A61F2/24 , A61L31/00 , A61L31/02 , A61L31/04 , A61L31/06
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.

2. 发明授权

US07252632B2 Cardiac disease treatment and device 有权
标题翻译：心脏病治疗及器械
公开(公告)号：US07252632B2
公开(公告)日：2007-08-07
申请号：US10172523
申请日：2002-06-13
申请人： J. Edward Shapland , Robert G. Walsh , John David Dockter , John C. Vanden Hoek
发明人： J. Edward Shapland , Robert G. Walsh , John David Dockter , John C. Vanden Hoek
IPC分类号： A61F2/00 , A61N1/39
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.
摘要翻译：一种心脏约束装置，其包括生物相容性材料夹套和调节构件。护套适于固定在心脏上，以紧密地符合心脏的外部几何形状，并采取最大调节体积，以限制心脏周围的舒张超过舒张期的最大调节体积，并允许心脏收缩期间不受阻碍的收缩。调整机构被配置成在护套被固定到心脏之后改变由夹克限定的内部容积。本发明还提供了治疗心脏病的方法。

3. 发明授权

US06425856B1 Cardiac disease treatment and device 失效
公开(公告)号：US06425856B1
公开(公告)日：2002-07-30
申请号：US09567726
申请日：2000-05-10
申请人： J. Edward Shapland , Robert G. Walsh , John David Dockter
发明人： J. Edward Shapland , Robert G. Walsh , John David Dockter
IPC分类号： A61F1300
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.

4. 发明授权

US06908426B2 Cardiac disease treatment and device 有权
标题翻译：心脏病治疗及器械
公开(公告)号：US06908426B2
公开(公告)日：2005-06-21
申请号：US10639875
申请日：2003-08-12
申请人： J. Edward Shapland , Robert G. Walsh , John David Dockter , John C. Vanden Hoek
发明人： J. Edward Shapland , Robert G. Walsh , John David Dockter , John C. Vanden Hoek
IPC分类号： A61B17/00 , A61F2/00 , A61F2/24 , A61L27/00 , A61L29/00 , A61L31/00 , A61L31/02 , A61L31/04 , A61L31/06 , A61L31/14 , A61F2/04 , A61B19/00
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.
摘要翻译：一种心脏约束装置，其包括生物相容性材料夹套和调节构件。护套适于固定在心脏上，以紧密地符合心脏的外部几何形状，并采取最大调节体积，以限制心脏周围的舒张超过舒张期的最大调节体积，并允许心脏收缩期间不受阻碍的收缩。调整机构被配置成在护套被固定到心脏之后改变由夹克限定的内部容积。本发明还提供了治疗心脏病的方法。

5. 发明授权

US06482146B1 Cardiac disease treatment and device 有权
标题翻译：心脏病治疗及器械
公开(公告)号：US06482146B1
公开(公告)日：2002-11-19
申请号：US09593251
申请日：2000-06-13
申请人： Clifton A. Alferness , Donald G. Rohrbaugh , J. Edward Shapland , Michael J. Girard , Donald F. Palme, II , James E. Cox
发明人： Clifton A. Alferness , Donald G. Rohrbaugh , J. Edward Shapland , Michael J. Girard , Donald F. Palme, II , James E. Cox
IPC分类号： A61F200
CPC分类号： A61F2/2481 , Y10S623/904
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.
摘要翻译：生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端。护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩。

6. 发明授权

US5746217A Interstitial fluid collection and constituent measurement 失效
公开(公告)号：US5746217A
公开(公告)日：1998-05-05
申请号：US555314
申请日：1995-11-08
申请人： Brian J. Erickson , Michael E. Hilgers , Tracy A. Hendrickson , J. Edward Shapland , Frank A. Solomon , Mark B. Knudson
发明人： Brian J. Erickson , Michael E. Hilgers , Tracy A. Hendrickson , J. Edward Shapland , Frank A. Solomon , Mark B. Knudson
IPC分类号： A61B5/00 , A61B5/1459 , A61B5/15 , A61B10/00
CPC分类号： A61B5/1455 , A61B10/0045 , A61B5/14514 , A61B5/14532 , A61B2010/008
摘要： An apparatus and method is disclosed for obtaining and measuring constituents in a sample of body fluid. The apparatus includes a member which is sized to penetrate into at least the dermal layer of skin to collect a sample of body fluid located within the dermal layer.

7. 发明授权

US5582184A Interstitial fluid collection and constituent measurement 失效
公开(公告)号：US5582184A
公开(公告)日：1996-12-10
申请号：US321305
申请日：1994-10-11
申请人： Brian J. Erickson , Michael E. Hilgers , Tracy A. Hendrickson , J. Edward Shapland , Frank A. Solomon , Mark B. Knudson
发明人： Brian J. Erickson , Michael E. Hilgers , Tracy A. Hendrickson , J. Edward Shapland , Frank A. Solomon , Mark B. Knudson
IPC分类号： A61B5/00 , A61B5/1459 , A61B5/15 , A61B10/00
CPC分类号： A61B5/1455 , A61B10/0045 , A61B5/14514 , A61B5/14532 , A61B2010/008
摘要： An apparatus and method is disclosed for obtaining and measuring constituents in a sample of body fluid. The apparatus includes a member which is sized to penetrate into at least the dermal layer of skin to collect a sample of body fluid located within the dermal layer.

8. 发明授权

US5545205A Unitary intravascular defibrillating catheter with bipolar sensing 失效
标题翻译：单一血管内除颤导管与双极感应
公开(公告)号：US5545205A
公开(公告)日：1996-08-13
申请号：US386210
申请日：1995-02-09
申请人： Theodore J. Schulte , Roger W. Dahl , Stanley M. Bach, Jr. , J. Edward Shapland , Douglas J. Lang
发明人： Theodore J. Schulte , Roger W. Dahl , Stanley M. Bach, Jr. , J. Edward Shapland , Douglas J. Lang
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/056 , A61N1/3918
摘要： A unitary intravascular defibrillating catheter includes distal and proximal spring electrodes, displaced to such distance from one another that defibrillating shock is effected through a field including the interventricular septum and left ventricular free wall. In one embodiment of this catheter, the proximal electrode is placed in the region of the subclavian vein. Alternatively, it may be placed in the region of the third through seventh intercostal space. A unitary catheter is also described which includes an intermediate electrode, placed between distal and proximal electrodes. Selection of placement of electrodes either in the superior vena cava or in the region of the subclavian vein is medically indicated by physiological conditions of the individual patient. The cardioversion system further includes a unipolar or bipolar sensing circuit with at least one sensing electrode, and a cardioversion/defibrillation circuit with either two or three spaced apart spring electrodes. The sensing electrodes are spaced apart from one another, but they are kept sufficiently close to one another for isolated, localized R-wave sensing. The sensing electrodes further are positioned remotely of the cardioversion/defibrillation electrodes, to avoid post-shock abnormalities which otherwise would interfere with a timely R-wave sensing, and to substantially prevent the discharge of an unnecessary cardioversion pulse after return of the heart to normal cardiac rhythm.
摘要翻译：单一的血管内除颤导管包括远端和近端的弹簧电极，彼此相距移动，使得去纤维化的休克通过包括室间隔和左心室游离壁的场进行。在该导管的一个实施例中，近端电极被放置在锁骨下静脉的区域中。或者，其可以放置在第三至第七肋间空间的区域中。还描述了包括放置在远端和近端电极之间的中间电极的单一导管。在上腔静脉或锁骨下静脉区域中放置电极的选择由个体患者的生理条件医学指示。心脏复律系统还包括具有至少一个感测电极的单极或双极检测电路，以及具有两个或三个间隔开的弹簧电极的心电复律/除颤电路。感测电极彼此间隔开，但它们彼此保持足够接近以进行隔离的局部R波感测。感测电极进一步位于心脏复律/除颤电极的远端，以避免冲击后异常，否则将干扰及时的R波感测，并且在将心脏恢复正常后基本上防止不必要的心脏复律脉冲的放电心律

9. 发明授权

US07214181B2 Septum attached ventricular support 有权
标题翻译：隔垫附着心室支持
公开(公告)号：US07214181B2
公开(公告)日：2007-05-08
申请号：US11338571
申请日：2006-01-24
申请人： J. Edward Shapland , Clif Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
发明人： J. Edward Shapland , Clif Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F2/2481
摘要： A method and device are disclosed for treating congestive heart disease. The material of the device is secured to the heart proximate the septal wall. The material covering the ventricles may or may not have the same tension and or compliance. The device can be constructed as a unitary “jacket” that is slipped over the apex of the heart. Alternately, the device implanted as one, two or more separate components. In one embodiment, the material covers both the left and right ventricles. In another embodiment, the material covers only one ventricle. The device may include at least one adjustment mechanism configured to adjust the tension of the material. Preferably, the device includes a first adjustment mechanism configured to adjust a tension of the material covering the right ventricle and a second adjustment mechanism configured to adjust the tension of the material covering the left ventricle such that the tension of the material covering the left ventricle can be different than the tension of the material covering the right ventricle.
摘要翻译：公开了治疗充血性心脏病的方法和装置。该装置的材料固定在靠近隔壁的心脏上。覆盖心室的材料可能具有或不具有相同的张力和/或顺应性。该装置可以被构造成整体的“夹克”，其被滑过心脏的顶点。或者，该装置作为一个，两个或更多个分离的部件植入。在一个实施例中，材料覆盖左心室和右心室。在另一个实施例中，材料仅覆盖一个心室。该装置可以包括被配置为调节材料张力的至少一个调节机构。优选地，该装置包括被配置为调节覆盖右心室的材料的张力的第一调节机构和被配置为调节覆盖左心室的材料的张力的第二调节机构，使得覆盖左心室的材料的张力可以与覆盖右心室的材料的张力不同。

10. 发明授权

US07014615B2 Interstitial fluid collection and constituent measurement 有权
公开(公告)号：US07014615B2
公开(公告)日：2006-03-21
申请号：US10354503
申请日：2003-01-29
申请人： Brian J. Erickson , Michael E. Hilgers , Tracy A. Hendrickson , J. Edward Shapland , Frank A. Solomon , Mark B. Knudson
发明人： Brian J. Erickson , Michael E. Hilgers , Tracy A. Hendrickson , J. Edward Shapland , Frank A. Solomon , Mark B. Knudson
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14514 , A61B5/14532 , A61B10/0045 , A61B2010/008
摘要： An apparatus and method is disclosed for obtaining and measuring constituents in a sample of body fluid. The apparatus includes a member which is sized to penetrate into at least the dermal layer of skin to collect a sample of body fluid located within the dermal layer.

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