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1. 发明申请

US20060193921A1 Hydrophilic beads for use in topical formulations 审中-公开
标题翻译：用于局部制剂的亲水珠
公开(公告)号：US20060193921A1
公开(公告)日：2006-08-31
申请号：US11340310
申请日：2006-01-26
申请人： J. Brown , John Hill , J. Tryon , Michele Ward
发明人： J. Brown , John Hill , J. Tryon , Michele Ward
IPC分类号： A61K36/886 , A61K8/73 , A61K9/14
CPC分类号： A61K9/1611 , A61K8/11 , A61K8/20 , A61K8/73 , A61K9/0014 , A61K9/1652 , A61K2800/56 , A61Q19/00
摘要： A composition and method for producing hydrophilic beads for use in topical formulations is described as generally including gellan gum, salts of divalent cations and water. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to realize improved production and/or use of hydrophilic beads to achieve a particular desired purpose. Exemplary embodiments of the present invention generally provide hydrophilic beads that may be comixed with cosmetic, cosmeceutical and/or topical preparations for surface abrasion or as carriers for the delivery of other compounds; such as, aloe vera, ascorbic acid, active agents, and/or the like.
摘要翻译：用于制备用于局部制剂的亲水珠的组合物和方法通常包括结冷胶，二价阳离子的盐和水。公开的特征和规格可以被不同地控制，适应或以其他方式任意地修改以实现改进的亲水珠的生产和/或使用以实现特定的期望目的。本发明的示例性实施方案通常提供亲水性珠粒，其可与用于表面磨损的化妆品，药妆和/或局部制剂混合，或用作递送其它化合物的载体; 如芦荟，抗坏血酸，活性剂和/或类似物。

2. 发明申请

US20060188533A1 Delivery of bio-available compounds with anhydrous topical preparations 审中-公开
标题翻译：用无水局部制剂递送生物可用化合物
公开(公告)号：US20060188533A1
公开(公告)日：2006-08-24
申请号：US11340043
申请日：2006-01-26
申请人： J. Brown , John Hill , J. Tryon , Michele Ward
发明人： J. Brown , John Hill , J. Tryon , Michele Ward
IPC分类号： A61K36/18 , A61K8/02
CPC分类号： A61K8/02 , A61K8/676 , A61K8/922 , A61K36/00 , A61K2800/242 , A61K2800/31 , A61Q19/00 , A61K2300/00
摘要： The disclosed systems and methods for delivery of bio-available compounds in topical preparations generally include anhydrous carrier particles adapted to carry bio-available compounds. The carrier particles may be admixed with anhydrous formulation material that is suitably adapted to suspend and/or separate the carrier particles. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to realize improved production and/or use of carrier particles that may be employed to deliver bio-available compounds in order to achieve a desired purpose. Exemplary embodiments of the present invention generally provide anhydrous carrier particles that may be mixed with substantially anhydrous topical preparations.
摘要翻译：用于在局部制剂中递送生物可利用化合物的所公开的系统和方法通常包括适于携带生物可利用化合物的无水载体颗粒。载体颗粒可以与适于适于悬浮和/或分离载体颗粒的无水配方材料混合。公开的特征和规格可以被不同地控制，适应或以其他方式任意地修改以实现可用于递送生物可利用化合物以实现期望目的的载体颗粒的改进的生产和/或使用。本发明的示例性实施方案通常提供可与基本上无水的局部制剂混合的无水载体颗粒。

3. 发明申请

US20060193800A1 Variable tint cosmetics 审中-公开
标题翻译：变色调化妆品
公开(公告)号：US20060193800A1
公开(公告)日：2006-08-31
申请号：US11340297
申请日：2006-01-26
申请人： John Reinhardt , John Hill , Michele Ward , J. Brown
发明人： John Reinhardt , John Hill , Michele Ward , J. Brown
IPC分类号： A61K8/02 , A61K8/97
CPC分类号： A61Q1/02 , A61K8/0241 , A61K8/11 , A61K8/31 , A61K8/37 , A61K8/8111 , A61K8/922 , A61K8/97 , A61K2800/31 , A61K2800/412 , A61K2800/43 , A61Q1/12
摘要： The disclosed systems and methods for delivery of variable tint pigment materials in cosmetic concealer/foundation products generally include anhydrous carrier particles adapted to carry pigment. The pigmentation carrier particles may be optionally admixed with anhydrous (optionally tinted) base formulation material that is suitably adapted to suspend and/or separate the pigmentation carrier particles. Disclosed features and specifications may be variously controlled, adapted or otherwise modified to realize improved site-specific delivery of pigment in customized concentrations in order to achieve a desired result. Exemplary embodiments of the present invention generally provide anhydrous pigmentation carrier particles that may be mixed with substantially anhydrous topical base formulations that allow a user to deliver a selected concentration of concealer/foundation tint to a specific region of the skin, for example, in order to obscure a blemish.
摘要翻译：用于在化妆品遮瑕膏/粉底产品中递送可变色素材料的所公开的系统和方法通常包括适于承载颜料的无水载体颗粒。色素载体颗粒可以任选地与适当地适于悬浮和/或分离着色载体颗粒的无水（任选着色的）基础制剂材料混合。公开的特征和规格可以被不同地控制，适应或以其他方式修饰，以实现改变的定制浓度的颜料的位置特异性递送，以获得期望的结果。本发明的示例性实施方案通常提供可与基本上无水的局部基础制剂混合的无水色素沉淀载体颗粒，其允许使用者将选定浓度的遮瑕膏/基质着色剂递送至皮肤的特定区域，以便晦涩难懂

4. 发明申请

US20060137851A1 Shaped direct chill aluminum ingot 审中-公开
公开(公告)号：US20060137851A1
公开(公告)日：2006-06-29
申请号：US11286401
申请日：2005-11-25
申请人： Gyan Jha , J. Brown , Shridas Ningileri , Weimin Yin , Randall Bowers
发明人： Gyan Jha , J. Brown , Shridas Ningileri , Weimin Yin , Randall Bowers
IPC分类号： B22D11/00 , B22D11/126
CPC分类号： B21B1/026 , B21B3/00 , B21B2003/001 , B21B2263/16 , B21B2263/20 , B21D3/00 , B22D7/005 , B22D11/003 , Y10T29/49989 , Y10T29/49991 , Y10T29/49995 , Y10T428/12271 , Y10T428/12278 , Y10T428/12285 , Y10T428/12382
摘要： Method and apparatus for forming aluminum ingot having shaped ends to avoid alligatoring during rolling.

5. 发明申请

US20050245401A1 Propped fracture with high effective surface area 有权
$Propped fracture with high effective surface area$
标题翻译：支撑骨折有效表面积高
公开(公告)号：US20050245401A1
公开(公告)日：2005-11-03
申请号：US11175874
申请日：2005-07-05
申请人： Keng Chan , J. Brown , Arthur Milne , Brett Rimmer , Mark Brady
发明人： Keng Chan , J. Brown , Arthur Milne , Brett Rimmer , Mark Brady
IPC分类号： C09K8/72 , C09K8/80 , E21B43/267 , E21B43/00
CPC分类号： C09K8/72 , C09K8/80 , E21B43/267 , Y10S507/923 , Y10S507/933 , Y10S507/934
摘要： Propped fractures in formations from which fluids are produced are described that have wormholes extending out into the formations from the faces of the fractures at locations distant from boreholes. Methods are given for creating such propped fractures having wormholes in which either a closed propped fracture is formed and then the wormholes are formed, or the entire fracture and channel system is formed before the closure occurs.
摘要翻译：描述了产生流体的地层中的支撑的裂缝，其具有从远离钻孔的位置处的裂缝的表面延伸到地层中的虫洞。给出了创建具有蠕虫洞的这种支撑裂缝的方法，其中形成闭合的支撑断裂，然后形成虫洞，或者在闭合发生之前形成整个断裂和通道系统。

6. 发明申请

US20050113263A1 Differential etching in acid fracturing 审中-公开
$Differential etching in acid fracturing$
标题翻译：酸压裂中的差分蚀刻
公开(公告)号：US20050113263A1
公开(公告)日：2005-05-26
申请号：US10941385
申请日：2004-09-15
申请人： J. Brown , John Still , Diankui Fu , Zhijun Xiao
发明人： J. Brown , John Still , Diankui Fu , Zhijun Xiao
IPC分类号： C09K8/03 , C09K8/06 , C09K8/504 , C09K8/506 , C09K8/72 , C09K8/74 , C09K7/00
CPC分类号： C09K8/70 , C09K8/72 , C09K8/74 , C09K8/80
摘要： A method for fracturing a subterranean formation is provided in which inert masking material particles are injected into the formation with a dissolution agent so that the masking material inhibits dissolution where it contacts a portion of one or both fracture faces. The undissolved regions provide support to keep the fracture open after the treatment and the dissolved regions provide a conductive pathway for flow of fluid to or from the wellbore.
摘要翻译：提供了一种用于压裂地层的方法，其中惰性掩蔽材料颗粒用溶解剂注入到地层中，使得掩蔽材料在其接触一个或两个断裂面的一部分时抑制溶解。未溶解区域提供支撑以在处理后保持断裂，并且溶解区域提供用于将流体流入或流出井眼的导电路径。

7. 发明申请

US20060054325A1 Solid sandstone dissolver 审中-公开
公开(公告)号：US20060054325A1
公开(公告)日：2006-03-16
申请号：US10941355
申请日：2004-09-15
申请人： J. Brown , John Still , Diankui Fu , Zhijun Xiao , Wayne Frenier
发明人： J. Brown , John Still , Diankui Fu , Zhijun Xiao , Wayne Frenier
IPC分类号： E21B43/26
CPC分类号： C09K8/62
摘要： A dry solid composition is disclosed that, when added to an aqueous liquid, provides a slurry that can be used in sandstone acid fracturing. The slurry generates hydrofluoric acid downhole to etch the sandstone fracture faces created. The chemical and physical properties of the composition result in very uneven etching of the fracture faces, enhancing the fluid conductivity of the final fracture. Optionally, inert masking materials may be included in the dry composition, or added to the slurry, to increase the inhomogeneity of the etching and further increase the fluid conductivity.

8. 发明申请

US20060046235A1 Interface device and method for interfacing instruments to medical procedure simulation systems 有权
公开(公告)号：US20060046235A1
公开(公告)日：2006-03-02
申请号：US11204646
申请日：2005-08-15
申请人： David Alexander , J. Brown , Eric Cabahug , Philip Churchill , Robert Cohen , Richard Cunningham , Ben Feldman , Diego Fontayne , Gregory Merril , Marlo Turchi
发明人： David Alexander , J. Brown , Eric Cabahug , Philip Churchill , Robert Cohen , Richard Cunningham , Ben Feldman , Diego Fontayne , Gregory Merril , Marlo Turchi
IPC分类号： G09B23/28
CPC分类号： G09B23/285
摘要： An interface device and method for interfacing instruments to a medical procedure simulation system serve to interface peripherals in the form of mock medical instruments to the medical procedure simulation system computer to enable simulation of medical procedures. The interface device includes a housing having a mock bodily region of interest to facilitate insertion of a mock instrument, such as an endoscope tube, into the interface device. The mock bodily region of interest may be pivotable to simulate various patient orientations. The instrument is engaged by a capture mechanism in order to measure rotational and translational motion of the instrument. An actuator is disposed within the interface device to provide force feedback to the instrument. The measured motion is provided to the computer system to reflect instrument motion on the display during the simulation. Alternatively, the interface device may be configured to accommodate instrument assemblies having a plurality of nested instruments (e.g., sheath, catheter and wire), whereby the interface device individually grasps, measures manipulation of and provides force feedback to the nested instruments. In addition, the interface device may be configured to simultaneously accommodate a plurality of independently inserted instruments.

9. 发明申请

US20050252659A1 Degradable additive for viscoelastic surfactant based fluid systems 有权
标题翻译：用于粘弹性表面活性剂的流体系统的可降解添加剂
公开(公告)号：US20050252659A1
公开(公告)日：2005-11-17
申请号：US11159023
申请日：2005-06-22
申请人： Philip Sullivan , J. Brown , Jesse Lee , Golchehreh Salamat
发明人： Philip Sullivan , J. Brown , Jesse Lee , Golchehreh Salamat
IPC分类号： C09K8/68 , C09K8/70 , E21B43/267
CPC分类号： C09K8/68 , C09K8/506 , C09K8/62 , C09K8/70 , C09K8/72 , C09K8/74 , C09K2208/26 , C09K2208/30 , Y10S507/902
摘要： A method is given for treating a subterranean formation penetrated by a wellbore with a viscosified fluid. The fluid contains a solid hydrolysable polyacid that upon dissolution and hydrolysis releases an acid that is a breaker for the viscosifying system. Suitable solid hydrolysable polyacids include polylactic acid and polyglycolic acid. The fluid also contains a pH control agent, present in an amount sufficient to neutralize any acid present in the solid hydrolysable polyacid before the injection and to neutralize any acid generated by the solid hydrolysable polyacid during the injection, so that the acid breaker is not available to break the fluid during the injection. In one embodiment the viscosifier is a viscoelastic surfactant fluid system and the solid hydrolysable polyacid is of a size selected to be a fluid loss additive, for example in fracturing or gravel packing. In another embodiment, the solid hydrolysable polyacid is used in particles sufficiently small that they enter the pores of the formation. In either case, the viscosifier is broken after the solid releases more acid than can be neutralized by the pH control agent.
摘要翻译：给出了用增稠液体处理井眼渗透的地层的方法。流体包含固体可水解的多酸，其在溶解和水解时释放酸，该酸是用于增粘体系的断裂剂。合适的固体可水解的多元酸包括聚乳酸和聚乙醇酸。流体还含有pH控制剂，其量足以中和注射前固体可水解的多元酸中存在的任何酸，并且在注射期间中和由固体可水解的多元酸产生的任何酸，使得酸性破坏剂不可用在注射期间打破流体。在一个实施方案中，增粘剂是粘弹性表面活性剂流体系统，并且固体可水解的多元酸的尺寸被选择为流体损失添加剂，例如在压裂或砾石包装中。在另一个实施方案中，固体可水解的多元酸以足够小的颗粒使用，使得它们进入地层的孔。在任一种情况下，在固体释放比可以被pH控制剂中和的酸更多之后，粘稠剂被破坏。

10. 发明申请

US20070193737A1 METHOD OF INTENSIFICATION OF NATURAL GAS PRODUCTION FROM COAL BEDS 审中-公开
标题翻译：从煤层中强化天然气生产的方法
公开(公告)号：US20070193737A1
公开(公告)日：2007-08-23
申请号：US11677263
申请日：2007-02-21
申请人： Matthew Miller , J. Brown , Alexey Barykin
发明人： Matthew Miller , J. Brown , Alexey Barykin
IPC分类号： E21B43/267 , E21B37/00
CPC分类号： E21B28/00 , E21B43/003 , E21B43/006 , E21B43/267
摘要： A method of intensification of natural gas production from the coal beds, comprising exposure of the coal bed to pressure pulsing is disclosed. An embodiment comprises exposure of the coal bed to pressure pulsing in combination with hydraulic fracturing of the coal bed. Another embodiment comprises exposure of the coal bed to pressure pulsing in combination with creation of a cavity in the coal bed by cyclically increasing pressure of the fluid in the well and depressurizing rapidly the fluid.
摘要翻译：公开了一种从煤层中强化天然气生产的方法，包括将煤层暴露于压力脉动。一个实施例包括煤层与煤层的水力压裂相结合的压力脉冲暴露。另一个实施例包括通过循环地增加井中的流体的压力并快速地使流体减压，将煤层暴露于压力脉动与煤层中的空腔的产生相结合。

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