专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08417344B2 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 有权
标题翻译：基于心脏数据的脑状态测定的动态颅神经刺激
公开(公告)号：US08417344B2
公开(公告)日：2013-04-09
申请号：US12258019
申请日：2008-10-24
申请人： John C. Colborn , Mark G. Frei , Ivan Osorio
发明人： John C. Colborn , Mark G. Frei , Ivan Osorio
IPC分类号： A61N1/00
CPC分类号： A61B5/0205 , A61B5/04012 , A61N1/36082 , A61N1/36114
摘要： A method of treating a medical condition in a patient using an implantable medical device, comprising providing an electrical signal generator; providing at least a first electrode operatively coupled to the electrical signal generator and to a vagus nerve of the patient; sensing cardiac data of the patient; determining at least a first cardiac parameter based upon said cardiac data; setting at least a first value; declaring an unstable brain state of a patient from said at least a first cardiac parameter and said at least a first value; and adjusting the at least a first value. Also, a computer readable program storage device encoded with instructions that, when executed by a computer, performs the method. In addition, the implantable medical device used in the method.
摘要翻译：一种使用可植入医疗装置治疗患者的医疗状况的方法，包括提供电信号发生器; 提供至少可操作地耦合到所述电信号发生器和所述患者的迷走神经的第一电极; 感测患者的心脏数据; 基于所述心脏数据确定至少第一心脏参数; 设置至少第一个值; 从所述至少第一心脏参数和所述至少第一值宣告患者的不稳定脑状态; 以及调整所述至少第一值。另外，一种计算机可读程序存储装置，其编码有由计算机执行时执行该方法的指令。此外，该方法中使用的可植入医疗装置。

2. 发明授权

US08348842B1 Method and system for implantable glucose monitoring and control of a glycemic state of a subject 失效
标题翻译：监测和控制受试者血糖状态的方法和系统
公开(公告)号：US08348842B1
公开(公告)日：2013-01-08
申请号：US13135375
申请日：2011-07-01
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/4839 , A61B5/14528 , A61B5/14532 , A61B5/686 , A61M5/14244 , A61M5/16877 , A61M5/1723 , A61M2205/50 , A61M2230/201
摘要： A method and system for monitoring and/or controlling a glycemic state of a subject, comprising a housing device having one or more chambers, extendable and retractable sensors, extendable and retractable catheters, insulin reservoir, neuroprotective agent reservoir, release mechanism for releasing insulin and neuroprotective agent into the subject, and a control mechanism with a processor for receiving and analyzing outputs from the sensors and for controlling the release mechanism, a clock mechanism for providing logging and/or circadian information to the processor.
摘要翻译：一种用于监测和/或控制受试者血糖状态的方法和系统，包括具有一个或多个腔室，可伸缩和可伸缩传感器，可伸缩导管，胰岛素储存器，神经保护剂储存器，用于释放胰岛素的释放机构的壳体装置和神经保护剂，以及具有处理器的控制机构，用于接收和分析来自传感器的输出和用于控制释放机构的时钟机构，用于向处理器提供记录和/或昼夜节律信息。

3. 发明授权

US08209018B2 Probabilistic neurological disorder treatment 有权
标题翻译：概率神经障碍治疗
公开(公告)号：US08209018B2
公开(公告)日：2012-06-26
申请号：US11380752
申请日：2006-04-28
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61N1/18 , A61B5/02
CPC分类号： G16H50/20 , A61B5/0006 , A61B5/0476 , A61B5/4094 , A61N1/36082 , A61N1/361 , G06F19/00 , G06F19/3481
摘要： Disclosed are probabilistic approaches to patient evaluation, warning and treatment of a neurological disorder. Disclosed techniques estimate probability distribution functions or cumulative distribution functions, determined by relying on representative historical profiles, comprising information in short and/or long timescales obtained at times that may be intermittent or temporally discontinuous from each other or from other events of interest. The patient may thereby be treated based on the determined probability information.
摘要翻译：公开了患者评估，警告和治疗神经障碍的概率方法。披露的技术估计概率分布函数或累积分布函数，其通过依赖于代表性历史概况确定，包括在可能彼此间断或间断不连续的时间或从其他感兴趣事件的时间获得的短时间和/或长时间尺度的信息。因此，可以基于所确定的概率信息来对患者进行治疗。

4. 发明授权

US07146211B2 Signal quality monitoring and control for a medical device system 有权
标题翻译：医疗器械系统的信号质量监测和控制
公开(公告)号：US07146211B2
公开(公告)日：2006-12-05
申请号：US10687348
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio
发明人： Mark G. Frei , Ivan Osorio
IPC分类号： A61N1/00
CPC分类号： A61B5/04012 , A61B5/048 , A61B5/4094 , A61B5/7203 , A61B5/7217 , A61B5/7221 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/3702 , A61N1/37229 , A61N1/37252
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

5. 发明授权

US07079977B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07079977B2
公开(公告)日：2006-07-18
申请号：US10687566
申请日：2003-10-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G04F1/00 , A61B5/00 , A61B1/36
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, includes a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

6. 发明授权

US09050469B1 Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals 有权
标题翻译：记录定量癫痫发作信息的方法和系统，并使用心脏信号评估治疗效果
公开(公告)号：US09050469B1
公开(公告)日：2015-06-09
申请号：US10997540
申请日：2004-11-24
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/04 , A61N1/36
CPC分类号： A61N1/36064 , A61B5/04012 , A61B5/0452 , A61B5/0456 , A61B5/4094 , A61B5/4836 , A61B5/7282 , G06F19/3481 , G16H50/20
摘要： A system and method for analyzing and logging changes in brain state of a subject for administering therapy to the subject based on the at least one cardiac signal wherein the system and method comprises the steps of receiving at least one cardiac signal of the subject into a processor, analyzing the cardiac signal to detect at least one cardiac signal change indicative of a brain state change, and logging at least one characteristic of the detected signal change or the brain state change.
摘要翻译：一种用于基于所述至少一个心脏信号来分析和记录受试者脑部状态变化以对受试者进行治疗的系统和方法，其中所述系统和方法包括以下步骤：将所述受试者的至少一个心脏信号接收到处理器分析心脏信号以检测指示脑状态改变的至少一个心脏信号变化，以及记录检测到的信号改变或脑状态改变的至少一个特征。

7. 发明授权

US08515538B1 Medical device failure detection and warning system 有权
标题翻译：医疗器械故障检测和警告系统
公开(公告)号：US08515538B1
公开(公告)日：2013-08-20
申请号：US12157955
申请日：2008-06-13
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/08
CPC分类号： A61B5/7221 , A61B5/0022 , A61B5/01 , A61B5/04005 , A61B5/4094 , A61B5/686 , A61B5/746 , A61B7/00 , A61N1/36142 , A61N1/3706 , A61N1/37258 , G16H40/63
摘要： A failure detection and warning system for monitoring a medical device wherein the system includes means structured to passively or actively detect faults occurring in the medical device being monitored, and wherein the fault includes an unprogrammed and/or undesired shut off of the medical device being monitored or an unprogrammed and/or undesired shut-off of the output of the medical device being monitored by the system.
摘要翻译：一种用于监测医疗装置的故障检测和警告系统，其中所述系统包括构造成被动地或主动地检测正被监视的医疗装置中发生的故障的装置，并且其中所述故障包括被监视的医疗装置的未编程和/或不期望的切断或者由系统监视的未编程和/或非期望的关闭医疗设备的输出。

8. 发明授权

US08024032B1 Method and system for the prediction, rapid detection, warning, prevention, or control of changes in the brain states of a subject using hurst parameter estimation 有权
标题翻译：使用赫斯特参数估计预测，快速检测，警告，预防或控制受试者脑状态变化的方法和系统
公开(公告)号：US08024032B1
公开(公告)日：2011-09-20
申请号：US11604407
申请日：2006-11-27
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/04
CPC分类号： A61B5/0476 , A61B5/16 , A61B5/165 , A61B5/4094 , A61B5/6814
摘要： A system for analyzing signals representative of a subject's brain activity in a signal processor for information indicating the subject's current activity state and for detecting or predicting a change in the activity state. One preferred embodiment uses a method for estimating the Hurst parameter to perform real-time analysis of the electroencephalogram (EEG) or electrocorticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
摘要翻译：一种用于分析表示受试者在脑部活动信号的信号的系统，用于指示受试者的当前活动状态的信息，以及用于检测或预测活动状态的变化。一个优选实施例使用用于估计Hurst参数的方法来执行来自对象患者的脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成所需的分析至少在临床发作发作前。优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

9. 发明授权

US07966156B1 Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale 有权
标题翻译：方法，计算机程序和系统，用于任意原点或时间尺度信号的固有时间尺度分解，滤波和自动分析
公开(公告)号：US07966156B1
公开(公告)日：2011-06-21
申请号：US12217893
申请日：2008-07-09
申请人： Mark G. Frei , Ivan Osorio
发明人： Mark G. Frei , Ivan Osorio
IPC分类号： G06F17/00 , G06F19/00
CPC分类号： G06K9/00503 , G06F17/14 , G06K9/00523
摘要： A method and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale including receiving an input signal, determining a baseline segment and a monotonic residual segment with strictly negative minimum and strictly positive maximum between two successive extrema of the input signal, and producing a baseline output signal and a residual output signal. The method and system also includes determining at least one instantaneous frequency estimate from a proper rotation signal, determining a zero-crossing and a local extremum of the proper rotation signal, and applying interpolation thereto to determine an instantaneous frequency estimate thereof. The method and system further includes determining at least one instantaneous frequency estimate from a proper rotation signal, extracting an amplitude-normalized half wave therefrom and applying an arcsine function to the amplitude-normalized half wave to determine an instantaneous frequency estimate of the proper rotation signal.
摘要翻译：用于固有时间尺度分解，过滤和任意来源或时间尺度信号的自动分析的方法和系统，包括接收输入信号，确定基线段和具有严格为负的最小值和严格正的最大值的两个连续极值之间的单调残差段输入信号，并产生基线输出信号和残留输出信号。所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，确定适当旋转信号的过零点和局部极值，以及对其进行插值以确定其瞬时频率估计。所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，从其中提取幅度归一化的半波，并对所述幅度归一化的半波应用反正弦函数，以确定适当旋转信号的瞬时频率估计。

10. 发明授权

US07917206B2 Signal quality monitoring and control for a medical device system 有权
标题翻译：医疗器械系统的信号质量监测和控制
公开(公告)号：US07917206B2
公开(公告)日：2011-03-29
申请号：US11557433
申请日：2006-11-07
申请人： Mark G. Frei , Ivan Osorio
发明人： Mark G. Frei , Ivan Osorio
IPC分类号： A61N1/00
CPC分类号： A61B5/04012 , A61B5/048 , A61B5/4094 , A61B5/7203 , A61B5/7217 , A61B5/7221 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/3702 , A61N1/37229 , A61N1/37252
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式