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1. 发明授权

US08417344B2 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 有权
标题翻译：基于心脏数据的脑状态测定的动态颅神经刺激
公开(公告)号：US08417344B2
公开(公告)日：2013-04-09
申请号：US12258019
申请日：2008-10-24
申请人： John C. Colborn , Mark G. Frei , Ivan Osorio
发明人： John C. Colborn , Mark G. Frei , Ivan Osorio
IPC分类号： A61N1/00
CPC分类号： A61B5/0205 , A61B5/04012 , A61N1/36082 , A61N1/36114
摘要： A method of treating a medical condition in a patient using an implantable medical device, comprising providing an electrical signal generator; providing at least a first electrode operatively coupled to the electrical signal generator and to a vagus nerve of the patient; sensing cardiac data of the patient; determining at least a first cardiac parameter based upon said cardiac data; setting at least a first value; declaring an unstable brain state of a patient from said at least a first cardiac parameter and said at least a first value; and adjusting the at least a first value. Also, a computer readable program storage device encoded with instructions that, when executed by a computer, performs the method. In addition, the implantable medical device used in the method.
摘要翻译：一种使用可植入医疗装置治疗患者的医疗状况的方法，包括提供电信号发生器; 提供至少可操作地耦合到所述电信号发生器和所述患者的迷走神经的第一电极; 感测患者的心脏数据; 基于所述心脏数据确定至少第一心脏参数; 设置至少第一个值; 从所述至少第一心脏参数和所述至少第一值宣告患者的不稳定脑状态; 以及调整所述至少第一值。另外，一种计算机可读程序存储装置，其编码有由计算机执行时执行该方法的指令。此外，该方法中使用的可植入医疗装置。

2. 发明申请

US20100106217A1 DYNAMIC CRANIAL NERVE STIMULATION BASED ON BRAIN STATE DETERMINATION FROM CARDIAC DATA 有权
标题翻译：基于心脏数据的脑状态确定动态神经刺激
公开(公告)号：US20100106217A1
公开(公告)日：2010-04-29
申请号：US12258019
申请日：2008-10-24
申请人： John C. Colborn
发明人： John C. Colborn
IPC分类号： A61N1/36
CPC分类号： A61B5/0205 , A61B5/04012 , A61N1/36082 , A61N1/36114
摘要： A method of treating a medical condition in a patient using an implantable medical device, comprising providing an electrical signal generator; providing at least a first electrode operatively coupled to the electrical signal generator and to a vagus nerve of the patient; sensing cardiac data of the patient; determining at least a first cardiac parameter based upon said cardiac data; setting at least a first value; declaring an unstable brain state of a patient from said at least a first cardiac parameter and said at least a first value; and adjusting the at least a first value. Also, a computer readable program storage device encoded with instructions that, when executed by a computer, performs the method. In addition, the implantable medical device used in the method.
摘要翻译：一种使用可植入医疗装置治疗患者的医疗状况的方法，包括提供电信号发生器; 提供至少可操作地耦合到所述电信号发生器和所述患者的迷走神经的第一电极; 感测患者的心脏数据; 基于所述心脏数据确定至少第一心脏参数; 设置至少第一个值; 从所述至少第一心脏参数和所述至少第一值宣告患者的不稳定脑状态; 以及调整所述至少一个第一值。另外，一种计算机可读程序存储装置，其编码有由计算机执行时执行该方法的指令。此外，该方法中使用的可植入医疗装置。

3. 发明授权

US08761884B2 Device longevity prediction for a device having variable energy consumption 有权
标题翻译：具有可变能量消耗的设备的设备寿命预测
公开(公告)号：US08761884B2
公开(公告)日：2014-06-24
申请号：US13086667
申请日：2011-04-14
申请人： John C. Colborn
发明人： John C. Colborn
IPC分类号： A61N1/08
CPC分类号： A61N1/378 , A61N1/36053 , A61N1/36064 , A61N1/36114 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37235 , A61N1/37247 , A61N1/37264
摘要： A system and method for estimating the longevity of an implantable medical device (IMD). In one embodiment of a method for estimating a life of a power source of an implantable medical device, a first life estimate of the power source is determined based on a first open-loop value corresponding to an open-loop parameter for open-loop therapy delivery, a first closed loop value corresponding to a closed-loop parameter for closed-loop therapy delivery, and prior usage data corresponding to prior therapy delivery. The first life estimate of the power source is displayed. The first life estimate displayed includes a first open-loop portion associated with open-loop therapy delivery and a first closed-loop portion associated with closed-loop therapy delivery.
摘要翻译：用于估计可植入医疗装置（IMD）的寿命的系统和方法。在用于估计可植入医疗装置的电源的寿命的方法的一个实施例中，基于与开环治疗的开环参数相对应的第一开环值来确定电源的第一寿命估计递送，对应于用于闭环治疗递送的闭环参数的第一闭环值以及对应于先前治疗递送的先前使用数据。显示电源的第一次生命估计。显示的第一寿命估计包括与开环治疗递送相关联的第一开环部分和与闭环治疗递送相关联的第一闭环部分。

4. 发明申请

US20120277605A1 DYNAMIC HEART RATE THRESHOLD FOR NEUROLOGICAL EVENT DETECTION 有权
标题翻译：用于神经病学检测的动态心率阈值
公开(公告)号：US20120277605A1
公开(公告)日：2012-11-01
申请号：US13097439
申请日：2011-04-29
申请人： John C. Colborn
发明人： John C. Colborn
IPC分类号： A61B5/024 , A61N1/36
CPC分类号： A61B5/024 , A61B5/02 , A61B5/0476 , A61B5/7275
摘要： A method may include sensing a time of beat sequence of a patient's heart and processing said time of beat sequence with a medical device to identify a change in heart rate of a patient from a first heart rate to a second heart rate. The method may continue by determining with the medical device at least one of a) a ratio of the second heart rate to the first heart rate and b) a difference between the second heart rate and the first heart rate. The method may include determining with the medical device at least one of a) a dynamic ratio threshold for the ratio and b) a dynamic difference threshold for the difference, wherein the at least one threshold is based upon the first heart rate. The ratio and/or the difference may be compared to the threshold(s) to detect a neurological event, for example, an epileptic seizure.
摘要翻译：方法可以包括感测患者心脏的搏动序列的时间并且利用医疗装置处理所述搏动序列的所述时间，以识别患者从第一心率到第二心率的心率变化。该方法可以通过用医疗装置确定a）第二心率与第一心率的比率和b）第二心率和第一心率之间的差别中的至少一个来继续。该方法可以包括用医疗设备确定a）比率的动态比率阈值和b）差异的动态差异阈值中的至少一个，其中所述至少一个阈值基于第一心率。比率和/或差异可以与阈值进行比较以检测神经系统事件，例如癫痫发作。

5. 发明授权

US08874229B2 Delivering scheduled and unscheduled therapy without detriment to battery life or accuracy of longevity predictions 有权
标题翻译：提供定期和非计划的治疗，而不损害电池寿命或寿命预测的准确性
公开(公告)号：US08874229B2
公开(公告)日：2014-10-28
申请号：US12769134
申请日：2010-04-28
申请人： John C. Colborn
发明人： John C. Colborn
IPC分类号： A61N1/00 , A61N1/02 , A61N1/36 , A61N1/378 , A61N1/08
CPC分类号： A61N1/025 , A61N1/08 , A61N1/36114 , A61N1/378
摘要： A method comprises applying a first open-loop electrical signal to a neural structure at a first rate. The method also comprises applying a closed-loop electrical signal to the neural structure in response to an event detection, thus causing an overall rate at which electrical stimulation is applied to the neural structure to exceed the first rate. The method further comprises applying a second open-loop electrical signal to a neural structure at a second rate that is lower than the first rate, thus causing the overall rate to be reduced to the first rate.
摘要翻译：一种方法包括以第一速率向神经结构施加第一开环电信号。该方法还包括响应于事件检测向神经结构应用闭环电信号，从而导致电刺激对神经结构施加超过第一速率的总速率。该方法还包括以低于第一速率的第二速率将神经结构应用第二开环电信号，从而使整体速率降低到第一速率。

6. 发明授权

US07818069B2 Ribbon electrode 失效
标题翻译：带状电极
公开(公告)号：US07818069B2
公开(公告)日：2010-10-19
申请号：US11829372
申请日：2007-07-27
申请人： John C. Colborn , J. Nick Marsh-Chetter , Shawn D. Kollatschny , Bryan Byerman
发明人： John C. Colborn , J. Nick Marsh-Chetter , Shawn D. Kollatschny , Bryan Byerman
IPC分类号： A61N1/00
CPC分类号： A61N1/0553
摘要： We disclose an electrode assembly comprising a ribbon electrode having a first surface and a second surface; a plurality of bosses disposed on the second surface of the ribbon electrode, wherein each boss has a third surface substantially not in contact with the second surface of the ribbon electrode and at least one boss is electrically conducting; and an insulator contacting substantially the entire second surface of the ribbon electrode and substantially the entire third surface of each boss; wherein the insulator is substantially not in contact with the first surface of the ribbon electrode. We also disclose an implantable medical device system comprising an implantable medical device for generating an electrical signal; an electrode assembly as described; and a lead wire electrically coupled to both the implantable medical device and at least one electrically conducting boss of the electrode assembly.
摘要翻译：我们公开了一种电极组件，其包括具有第一表面和第二表面的带状电极; 设置在带状电极的第二表面上的多个凸起，其中每个凸台具有与带状电极的第二表面基本不接触的第三表面，并且至少一个凸台是导电的; 以及基本上与所述带状电极的整个第二表面和基本上每个凸起的整个第三表面接触的绝缘体; 其中所述绝缘体基本上不与所述带状电极的第一表面接触。我们还公开了一种可植入医疗设备系统，其包括用于产生电信号的可植入医疗设备; 如上所述的电极组件; 以及引线，其电连接到所述可植入医疗装置和所述电极组件的至少一个导电凸台。

7. 发明申请

US20090030493A1 Ribbon Electrode 失效
标题翻译：丝带电极
公开(公告)号：US20090030493A1
公开(公告)日：2009-01-29
申请号：US11829372
申请日：2007-07-27
申请人： John C. Colborn , J. Nick Marsh-Chetter , Shawn D. Kollatschny , Bryan Byerman
发明人： John C. Colborn , J. Nick Marsh-Chetter , Shawn D. Kollatschny , Bryan Byerman
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： We disclose an electrode assembly comprising a ribbon electrode having a first surface and a second surface; a plurality of bosses disposed on the second surface of the ribbon electrode, wherein each boss has a third surface substantially not in contact with the second surface of the ribbon electrode and at least one boss is electrically conducting; and an insulator contacting substantially the entire second surface of the ribbon electrode and substantially the entire third surface of each boss; wherein the insulator is substantially not in contact with the first surface of the ribbon electrode. We also disclose an implantable medical device system comprising an implantable medical device for generating an electrical signal; an electrode assembly as described; and a lead wire electrically coupled to both the implantable medical device and at least one electrically conducting boss of the electrode assembly.
摘要翻译：我们公开了一种电极组件，其包括具有第一表面和第二表面的带状电极; 设置在带状电极的第二表面上的多个凸起，其中每个凸台具有与带状电极的第二表面基本不接触的第三表面，并且至少一个凸台是导电的; 以及基本上与所述带状电极的整个第二表面和基本上每个凸起的整个第三表面接触的绝缘体; 其中所述绝缘体基本上不与所述带状电极的第一表面接触。我们还公开了一种可植入医疗设备系统，其包括用于产生电信号的可植入医疗设备; 如上所述的电极组件; 以及引线，其电连接到所述可植入医疗装置和所述电极组件的至少一个导电凸台。

8. 发明授权

US08641646B2 Seizure detection using coordinate data 有权
标题翻译：使用坐标数据进行检测检测
公开(公告)号：US08641646B2
公开(公告)日：2014-02-04
申请号：US12847922
申请日：2010-07-30
申请人： John C. Colborn
发明人： John C. Colborn
IPC分类号： A61B5/00
CPC分类号： A61N1/37252 , A61B5/002 , A61B5/0215 , A61B5/0245 , A61B5/053 , A61B5/1112 , A61B5/1116 , A61B5/1118 , A61B5/4094 , A61B5/4836 , A61B5/6833 , A61B5/6847 , A61B2562/0219 , A61B2562/0247 , A61N1/36064 , A61N1/36114 , A61N1/36139 , A61N1/37282 , G06F19/00 , G06F19/3418 , G16H50/20
摘要： A seizure detection device includes a coordinate data interface configured to receive coordinate data for a human, a memory to store coordinate data for a defined location of the human, and a seizure detector configured to identify a seizure event responsive to the coordinate data.
摘要翻译：缉获检测装置包括被配置为接收人的坐标数据的坐标数据接口，存储器，用于存储针对人的定义位置的坐标数据;以及检测检测器，被配置为根据坐标数据识别发作事件。

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