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1. 发明申请

US20110174614A1 ELECTRODE, METHOD AND SYSTEM FOR DETERMINING AN ANALYTE IN A LIQUID MEDIUM 审中-公开
标题翻译：用于确定液体介质中的分析仪的电极，方法和系统
公开(公告)号：US20110174614A1
公开(公告)日：2011-07-21
申请号：US12999359
申请日：2009-06-10
申请人： Itamar Willner , Ran Tel-Vered , Ilina Baravik
发明人： Itamar Willner , Ran Tel-Vered , Ilina Baravik
IPC分类号： G01N27/30 , C25B11/04 , C25B9/00
CPC分类号： G01N33/5438 , C12Q1/001
摘要： Disclosed is an electrode for determining an analyte in a liquid medium, such as glucose in body subcutaneous fluids. The electrode includes a conductive surface and a matrix bound thereto. The matrix includes at least two species of components that comprise one or more species of enzymes and one or more species of metal nanonparticle. The components may be covalently bound to one another through one or more first binding moieties and the matrix may be covalently bound to the conductive surface through one or more same or different second binding moieties. The one or more enzyme species can catalyze a reaction in which an analyte is reacted to yield a product. The catalysis may alter the electric properties or response of the electrode.
摘要翻译：公开了一种用于确定液体介质中的分析物的电极，例如体内皮下液体中的葡萄糖。电极包括导电表面和与其结合的基体。该基质包括至少两种包含一种或多种酶和一种或多种金属纳米颗粒的组分。组分可以通过一个或多个第一结合部分彼此共价结合，并且基质可以通过一个或多个相同或不同的第二结合部分共价结合到导电表面。一种或多种酶物质可以催化其中分析物反应以产生产物的反应。催化可能改变电极的电性能或响应。

2. 发明申请

US20130000723A1 PHOTOCHEMICAL ELECTRODE, CONSTRUCTION AND USES THEREOF 审中-公开
标题翻译：光电化学电极，其结构及其用途
公开(公告)号：US20130000723A1
公开(公告)日：2013-01-03
申请号：US13635146
申请日：2011-03-24
申请人： Itamar Willner , Rachel Nechushtal , Ran Tel-Vered , Omer Yehezkeli , Ofer Israel Willner , Dan Roizman-Sade
发明人： Itamar Willner , Rachel Nechushtal , Ran Tel-Vered , Omer Yehezkeli , Ofer Israel Willner , Dan Roizman-Sade
IPC分类号： H01L31/0224 , C25D15/00
CPC分类号： H01G9/2059 , B82Y10/00 , H01L51/0093 , Y02E10/542 , Y02E10/549
摘要： The present invention provides an electrode comprising a conductive surface connected to a composite matrix of at least one noble metal nano-particle, at least one photo-catalytic element and at least one connecting group, photovoltaic cells and devices comprising said electrode and processes for preparing said electrode.
摘要翻译：本发明提供了一种电极，其包括连接到至少一种贵金属纳米颗粒，至少一种光催化元素和至少一个连接基团的复合基质的导电表面，包含所述电极的光伏电池和装置及其制备方法所述电极。

3. 发明申请

US20110177606A1 DETECTION OF TRINITROTOLUENE 审中-公开
标题翻译：三氯硝基苯的检测
公开(公告)号：US20110177606A1
公开(公告)日：2011-07-21
申请号：US13001972
申请日：2009-06-30
申请人： Itamar Willner , Ran Tel-Vered , Michael Riskin
发明人： Itamar Willner , Ran Tel-Vered , Michael Riskin
IPC分类号： G01N33/22 , G01N27/00 , B82Y30/00
CPC分类号： G01N33/0057 , G01N2600/00 , Y10T436/173076
摘要： An ultrasensitive method for detecting analytes in a sample is provided. The method involves the use of a matrix of nanoparticles which are associated with recognition groups capable of undergoing interaction with the analyte.
摘要翻译：提供了一种用于检测样品中分析物的超灵敏方法。该方法涉及使用与能够与分析物相互作用的识别基团相关联的纳米颗粒的基质。

4. 发明授权

US08597956B2 Method and device for detection of nitroamines 有权
标题翻译：硝基胺检测方法和装置
公开(公告)号：US08597956B2
公开(公告)日：2013-12-03
申请号：US13512380
申请日：2010-12-07
申请人： Itamar Willner , Ran Tel-Vered , Michael Riskin
发明人： Itamar Willner , Ran Tel-Vered , Michael Riskin
IPC分类号： G01N33/22 , G01N33/00 , G01N27/22 , G01N21/55
CPC分类号： G01N33/0057 , G01N21/554 , G01N2600/00 , Y10T436/14 , Y10T436/145555 , Y10T436/147777 , Y10T436/173845
摘要： An ultrasensitive method for detecting non-aromatic non-planar nitroamine analytes in a sample is provided.
摘要翻译：提供了一种用于检测样品中非芳族非平面硝基胺分析物的超灵敏方法。

5. 发明申请

US20120264222A1 Method and Device for Detection of Nitroamines 有权
标题翻译：硝基胺检测方法和装置
公开(公告)号：US20120264222A1
公开(公告)日：2012-10-18
申请号：US13512380
申请日：2010-12-07
申请人： Itamar Willner , Ran Tel-Vered , Michael Riskin
发明人： Itamar Willner , Ran Tel-Vered , Michael Riskin
IPC分类号： G01N33/22 , G01N27/22 , G01N21/55 , B82Y15/00
CPC分类号： G01N33/0057 , G01N21/554 , G01N2600/00 , Y10T436/14 , Y10T436/145555 , Y10T436/147777 , Y10T436/173845
摘要： An ultrasensitive method for detecting non-aromatic non-planar nitroamine analytes in a sample is provided.
摘要翻译：提供了一种用于检测样品中非芳族非平面硝基胺分析物的超灵敏方法。

6. 发明申请

US20110094582A1 PHOTOCHEMICAL ELECTRODE, CONSTRUCTION AND USES THEREOF 审中-公开
标题翻译：光电化学电极，其结构及其用途
公开(公告)号：US20110094582A1
公开(公告)日：2011-04-28
申请号：US12994821
申请日：2009-06-28
申请人： Itamar Willner , Ran Tel-Vered , Huseyin Bekir Yildiz
发明人： Itamar Willner , Ran Tel-Vered , Huseyin Bekir Yildiz
IPC分类号： H01L31/0352 , H01L29/15 , H01L21/20 , B82Y99/00
CPC分类号： H01L51/426 , B82Y30/00 , C01G7/00 , C01G11/00 , C01P2004/62 , C01P2004/64 , C01P2006/40 , C09K11/565 , Y02E10/549
摘要： Provided is an electrode including a conductive surface connected to a matrix; the matrix including a plurality of semiconductor nanoparticles and noble metal nanoparticles, substantially each of which is connected to another nanoparticle of the plurality of nanoparticles by at least one matrix connecting group and at least a portion of the plurality of nanoparticles of the matrix is each connected to the conductive surface by at least one surface connecting group. Further provided are photovoltaic cells and devices including electrode of the invention.
摘要翻译：提供了包括连接到基体的导电表面的电极; 所述基质包括多个半导体纳米颗粒和贵金属纳米颗粒，其基本上各自通过至少一个矩阵连接基团连接到所述多个纳米颗粒的另一纳米颗粒，并且所述基质的所述多个纳米颗粒的至少一部分各自连接通过至少一个表面连接组到导电表面。还提供了包括本发明的电极的光伏电池和器件。

7. 发明授权

US07135295B1 Detection of small molecules by use of a piezoelectric sensor 失效
标题翻译：通过使用压电传感器检测小分子
公开(公告)号：US07135295B1
公开(公告)日：2006-11-14
申请号：US09889936
申请日：2000-01-25
申请人： Itamar Willner , Zelig Eshhar
发明人： Itamar Willner , Zelig Eshhar
IPC分类号： G01N33/53
CPC分类号： C07K16/00 , G01N33/54373
摘要： A protein comprising an antigen-binding portion formed by two cooperating peptide sequences of FIGS. 3A and 3B of the application. The protein may alternatively comprise an altered antigen-binding portion where at least one of the peptide sequences is an altered sequence, an altered sequence being a sequence of FIG. 3A or 3B in which one or more of an amino acid residue has been added, deleted or replaced by another amino acid residue. The altered antigen-binding portion retains substantially the same antigen-binding specificity as said antigen-binding portion. Also disclosed are apparatus, systems and methods for detecting small assayed molecules in a sample using the protein.
摘要翻译：包含由图1和2的两个协同肽序列形成的抗原结合部分的蛋白质。 3 A和3 B的应用程序。蛋白质可以可选地包含改变的抗原结合部分，其中至少一个肽序列是改变的序列，改变的序列是图1的序列。 3 A或3 B，其中一个或多个氨基酸残基已经被另一个氨基酸残基加入，缺失或替换。改变的抗原结合部分保持与所述抗原结合部分基本相同的抗原结合特异性。还公开了用于使用蛋白质检测样品中的小测定分子的装置，系统和方法。

8. 发明申请

US20050130248A1 Biosensor carrying redox enzymes 审中-公开
标题翻译：携带氧化还原酶的生物传感器
公开(公告)号：US20050130248A1
公开(公告)日：2005-06-16
申请号：US10503465
申请日：2003-01-30
申请人： Itamar Willner , Eugenii Katz , Maya Zayats
发明人： Itamar Willner , Eugenii Katz , Maya Zayats
IPC分类号： C12Q1/00 , C12Q1/54
CPC分类号： C12Q1/004
摘要： The present invention concerns an electrode carrying immobilized redox enzymes such that electric charge can flow between an electron mediator group to the enzyme cofactor by the use of boronic acid or a boronic acid derivative that acts as a linker moiety between the cofactor and the electron mediator group. The invention also concerns devices and systems that make use of the electrode of the invention, such as biosensors and fuel cells, the electrode being one of the components thereof.
摘要翻译：本发明涉及携带固定化氧化还原酶的电极，使得电荷可以通过使用硼酸或作为辅因子和电子介体基团之间的连接体部分的硼酸衍生物在电子介体基团与酶辅因子之间流动。本发明还涉及利用本发明的电极，例如生物传感器和燃料电池的电极是其组成部分之一的装置和系统。

9. 发明授权

US5443701A Electrobiochemical analytical method and electrodes 失效
标题翻译：电化学分析方法和电极
公开(公告)号：US5443701A
公开(公告)日：1995-08-22
申请号：US109922
申请日：1993-08-23
申请人： Itamar Willner , Evgeny Katz , Azalia Riklin , Ron Kasher , Benjamin Shoham
发明人： Itamar Willner , Evgeny Katz , Azalia Riklin , Ron Kasher , Benjamin Shoham
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/26
CPC分类号： C12Q1/004 , C12Q1/003 , Y10S435/817
摘要： An analytical method for determining the presence or concentration of an analyte in a liquid medium is provided in which electrons are transferred from an electrode material of an electrode to the redox center of an enzyme, by the mediation of an electron mediator, whereby in the presence of an analyte the enzyme calalyzed a redox reaction in which the analyte is converted into a product. By measuring either the concentration or the product or the charge which flows in this process, the presence and/or concentration of the analyte in the medium is determined. Either or both of the enzyme and the electron mediator are immobilized on the electrode.
摘要翻译：提供了一种用于确定液体介质中分析物的存在或浓度的分析方法，其中电子通过电子介体的介导从电极的电极材料转移到酶的氧化还原中心，由此在存在的分析物，酶催化氧化还原反应，其中分析物转化成产物。通过测量在该过程中流动的浓度或产物或电荷，确定介质中分析物的存在和/或浓度。酶和电子介体中的任一个或两者被固定在电极上。

10. 发明授权

US07485212B2 Self-powered biosensor 失效
标题翻译：自供电生物传感器
公开(公告)号：US07485212B2
公开(公告)日：2009-02-03
申请号：US10487694
申请日：2002-08-12
申请人： Itamar Willner , Evgeny Katz
发明人： Itamar Willner , Evgeny Katz
IPC分类号： G01N27/327
CPC分类号： H01M8/16 , C12Q1/004 , Y02E60/527
摘要： The present invention provides a system for the determination of an analyte in a liquid medium. The system comprises a self-powered biosensor and a detector for measuring an electrical signal generated by said biosensor while the analyte is being oxidized or reduced, the biosensor comprising a pair of electrodes, one of the electrodes being an anode and the other a cathode, both of which carry redox enzymes on their surface. An enzyme carried on one of the electrodes can catalyze an oxidation or reduction reaction in which the analyte is oxidized or reduced, respectively, and the other of said pair of electrodes carries on its surface enzymes that can catalyze a reaction in which the oxidizer or the reducer are reduced or oxidized, respectively, in the presence of the analyte.
摘要翻译：本发明提供了一种用于确定液体介质中的分析物的系统。该系统包括自供电的生物传感器和用于在分析物被氧化或还原时测量由所述生物传感器产生的电信号的检测器，所述生物传感器包括一对电极，一个电极是阳极，另一个是阴极，两者都在其表面携带氧化还原酶。携带在其中一个电极上的酶可以催化氧化或还原反应，其中分析物分别被氧化或还原，并且所述一对电极中的另一个在其表面上承载可以催化反应的酶，其中氧化剂或还原剂分别在分析物存在下还原或氧化。

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