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1. 发明申请

US20090104119A1 Dendrimer Based Compositions And Methods Of Using The Same 审中-公开
标题翻译：基于树枝状聚合物的组合物及其使用方法
公开(公告)号：US20090104119A1
公开(公告)日：2009-04-23
申请号：US11661465
申请日：2005-08-25
申请人： Istvan J. Majoros , Thommey P. Thomas , James R. Baker , Zhengyi Cao , Jolanta F. Kukowska-Latallo
发明人： Istvan J. Majoros , Thommey P. Thomas , James R. Baker , Zhengyi Cao , Jolanta F. Kukowska-Latallo
IPC分类号： A61K47/48 , C08G69/26 , A61P35/00 , A61K31/519 , A61K51/06 , A61K38/00 , A61K49/00 , A61K31/166 , A61K31/675 , A61K31/4375 , A61K31/704 , A61K31/407 , A61K31/7048 , A61K31/138 , A61K31/337 , A61K31/505 , A61K31/7088 , A61K39/395 , A61K39/385
CPC分类号： C08G83/003 , A61K47/595 , A61K47/64 , A61K49/0041 , A61K49/0043 , A61K49/0054 , C08G73/0206 , C08G73/028
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及用于疾病诊断和治疗（例如癌症诊断和治疗）的基于树枝状大分子的多功能组合物和系统。组合物和系统包含用于靶向，成像，感测和/或提供治疗或诊断材料并监测对细胞或组织（例如肿瘤）的治疗的反应的一种或多种组分。

2. 发明授权

US09223064B2 Photonic crystal-metallic structures and applications 有权
标题翻译：光子晶体金属结构及应用
公开(公告)号：US09223064B2
公开(公告)日：2015-12-29
申请号：US13700378
申请日：2011-05-26
申请人： Yunbo Guo , Theodore B. Norris , James R. Baker , Lingjie Jay Guo , Nils G. Walter
发明人： Yunbo Guo , Theodore B. Norris , James R. Baker , Lingjie Jay Guo , Nils G. Walter
IPC分类号： G02B5/00 , G02B1/00 , B82Y20/00
CPC分类号： G02B5/008 , B82Y20/00 , G02B1/005 , Y10S977/70
摘要： A photonic crystal-metallic (PCM) structure receives an input light signal from a light source. The PCM structure includes a metal structure and a photonic crystal structure disposed adjacent the metal structure. The photonic crystal structure is configured to receive the input light signal such that the input light signal excites surface plasmons of the metallic structure and such that the input light signal is internally reflected within the photonic crystal structure.
摘要翻译：光子晶体金属（PCM）结构接收来自光源的输入光信号。 PCM结构包括邻近金属结构设置的金属结构和光子晶体结构。光子晶体结构被配置为接收输入光信号，使得输入光信号激发金属结构的表面等离子体，并且使得输入光信号在光子晶体结构内部被反射。

3. 发明授权

US08703164B2 Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof 有权
标题翻译：用于灭活病原微生物的组合物，制备组合物的方法及其使用方法
公开(公告)号：US08703164B2
公开(公告)日：2014-04-22
申请号：US11930535
申请日：2007-10-31
申请人： Ted C. Annis , James R. Baker , Tarek Hamouda
发明人： Ted C. Annis , James R. Baker , Tarek Hamouda
IPC分类号： A01N25/00 , A01N33/12 , A61K9/00
CPC分类号： A01N25/04 , A01N25/02 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0073 , A61K9/1075 , A61K31/7048 , A61K39/00 , A61K2039/5252 , C12N7/00 , C12N2760/16163
摘要： Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
摘要翻译：描述了显示出微生物的广谱灭活或预防疾病的低毒性的纳米乳剂组合物。纳米乳剂含有水相，包含油和有机溶剂的油相和一种或多种表面活性剂。还提供了制备纳米乳剂和灭活病原微生物的方法。

4. 发明授权

US08486371B2 Quantitative two-photon flow cytometry 有权
标题翻译：定量双光子流式细胞术
公开(公告)号：US08486371B2
公开(公告)日：2013-07-16
申请号：US11662835
申请日：2005-09-16
申请人： Jing Yong Ye , Theodore B. Norris , Cheng Frank Zhong , James R. Baker
发明人： Jing Yong Ye , Theodore B. Norris , Cheng Frank Zhong , James R. Baker
IPC分类号： A61K49/00
CPC分类号： G01N15/1459 , G01N15/1404 , G01N15/1484 , G01N2015/1075 , G01N2015/145 , G01N2015/1472 , G01N2015/1493
摘要： A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
摘要翻译：使用流式细胞仪对颗粒进行多染色分析的方法和装置。该方法包括使用两种或更多种染料染色待检测的颗粒; 以不均匀的流动促使颗粒通过毛细管; 使用多光子激发激光束激发毛细管内的第一颗粒，使得两种或更多种染料各自发荧光，从而分别产生第一输出信号和第二输出信号; 以及检测第一输出信号和第二输出信号。使用多光子激发激光束激发毛细管内的第二颗粒，使得两种或更多种染料各自发出荧光，从而分别产生第三输出信号和第四输出信号。该方法最后包括将第一输出信号和第二输出信号的比率与第三输出信号和第四输出信号的比率进行比较，以检测颗粒中期望的变化。

5. 发明授权

US07796675B1 Burst spread spectrum radio system and method for site monitoring 有权
标题翻译：突发扩频无线电系统和现场监测方法
公开(公告)号：US07796675B1
公开(公告)日：2010-09-14
申请号：US12046950
申请日：2008-03-12
申请人： David Carter , Sy Prestwich , James R. Baker , Scott Bevan
发明人： David Carter , Sy Prestwich , James R. Baker , Scott Bevan
IPC分类号： H04B1/00
CPC分类号： H04J13/102 , G08B25/007 , G08B25/009 , G08B25/10 , H04J13/0022
摘要： A device for site monitoring is disclosed. The device may include a communication interface configured to receive site monitoring data from a site monitoring system. The communication interface may also be configured to wirelessly transmit the site monitoring data to a base station. The site monitoring data may include a device identification. The device also may include a processor and memory. The memory also may include two pseudonoise (PN) codes, namely a first PN code and a second PN code. The site monitoring data may be received from the site monitoring system. The site monitoring data may be spread using the first PN code to provide first spread site monitoring data. The first spread site monitoring data may be spread using the second PN code to provide second spread site monitoring data. The second spread site monitoring data may be transmitted using a burst direct sequence spread spectrum radio signal.
摘要翻译：公开了一种用于现场监控的设备。该设备可以包括被配置为从站点监视系统接收站点监视数据的通信接口。通信接口还可以被配置为将站点监视数据无线地发送到基站。站点监视数据可以包括设备标识。该设备还可以包括处理器和存储器。存储器还可以包括两个伪噪声（PN）码，即第一PN码和第二PN码。站点监视数据可以从站点监视系统接收。可以使用第一PN码来传播站点监视数据，以提供第一扩散站监视数据。可以使用第二PN码来扩展第一扩散站点监视数据，以提供第二扩散站点监视数据。可以使用突发直接序列扩频无线电信号来发送第二扩展站点监视数据。

6. 发明授权

US07314624B2 Nanoemulsion vaccines 有权
标题翻译：纳米乳剂疫苗
公开(公告)号：US07314624B2
公开(公告)日：2008-01-01
申请号：US10162970
申请日：2002-06-05
申请人： James R. Baker , Tarek Hamouda
发明人： James R. Baker , Tarek Hamouda
IPC分类号： A61K39/12
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
摘要翻译：本发明提供了用于刺激免疫应答的方法和组合物。具体地，本发明提供了使用纳米乳液化合物作为粘膜佐剂以诱导对环境病原体免疫的方法和组合物。因此，在一些实施方案中，本发明提供了包含纳米乳剂和衍生自病原体的灭活病原体或蛋白质的纳米乳剂疫苗。因此，本发明提供了针对各种环境和人释放的病原体的改进的疫苗。

7. 发明授权

US08747872B2 Nanoemulsion therapeutic compositions and methods of using the same 有权
标题翻译：纳米乳剂治疗组合物及其使用方法
公开(公告)号：US08747872B2
公开(公告)日：2014-06-10
申请号：US12114573
申请日：2008-05-02
申请人： James R. Baker , Sivaprakash Rathinavelu , Paul E. Makidon , John J. LiPuma , Shraddha Nigavekar
发明人： James R. Baker , Sivaprakash Rathinavelu , Paul E. Makidon , John J. LiPuma , Shraddha Nigavekar
IPC分类号： A01N25/00 , A61K9/00 , A01N25/04 , A61K9/107 , A61K6/00
CPC分类号： A61K31/198 , A01N25/04 , A23L29/10 , A23L33/135 , A23V2002/00 , A61K6/0008 , A61K9/0078 , A61K9/1075 , A61K31/22 , A61K31/337 , A61K31/573 , A61K31/7048 , A61K33/14 , A61K45/06 , A61K47/32 , B82Y5/00 , A23V2200/25
摘要： The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
摘要翻译：本发明涉及治疗肺部感染的方法和组合物。特别地，本发明提供纳米乳剂组合物及其使用方法来治疗与生物膜相关的细菌（例如在肺部感染中发现）。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物），工业和研究应用。

8. 发明授权

US07729767B2 Implantable generating system 失效
标题翻译：植入式发电系统
公开(公告)号：US07729767B2
公开(公告)日：2010-06-01
申请号：US11058403
申请日：2005-02-15
申请人： Rex M. Baker, III , James R. Baker
发明人： Rex M. Baker, III , James R. Baker
IPC分类号： A61N1/378
CPC分类号： A61N1/3785
摘要： An implantable generating system includes a generator assembly configured to be positioned within a living organism for converting mechanical motion into electrical energy. A linkage assembly is configured to be positioned within the living organism for mechanically coupling the generator assembly with one or more body parts displaceable during respiratory-based diaphragm motion.
摘要翻译：植入式发电系统包括发电机组件，其被配置为定位在活体内用于将机械运动转换为电能。连杆组件被配置为定位在活体内，用于将发生器组件与在基于呼吸的隔膜运动期间可移位的一个或多个主体部件机械联接。

9. 发明授权

US5714166A Bioactive and/or targeted dendrimer conjugates 失效
标题翻译：生物活性和/或靶向树枝状大分子缀合物
公开(公告)号：US5714166A
公开(公告)日：1998-02-03
申请号：US400203
申请日：1995-03-07
申请人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
发明人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
IPC分类号： C12N15/02 , A01N25/10 , A61K20060101 , A61K31/70 , A61K38/00 , A61K39/385 , A61K39/44 , A61K45/00 , A61K47/34 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/00 , C07C211/29 , C07C233/11 , C07C237/20 , C07K20060101 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/555 , C07K17/06 , C07K17/08 , C08G73/00 , C08G83/00 , C08L101/00 , C12N20060101 , C12N5/10 , C12N15/09 , C12N15/57 , C12N15/87 , C12P21/02 , C12P21/08 , C12R1/91 , A61K31/74 , A61K9/14 , A61K31/785
CPC分类号： A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/4823 , A61K47/48961 , A61K49/085 , A61K49/124 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.
摘要翻译：已经制备了由载体材料可以是生物反应调节剂的至少一种携带材料的至少一个单元组成的树枝状聚合物共轭物。缀合物还可以存在目标导向剂，并且当其存在时，所携带的材料可以是生物活性剂。优选的树枝状聚合物是与生物反应调节剂复合的致密星形聚合物。这些共轭物和配合物由于其独特的特性而具有特别有利的性质。

10. 发明授权

US3951869A Modified zinc ferrite oxidative dehydrogenation catalysts 失效
标题翻译：改性锌铁氧体脱氢催化剂
公开(公告)号：US3951869A
公开(公告)日：1976-04-20
申请号：US502775
申请日：1974-09-03
申请人： James R. Baker
发明人： James R. Baker
IPC分类号： C07D213/127 , B01J23/80 , B01J23/889 , C07B31/00 , C07B35/04 , C07B61/00 , C07C1/00 , C07C5/48 , C07C5/56 , C07C11/00 , C07C17/00 , C07C17/357 , C07C21/04 , C07C67/00
CPC分类号： C07C5/56 , B01J23/8892 , C07C5/48 , Y10S585/906
摘要： Improved oxidative dehydrogenation catalysts are prepared by modifying a zinc ferrite oxidative dehydrogenation catalyst with manganese oxide. The resulting catalyst compositions exhibit higher conversions and yields.
摘要翻译：通过用氧化锰改性锌铁氧体脱氢催化剂制备改进的氧化脱氢催化剂。所得催化剂组合物显示出更高的转化率和产率。

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