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1. 发明申请

US20090104119A1 Dendrimer Based Compositions And Methods Of Using The Same 审中-公开
标题翻译：基于树枝状聚合物的组合物及其使用方法
公开(公告)号：US20090104119A1
公开(公告)日：2009-04-23
申请号：US11661465
申请日：2005-08-25
申请人： Istvan J. Majoros , Thommey P. Thomas , James R. Baker , Zhengyi Cao , Jolanta F. Kukowska-Latallo
发明人： Istvan J. Majoros , Thommey P. Thomas , James R. Baker , Zhengyi Cao , Jolanta F. Kukowska-Latallo
IPC分类号： A61K47/48 , C08G69/26 , A61P35/00 , A61K31/519 , A61K51/06 , A61K38/00 , A61K49/00 , A61K31/166 , A61K31/675 , A61K31/4375 , A61K31/704 , A61K31/407 , A61K31/7048 , A61K31/138 , A61K31/337 , A61K31/505 , A61K31/7088 , A61K39/395 , A61K39/385
CPC分类号： C08G83/003 , A61K47/595 , A61K47/64 , A61K49/0041 , A61K49/0043 , A61K49/0054 , C08G73/0206 , C08G73/028
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及用于疾病诊断和治疗（例如癌症诊断和治疗）的基于树枝状大分子的多功能组合物和系统。组合物和系统包含用于靶向，成像，感测和/或提供治疗或诊断材料并监测对细胞或组织（例如肿瘤）的治疗的反应的一种或多种组分。

2. 发明授权

US5840814A Multi-arm star polymers having a well-defined core and methods for the synthesis thereof 失效
标题翻译：具有明确核心的多臂星形聚合物及其合成方法
公开(公告)号：US5840814A
公开(公告)日：1998-11-24
申请号：US693418
申请日：1996-08-07
申请人： Istvan J. Majoros , Timea M. Marsalko , Joseph P. Kennedy
发明人： Istvan J. Majoros , Timea M. Marsalko , Joseph P. Kennedy
IPC分类号： C07C43/215 , C07C69/00 , C07C69/712 , C08F8/14 , C08G77/38 , C08G77/52 , C08G81/02 , C08G85/00
CPC分类号： C07C43/215 , C07C69/00 , C08G77/38 , C08G77/52 , C08G81/024 , C07C2103/00 , C07C2103/92
摘要： The synthesis of star polymers having well-defined arms emanating from well-defined and readily controllable calix�n!arene (n=4 to 16) cores are described. The synthesis is particularly suitable for polyisobutylene and/or polysiloxane star polymers. The synthesis has been achieved using carbocationic and/or anionic ring-opening polymerization techniques to form polymer arms of desired molecular weights, then separately preparing the calixarene derivative core, and finally, linking the arms to the core by transesterification or hydrosilation.
摘要翻译：描述了从明确定义且容易控制的杯[n]芳烃（n = 4至16）核发出具有明确定义的臂的星形聚合物的合成。该合成特别适用于聚异丁烯和/或聚硅氧烷星形聚合物。已经使用碳阳离子和/或阴离子开环聚合技术来合成以形成所需分子量的聚合物臂，然后单独制备杯芳烃衍生物核心，最后通过酯交换或硅氢化将臂与核心连接。

3. 发明授权

US5804664A Star polymers having multiple arms emanating from a calixarene core, initiators therefor, and method for the synthesis thereof 失效
标题翻译：具有从杯芳烃核心发出的多臂的星形聚合物，其引发剂及其合成方法
公开(公告)号：US5804664A
公开(公告)日：1998-09-08
申请号：US862581
申请日：1997-05-23
申请人： Joseph P. Kennedy , Istvan J. Majoros , Sunny Jacob
发明人： Joseph P. Kennedy , Istvan J. Majoros , Sunny Jacob
IPC分类号： C08F4/14 , C08F10/10 , C08F297/06 , C08L53/02
CPC分类号： C08F297/06 , C08F10/10
摘要： The synthesis and characterization of novel linear polymers and multi-arm star polymers comprising polyisobutylene arms connected to a well-defined calixarene core are described. The synthesis has been achieved using the "core first" method wherein multifunctional calix�n!arene (where n=4 to 16) derivatives or their monofunctional analogues are used as initiators which, in conjunction with certain Freidel-Crafts acids as co-initiators, induce the living polymerization of isobutylene or a similar carbocationic polymerizable monomer to form star polymers or block copolymers. Novel initiators suitable for inducing the polymerization are also described.
摘要翻译：描述了包含连接到明确定义的杯芳烃核心的聚异丁烯臂的新型线性聚合物和多臂星形聚合物的合成和表征。使用其中多功能杯[n]芳烃（其中n = 4至16）衍生物或其单官能类似物用作引发剂的“核心优先”方法已经实现了合成，其结合某些Freidel-Crafts酸作为共引发剂诱导异丁烯或类似的碳阳离子聚合单体的活性聚合形成星形聚合物或嵌段共聚物。还描述了适合于引发聚合的新型引发剂。

4. 发明授权

US5395885A Multi-arm cationic star-polymers 失效
标题翻译：多臂阳离子星形聚合物
公开(公告)号：US5395885A
公开(公告)日：1995-03-07
申请号：US169434
申请日：1993-12-17
申请人： Joseph P. Kennedy , Timea M. Marsalko , Istvan J. Majoros
发明人： Joseph P. Kennedy , Timea M. Marsalko , Istvan J. Majoros
IPC分类号： C08F293/00 , C08F297/00 , C08G81/00
CPC分类号： C08F297/00
摘要： The first synthesis of a multi-arm radial-star polyisobutylene is described. The synthesis occurred by the addition of excess divinylbenzene (DVB) linking reagent to a living polyisobutylene (PIB.sup..sym.), charge, i.e., by the "arm first" method under specific conditions. The radial structure of the star-PIB was proven by determining the molecular weight of a sample by light scattering, then selectively destroying the aromatic polydivinylbenzene core, and finally determining the molecular weight of the surviving aliphatic PIB arms. The synthesis strategy, kinetic observations during synthesis, and procedures leading to a representative star-PIB are described. This product whose M.sub.w =1,134,400 g/mole with M.sub.w /M.sub.n =2.83, contained .about.90.3 mole % (.about.78 wt. %) PIB arms and .about.9.7 mole % (.about.22 wt. %) aromatic core; thus the number of PIB arms emanating from the core was N.sub.n, arm =56 or N.sub.w, arm (weight average number of arms)=110.
摘要翻译：描述了多臂径向星形聚异丁烯的第一次合成。通过在特定条件下通过加入过量的二乙烯基苯（DVB）连接试剂与活性聚异丁烯（PIB（+））进行合成，即通过“臂第一”方法进行加料。通过用光散射确定样品的分子量，然后选择性地破坏芳族聚二乙烯基苯核心，最后确定存活的脂族PIB臂的分子量，证明了星形PIB的径向结构。描述了合成策略，合成过程中的动力学观察以及导致代表性的星形-PIB的程序。该产品的＆upbar＆Mw = 1,134,400克/摩尔＆lt;上升＆Mw /＆upbar＆Mn = 2.83，含有差异90.3摩尔％（差异78重量％）PIB臂和差异9.7摩尔％（差异22重量％）芳香核; 因此从核心发出的PIB武器的数量是＆upbar＆Nn，arm = 56或＆upbar＆Nw，手臂（重量平均臂数）= 110。

5. 发明授权

US07078461B2 Biocompatible dendrimers 失效
标题翻译：生物相容性树枝状大分子
公开(公告)号：US07078461B2
公开(公告)日：2006-07-18
申请号：US10431956
申请日：2003-05-08
申请人： Donald A. Tomalia , Istvan J. Majoros
发明人： Donald A. Tomalia , Istvan J. Majoros
IPC分类号： C08L67/00 , C08G63/48
CPC分类号： C08L79/02 , C08L2205/02 , C12N15/895 , C08L2666/20
摘要： The present invention relates to compositions and methods involving biocompatible dendrimers. In particular, the present invention provides dendrimeric copolymers with poly(propyleneimine) (POPAM) interiors and poly(amidoamine) (PAMAM) exteriors for use in transfection and imaging applications.
摘要翻译：本发明涉及涉及生物相容性树枝状大分子的组合物和方法。特别地，本发明提供了用于转染和成像应用的聚（丙烯亚胺）（POPAM）内部和聚（酰氨基胺）（PAMAM）外观的树枝状聚合物。

6. 发明授权

US5844056A Star polymers having multiple polyisobutylene arms emanating from a calixarene core, initiators therefor, and method for the synthesis thereof 失效
标题翻译：具有从杯芳烃核发出的多个聚异丁烯臂的星形聚合物，其引发剂及其合成方法
公开(公告)号：US5844056A
公开(公告)日：1998-12-01
申请号：US693433
申请日：1996-08-07
申请人： Joseph P. Kennedy , Istvan J. Majoros , Sunny Jacob
发明人： Joseph P. Kennedy , Istvan J. Majoros , Sunny Jacob
IPC分类号： C08F4/14 , C08F10/10 , C08F297/06 , C07C43/225 , C07C43/23
CPC分类号： C08F297/06 , C08F10/10 , Y10S525/918 , Y10S526/941
摘要： The synthesis and characterization of novel linear polymers and multi-arm star polymers comprising polyisobutylene arms connected to a well-defined calixarene core are described. The polymers are directly telechelic. They synthesis has been achieved using the "core first" method wherein multifunctional calix�n!arene (where n=4 to 16) derivatives or their monofunctional analogues are used as initiators which, in conjunction with certain Freidel-Crafts acids as co-initiators, induce the living polymerization of isobutylene or a similar carbocationic polymerizable monomer. Novel initiators suitable for inducing the polymerization are also described.
摘要翻译：描述了包含连接到明确定义的杯芳烃核心的聚异丁烯臂的新型线性聚合物和多臂星形聚合物的合成和表征。聚合物是直接遥爪的。使用其中多功能杯[n]芳烃（其中n = 4至16）衍生物或其单官能类似物用作引发剂的“核心优先”方法已经实现了它们的合成，这些引发剂与某些Freidel-Crafts酸作为共引发剂诱导异丁烯或类似的碳阳离子聚合性单体的活性聚合。还描述了适合于引发聚合的新型引发剂。

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