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1. 发明授权

US5217493A Antibacterial coated medical implants 失效
标题翻译：抗菌涂层医疗植入物
公开(公告)号：US5217493A
公开(公告)日：1993-06-08
申请号：US850197
申请日：1992-03-11
申请人： Issam I. Raad , Rabih O. Darouiche
发明人： Issam I. Raad , Rabih O. Darouiche
IPC分类号： A61L29/00 , A01N1/02 , A61K31/65 , A61L27/00 , A61L27/54 , A61L29/16 , A61M25/00
CPC分类号： A61K31/65 , A61K31/70 , A61L27/54 , A61L29/16 , A61L2300/406 , A61L2300/45 , A61L2300/606
摘要： An implantable medical device having long lasting resistance to staphylococcal biofilm colonization is provided. Implantable medical devices such as catheters, shunts, prosthesis, pacemakers, etc. are susceptible to colonization by biofilm adherent microorganisms, especially staphylococci. While systemic staphylococcal infections are effectively treated by many antibiotics, vancomycin being the antibiotic of choice, this same bacteria when encased in biofilm adhering to indwelling medical devices is generally resistant to antibiotic treatment. By the present invention, the combination of rifampin and minocycline or the combination of rifampin and novobiocin when coated on the surfaces of implantable medical devices unexpectedly provides superior antibacterial activity against staphylococcal biofilm colonization on the coated surface of indwelling medical devices.
摘要翻译：提供了具有对葡萄球菌生物膜定植具有长期抗性的可植入医疗装置。诸如导管，分流器，假体，起搏器等的植入式医疗装置易受生物膜粘附微生物特别是葡萄球菌的定植。虽然系统性葡萄球菌感染被许多抗生素有效地治疗，万古霉素是选择的抗生素，但是当包裹在附着在留置医疗器械上的生物膜中时，这种相同的细菌通常抗抗生素治疗。通过本发明，当涂覆在可植入医疗装置的表面上时，利福平和米诺环素的组合或利福平和新生霉素的组合意外地在留置医疗装置的涂覆表面上提供了优异的抗葡萄球菌生物膜定植的抗细菌活性。

2. 发明授权

US5902283A Antimicrobial impregnated catheters and other medical implants 失效
标题翻译：抗菌浸渍导管和其他医疗植入物
公开(公告)号：US5902283A
公开(公告)日：1999-05-11
申请号：US824595
申请日：1997-03-26
申请人： Rabih O. Darouiche , Issam Raad
发明人： Rabih O. Darouiche , Issam Raad
IPC分类号： A61M25/00 , A61F2/00 , A61F2/06 , A61F2/24 , A61F2/26 , A61L27/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L33/00 , A61M25/16
CPC分类号： A61L29/16 , A61L27/54 , A61F2/26 , A61F2250/0067 , A61L2300/404 , A61L2300/406 , A61L2300/802 , A61M25/0017
摘要： A non-metallic antimicrobial impregnated medical implant, such as a catheter, and a method for impregnating a non-metallic medical implant with an antimicrobial agent is provided. The method for making the impregnated implant comprises the steps of forming an antimicrobial composition of an effective concentration to inhibit the growth of organisms, such as staphylococci, other gram-positive bacteria, gram-negative bacilli and Candida and applying the antimicrobial composition to at least a portion of the medical implant under conditions where the antimicrobial composition permeates the material of the medical implant. The antimicrobial composition is formed by dissolving an antimicrobial agent in an organic solvent, adding a penetrating agent to the composition, and adding an alkalinizing agent to the composition. The antimicrobial composition is preferably heated to a temperature between about 30.degree. C. and 70.degree. C. prior to applying the composition to the medical implant to enhance the adherence of the antimicrobial agent to the medical implant material. After the impregnated implant is removed from the antimicrobial solution, the impregnated implant is allowed to dry then rinsed with a liquid and milked to remove excess granular deposits and ensure uniform color of the impregnated implant.
摘要翻译：提供非金属抗菌浸渍医用植入物，例如导管，以及用抗微生物剂浸渍非金属医用植入物的方法。制备浸渍植入物的方法包括以下步骤：形成有效浓度的抗微生物组合物，以抑制诸如葡萄球菌，其它革兰氏阳性菌，革兰氏阴性杆菌和假丝酵母等生物体的生长，并将抗微生物组合物施用至少医疗植入物的一部分在抗微生物组合物渗透到医用植入物的材料的条件下。抗微生物组合物通过将抗微生物剂溶解在有机溶剂中，向组合物中加入渗透剂，并向组合物中加入碱化剂形成。在将组合物施用于医用植入物之前，抗微生物组合物优选加热至约30℃至70℃之间的温度，以增强抗微生物剂对医用植入材料的粘附性。在将浸渍的植入物从抗微生物溶液中取出后，将浸渍的植入物干燥，然后用液体冲洗并挤压以除去多余的颗粒沉积物，并确保浸渍的植入物的均匀颜色。

3. 发明授权

US5853745A Medical implant having a durable, resilient and effective antimicrobial coating 失效
标题翻译：医疗植入物具有耐用，有弹性和有效的抗微生物涂层
公开(公告)号：US5853745A
公开(公告)日：1998-12-29
申请号：US824596
申请日：1997-03-26
申请人： Rabih O. Darouiche
发明人： Rabih O. Darouiche
IPC分类号： A61F2/00 , A61F2/30 , A61L27/28 , A61L27/34 , A61F2/02 , A61M25/00
CPC分类号： A61L27/34 , A61F2/30767 , A61L27/28 , A61F2002/3007 , A61F2002/30677 , A61F2002/30929
摘要： A medical implant, such as an orthopedic implant, having a first antimicrobial coating layer and a second protective layer, and a method for coating such an implant is provided. The medical implant has one or more of its surfaces coated with an antimicrobial coating layer and a protective coating layer formed over the antimicrobial coating layer. The protective coating layer includes a durable coating layer composed of material such as collodion and nylon, and a resilient coating layer composed of material such as collodion. The coating layers are applied by applying an antimicrobial coating layer to at least a portion of the surfaces of the medical implant, applying a durable coating layer over the antimicrobial coating layer, and applying a resilient coating layer over the durable coating layer.
摘要翻译：提供了具有第一抗微生物涂层和第二保护层的医疗植入物，例如矫形植入物，以及用于涂覆这种植入物的方法。医疗植入物具有一个或多个表面，其涂覆有抗微生物涂层和形成在抗微生物涂层上的保护性涂层。保护涂层包括由诸如火棉和尼龙的材料组成的耐久涂层，以及由诸如火棉胶的材料构成的弹性涂层。通过将抗微生物涂层施加到医用植入物的表面的至少一部分上，在抗微生物涂层上施加耐久的涂层并在耐久涂层上施加弹性涂层来施加涂层。

4. 发明授权

US07238363B2 Modification of medical prostheses 失效
标题翻译：医用假体修改
公开(公告)号：US07238363B2
公开(公告)日：2007-07-03
申请号：US11095975
申请日：2005-03-31
申请人： Mohammad D. Mansouri , Rabih O. Darouiche
发明人： Mohammad D. Mansouri , Rabih O. Darouiche
IPC分类号： A61F2/00 , A61L33/00
CPC分类号： A61L27/54 , A61F2250/0067 , A61L2/0082 , A61L29/16 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61L2300/608
摘要： The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.
摘要翻译：提供了一种或多种治疗剂在金属和非金属医用假体上的并入。治疗剂可用于例如预防，治疗或减少与这些植入物相关的细菌和真菌感染。另外，治疗剂可用于实现其它治疗益处。具体地说，双层治疗涂层分两步施加。此外，非抗微生物治疗剂可并入该涂层中以治疗，预防，改变或刺激某些临床生物活性。

5. 发明授权

US06719991B2 Combination of antimicrobial agents and bacterial interference to coat medical devices 有权
公开(公告)号：US06719991B2
公开(公告)日：2004-04-13
申请号：US09877898
申请日：2001-06-08
申请人： Rabih O. Darouiche , Richard Hull
发明人： Rabih O. Darouiche , Richard Hull
IPC分类号： A61F1300
CPC分类号： A61L29/08 , A61L29/005 , A61L29/16 , A61L2300/30 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61L2300/61 , A61L2420/02
摘要： This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

6. 发明授权

US07452345B2 Anti-infective endotracheal tube 失效
标题翻译：抗感染性气管内导管
公开(公告)号：US07452345B2
公开(公告)日：2008-11-18
申请号：US10664519
申请日：2003-09-17
申请人： Rabih O. Darouiche , Randall A. Prince
发明人： Rabih O. Darouiche , Randall A. Prince
IPC分类号： A61B17/20
CPC分类号： A61M16/04 , A61M16/0484
摘要： A multi-lumen endotracheal tube has means for coating an inside and an outside surface of the endotracheal tube with antimicrobial and antibiofilm agents; means for releasing antimicrobial and antibiofilm agents from the endotracheal tube; means for using electrical current to enhance the efficacy of the antimicrobial and antibiofilm agents; and means for using ultrasound energy to enhance the efficacy of the antimicrobial and antibiofilm agents. In another feature of the present invention, the multi-lumen tube further has an outer lumen, and a concentric inner lumen, and the outer lumen contains the means for coating, the means for releasing, the means for using electrical current, and the means for using ultrasound energy. In another feature of the present invention, the inside and outside surfaces have a surface coating to reduce the buildup of bacteria and biofilm on the surface.
摘要翻译：多腔气管内管具有用抗微生物剂和抗菌剂来涂覆气管内管的内表面和外表面的装置; 用于从气管内管释放抗微生物剂和抗菌剂的方法; 使用电流增强抗微生物剂和抗菌剂的功效的方法; 以及使用超声波能量来增强抗微生物剂和抗菌剂的功效的方法。在本发明的另一个特征中，多腔管还具有外腔和同心的内腔，并且外腔包含用于涂覆的装置，用于释放用于使用电流的装置的装置，使用超声能量。在本发明的另一个特征中，内表面和外表面具有表面涂层，以减少表面上细菌和生物膜的积累。

7. 发明授权

US5624704A Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent 失效
标题翻译：抗微生物浸渍导管和其他医用植入物以及用抗菌剂浸渍导管和其它医用植入物的方法
公开(公告)号：US5624704A
公开(公告)日：1997-04-29
申请号：US427379
申请日：1995-04-24
申请人： Rabih O. Darouiche , Issam Raad
发明人： Rabih O. Darouiche , Issam Raad
IPC分类号： A61M25/00 , A61F2/00 , A61F2/06 , A61F2/24 , A61F2/26 , A61L27/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L33/00 , A61M25/16 , B05D3/12 , B05D7/02 , B05D10/34
CPC分类号： A61L29/16 , A61L27/54 , A61F2/26 , A61F2250/0067 , A61L2300/404 , A61L2300/406 , A61L2300/802 , A61M25/0017
摘要： A non-metallic antimicrobial impregnated medical implant, such as a catheter, and a method for impregnating a non-metallic medical implant with an antimicrobial agent is provided. The method for making the impregnated implant comprises the steps of forming an antimicrobial composition of an effective concentration to inhibit the growth of organisms, such as staphylococci, other gram-positive bacteria, gram-negative bacilli and Candida and applying the antimicrobial composition to at least a portion of the medical implant under conditions where the antimicrobial composition permeates the material of the medical implant. The antimicrobial composition is formed by dissolving an antimicrobial agent in an organic solvent, adding a penetrating agent to the composition, and adding an alkalinizing agent to the composition. The antimicrobial composition is preferably heated to a temperature between about 30.degree. C. and 70.degree. C. prior to applying the composition to the medical implant to enhance the adherence of the antimicrobial agent to the medical implant material. After the impregnated implant is removed from the antimicrobial solution, the impregnated implant is allowed to dry then rinsed with a liquid and milked to remove excess granular deposits and ensure uniform color of the impregnated implant.
摘要翻译：提供非金属抗菌浸渍医用植入物，例如导管，以及用抗微生物剂浸渍非金属医用植入物的方法。制备浸渍植入物的方法包括以下步骤：形成有效浓度的抗微生物组合物，以抑制诸如葡萄球菌，其它革兰氏阳性菌，革兰氏阴性杆菌和假丝酵母等生物体的生长，并将抗微生物组合物施用至少医疗植入物的一部分在抗微生物组合物渗透到医用植入物的材料的条件下。抗微生物组合物通过将抗微生物剂溶解在有机溶剂中，向组合物中加入渗透剂，并向组合物中加入碱化剂形成。在将组合物施用于医用植入物之前，抗微生物组合物优选加热至约30℃至70℃之间的温度，以增强抗微生物剂对医用植入材料的粘附性。在将浸渍的植入物从抗微生物溶液中取出后，将浸渍的植入物干燥，然后用液体冲洗并挤压以除去多余的颗粒沉积物，并确保浸渍的植入物的均匀颜色。

8. 发明授权

US07790183B2 Combination of antimicrobial agents and bacterial interference to coat medical devices 有权
标题翻译：抗微生物剂与细菌干扰的组合以覆盖医疗器械
公开(公告)号：US07790183B2
公开(公告)日：2010-09-07
申请号：US10788060
申请日：2004-02-26
申请人： Rabih O. Darouiche , Richard Hull
发明人： Rabih O. Darouiche , Richard Hull
IPC分类号： A61F13/00 , A61F2/00 , A01N63/00 , A61K39/38 , A61K39/02 , A61K9/50 , A61K39/108 , A61K39/112 , A61L33/00
CPC分类号： A61L29/08 , A61L29/005 , A61L29/16 , A61L2300/30 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61L2300/61 , A61L2420/02
摘要： This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.
摘要翻译：本发明涉及一种医疗器械的涂覆方法，包括以下步骤：向所述医疗器械表面的至少一部分施加抗微生物涂层和非致病细菌涂层，其中所述抗微生物和非病原菌涂层抑制病原菌和真菌生物的生长。用于细菌涂层的非致病细菌对抗微生物剂具有抗性。此外，非致病性细菌层包括以下中的至少一种：活的全细胞，非活的全细胞或细胞结构或提取物。抗微生物剂和非病原菌用于在一个容器或分开的容器中开发包含这些组合物的试剂盒。该套件用于在植入哺乳动物之前涂覆导管。

9. 发明授权

US06475434B1 Composition and methods for preventing and removing biofilm embedded microorganisms from the surface of medical devices 有权
标题翻译：用于从医疗器械表面预防和去除生物膜嵌入的微生物的组合物和方法
公开(公告)号：US06475434B1
公开(公告)日：2002-11-05
申请号：US09455985
申请日：1999-12-06
申请人： Rabih O. Darouiche
发明人： Rabih O. Darouiche
IPC分类号： A61L200
CPC分类号： A61L29/16 , A61L2/0082 , A61L2/0088 , A61L27/28 , A61L29/08 , A61L31/08 , A61L2300/214 , A61L2300/404 , A61L2300/606
摘要： A biofilm penetrating composition for coating medical devices for substantially preventing the growth or proliferation of biofilm embedded microorganisms on at least one surface of the medical device is disclosed. A biofilm penetrating composition solution for cleaning medical devices which is capable of substantially removing all of the biofilm embedded microorganisms from at least one surface of medical devices is also disclosed. The biofilm penetrating composition coating and solution include a biofilm penetrating agent and may also include a base material. Medical devices coated with the biofilm penetrating composition and methods for coating medical devices and methods for removing biofilm embedded microorganisms from at least one surface of the medical devices are also disclosed.
摘要翻译：公开了用于涂覆医疗装置以用于基本上防止生物膜嵌入的微生物在医疗装置的至少一个表面上的生长或增殖的生物膜穿透组合物。还公开了一种用于清洁医疗装置的生物膜渗透组合物溶液，其能够从医疗装置的至少一个表面基本上除去所有生物膜嵌入的微生物。生物膜渗透组合物涂层和溶液包括生物膜渗透剂，还可以包括基材。还公开了涂覆有生物膜渗透组合物的医疗装置和用于涂覆医疗装置的方法和从医疗装置的至少一个表面去除生物膜嵌入的微生物的方法。

10. 发明授权

US5756145A Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor 失效
标题翻译：耐用，弹性和有效的医疗器械抗微生物涂层及其涂层方法
公开(公告)号：US5756145A
公开(公告)日：1998-05-26
申请号：US555028
申请日：1995-11-08
申请人： Rabih O. Darouiche
发明人： Rabih O. Darouiche
IPC分类号： A61F2/00 , A61F2/30 , A61L27/28 , A61L27/34 , B05D1/18 , B05D1/38 , B05D7/02
CPC分类号： A61L27/34 , A61F2/30767 , A61L27/28 , A61F2002/3007 , A61F2002/30677 , A61F2002/30929
摘要： A medical implant, such as an orthopedic implant, having a first antimicrobial coating layer and a second protective layer, and a method for coating such an implant is provided. The medical implant has one or more of its surfaces coated with an antimicrobial coating layer and a protective coating layer formed over the antimicrobial coating layer. The protective coating layer includes a durable coating layer composed of material such as collodion and nylon, and a resilient coating layer composed of material such as collodion. The coating layers are applied by applying an antimicrobial coating layer to at least a portion of the surfaces of the medical implant, applying a durable coating layer over the antimicrobial coating layer, and applying a resilient coating layer over the durable coating layer.
摘要翻译：提供了具有第一抗微生物涂层和第二保护层的医疗植入物，例如矫形植入物，以及用于涂覆这种植入物的方法。医疗植入物具有一个或多个表面，其涂覆有抗微生物涂层和形成在抗微生物涂层上的保护性涂层。保护涂层包括由诸如火棉和尼龙的材料组成的耐久涂层，以及由诸如火棉胶的材料构成的弹性涂层。通过将抗微生物涂层施加到医用植入物的表面的至少一部分上，在抗微生物涂层上施加耐久的涂层并在耐久涂层上施加弹性涂层来施加涂层。

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