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1. 发明授权

US5409467A Antimicrobial catheter 失效
标题翻译：抗菌导管
公开(公告)号：US5409467A
公开(公告)日：1995-04-25
申请号：US174223
申请日：1993-12-28
申请人： Issam I. Raad , Gerald P. Bodey , Alfonso Zermeno
发明人： Issam I. Raad , Gerald P. Bodey , Alfonso Zermeno
IPC分类号： A61M25/00 , A61N1/32 , A61N1/40 , A61M5/32
CPC分类号： A61M25/0017 , A61N1/32 , A61N1/40
摘要： Techniques and apparatus are described for applying alternating and/or pulsed, electrical charges to open circuitry incorporated into medical devices intended to be placed into contact with portions of the body. A catheter assembly is described which comprises a catheter tube, an exterior portion of which is circumferentially surrounded by at least two parallel elongated helical conductive elements which may be operably connected to a power source to create a open circuit to induce an antimicrobial effect in the area proximate the exterior conductive elements through oligodynamic activity. In another embodiment, an oligodynamic dressing is described which incorporates open circuitry which is presented to contact a subject wound.
摘要翻译：描述了用于将交替和/或脉冲的电荷施加到并入到旨在与身体的部分接触的医疗装置中的开放电路的技术和装置。描述了一种导管组件，其包括导管，其外部部分由至少两个平行的细长螺旋导电元件围绕，所述至少两个平行的细长螺旋导电元件可操作地连接到电源，以产生开路以在该区域中产生抗微生物作用靠近外部导电元件通过低能动力活动。在另一个实施例中，描述了一种包含被呈现为接触受试者伤口的开放电路的小动物敷料。

2. 发明授权

US5217493A Antibacterial coated medical implants 失效
标题翻译：抗菌涂层医疗植入物
公开(公告)号：US5217493A
公开(公告)日：1993-06-08
申请号：US850197
申请日：1992-03-11
申请人： Issam I. Raad , Rabih O. Darouiche
发明人： Issam I. Raad , Rabih O. Darouiche
IPC分类号： A61L29/00 , A01N1/02 , A61K31/65 , A61L27/00 , A61L27/54 , A61L29/16 , A61M25/00
CPC分类号： A61K31/65 , A61K31/70 , A61L27/54 , A61L29/16 , A61L2300/406 , A61L2300/45 , A61L2300/606
摘要： An implantable medical device having long lasting resistance to staphylococcal biofilm colonization is provided. Implantable medical devices such as catheters, shunts, prosthesis, pacemakers, etc. are susceptible to colonization by biofilm adherent microorganisms, especially staphylococci. While systemic staphylococcal infections are effectively treated by many antibiotics, vancomycin being the antibiotic of choice, this same bacteria when encased in biofilm adhering to indwelling medical devices is generally resistant to antibiotic treatment. By the present invention, the combination of rifampin and minocycline or the combination of rifampin and novobiocin when coated on the surfaces of implantable medical devices unexpectedly provides superior antibacterial activity against staphylococcal biofilm colonization on the coated surface of indwelling medical devices.
摘要翻译：提供了具有对葡萄球菌生物膜定植具有长期抗性的可植入医疗装置。诸如导管，分流器，假体，起搏器等的植入式医疗装置易受生物膜粘附微生物特别是葡萄球菌的定植。虽然系统性葡萄球菌感染被许多抗生素有效地治疗，万古霉素是选择的抗生素，但是当包裹在附着在留置医疗器械上的生物膜中时，这种相同的细菌通常抗抗生素治疗。通过本发明，当涂覆在可植入医疗装置的表面上时，利福平和米诺环素的组合或利福平和新生霉素的组合意外地在留置医疗装置的涂覆表面上提供了优异的抗葡萄球菌生物膜定植的抗细菌活性。

3. 发明授权

US5324275A Antimicrobial medical devices 失效
标题翻译：抗微生物医疗器械
公开(公告)号：US5324275A
公开(公告)日：1994-06-28
申请号：US956642
申请日：1992-10-02
申请人： Issam I. Raad , Gerald P. Bodey , Alfonso Zermeno
发明人： Issam I. Raad , Gerald P. Bodey , Alfonso Zermeno
IPC分类号： A61M25/00 , A61N1/40 , A61M5/32
CPC分类号： A61N1/40 , A61M25/0017
摘要： A catheter assembly is described which comprises a catheter tube, an exterior portion of which is circumferentially surrounded by at least two parallel elongated helical conductive elements which may be operably connected to a first power source to create a first open circuit to induce an antimicrobial effect in the area proximate the exterior conductive elements through oligodynamic activity. The catheter assembly further comprises a hub at its proximal end having a cap containing a second power source. At least two internal conductive elements are disposed along the internal length of the hub and are operably connected to the second power source upon closure of the hub with the cap to create a second open circuit which creates an antimicrobial effect proximate the hub through oligodynamic activity.
摘要翻译：描述了一种导管组件，其包括导管管，其外部部分由至少两个平行细长的螺旋导电元件围绕，所述至少两个平行细长的螺旋导电元件可操作地连接到第一电源，以产生第一开路以诱导抗微生物效果靠近外部导电元件的区域通过低能动力活动。导管组件还包括其近端处的毂，其具有包含第二电源的帽。至少两个内部导电元件沿着毂的内部长度设置，并且在与盖子封闭的情况下可操作地连接到第二电源，以产生第二开路，其通过低能动力活动产生靠近轮毂的抗微生物作用。

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