专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08163791B2 Imidazole derivatives that induce apoptosis and their therapeutic uses 有权
标题翻译：诱导凋亡的咪唑衍生物及其治疗用途
公开(公告)号：US08163791B2
公开(公告)日：2012-04-24
申请号：US12528680
申请日：2007-02-26
申请人： In-Jae Shin , Myung-ryul Lee , Darren Williams
发明人： In-Jae Shin , Myung-ryul Lee , Darren Williams
IPC分类号： A61K31/415 , C07D233/64
CPC分类号： C07D233/64
摘要： The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cells are incubated with the said pharmaceutical composition and detected.
摘要翻译：本发明涉及包含用于诱导凋亡的化合物的药物组合物，诱导癌细胞凋亡的方法，抑制淋巴细胞活化的方法，改善错误折叠的突变体的细胞内运输的方法以及鉴定用于诱导的另外的化合物的筛选方法细胞凋亡，更具体地说，涉及包含咪唑衍生物作为诱导凋亡的活性梯度以治疗各种疾病（包括癌症和免疫相关疾病）的药物组合物，通过用药物组合物治疗癌细胞诱导凋亡的方法，通过用药物组合物治疗淋巴细胞来灭活人淋巴细胞，通过用药物组合物处理含有突变体的细胞来改善错误折叠的突变体的细胞内运输的方法，以及鉴定用于诱导的另外的化合物的筛选方法 g细胞凋亡，其中将细胞与所述药物组合物孵育并检测。

2. 发明授权

US07718685B2 4,5-bis(4-methoxyphenyl)imidizole compound inducing differentiation of myoblasts or muscle fibers and pharmaceutical compositions including said compound 有权
标题翻译：诱导成肌细胞或肌肉纤维分化的4,5-双（4-甲氧基苯基）亚胺唑酮化合物和包含所述化合物的药物组合物
公开(公告)号：US07718685B2
公开(公告)日：2010-05-18
申请号：US11337145
申请日：2006-01-20
申请人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
发明人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
IPC分类号： A01N43/50
CPC分类号： C07D405/04 , C07D233/64
摘要： The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells and a pharmaceutical composition including said compound. More specifically, it relates to 2-(2-fluorenyl)-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug thereof, and a pharmaceutical composition including said compound.
摘要翻译：本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物和包含所述化合物的药物组合物。更具体地说，本发明涉及诱导成肌细胞或肌纤维分化的2-（2-芴基）-4,5-双（4-甲氧基苯基）咪唑，其所有药学上可接受的异构体，盐，水合物，溶剂合物和前药，以及包含所述化合物的药物组合物。

3. 发明授权

US07888118B2 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole and methods for inducing differentiation of myoblasts or muscle fibers into neuron cells 有权
标题翻译： 2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑和诱导成肌细胞或肌纤维分化成神经元细胞的方法
公开(公告)号：US07888118B2
公开(公告)日：2011-02-15
申请号：US12749922
申请日：2010-03-30
申请人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
发明人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
IPC分类号： C12N5/00
CPC分类号： C07D405/04 , C07D233/64
摘要： The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers into neuron cells, all pharmaceutically acceptable isomers, salts, and a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation.
摘要翻译：本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物，包含所述化合物的药物组合物，诱导神经元细胞分化的方法和鉴定另外的化合物的筛选方法可用于诱导神经细胞分化。更具体地说，它涉及诱导成肌细胞或肌纤维分化成神经细胞的2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑，所有药学上可接受的异构体盐，以及包含所述化合物的药物组合物，诱导神经元细胞分化的方法以及鉴定用于诱导神经元细胞分化的其它化合物的筛选方法。

4. 发明申请

US20100105726A1 IMIDAZOLE DERIVATIVES THAT INDUCE APOPTOSIS AND THEIR THERAPEUTIC USES 有权
标题翻译：诱发病毒的咪唑衍生物及其治疗用途
公开(公告)号：US20100105726A1
公开(公告)日：2010-04-29
申请号：US12528680
申请日：2007-02-26
申请人： In-Jae Shin , Myung-ryul Lee , Darren Williams
发明人： In-Jae Shin , Myung-ryul Lee , Darren Williams
IPC分类号： A61K31/4178 , C12Q1/06 , C40B30/06 , A61K31/4725 , C07D401/04 , C07D405/06 , C07D403/06 , C07D233/61 , A61P35/00
CPC分类号： C07D233/64
摘要： The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the said pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the said pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the said pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cells are incubated with the said pharmaceutical composition and detected.
摘要翻译：本发明涉及包含用于诱导凋亡的化合物的药物组合物，诱导癌细胞凋亡的方法，抑制淋巴细胞活化的方法，改善错误折叠的突变体的细胞内运输的方法以及鉴定用于诱导的另外的化合物的筛选方法更具体地，涉及包含咪唑衍生物作为用于诱导凋亡以用于治疗各种疾病（包括癌症和免疫相关疾病）的活性梯度的药物组合物，通过用所述药物组合物治疗癌细胞诱导凋亡的方法，该方法通过用所述药物组合物处理淋巴细胞来灭活人淋巴细胞，通过用所述药物组合物处理含有突变体的细胞来改善错误折叠突变体的细胞内运输的方法，以及用于鉴定另外的化合物用途的筛选方法用于诱导细胞凋亡，其中细胞与所述药物组合物一起孵育并检测。

5. 发明申请

US20100184097A1 4,5-BIS(4-METHOXYPHENYL)IMIDAZOLE COMPOUND INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, A PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUND, A METHOD OF INDUCING NEURON CELLS DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUND USEFUL FOR INDUCING NEURON CELLS DIFFERENTIATION 有权
标题翻译： 4-BIS（4-甲氧基苯基）咪唑化合物诱导将神经细胞分解成神经细胞或肌肉纤维，包括化合物的药物组合物，诱导神经细胞分化的方法和用于鉴定用于诱导神经细胞的附加化合物的筛选方法差异化
公开(公告)号：US20100184097A1
公开(公告)日：2010-07-22
申请号：US12749922
申请日：2010-03-30
申请人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
发明人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
IPC分类号： G01N33/567 , C07D233/54 , C12N5/071
CPC分类号： C07D405/04 , C07D233/64
摘要： The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers into neuron cells, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug thereof, and a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation.
摘要翻译：本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物，包含所述化合物的药物组合物，诱导神经元细胞分化的方法和鉴定另外的化合物的筛选方法可用于诱导神经细胞分化。更具体地说，它涉及诱导成肌细胞或肌纤维分化成神经细胞的2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑，所有药学上可接受的异构体，盐，水合物，溶剂化物和前药，以及包含所述化合物的药物组合物，诱导神经元细胞分化的方法和用于鉴定用于诱导神经元细胞分化的另外的化合物的筛选方法。

6. 发明申请

US20070123576A1 Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation 有权
标题翻译：诱导成肌细胞或肌纤维分化成神经元细胞的化合物，包括所述化合物的药物组合物，诱导神经元分化的方法和用于鉴定用于诱导神经元分化的其它化合物的筛选方法
公开(公告)号：US20070123576A1
公开(公告)日：2007-05-31
申请号：US11337145
申请日：2006-01-20
申请人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
发明人： In-Jae Shin , Myung-Ryul Lee , Darren Williams
IPC分类号： A61K31/4178 , A61K31/4164 , C07D405/04 , C07D233/58
CPC分类号： C07D405/04 , C07D233/64
摘要： The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation. More specifically, it relates to compounds that induce neuron differentiation from myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrugs thereof, the method of inducing differentiation of myoblasts or muscle fibers into neuron cells by treating myoblasts and muscle fibers with a compound of the present invention, whereby the myoblasts and muscle fibers differentiate into neuron cells, and the screening method for identifying additional compounds useful for inducing neuron differentiation, wherein myoblasts and muscle fibers are incubated with a compound of the present invention and detected.
摘要翻译：本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的化合物，包括所述化合物的药物组合物，诱导神经元分化的方法和用于鉴定用于诱导神经元分化的其它化合物的筛选方法。更具体地说，本发明涉及从成肌细胞或肌肉纤维诱导神经元分化的化合物，其所有药学上可接受的异构体，盐，水合物，溶剂合物和前药，通过治疗成肌细胞和肌纤维诱导成肌细胞或肌纤维分化成神经细胞的方法与本发明的化合物，由此成肌细胞和肌肉纤维分化成神经元细胞，以及用于鉴定用于诱导神经元分化的其它化合物的筛选方法，其中成肌细胞和肌肉纤维与本发明的化合物一起孵育并检测。

7. 发明授权

US06949654B2 N-alkyl-N-phenylhydroxylamine compounds containing metal chelating groups, their preparation and their therapeutic uses 失效
标题翻译：含有金属螯合基团的N-烷基-N-苯基羟胺化合物，其制备及其治疗用途
公开(公告)号：US06949654B2
公开(公告)日：2005-09-27
申请号：US10456024
申请日：2003-06-05
申请人： Eu-Gene Oh , Sung-Bo Ko , Won-Yeob Kim , Kyung-Hwa Kim , Dennis W. Choi , Laura L. Dugan , Tae-Cheon Kang , Jae-Young Koh , Kyung-Mi Kim , In-Jae Shin
发明人： Eu-Gene Oh , Sung-Bo Ko , Won-Yeob Kim , Kyung-Hwa Kim , Dennis W. Choi , Laura L. Dugan , Tae-Cheon Kang , Jae-Young Koh , Kyung-Mi Kim , In-Jae Shin
IPC分类号： C07C239/18 , C07D213/75 , C07D215/38 , C07D231/42 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D263/48 , C07D277/46 , C07D277/48 , C07D307/66 , C07D333/36 , C07D277/44 , A61K31/425 , A61K31/44
CPC分类号： C07D213/75 , C07C239/18 , C07D215/38 , C07D231/42 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D263/48 , C07D277/46 , C07D307/66 , C07D333/36
摘要： The present invention provides novel N-alkyl-N-phenylhydroxylamine derivatives containing metal chelating groups, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species (ROS) and/or excess Zn ions, in particular stroke, Parkinson's disease and Alzheimer's disease. The compounds of the invention possess similar or superior LPO inhibition activity to the reference compounds of Trolox and Ebselen. While showing lower toxicity, they also effectively inhibit the cerebral neuronal cell death caused by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
摘要翻译：本发明提供了含有金属螯合基团的新型N-烷基-N-苯基羟胺衍生物及其制备方法，该新化合物用作治疗和/或预防各种医学功能障碍和由活性氧产生的疾病的用途（ ROS）和/或过量的Zn离子，特别是中风，帕金森病和阿尔茨海默病。本发明的化合物对Trolox和依布硒林的参考化合物具有相似或优异的LPO抑制活性。虽然毒性较低，但也有效地抑制由ROS和/或锌离子引起的脑神经元细胞死亡，并显示对缺血性神经元变性的神经保护作用。

8. 发明授权

US07229988B2 Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses 有权
标题翻译：含金属螯合基团的二烷基羟基苯甲酸衍生物及其治疗用途
公开(公告)号：US07229988B2
公开(公告)日：2007-06-12
申请号：US10456399
申请日：2003-06-05
申请人： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis W. Choi , Laura L. Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
发明人： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis W. Choi , Laura L. Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
IPC分类号： A61K31/54
CPC分类号： C07D213/40 , C07D207/34 , C07D213/26 , C07D213/38 , C07D213/75 , C07D215/38 , C07D231/40 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D261/14 , C07D263/48 , C07D263/58 , C07D271/10 , C07D271/113 , C07D275/02 , C07D275/03 , C07D277/46 , C07D277/56 , C07D285/12 , C07D285/135 , C07D307/66 , C07D333/36
摘要： The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds of the invention have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
摘要翻译：本发明提供了含有金属螯合基团的新型二烷基羟基苯甲酸衍生物以及该新化合物作为治疗剂用于治疗和/或预防各种医学功能障碍和由活性氧和/或过量的Zn离子，特别是中风，帕金森病引起的疾病，阿尔茨海默氏病。本发明的化合物不仅具有低毒性，而且具有与参考物相似或优异的LPO抑制活性。它们还有效地抑制了由ROS和/或锌离子引起的脑神经元细胞死亡，并显示对缺血性神经元变性的神经保护作用。

9. 发明授权

US07511034B2 Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses 失效
标题翻译：含金属螯合基团的二烷基羟基苯甲酸衍生物及其治疗用途
公开(公告)号：US07511034B2
公开(公告)日：2009-03-31
申请号：US11329926
申请日：2006-01-11
申请人： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis W. Choi , Laura L. Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
发明人： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis W. Choi , Laura L. Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
IPC分类号： A61K31/54 , A61K31/35 , C07D279/00 , C07D277/04 , C07D207/46
CPC分类号： C07D213/40 , C07D207/34 , C07D213/26 , C07D213/38 , C07D213/75 , C07D215/38 , C07D231/40 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D261/14 , C07D263/48 , C07D263/58 , C07D271/10 , C07D271/113 , C07D275/02 , C07D275/03 , C07D277/46 , C07D277/56 , C07D285/12 , C07D285/135 , C07D307/66 , C07D333/36
摘要： Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
摘要翻译：公开了含有金属螯合基团的新型二烷基羟基苯甲酸衍生物。新化合物用作治疗和/或预防由活性氧和/或过量的Zn离子，特别是中风，帕金森氏病，阿尔茨海默病引起的各种医学功能障碍和疾病的治疗剂。该化合物不仅具有低毒性，而且对参考物具有相似或优异的LPO抑制活性。它们还有效地抑制了由ROS和/或锌离子引起的脑神经元细胞死亡，并显示对缺血性神经元变性的神经保护作用。

10. 发明申请

US20060116377A1 Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses 失效
公开(公告)号：US20060116377A1
公开(公告)日：2006-06-01
申请号：US11329926
申请日：2006-01-11
申请人： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis Choi , Laura Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
发明人： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis Choi , Laura Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
IPC分类号： A61K31/53 , A61K31/50 , A61K31/4965 , A61K31/505 , A61K31/4706 , A61K31/44 , A61K31/433 , A61K31/426 , A61K31/425 , A61K31/421 , A61K31/42
CPC分类号： C07D213/40 , C07D207/34 , C07D213/26 , C07D213/38 , C07D213/75 , C07D215/38 , C07D231/40 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D261/14 , C07D263/48 , C07D263/58 , C07D271/10 , C07D271/113 , C07D275/02 , C07D275/03 , C07D277/46 , C07D277/56 , C07D285/12 , C07D285/135 , C07D307/66 , C07D333/36
摘要： Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式