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    • 7. 发明授权
    • Process for preparing cyclopropane carboxylic acid ester derivatives
    • 制备环丙烷羧酸酯衍生物的方法
    • US4436667A
    • 1984-03-13
    • US252892
    • 1981-04-10
    • Michael J. Bull
    • Michael J. Bull
    • C07C253/00A01N37/34A01N53/08A01P7/04C07C67/00C07C253/34C07C255/39C07C255/53C07C121/75
    • C07C255/53
    • This invention relates to the preparation of cyclopropane carboxylic acid ester derivatives, which are useful as pesticides.There is provided a process for preparing a mixture of cis-isomers of a compound of formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from chlorine, bromine and methyl, consisting predominantly of the 1R cis S- and 1S cis R- isomers, which process comprises dissolving a mixture of 1S cis S- and 1R cis R- isomers of the compound of formula I, alone or in the presence of 1R cis S- and 1S cis R-isomers, in an organic amine base containing from 5 to 7 carbon atoms and being a secondary amine containing two branched alkyl groups or a tertiary amine, crystallizing out from a resulting solution of cis- isomers of formula I in the organic amine base a 1:1 mixture of the 1R cis S- and 1S cis R- isomers, and evaporating off the organic amine base.The process of the invention yields a product which may contain up to twice as much of the most active isomer of the compound of formula I as a racemic mixture of all four cis-isomers, and is a readily effected process which does not involve any sterospecific synthesis or optical resolution steps.
    • 本发明涉及可用作杀虫剂的环丙烷羧酸酯衍生物的制备。 提供了制备式(I)化合物的顺式异构体的混合物的方法,其中R 1和R 2独立地选自氯,溴和甲基,主要由1R顺式和1S和1S顺式R - 异构体,该方法包括将式I化合物的1S顺式S-和1R顺式R-异构体的混合物单独或在1R顺式S-和1S顺式R-异构体的存在下溶解在含有 5至7个碳原子,并且是含有两个支链烷基或叔胺的仲胺,从有机胺碱中得到的式I的顺式异构体溶液中结晶出1顺式S- 和1S顺式R-异构体,并蒸发掉有机胺碱。 本发明的方法产生一种产品,其可以含有至多两倍于式I化合物的最活泼的异构体作为所有四种顺式异构体的外消旋混合物,并且是一种容易实现的方法,其不涉及任何甾体特异性 合成或光学解析步骤。