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    • 5. 发明授权
    • Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
    • 由微粒和可生物降解的凝胶组成的具有改进的释放特征的药剂递送系统及其使用方法
    • US06287588B1
    • 2001-09-11
    • US09559507
    • 2000-04-27
    • Chung ShihGaylen M. Zentner
    • Chung ShihGaylen M. Zentner
    • A61F200
    • A61K47/34A61K9/06
    • A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.
    • 公开了以可控制的方式在生物环境中释放生物活性剂或药物的组合物和方法。 组合物是双相聚合物递送组合物,其包含连续的生物相容性凝胶相,包含限定的微粒的不连续颗粒相和待递送的试剂。 含有生物活性剂的微粒可释放地夹带在生物相容性聚合物凝胶基质内。 生物活性剂释放可以单独包含在微粒相中,也可以包含在微粒和凝胶基质中。 试剂的释放在一段时间内延长,并且递送可以被调节和/或控制。 另外,第二种试剂可以装载在一些微粒和/或凝胶基质中。