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1. 发明申请

US20050214832A1 Method and kit for performing functional tests on biological cells 审中-公开
标题翻译：用于对生物细胞进行功能测试的方法和试剂盒
公开(公告)号：US20050214832A1
公开(公告)日：2005-09-29
申请号：US11051315
申请日：2005-02-04
申请人： Hugo Haemmerle , Thomas Joos , Markus Templin , Hansjurgen Volkmer , Kerstin Ragnitz , Susanne Stumpf , Cornelia Kuschel
发明人： Hugo Haemmerle , Thomas Joos , Markus Templin , Hansjurgen Volkmer , Kerstin Ragnitz , Susanne Stumpf , Cornelia Kuschel
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5005
摘要： A process for carrying out functional assays on test cells is described comprising the following steps: a) providing an array of measuring points which are separate from each other and to which in each case capture molecules to which said test cells can bind are immobilized, b) generating a mixture of said test cells and of reference particles which are capable of binding to said capture molecules and which are distinguishable from said test cells, c) contacting the mixture of step b) with the array so that test cells and reference particles can bind to each measuring point, and d) determining the ratio of bound test cells of interest to bound reference particles for at least some of the measuring points. In a further process, at least one measuring point with its assigned capture molecules is distributed between a plurality of measuring areas in the array, which are arranged at various sites in said array. In another process, the array is agitated, after contacting with the test cells and, where appropriate, the reference particles.
摘要翻译：描述了用于在测试细胞上进行功能测定的方法，其包括以下步骤：a）提供彼此分离的测量点阵列，并且在每种情况下捕获所述测试细胞可以结合的分子被固定化，b ）产生所述测试细胞和能够结合所述捕获分子并且可与所述测试细胞区分的参考颗粒的混合物，c）使步骤b）的混合物与阵列接触，使得测试细胞和参考颗粒可以结合到每个测量点，以及d）确定至少一些测量点的目标结合测试细胞与结合参考颗粒的比例。在另一个过程中，具有其分配的捕获分子的至少一个测量点分布在阵列中的多个测量区域之间，其被布置在所述阵列中的各个位置。在另一个方法中，在与测试电池接触并且在适当的时候搅拌参考颗粒。

2. 发明申请

US20100331199A1 METHOD FOR THE DETECTION AND/OR ENRICHMENT OF ANALYTE PROTEINS AND/OR ANALYTE PEPTIDES FROM A COMPLEX PROTEIN MIXTURE 审中-公开
标题翻译：检测和/或分析分析蛋白和/或从复合蛋白混合物分析肽的方法
公开(公告)号：US20100331199A1
公开(公告)日：2010-12-30
申请号：US12294854
申请日：2007-03-29
申请人： Dieter Stoll , Thomas Joos , Markus Templin , Oliver Poetz
发明人： Dieter Stoll , Thomas Joos , Markus Templin , Oliver Poetz
IPC分类号： C40B30/04 , G01N33/53 , G01N27/26
CPC分类号： G01N33/6842 , C07K16/44
摘要： The present invention relates to a method for the detection and/or enrichment of a large number of different analyte proteins and/or analyte peptides from a sample mixture which includes proteins and/or peptides. The method includes the following steps: a) provision of the sample mixture and, where appropriate, fragmentation of the proteins contained therein into defined peptides, b) provision of first binding molecules which are specific for a peptide epitope of at least one of the various analyte proteins and/or analyte peptides, whereby the peptide epitope includes up to a maximum of five, preferably two to three, amino acids, c) incubation of the first binding molecules with the sample mixture, and d) detection and/or enrichment of the analyte proteins and/or analyte peptides bound to the first binding molecules. The invention also relates to binding molecules which are specific for the terminal peptide epitope of various peptide analytes, whereby the terminal peptide epitope includes the free NH2 group or the free COOH group, one or more than one amino acid defined by the protease specificity, and in each case up to a maximum of three further terminal amino acids.
摘要翻译：本发明涉及从包括蛋白质和/或肽的样品混合物中检测和/或富集大量不同分析物蛋白质和/或分析物肽的方法。该方法包括以下步骤：a）提供样品混合物，并在适当情况下将其中包含的蛋白质碎裂成定义的肽，b）提供对多种抗原决定簇中的至少一种的肽表位是特异性的第一结合分子分析物蛋白质和/或分析物肽，其中肽表位包含最多5个，优选2至3个氨基酸，c）将第一结合分子与样品混合物孵育，以及d）检测和/或富集分析物蛋白和/或与第一结合分子结合的分析物肽。本发明还涉及对各种肽分析物的末端肽表位特异的结合分子，其中末端肽表位包括游离NH 2基团或游离COOH基团，由蛋白酶特异性定义的一个或多于一个氨基酸，以及在每种情况下，最多三个其他末端氨基酸。

3. 发明申请

US20070132841A1 PORTABLE VIDEO OCULOGRAPHY SYSTEM WITH INTEGRAL CALIBRATION LIGHT 有权
标题翻译：具有集成校准光的便携式视频成像系统
公开(公告)号：US20070132841A1
公开(公告)日：2007-06-14
申请号：US11549193
申请日：2006-10-13
申请人： Hamish MacDougall , Alexander Kiderman , John Schroeder , Thomas Joos , Floris Wuyts , Steven Moore
发明人： Hamish MacDougall , Alexander Kiderman , John Schroeder , Thomas Joos , Floris Wuyts , Steven Moore
IPC分类号： H04N7/18
CPC分类号： A61B3/113
摘要： A goggle based light-weight VOG system includes an integral calibration laser and at least one digital camera connected to and powered by a laptop computer through a firewire connection. The digital camera may digitally center the pupil in both the X and Y directions. A calibration mechanism may be incorporated onto the goggle base. An EOG system may also be incorporated directly into the goggle. The VOG system may track and record 3-D movement of the eye, track pupil dilation, head position and goggle slippage. An animated eye display provides data in a more meaningful fashion. The VOG system is a modular design whereby the same goggle frame or base is used to build a variety of digital camera VOG systems.
摘要翻译：基于护目镜的轻量级VOG系统包括整体校准激光器和至少一个数字照相机，其通过火线连接连接到膝上型计算机并由其供电。数码相机可以在X和Y方向上数字地居中瞳孔。校准机构可以结合到护目镜基座上。 EOG系统也可以直接并入护目镜中。 VOG系统可以跟踪和记录眼睛的三维运动，跟踪瞳孔扩张，头部位置和护目镜滑移。动画眼睛显示器以更有意义的方式提供数据。 VOG系统是一种模块化设计，使用相同的护目镜框架或底座来构建各种数码相机VOG系统。

4. 发明申请

US20080049187A1 PORTABLE VIDEO OCULOGRAPHY WITH REGION OF INTEREST IMAGE PROCESSING 有权
标题翻译：具有利益影响区域的便携式视频摄影
公开(公告)号：US20080049187A1
公开(公告)日：2008-02-28
申请号：US11926806
申请日：2007-10-29
申请人： Thomas Joos , Alexander Kiderman , John Schroeder , Floris Wuyts , Steven Moore , Hamish MacDougall
发明人： Thomas Joos , Alexander Kiderman , John Schroeder , Floris Wuyts , Steven Moore , Hamish MacDougall
IPC分类号： A61B3/14
CPC分类号： A61B3/113
摘要： A goggle based light-weight VOG system includes at least one digital camera connected to and powered by a laptop computer through a firewire connection and allows for region of interest image processing. An EOG system may be incorporated directly into a goggle base. The digital camera may digitally center the pupil in both the X and Y directions. A calibration mechanism may be incorporated onto the goggle base. The VOG system may track and record head position and goggle slippage. An animated eye display may provide data in a more meaningful fashion. The VOG system may be a modular design whereby the same goggle frame or base is used to build a variety of digital camera VOG systems.
摘要翻译：基于护目镜的轻量级VOG系统包括通过火线连接连接到膝上型计算机并由其供电的至少一个数字照相机，并且允许感兴趣的图像处理区域。 EOG系统可以直接并入护目镜基座。数码相机可以在X和Y方向上数字地居中瞳孔。校准机构可以结合到护目镜基座上。 VOG系统可以跟踪和记录头部位置和护目镜滑移。动画眼睛显示器可以以更有意义的方式提供数据。 VOG系统可以是模块化设计，其中相同的护目镜框架或基座用于构建各种数字照相机VOG系统。

5. 发明申请

US20070121068A1 Portable video oculography system with integral light stimulus system 有权
标题翻译：具有整体光刺激系统的便携式视频眼图系统
公开(公告)号：US20070121068A1
公开(公告)日：2007-05-31
申请号：US11549185
申请日：2006-10-13
申请人： Hamish MacDougall , Alexander Kiderman , John Schroeder , Thomas Joos , Floris Wuyts , Steven Moore
发明人： Hamish MacDougall , Alexander Kiderman , John Schroeder , Thomas Joos , Floris Wuyts , Steven Moore
IPC分类号： A61B3/10
CPC分类号： A61B3/113
摘要： A goggle based light-weight VOG system includes at least one digital camera connected to and powered by a laptop computer through a firewire connection together with an integral visual light stimulus source. The digital camera may digitally center the pupil in both the X and Y directions. A calibration mechanism may be incorporated onto the goggle base. An EOG system may also be incorporated directly into the goggle. The VOG system may track and record 3-D movement of the eye, track pupil dilation, head position and goggle slippage. An animated eye display provides data in a more meaningful fashion. The VOG system is a modular design whereby the same goggle frame or base is used to build a variety of digital camera VOG systems.
摘要翻译：基于护目镜的轻量级VOG系统包括至少一个连接到膝上型计算机并通过火线连接并与整体的视觉光刺激源一起的数字照相机。数码相机可以在X和Y方向上数字地居中瞳孔。校准机构可以结合到护目镜基座上。 EOG系统也可以直接并入护目镜中。 VOG系统可以跟踪和记录眼睛的三维运动，跟踪瞳孔扩张，头部位置和护目镜滑移。动画眼睛显示器以更有意义的方式提供数据。 VOG系统是一种模块化设计，使用相同的护目镜框架或底座来构建各种数码相机VOG系统。

6. 发明申请

US20060063260A1 Method for producing a support carrying immobilized viruses, and the use of such a support 审中-公开
标题翻译：用于制备携带固定化病毒的载体的方法，以及使用这种载体
公开(公告)号：US20060063260A1
公开(公告)日：2006-03-23
申请号：US11219122
申请日：2005-09-02
申请人： Hansjuergen Volkmer , Frank Weise , Thomas Joos
发明人： Hansjuergen Volkmer , Frank Weise , Thomas Joos
IPC分类号： C12N15/86 , C12N15/74
CPC分类号： G01N33/54386 , B01J19/0046 , B01J2219/00533 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/0074 , G01N33/566 , G01N33/56911 , G01N33/56966 , G01N2333/005
摘要： A method for producing a support possessing a functionalized surface which is suitable for immobilizing viruses and carrying viruses which are immobilized on the functionalized surface and which are preferably infectious, as well as the use of such supports, are described. In this connection, a support material is initially provided and at least one surface of the support material is then coated, preferably with a nitrocellulose material, in order to form the functionalized surface. In a following step, a solution which contains viruses, which are preferably infectious, is applied to the functionalized surface, after which the viruses are subsequently enabled to adhere to the functionalized surface over a period of from preferably 10 minutes to 36 hours. After that, the surface is, where appropriate, covered with a fluid.
摘要翻译：描述了一种制备具有功能化表面的支持物的方法，该功能化表面适用于固定在功能化表面上并且优选感染的病毒和携带病毒，以及使用这种载体。在这方面，首先提供支撑材料，然后涂覆支撑材料的至少一个表面，优选用硝酸纤维素材料涂覆以形成官能化表面。在随后的步骤中，将含有优选感染性病毒的溶液施用于官能化表面，之后随后使病毒能够在优选10分钟至36小时的时间内粘附到官能化表面。之后，在适当的情况下，表面被流体覆盖。

7. 发明申请

US20100094161A1 QUANTITATIVE, NON-INVASIVE, CLINICAL DIAGNOSIS OF TRAUMATIC BRAIN INJURY USING SIMULATED DISTANCE VISUAL STIMULUS DEVICE FOR NEUROLOGIC TESTING 有权
标题翻译：定量，非侵入性临床诊断使用模拟距离视觉刺激装置进行神经病理测试的TRAUMATIC脑损伤
公开(公告)号：US20100094161A1
公开(公告)日：2010-04-15
申请号：US12577143
申请日：2009-10-09
申请人： Alexander D. Kiderman , Howison Schroeder , Thomas Joos , Greg Frank
发明人： Alexander D. Kiderman , Howison Schroeder , Thomas Joos , Greg Frank
IPC分类号： A61B5/00
CPC分类号： A61B3/113 , A61B5/16 , A61B5/4023 , A61B5/4863 , G02B27/0093 , G02B27/017 , G02B2027/0138 , G02B2027/014
摘要： A portable virtual reality device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same virtual reality portable device will allow more advanced usage for clinicians providing ongoing evaluation and treatment.
摘要翻译：公开了一种便携式虚拟现实设备，其将有助于在向前部署的军事设施或偏远地区的军事人员中使用受过最少培训的人员进行TBI的有效和高效的筛选。这包括制定一项议定书，在部署之前提供对军事人员进行成本有效的预筛选，以便在将来受伤之前建立脑功能基线。该装置的效率将促进随后的后续筛查，以评估规定的TBI治疗的有效性。使用相同的虚拟现实便携式设备的诊断和康复应用的进一步协议将允许为提供持续评估和治疗的临床医生提供更高级的使用。

8. 发明申请

US20130122517A1 METHOD OF PERFORMING AN ASSAY 审中-公开
标题翻译：执行测定方法
公开(公告)号：US20130122517A1
公开(公告)日：2013-05-16
申请号：US13811743
申请日：2011-06-30
申请人： Tanja Henzler , Karl Holschuh , Johann Bauer , Thomas Herget , Michael Hartmann , Oliver Poetz , Thomas Joos
发明人： Tanja Henzler , Karl Holschuh , Johann Bauer , Thomas Herget , Michael Hartmann , Oliver Poetz , Thomas Joos
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B82Y15/00 , G01N33/54346 , G01N33/588
摘要： The present invention relates to a method and kit for performing assays like immunoassays. The assays are performed by using two different types of magnetic beads.
摘要翻译：本发明涉及用于进行如免疫测定法的测定的方法和试剂盒。通过使用两种不同类型的磁珠来进行测定。

9. 发明申请

US20110129943A1 Method for Analyzing Proteins 有权
标题翻译：分析蛋白质的方法
公开(公告)号：US20110129943A1
公开(公告)日：2011-06-02
申请号：US12957992
申请日：2010-12-01
申请人： Thomas Joos , Dieter Stoll
发明人： Thomas Joos , Dieter Stoll
IPC分类号： G01N33/53
CPC分类号： C40B30/04 , G01N33/6845
摘要： A method for analyzing proteins makes use of an array of first capture molecules which are specific for peptide epitopes. The proteins to be analyzed or a protein mixture containing the proteins to be analyzed is degraded to peptide fragments corresponding to the peptide epitopes, after which the array of capture molecules is incubated with the peptide fragments. The peptide fragments bound to the capture molecules are then detected.
摘要翻译：分析蛋白质的方法利用了对肽表位特异的第一捕获分子阵列。要分析的蛋白质或含有待分析蛋白质的蛋白质混合物降解成对应于肽表位的肽片段，之后将该阵列的捕获分子与肽片段一起孵育。然后检测与捕获分子结合的肽片段。

10. 发明申请

US20050012420A1 Direct drive high torque compact synchronous motor 有权
标题翻译：直接驱动高扭矩紧凑型同步电机
公开(公告)号：US20050012420A1
公开(公告)日：2005-01-20
申请号：US10888207
申请日：2004-07-09
申请人： Alexander Kiderman , John Schroeder , Thomas Joos
发明人： Alexander Kiderman , John Schroeder , Thomas Joos
IPC分类号： H02K5/04 , H02K7/00 , H02K7/14 , H02K9/19 , H02K11/00 , H02K21/14 , H02K29/06 , H02K15/00 , H02K19/00 , H02K21/00
CPC分类号： H02K9/19 , H02K5/04 , H02K7/003 , H02K7/14 , H02K11/21 , H02K21/14 , H02K29/06
摘要： A synchronous motor includes a housing 20, a stator assembly 30 mounted within the housing 20, a rotor assembly 40 rotationally mounted within the housing 20, a rotor shaft 50 having an upper mounting surface 52 attached to the rotor assembly 40, a bearing assembly 60 coupled to the housing 20 and positioned axially between the rotor assembly 40 and the upper mounting surface 52, a slip ring assembly 70 supported by the housing 20 and positioned axially at least partially within the stator assembly 30 and the rotor assembly 40, and an encoder assembly 80 adjacent the slip ring assembly 70.
摘要翻译：同步电动机包括壳体20，安装在壳体20内的定子组件30，旋转地安装在壳体20内的转子组件40，具有附接到转子组件40的上安装表面52的转子轴50，轴承组件60 联接到壳体20并且轴向定位在转子组件40和上安装表面52之间;滑环组件70，其由壳体20支撑并且轴向至少部分地定位在定子组件30和转子组件40内;以及编码器组件80邻近滑环组件70。

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