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1. 发明申请

US20050214832A1 Method and kit for performing functional tests on biological cells 审中-公开
标题翻译：用于对生物细胞进行功能测试的方法和试剂盒
公开(公告)号：US20050214832A1
公开(公告)日：2005-09-29
申请号：US11051315
申请日：2005-02-04
申请人： Hugo Haemmerle , Thomas Joos , Markus Templin , Hansjurgen Volkmer , Kerstin Ragnitz , Susanne Stumpf , Cornelia Kuschel
发明人： Hugo Haemmerle , Thomas Joos , Markus Templin , Hansjurgen Volkmer , Kerstin Ragnitz , Susanne Stumpf , Cornelia Kuschel
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5005
摘要： A process for carrying out functional assays on test cells is described comprising the following steps: a) providing an array of measuring points which are separate from each other and to which in each case capture molecules to which said test cells can bind are immobilized, b) generating a mixture of said test cells and of reference particles which are capable of binding to said capture molecules and which are distinguishable from said test cells, c) contacting the mixture of step b) with the array so that test cells and reference particles can bind to each measuring point, and d) determining the ratio of bound test cells of interest to bound reference particles for at least some of the measuring points. In a further process, at least one measuring point with its assigned capture molecules is distributed between a plurality of measuring areas in the array, which are arranged at various sites in said array. In another process, the array is agitated, after contacting with the test cells and, where appropriate, the reference particles.
摘要翻译：描述了用于在测试细胞上进行功能测定的方法，其包括以下步骤：a）提供彼此分离的测量点阵列，并且在每种情况下捕获所述测试细胞可以结合的分子被固定化，b ）产生所述测试细胞和能够结合所述捕获分子并且可与所述测试细胞区分的参考颗粒的混合物，c）使步骤b）的混合物与阵列接触，使得测试细胞和参考颗粒可以结合到每个测量点，以及d）确定至少一些测量点的目标结合测试细胞与结合参考颗粒的比例。在另一个过程中，具有其分配的捕获分子的至少一个测量点分布在阵列中的多个测量区域之间，其被布置在所述阵列中的各个位置。在另一个方法中，在与测试电池接触并且在适当的时候搅拌参考颗粒。

2. 发明授权

US5723007A Biocompatible composite material and process for its production 失效
标题翻译：生物相容性复合材料及其生产工艺
公开(公告)号：US5723007A
公开(公告)日：1998-03-03
申请号：US694020
申请日：1996-08-08
申请人： Eva Maria Engel , Hugo Haemmerle , Guenter Hoff , Otto Inacker , Bernhard Kneissel , Wilfried Nisch , Lutz Scheideler , Heiner Weber
发明人： Eva Maria Engel , Hugo Haemmerle , Guenter Hoff , Otto Inacker , Bernhard Kneissel , Wilfried Nisch , Lutz Scheideler , Heiner Weber
IPC分类号： A61F2/00 , A61F2/06 , A61F2/24 , A61K6/087 , A61L27/24 , A61L27/26 , B29C70/10 , B32B9/02 , B32B38/10 , A61F2/02
CPC分类号： B32B38/10 , A61L27/24 , A61L27/26 , B29C70/10 , B32B9/02 , A61F2/062 , A61F2/24 , A61F2310/00365 , B29K2089/00 , B29K2105/0005 , B29K2105/128 , B29L2031/7532
摘要： A biocompatible composite material and a method for its production are provided, wherein the composite material is made of a plastic matrix having a felt of collagen fibers contained therein, wherein the collagen fibers project out of a surface of the composite material, wherein the composite material is produced by a process involving: a) providing a collagen fiber felt wherein the collagen fibers have a structure of native collagen; b) impregnating the collagen fiber felt with one or more polymerizable monomers, c) partially curing the one or more polymerizable monomers to provide a polymer containing unpolymerized monomers, shortchain oligomers or both therein; d) removing the unpolymerized monomers and shortchain oligomers from the surface of the composite material to expose the collagen fiber felt on the surface, wherein the composite material is useful for the production of implants, especially dental implants and the implants can be colonized with human cells prior to implantation.
摘要翻译：提供生物相容性复合材料及其生产方法，其中复合材料由其中含有胶原纤维毡的塑料基质制成，其中胶原纤维从复合材料的表面突出，其中复合材料通过以下方法生产：a）提供胶原纤维毡，其中胶原纤维具有天然胶原蛋白的结构; b）用一种或多种可聚合单体浸渍胶原纤维毡，c）部分固化一种或多种可聚合单体以提供含有未聚合单体，短链低聚物或二者的聚合物; d）从复合材料的表面除去未聚合的单体和短链低聚物以暴露表面上的胶原纤维毡，其中复合材料可用于生产植入物，特别是牙种植体，并且植入物可以被人类细胞定植植入前。

3. 发明申请

US20060184245A1 Active retina implant with a multiplicity of pixel elements 有权
标题翻译：活性视网膜植入物具有多个像素元素
公开(公告)号：US20060184245A1
公开(公告)日：2006-08-17
申请号：US11305920
申请日：2005-12-19
申请人： Heinz-Gerhard Graf , Alexander Dollberg , Bernd Hoefflinger , Wilfried Nisch , Hugo Haemmerle , Alfred Stett , Martin Stelzle , Eberhart Zrenner
发明人： Heinz-Gerhard Graf , Alexander Dollberg , Bernd Hoefflinger , Wilfried Nisch , Hugo Haemmerle , Alfred Stett , Martin Stelzle , Eberhart Zrenner
IPC分类号： A61F2/14
CPC分类号： A61N1/36046
摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.
摘要翻译：活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极，刺激信号。还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

4. 发明申请

US20060069416A1 Retina implant for stimulating a retina as a function of incident light 审中-公开
标题翻译：用于刺激视网膜作为入射光的函数的视网膜植入物
公开(公告)号：US20060069416A1
公开(公告)日：2006-03-30
申请号：US11194017
申请日：2005-07-29
申请人： Wilfried Nisch , Martin Stelzle , Heinz-Gerhard Graf , Eberhart Zrenner , Markus Schubert , Hugo Haemmerle
发明人： Wilfried Nisch , Martin Stelzle , Heinz-Gerhard Graf , Eberhart Zrenner , Markus Schubert , Hugo Haemmerle
IPC分类号： A61N1/18
CPC分类号： A61N1/36046
摘要： The present invention relates to a retina implant for the functional electrostimulation of a retina as a function of incident light. The retina implant has a stimulation chip that is designed to be implanted in the area of the retina of an eye. It further includes a radiation receiver that provides energy for the stimulation chip as a function of invisible radiation that occurs. In accordance with one aspect of the present invention, the radiation receiver is designed so as to be implanted in the area of the eye in a fashion spatially separated from the stimulation chip. The stimulation chip also has decoupling means in order to separate invisible scattered radiation from impinging visible light.
摘要翻译：本发明涉及视网膜植入物，用于根据入射光的功能性电刺激视网膜。视网膜植入物具有被设计成植入眼睛视网膜区域的刺激芯片。它还包括辐射接收器，其作为发生的不可见辐射的函数为刺激芯片提供能量。根据本发明的一个方面，辐射接收器设计成以与刺激芯片空间分离的方式植入眼睛区域。刺激芯片还具有去耦装置，以便将不可见的散射辐射与入射的可见光分开。

5. 发明授权

US6050979A Medical device for improving skin fixation of indwelling catheters and other transcutaneous implants with a reduced risk of infection 失效
标题翻译：用于改善留置导管和其他经皮植入物的皮肤固定的医疗装置，其感染风险降低
公开(公告)号：US6050979A
公开(公告)日：2000-04-18
申请号：US110126
申请日：1998-07-06
申请人： Hugo Haemmerle , Fritz Schindler
发明人： Hugo Haemmerle , Fritz Schindler
IPC分类号： A61L29/00 , A61L31/10 , A61L31/12 , A61M25/02 , A61M25/16 , A61M5/32
CPC分类号： A61L31/10 , A61L31/129 , A61M2025/0266 , A61M2025/0286 , A61M25/02
摘要： A transcutaneous medical device which has on its surface a fibrous material with free collagen fibers which are present in a natural structure. The transcutaneous medical device is prepared by applying to the surface of such a device a fibrous material with free collagen fibers present in a natural structure.
摘要翻译：一种经皮医疗装置，其表面上具有以自然结构存在的自由胶原纤维的纤维材料。经皮医疗装置通过将具有自然结构中存在的游离胶原纤维的纤维材料应用于该装置的表面来制备。

6. 发明授权

US07751896B2 Active retina implant with a multiplicity of pixel elements 有权
标题翻译：活性视网膜植入物具有多个像素元素
公开(公告)号：US07751896B2
公开(公告)日：2010-07-06
申请号：US11305920
申请日：2005-12-19
申请人： Heinz-Gerhard Graf , Alexander Dollberg , Bernd Hoefflinger , Wilfried Nisch , Hugo Haemmerle , Alfred Stett , Martin Stelzle , Eberhart Zrenner
发明人： Heinz-Gerhard Graf , Alexander Dollberg , Bernd Hoefflinger , Wilfried Nisch , Hugo Haemmerle , Alfred Stett , Martin Stelzle , Eberhart Zrenner
IPC分类号： A61F2/14
CPC分类号： A61N1/36046
摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.
摘要翻译：活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极，刺激信号。还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

7. 发明授权

US5944524A Biohybrid dental implant 失效
标题翻译：生物混合牙种植体
公开(公告)号：US5944524A
公开(公告)日：1999-08-31
申请号：US864722
申请日：1997-05-28
申请人： Frank Hill, deceased , Fritz Schindler , Hugo Haemmerle , Lutz Scheideler
发明人： Frank Hill, deceased , Fritz Schindler , Hugo Haemmerle , Lutz Scheideler
IPC分类号： A61F2/00 , A61K6/04 , A61L27/06 , A61L27/28 , A61L27/30 , A61L27/34 , A61C8/00 , A61L27/00 , C12N11/02
CPC分类号： A61L27/34 , A61L27/06 , A61L27/28 , A61L27/306 , A61F2310/00023
摘要： A dental implant coated with a composition containing desmodontal cells, where the cells are not propagated in vitro prior to being coated on the implant.
摘要翻译：涂有含有去蛋白质细胞的组合物的牙齿植入物，其中细胞在被涂覆在植入物之前不在体外繁殖。

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