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1. 发明授权

US5835648A Surface illuminator for photodynamic therapy 失效
标题翻译：用于光动力疗法的表面照明器
公开(公告)号：US5835648A
公开(公告)日：1998-11-10
申请号：US813680
申请日：1997-03-07
申请人： Hugh L. Narciso, Jr. , Christine J. Radasky , Daniel R. Doiron , Steven C. Anderson
发明人： Hugh L. Narciso, Jr. , Christine J. Radasky , Daniel R. Doiron , Steven C. Anderson
IPC分类号： A61N5/06 , F21V8/00 , G02B6/24 , G02B6/26
CPC分类号： G02B6/241 , A61N5/062 , G02B6/0008 , A61N2005/0644 , A61N2005/0666
摘要： A device for delivering phototherapeutic light to uniformly illuminate a tissue surface. The device is a bowl-shaped shell with a more-or-less parabolic profile and having an open end and an apex. The inner surface of the shell is adapted to diffusely reflect light with very low absorption by the shell material. A light output end of a fiber optic is introduced into the interior of the shell through a fiber optic port in the shell wall near the apex. The light output end of the fiber is positioned such that light emanating therefrom impinges upon the inner surface of the shell. The shape of the shell causes greater than 60 percent of the light emanating from the fiber to intercept the shell's surface and be diffusely reflected. The diffusely reflected light may then undergo further diffuse reflection within the shell prior to reaching the treatment surface adjacent to the open end of the shell to provide more uniform illumination of the treatment surface than the fiber could otherwise provide. A highly reflective coating is applied to the outer surface of the shell to prevent loss of treatment light from the device. In addition, treatment light which is reflected from the tissue surface and normally lost is captured by the interior surface of the shell and re-reflected to reenter the tissue surface. Thus, little or no treatment light is lost due to reflection or scattering from tissue providing improved efficiency. The shell preferably includes a laterally extending flange around a portion of the open end which can be affixed to the tissue surface thereby preventing relative motion between the illuminator and tissue surface during treatment enabling accurate dosimetry.
摘要翻译：一种用于传送光治疗光以均匀地照射组织表面的装置。该装置是具有或多或少抛物面轮廓并具有开口端和顶点的碗状壳体。外壳的内表面适用于通过外壳材料以非常低的吸收扩散地反射光。光纤的光输出端通过靠近顶点的壳壁中的光纤端口引入壳体的内部。纤维的光输出端定位成使得其发出的光撞击到壳体的内表面上。壳的形状导致从纤维发出的光的大于60％拦截壳的表面并被漫反射。然后漫反射光可以在到达壳体的开口端处的处理表面之前在壳体内进一步的漫反射，以提供处理表面比纤维另有提供的更均匀的照明。将高反射涂层施加到外壳的外表面以防止来自该装置的处理光的损失。此外，由组织表面反射并且正常损失的处理光被壳体的内表面捕获并重新反射以重新进入组织表面。因此，由于来自组织的反射或散射，治疗光很少或不会丧失，从而提高了效率。壳体优选地包括围绕开口端的一部分的横向延伸的凸缘，其可以固定到组织表面，从而防止在治疗期间照明器和组织表面之间的相对运动，使得能够进行精确的剂量测定。

2. 发明授权

US5978541A Custom cylindrical diffusion tips 失效
标题翻译：定制圆柱形扩散提示
公开(公告)号：US5978541A
公开(公告)日：1999-11-02
申请号：US843601
申请日：1997-04-16
申请人： Daniel R. Doiron , Hugh L. Narciso, Jr. , Christine J. Radasky , Steven C. Anderson
发明人： Daniel R. Doiron , Hugh L. Narciso, Jr. , Christine J. Radasky , Steven C. Anderson
IPC分类号： A61B18/22 , A61N5/06 , G02B6/24 , G02B23/26
CPC分类号： G02B6/241 , A61N5/0601 , A61B2018/2261 , Y10S385/902
摘要： A light diffuser tip for use with an optical fiber. The diffuser tip is affixed to an optical fiber and comprises an optically transparent elastomer core positioned to receive light from the output terminus of the optical fiber. The concentration of scattering centers embedded in the transparent elastomer core varies along the length of the core to yield a particular light distribution pattern. For example, the scattering centers may be distributed within an optically transparent elastomeric core material such as silicone to provide a scatterer density gradient along the diffuser tip in the axial direction of the optical fiber. A diffuser tip which provides uniform cylindrical light output intensity in air will provide a different output intensity distribution in a medium with a different index of refraction such as human tissue. The distribution of scattering centers within the transparent core of the diffuser tip can be customized to provide a substantially uniform radiance along the length of the diffuser tip when the tip is embedded within a medium having an index of refraction different from air. Such a custom diffuser tip is particularly useful for laser radiation treatment of tumors. Similarly, the concentration gradient of scatterers within the transparent core of the diffuser tip can be adjusted to provide an output light intensity distribution which will uniformly illuminate the wall of an irregular cavity.
摘要翻译：一种用于光纤的光扩散器尖端。扩散器末端固定在光纤上并且包括光学透明的弹性体芯，其被定位成从光纤的输出端接收光。嵌入在透明弹性体芯中的散射中心的浓度沿芯的长度变化以产生特定的光分布图。例如，散射中心可以分布在诸如硅树脂之类的光学透明的弹性体芯材料中，以沿着光纤的轴向方向沿扩散器尖端提供散射体密度梯度。在空气中提供均匀圆柱形光输出强度的扩散器尖端将在具有不同折射率（例如人体组织）的介质中提供不同的输出强度分布。扩散器末端的透明芯内的散射中心的分布可以被定制，以便当尖端嵌入在具有不同于空气的折射率的介质中时，沿着扩散器尖端的长度提供基本均匀的辐射。这种定制的扩散器尖端对于肿瘤的激光辐射治疗特别有用。类似地，可以调节扩散器尖端的透明芯内的散射体的浓度梯度，以提供均匀地照亮不规则腔的壁的输出光强度分布。

3. 发明授权

US5454794A Steerable light diffusing catheter 失效
标题翻译：导向光漫射导管
公开(公告)号：US5454794A
公开(公告)日：1995-10-03
申请号：US138134
申请日：1993-10-15
申请人： Hugh L. Narciso, Jr. , Steven C. Anderson
发明人： Hugh L. Narciso, Jr. , Steven C. Anderson
IPC分类号： A61B17/22 , A61B18/22 , A61B18/24 , A61B19/00 , A61F2/00 , A61M25/01 , A61M29/02 , A61N5/06 , A61B17/36
CPC分类号： A61N5/062 , A61B18/24 , A61M25/0133 , A61N5/0601 , A61B2017/22051 , A61B2018/2261 , A61B90/39 , A61F2210/0019 , A61M25/0105 , A61M25/104 , A61N2005/061
摘要： A steerable catheter is disclosed which can treat luminal surfaces such as those occurring in the vascular tree, pulmonary tree, gastrointestinal tract, urological organs, etc. with Photodynamic Therapy (PDT) or other optical diffusing treatments. The catheter, which may include an inflatable balloon portion, has a light diffusing tip which can be deflected allowing the catheter to be steered precisely. The light diffusing tip on the steerable catheter is able to gain access to and enter virtually any sub-branch of the luminal system being treated. Since this catheter does not require a guidewire lumen for insertion, the profile is reduced. A low profile device allows treatment light to be delivered to the walls of the most distal, small diameter lumen.
摘要翻译：公开了一种可导向的导管，其可以用光动力疗法（PDT）或其它光学扩散处理来治疗诸如在血管树，肺部树，胃肠道，泌尿器官等中发生的腔表面。可以包括可膨胀气囊部分的导管具有可以偏转的光扩散尖端，从而允许导管精确地转向。可导向导管上的光扩散尖端能够进入和进入被治疗的管腔系统的几乎任何分支。由于该导管不需要用于插入的导丝管腔，因此减小轮廓。低调的装置允许治疗光被输送到最远端，小直径腔的壁。

4. 发明授权

US07285087B2 Shape memory devices and methods for reshaping heart anatomy 有权
标题翻译：形状记忆装置和重塑心脏解剖的方法
公开(公告)号：US07285087B2
公开(公告)日：2007-10-23
申请号：US11142078
申请日：2005-05-31
申请人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
发明人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
IPC分类号： A61F2/00
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

5. 发明授权

US07108710B2 Multi-element biased suture clip 有权
标题翻译：多元素偏向缝合夹
公开(公告)号：US07108710B2
公开(公告)日：2006-09-19
申请号：US10305923
申请日：2002-11-26
申请人： Steven C. Anderson
发明人： Steven C. Anderson
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B2017/0454 , A61B2017/0488 , Y10T24/202 , Y10T24/3929 , Y10T24/3936
摘要： A suture clamping system, including a plurality of elements positioned together in a row, wherein at least one of the elements is flexible, the plurality of elements each being dimensioned such that an opening slot is formed through the row of elements when the at least one flexible element is biased into a first position, and wherein a tortuous path is formed through the row of elements when the elements are not biased. A method of clamping a suture pair, including biasing a row of adjacent flexible elements to a first position in which an opening slot is formed therealong; receiving the suture pair into the opening slot; and removing the biasing such that the adjacent flexible elements move to positions which hold the suture pair in a tortuous path.
摘要翻译：一种缝合线夹紧系统，包括一排定位在一起的多个元件，其中至少一个元件是柔性的，所述多个元件的尺寸被设计成使得当所述至少一个元件柔性元件被偏压到第一位置，并且其中当所述元件没有偏置时，通过所述元件行形成曲折路径。一种夹紧缝合线对的方法，包括将一排相邻的柔性元件偏压到其中形成开口槽的第一位置; 将缝线对接收到开口槽中; 并且移除所述偏压使得相邻的柔性元件移动到将缝线对保持在曲折路径中的位置。

6. 发明授权

US5782825A Microlens tip assembly for light delivery catheter 失效
标题翻译：微透镜头组件用于光输送导管
公开(公告)号：US5782825A
公开(公告)日：1998-07-21
申请号：US611592
申请日：1996-03-07
申请人： Steven C. Anderson
发明人： Steven C. Anderson
IPC分类号： A61B18/22 , A61B18/24 , A61B17/39
CPC分类号： A61B18/24 , A61B2018/2266
摘要： A microlens tip assembly for focusing output light from a light delivery catheter upon a target tissue. Due to the inherent divergence of output light from diode lasers, when such divergent light is conducted from the proximal end of a catheter to the distal end by means of a fiber optic, a portion is reflected at the fiber/air/lens interface to impinge upon the microlens housing area thereby heating the housing assembly resulting in overheating at high power levels and possible device failure and/or tissue damage. The present high-powered microlens includes a rear and front mount, both of which are fabricated from a non-light-absorbing material such as transparent or white plastic. The use of transparent or non-ligh-absorbing plastic components decreases the amount of heating of the tip assembly during light delivery, thereby solving the problem of therapeutic light delivery device failures and/or tissue damage due to overheating.
摘要翻译：用于将来自光输送导管的输出光聚焦到目标组织上的微透镜末端组件。由于来自二极管激光器的输出光的固有偏差，当这种发散光通过光纤从导管的近端传导到远端时，部分在光纤/空气/透镜接口处被反射在微透镜壳体区域上，从而加热壳体组件，导致高功率水平的过热和可能的装置故障和/或组织损伤。目前的大功率微透镜包括后部和前部安装件，它们均由诸如透明或白色塑料的非光吸收材料制成。透明或非吸收性塑料部件的使用减少了在光输送期间针头组件的加热量，从而解决了由于过热导致的治疗性光输送装置故障和/或组织损伤的问题。

7. 发明授权

US08460339B2 Multi element biased suture clip 有权
标题翻译：多元偏向缝合夹
公开(公告)号：US08460339B2
公开(公告)日：2013-06-11
申请号：US12869014
申请日：2010-08-26
申请人： Steven C. Anderson
发明人： Steven C. Anderson
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B2017/0454 , A61B2017/0488 , Y10T24/202 , Y10T24/3929 , Y10T24/3936
摘要： A suture clamp comprising a plurality of elements positioned together in a row, each element of the plurality of elements having a lower portion separated from an upper portion by a flexible neck, each element of the plurality of elements including a slot having an outwardly facing opening, the slots from the plurality of elements configured to accept a suture element through the row of elements and secure the suture element. A method of clamping a suture, including applying a biasing force to at least one element into the first position to provide access to the outwardly facing opening of the slot, passing the suture through a tissue layer, receiving the suture into the slot through the outward facing opening, and removing the biasing force to form a tortuous path between adjacently positioned elements of the plurality of elements.
摘要翻译：缝合夹具包括多个位于一排的元件，多个元件中的每个元件具有通过柔性颈部与上部分离的下部，多个元件的每个元件包括具有向外的开口来自多个元件的槽被配置成通过该排元件接合缝合元件并固定缝合元件。一种夹紧缝合线的方法，包括向至少一个元件施加偏置力到第一位置以提供对缝隙向外开口的通路，使缝合线穿过组织层，通过向外的缝合线将缝线插入槽中并且去除偏压力以在多个元件的相邻定位的元件之间形成曲折的路径。

8. 发明授权

US07806910B2 Multi-element biased suture clip 有权
标题翻译：多元素偏向缝合夹
公开(公告)号：US07806910B2
公开(公告)日：2010-10-05
申请号：US11461323
申请日：2006-07-31
申请人： Steven C. Anderson
发明人： Steven C. Anderson
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B2017/0454 , A61B2017/0488 , Y10T24/202 , Y10T24/3929 , Y10T24/3936
摘要： A suture clamping system, including a plurality of elements positioned together in a row, wherein at least one of the elements is flexible, the plurality of elements each being dimensioned such that an opening slot is formed through the row of elements when the at least one flexible element is biased into a first position, and wherein a tortuous path is formed through the row of elements when the elements are not biased. A method of clamping a suture pair, including biasing a row of adjacent flexible elements to a first position in which an opening slot is formed there along; receiving the suture pair into the opening slot; and removing the biasing such that the adjacent flexible elements move to positions which hold the suture pair in a tortuous path.
摘要翻译：一种缝合线夹紧系统，包括一排定位在一起的多个元件，其中所述元件中的至少一个是柔性的，所述多个元件的尺寸被设计成使得当所述至少一个元件柔性元件被偏压到第一位置，并且其中当所述元件没有偏置时，通过所述元件行形成曲折路径。一种夹紧缝合线对的方法，包括将一排相邻的柔性元件偏置到第一位置，在第一位置中，沿着其中形成开口槽; 将缝线对接收到开口槽中; 并且移除所述偏压使得相邻的柔性元件移动到将缝线对保持在曲折路径中的位置。

9. 发明授权

US4305193A Zone control valve removal tool and method 失效
标题翻译：区域控制阀去除工具及方法
公开(公告)号：US4305193A
公开(公告)日：1981-12-15
申请号：US111374
申请日：1980-01-11
申请人： Steven C. Anderson
发明人： Steven C. Anderson
IPC分类号： B25B27/24 , B23P19/04
CPC分类号： B25B27/24 , Y10T29/53552 , Y10T29/53878
摘要： A tool and method are disclosed for removing a valve core or element from a valve which is under pressure without requiring that the system be shut down and the pressure relieved. A tool having a passage therethrough sized to accommodate the valve element to be serviced is bolted over the valve and the valve element is drawn therein and the tool closed to isolate the passage and the element from the pressurized system thereby allowing the element to be repaired or replaced.
摘要翻译：公开了一种用于从处于压力下的阀去除阀芯或元件的工具和方法，而不需要关闭系统并且释放压力。具有穿过其尺寸以容纳被维修的阀元件的通道的工具被螺栓连接在阀上并且阀元件被抽吸在其中并且工具关闭以将通道和元件与加压系统隔离，从而允许元件被修理或取而代之

10. 发明申请

US20110257741A1 IMPLANTS AND METHODS FOR RESHAPING HEART VALVES 审中-公开
标题翻译：用于修复心脏瓣膜的植入物和方法
公开(公告)号：US20110257741A1
公开(公告)日：2011-10-20
申请号：US13088189
申请日：2011-04-15
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian , Michael R. Henson , Richard S. Rhee , Steven C. Anderson
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian , Michael R. Henson , Richard S. Rhee , Steven C. Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. In certain embodiments, magnetic tissue shaping devices are implanted in tissue adjacent heart valve leaflets. The devices are mutually attractive or repulsive so as to remodel the heart tissue and improve heart valve function. In certain other embodiments, one or more tissue shaping devices including shape memory material are implanted in a patient's body within or on tissue adjacent a heart valve leaflet. The shape memory material can be activated within the patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The shape memory tissue shaping devices are implanted in a first configuration and then activated to remember a second configuration that displaces tissue so as to remodel the heart valve geometry and improve heart valve function. In certain other embodiments, a brace is crimped to the base of a heart valve leaflet to support the leaflet and improve valve closure.
摘要翻译：提供组织成形方法和装置用于加强和/或改造心脏瓣膜。在某些实施例中，将磁组织成形装置植入在心脏瓣膜小叶附近的组织中。这些装置是相互吸引或排斥的，以便改造心脏组织并改善心脏瓣膜功能。在某些其他实施例中，包括形状记忆材料的一个或多个组织成形装置植入在心脏瓣膜附近的组织内或组织附近的患者体内。形状记忆材料可以以较少侵入性或非侵入性方式在患者体内被激活，例如通过经皮或外部施加能量到患者身体。形状记忆组织成形装置以第一配置植入，然后被激活以记住置换组织的第二配置，以便改造心脏瓣膜几何形状并改善心脏瓣膜功能。在某些其他实施例中，支架卷曲到心脏瓣膜小叶的底部以支撑小叶并改善瓣膜关闭。

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