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1. 发明授权

US5835648A Surface illuminator for photodynamic therapy 失效
标题翻译：用于光动力疗法的表面照明器
公开(公告)号：US5835648A
公开(公告)日：1998-11-10
申请号：US813680
申请日：1997-03-07
申请人： Hugh L. Narciso, Jr. , Christine J. Radasky , Daniel R. Doiron , Steven C. Anderson
发明人： Hugh L. Narciso, Jr. , Christine J. Radasky , Daniel R. Doiron , Steven C. Anderson
IPC分类号： A61N5/06 , F21V8/00 , G02B6/24 , G02B6/26
CPC分类号： G02B6/241 , A61N5/062 , G02B6/0008 , A61N2005/0644 , A61N2005/0666
摘要： A device for delivering phototherapeutic light to uniformly illuminate a tissue surface. The device is a bowl-shaped shell with a more-or-less parabolic profile and having an open end and an apex. The inner surface of the shell is adapted to diffusely reflect light with very low absorption by the shell material. A light output end of a fiber optic is introduced into the interior of the shell through a fiber optic port in the shell wall near the apex. The light output end of the fiber is positioned such that light emanating therefrom impinges upon the inner surface of the shell. The shape of the shell causes greater than 60 percent of the light emanating from the fiber to intercept the shell's surface and be diffusely reflected. The diffusely reflected light may then undergo further diffuse reflection within the shell prior to reaching the treatment surface adjacent to the open end of the shell to provide more uniform illumination of the treatment surface than the fiber could otherwise provide. A highly reflective coating is applied to the outer surface of the shell to prevent loss of treatment light from the device. In addition, treatment light which is reflected from the tissue surface and normally lost is captured by the interior surface of the shell and re-reflected to reenter the tissue surface. Thus, little or no treatment light is lost due to reflection or scattering from tissue providing improved efficiency. The shell preferably includes a laterally extending flange around a portion of the open end which can be affixed to the tissue surface thereby preventing relative motion between the illuminator and tissue surface during treatment enabling accurate dosimetry.
摘要翻译：一种用于传送光治疗光以均匀地照射组织表面的装置。该装置是具有或多或少抛物面轮廓并具有开口端和顶点的碗状壳体。外壳的内表面适用于通过外壳材料以非常低的吸收扩散地反射光。光纤的光输出端通过靠近顶点的壳壁中的光纤端口引入壳体的内部。纤维的光输出端定位成使得其发出的光撞击到壳体的内表面上。壳的形状导致从纤维发出的光的大于60％拦截壳的表面并被漫反射。然后漫反射光可以在到达壳体的开口端处的处理表面之前在壳体内进一步的漫反射，以提供处理表面比纤维另有提供的更均匀的照明。将高反射涂层施加到外壳的外表面以防止来自该装置的处理光的损失。此外，由组织表面反射并且正常损失的处理光被壳体的内表面捕获并重新反射以重新进入组织表面。因此，由于来自组织的反射或散射，治疗光很少或不会丧失，从而提高了效率。壳体优选地包括围绕开口端的一部分的横向延伸的凸缘，其可以固定到组织表面，从而防止在治疗期间照明器和组织表面之间的相对运动，使得能够进行精确的剂量测定。

2. 发明授权

US5978541A Custom cylindrical diffusion tips 失效
标题翻译：定制圆柱形扩散提示
公开(公告)号：US5978541A
公开(公告)日：1999-11-02
申请号：US843601
申请日：1997-04-16
申请人： Daniel R. Doiron , Hugh L. Narciso, Jr. , Christine J. Radasky , Steven C. Anderson
发明人： Daniel R. Doiron , Hugh L. Narciso, Jr. , Christine J. Radasky , Steven C. Anderson
IPC分类号： A61B18/22 , A61N5/06 , G02B6/24 , G02B23/26
CPC分类号： G02B6/241 , A61N5/0601 , A61B2018/2261 , Y10S385/902
摘要： A light diffuser tip for use with an optical fiber. The diffuser tip is affixed to an optical fiber and comprises an optically transparent elastomer core positioned to receive light from the output terminus of the optical fiber. The concentration of scattering centers embedded in the transparent elastomer core varies along the length of the core to yield a particular light distribution pattern. For example, the scattering centers may be distributed within an optically transparent elastomeric core material such as silicone to provide a scatterer density gradient along the diffuser tip in the axial direction of the optical fiber. A diffuser tip which provides uniform cylindrical light output intensity in air will provide a different output intensity distribution in a medium with a different index of refraction such as human tissue. The distribution of scattering centers within the transparent core of the diffuser tip can be customized to provide a substantially uniform radiance along the length of the diffuser tip when the tip is embedded within a medium having an index of refraction different from air. Such a custom diffuser tip is particularly useful for laser radiation treatment of tumors. Similarly, the concentration gradient of scatterers within the transparent core of the diffuser tip can be adjusted to provide an output light intensity distribution which will uniformly illuminate the wall of an irregular cavity.
摘要翻译：一种用于光纤的光扩散器尖端。扩散器末端固定在光纤上并且包括光学透明的弹性体芯，其被定位成从光纤的输出端接收光。嵌入在透明弹性体芯中的散射中心的浓度沿芯的长度变化以产生特定的光分布图。例如，散射中心可以分布在诸如硅树脂之类的光学透明的弹性体芯材料中，以沿着光纤的轴向方向沿扩散器尖端提供散射体密度梯度。在空气中提供均匀圆柱形光输出强度的扩散器尖端将在具有不同折射率（例如人体组织）的介质中提供不同的输出强度分布。扩散器末端的透明芯内的散射中心的分布可以被定制，以便当尖端嵌入在具有不同于空气的折射率的介质中时，沿着扩散器尖端的长度提供基本均匀的辐射。这种定制的扩散器尖端对于肿瘤的激光辐射治疗特别有用。类似地，可以调节扩散器尖端的透明芯内的散射体的浓度梯度，以提供均匀地照亮不规则腔的壁的输出光强度分布。

3. 发明授权

US5231684A Optical fiber microlens 失效
标题翻译：光纤微透镜
公开(公告)号：US5231684A
公开(公告)日：1993-07-27
申请号：US902674
申请日：1992-06-22
申请人： Hugh L. Narciso, Jr. , Daniel R. Doiron
发明人： Hugh L. Narciso, Jr. , Daniel R. Doiron
IPC分类号： A61B18/22 , G02B6/32 , G02B6/38
CPC分类号： G02B6/32 , A61B2018/2266 , G02B6/3861
摘要： A microlens assembly for use with an optical fiber or fiber bundle that requires no crimping or mechanical distortion of the optical fiber. The microlens assembly has a front lens mounting portion and a rear portion. The rear portion is a cylindrical tube which is bonded to the sheath and cladding of the optical fiber or fiber bundle by means of suitable adhesive. The front lens mounting portion which houses the output lens is also tubular, having an inner diameter greater than the outer diameter of the rear portion. The front lens mounting portion is slid over the rear portion until the desired distribution of light emanating from the lens is achieved. The front lens mounting portion is then locked into position by bonding it to the rear portion by means of an appropriate adhesive. The adhesives are stable at high temperature and have an index of refractions suitable for preventing refractive loss of light from the lateral walls of the fiber core. In one embodiment, the cylindrical space in the microlens assembly between the output lens and the tip of the optical fiber or fiber bundle is filled with an optically transparent fluid or elastomer such as silicone. The filling excludes body fluids from entering the microlens assembly.
摘要翻译：用于光纤或光纤束的微透镜组件，其不需要光纤的卷曲或机械变形。微透镜组件具有前透镜安装部分和后部部分。后部是圆柱形管，其通过合适的粘合剂结合到光纤或纤维束的护套和包层。容纳输出透镜的前透镜安装部分也是管状的，其内径大于后部的外径。前透镜安装部分在后部部分上滑动，直到实现从透镜发出的光的期望分布。然后通过适当的粘合剂将前透镜安装部分通过将其固定到后部而被锁定到位。粘合剂在高温下是稳定的，并且具有适合于防止来自纤维芯侧壁的光的折射损失的折射率。在一个实施例中，在输出透镜和光纤或纤维束的尖端之间的微透镜组件中的圆柱形空间填充有光学透明的流体或弹性体，例如硅树脂。填充物不包括体液进入微透镜组件。

4. 发明授权

US5196005A Continuous gradient cylindrical diffusion tip for optical fibers and method for making 失效
标题翻译：用于光纤的连续梯度圆柱形扩散尖端和制造方法
公开(公告)号：US5196005A
公开(公告)日：1993-03-23
申请号：US799047
申请日：1991-11-26
申请人： Daniel R. Doiron , Hugh L. Narciso, Jr. , Paul Paspa
发明人： Daniel R. Doiron , Hugh L. Narciso, Jr. , Paul Paspa
IPC分类号： A61B18/22 , A61N5/06
CPC分类号： A61B18/22 , A61N5/0601 , A61B2018/2261
摘要： A cylindrical diffuser tip for use with an optical fiber is described. The diffuser tip comprises a silicone core containing scattering centers embedded therein abutted to the terminus of the conventional optical core of an optical fiber, and an outer protective plastic tube to provide controlled stiffness or rigidity to the silicone diffuser tip while maintaining a flexibility comparable to that of the optical fiber. The scattering centers embedded in the silicone core are distributed to provide a gradient that increases continuously in a direction perpendicular from the terminus face of the optical fiber. The tip provides a substantially uniform distribution of radiance along its length and is particularly useful for laser radiation treatment of tumors. The stiffness of the diffuser tip can be varied by choosing a protective tube of varying wall thickness and durometer. The diffuser tip is useful for providing uniform cylindrical illumination of target tissue in remote areas of the body and is particularly useful in such areas as Photodynamic Therapy of tumors, phototherapy of atheromas and hyperthermia.
摘要翻译：描述了与光纤一起使用的圆柱形扩散器尖端。扩散器末端包括含有嵌入其中的散射中心的硅芯芯，其邻接于光纤的常规光学核心的末端，以及外部保护塑料管，以提供与硅胶扩散器尖端的受控的刚度或刚度，同时保持与之相当的灵活性的光纤。嵌入在硅芯中的散射中心被分配以提供在与光纤的终端面垂直的方向上连续增加的梯度。尖端沿其长度提供基本均匀的辐射分布，并且对于肿瘤的激光辐射治疗特别有用。可以通过选择不同壁厚和硬度的保护管来改变扩散器尖端的刚度。扩散器尖端可用于在身体的偏远地区提供均匀的圆柱形照射目标组织，并且特别适用于诸如肿瘤的光动力治疗，动脉粥样化光疗和高热疗等领域。

5. 发明授权

US5267995A Optical waveguide with flexible tip 失效
标题翻译：具有柔性尖端的光波导
公开(公告)号：US5267995A
公开(公告)日：1993-12-07
申请号：US938707
申请日：1992-09-01
申请人： Daniel R. Doiron , Hugh L. Narciso, Jr.
发明人： Daniel R. Doiron , Hugh L. Narciso, Jr.
IPC分类号： A61B17/22 , A61B18/24 , A61B17/32
CPC分类号： A61B18/24 , A61B2017/22077
摘要： A flexible tip for a medical catheter suitable for the transmission of light and dimensioned to pass through extremely small tubular members is described. The flexible tip, preferably made of optically transparent silicone elastomer, is affixed to the terminal end of a conventional optical fiber. In a preferred embodiment, the flexible tip comprises a central silicone core surrounded by a cladding having an index of refraction less than that of the core, permitting internal reflection. The flexible tip is provided with an outer jacket which serves two purposes: a) it provides structural integrity for the tip, and b) it reinforces the union between the flexible tip and the optical fiber to which it is abutted. The tip enables the delivery of a comparable amount of light as a large glass fiber of equal core diameter but possesses much greater flexibility. The tip has the flexibility to be able to enter tortuous tubular members while retaining the light transmitting capabilities of relatively inflexible glass optical waveguides of the same diameter.
摘要翻译：描述了一种用于医疗导管的柔性尖端，适用于透射光并且尺寸适于通过极小的管状构件。优选由光学透明的硅氧烷弹性体制成的柔性末端固定到常规光纤的终端。在优选实施例中，柔性尖端包括由折射率小于芯的折射率的包层围绕的中心硅芯，允许内部反射。柔性尖端设置有外护套，其用于两个目的：a）其为尖端提供结构完整性，以及b）它加强了柔性尖端和与其邻接的光纤之间的联接。该尖端使得能够输送相当数量的光作为相同芯径的大玻璃纤维，但具有更大的灵活性。尖端具有能够进入曲折的管状构件的灵活性，同时保持相同直径的相对不弯曲的玻璃光波导的透光能力。

6. 发明授权

US5957917A Transluminal hyperthermia catheter and method for use 失效
标题翻译：腔内高热导管及使用方法
公开(公告)号：US5957917A
公开(公告)日：1999-09-28
申请号：US934537
申请日：1997-09-22
申请人： Daniel R. Doiron , Hugh L. Narciso, Jr.
发明人： Daniel R. Doiron , Hugh L. Narciso, Jr.
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/22 , A61N5/06 , A61B17/36
CPC分类号： A61N5/0601 , A61B2017/00274 , A61B2017/22059 , A61B2018/00023 , A61B2018/00547 , A61B2018/2261 , A61N2005/061
摘要： A catheter and a method for using the catheter for the transluminal hyperthermic treatment of target tissue is presented. The catheter comprises an elongate tubular member having two coolant circulating lumens and an optical waveguide coextensive therewith, the proximal end of the optical waveguide being adapted to receive light from a light source and the distal end of the optical waveguide terminating in a diffuser tip. The diffuser tip provides a means for radially distributing treatment light from the light source to tissue adjacent to the distal tip of the catheter to heat the tissue. A transparent, inflatable balloon surrounds the diffuser tip. The inflatable balloon permits the flow of an optically transparent coolant around the diffuser tip to cool the tissue immediately adjacent to the diffuser tip to prevent overheating. A method of using the device for the transurethral treatment of benign prostate hypertrophy is presented as an example.
摘要翻译：提出了导管和使用导管进行目标组织的腔内热疗治疗的方法。导管包括具有两个冷却剂循环腔和与其共同延伸的光波导的细长管状构件，光波导的近端适于接收来自光源的光，并且光波导的远端终止于扩散器尖端。扩散器末端提供用于将处理光从光源分散到与导管的远侧末端相邻的组织以加热组织的装置。透明的，可充气的气球围绕扩散器末端。可膨胀气囊允许在扩散器末端周围流动光学透明的冷却剂，以使紧邻扩散器末端的组织冷却以防止过热。以该器械为前列腺肥大的经尿道治疗方法为例。

7. 发明授权

US5269777A Diffusion tip for optical fibers 失效
标题翻译：光纤扩散端
公开(公告)号：US5269777A
公开(公告)日：1993-12-14
申请号：US853338
申请日：1992-03-16
申请人： Daniel R. Doiron , Hugh L. Narciso, Jr.
发明人： Daniel R. Doiron , Hugh L. Narciso, Jr.
IPC分类号： A61B18/22 , A61N5/06 , A61B17/36
CPC分类号： A61N5/062 , A61N5/0601 , A61B2018/2261
摘要： A cylindrical diffuser tip for use with an optical fiber is described. The diffuser tip comprises a silicone core abutted to the terminus of the conventional optical core of an optical fiber, an outer layer of silicone plus a suitable scatterer, and a final cladding of plastic tubing to provide controlled stiffness or rigidity to the silicone diffuser tip while maintaining a flexibility comparable to the optical fiber. The tip provides a substantially uniform distribution of radiance along its length and is particularly useful for laser radiation treatment of tumors. The stiffness of the diffuser tip can be varied by choosing an outer tubing of varying wall thickness and durometer. The diffuser tip is useful for providing uniform cylindrical illumination of target tissue in remote areas of the body and is particularly useful in such areas as Photodynamic Therapy of tumors and atheromas and hyperthermia.
摘要翻译：描述了与光纤一起使用的圆柱形扩散器尖端。扩散器末端包括与光纤的常规光学核心的末端邻接的硅氧烷芯，硅树脂的外层加上合适的散射体，以及塑料管的最终包层，以提供对硅氧烷扩散器尖端的受控刚度或刚性，同时保持与光纤相当的灵活性。尖端沿其长度提供基本均匀的辐射分布，并且对于肿瘤的激光辐射治疗特别有用。可以通过选择不同壁厚和硬度的外管来改变扩散器尖端的刚度。扩散器尖端可用于在身体的偏远区域中提供目标组织的均匀圆柱形照明，并且在诸如肿瘤和动脉粥样硬化的光动力疗法和热疗之类的区域中是特别有用的。

8. 发明授权

US5454794A Steerable light diffusing catheter 失效
标题翻译：导向光漫射导管
公开(公告)号：US5454794A
公开(公告)日：1995-10-03
申请号：US138134
申请日：1993-10-15
申请人： Hugh L. Narciso, Jr. , Steven C. Anderson
发明人： Hugh L. Narciso, Jr. , Steven C. Anderson
IPC分类号： A61B17/22 , A61B18/22 , A61B18/24 , A61B19/00 , A61F2/00 , A61M25/01 , A61M29/02 , A61N5/06 , A61B17/36
CPC分类号： A61N5/062 , A61B18/24 , A61M25/0133 , A61N5/0601 , A61B2017/22051 , A61B2018/2261 , A61B90/39 , A61F2210/0019 , A61M25/0105 , A61M25/104 , A61N2005/061
摘要： A steerable catheter is disclosed which can treat luminal surfaces such as those occurring in the vascular tree, pulmonary tree, gastrointestinal tract, urological organs, etc. with Photodynamic Therapy (PDT) or other optical diffusing treatments. The catheter, which may include an inflatable balloon portion, has a light diffusing tip which can be deflected allowing the catheter to be steered precisely. The light diffusing tip on the steerable catheter is able to gain access to and enter virtually any sub-branch of the luminal system being treated. Since this catheter does not require a guidewire lumen for insertion, the profile is reduced. A low profile device allows treatment light to be delivered to the walls of the most distal, small diameter lumen.
摘要翻译：公开了一种可导向的导管，其可以用光动力疗法（PDT）或其它光学扩散处理来治疗诸如在血管树，肺部树，胃肠道，泌尿器官等中发生的腔表面。可以包括可膨胀气囊部分的导管具有可以偏转的光扩散尖端，从而允许导管精确地转向。可导向导管上的光扩散尖端能够进入和进入被治疗的管腔系统的几乎任何分支。由于该导管不需要用于插入的导丝管腔，因此减小轮廓。低调的装置允许治疗光被输送到最远端，小直径腔的壁。

9. 发明授权

US5298018A Method for treating cardiovascular disease through adjunctive photodynamic therapy 失效
标题翻译：通过辅助光动力治疗治疗心血管疾病的方法
公开(公告)号：US5298018A
公开(公告)日：1994-03-29
申请号：US930860
申请日：1992-08-14
申请人： Hugh L. Narciso, Jr.
发明人： Hugh L. Narciso, Jr.
IPC分类号： A61K31/555 , A61N5/06 , A61N1/30
CPC分类号： A61N5/062 , A61K31/555 , A61N5/0601
摘要： Photodynamic Therapy (PDT) is used as an adjunctive or stand alone procedure for the treatment of cardiovascular disease. When used as an adjunctive therapy to Percutaneous Transluminal Coronary Angioplasty, laser angioplasty, atherectomy, stenting, or any other interventional or surgical procedure, it has been found that the treatment timing is critical to the success of the combined therapies. A photosensitizer is administered prior to the surgical or interventional procedure and then readministered after the procedure to maintain the photosensitizer concentration level in the atheromatous plaque and smooth muscle cells in the vicinity of the lesion for a period of about 5-18 days, the period in which cell proliferation can occur. The photosensitizer inhibits smooth muscle cell proliferation and, thus, minimizes or eliminates the possibility of re-stenosis. The photosensitizer is then illuminated at the end of this period, thereby lysing the atheromatous plaque and smooth muscles. The photosensitizer inhibits atheromatic smooth muscle cell proliferation.
摘要翻译：光动力疗法（PDT）用作治疗心血管疾病的辅助或独立手术。当用作经皮冠状动脉冠状动脉成形术，激光血管成形术，粥样斑块切除术，支架置入术或任何其他介入或外科手术的辅助治疗时，已经发现治疗时机对于联合治疗的成功至关重要。在手术或介入手术之前施用光敏剂，然后在手术后重新施用，以维持病变附近的动脉粥样硬化斑块和平滑肌细胞中的光敏剂浓度水平，持续约5-18天，哪些细胞增殖可能发生。光敏剂抑制平滑肌细胞增殖，从而使再狭窄的可能性最小化或消除。然后在此期间结束时照射光敏剂，从而裂解动脉粥样硬化斑块和平滑肌肉。光敏剂抑制无神经平滑肌细胞增殖。

10. 发明授权

US5217456A Device and method for intra-vascular optical radial imaging 失效
标题翻译：用于血管内光学径向成像的装置和方法
公开(公告)号：US5217456A
公开(公告)日：1993-06-08
申请号：US840478
申请日：1992-02-24
申请人： Hugh L. Narciso, Jr.
发明人： Hugh L. Narciso, Jr.
IPC分类号： A61B5/00
CPC分类号： A61B1/00177 , A61B1/043 , A61B5/0071 , A61B5/0084
摘要： An intra-vascular optical radial imaging system comprising an intra-vascular guidewire-compatible catheter, a source of illumination and a synchronous fluorescence detector. The catheter is inserted into a blood vessel until the tip is adjacent to a section of vessel to be imaged. A narrow beam of light emanating radially from an aperture underlying the segment to be imaged repetitively illuminates segments of the wall of the vessel in a scanning or sweeping manner with the light of a wavelength that induces fluorescence in molecules in the tissue. Fluorescence from molecules in the illuminated tissue enters the catheter through the aperture and is conveyed to a spectral analyzer. Properties of the fluorescence signal are characteristic of the particular tissue and may be used to differentiate healthy tissue from atherosclerotic plaque. The method yields not only the longitudinal position of a lesion along a vessel but also the cylindrical coordinates by determining the circular or angular position of the lesion on the interior wall of the vessel.
摘要翻译：一种血管内光学径向成像系统，其包括血管内导丝相容导管，照明源和同步荧光检测器。将导管插入血管，直到尖端与要成像的血管的一部分相邻。从被成像的片下面的孔径向辐射的窄光束以扫描或扫描方式以在组织中的分子中诱导荧光的波长的光重复地照射血管壁。来自照射组织中的分子的荧光通过孔进入导管并被传送到光谱分析仪。荧光信号的特性是特定组织的特征，可用于区分健康组织与动脉粥样硬化斑块。该方法不仅产生沿着血管的病变的纵向位置，而且通过确定血管内壁上的病变的圆形或角位置来产生圆柱坐标。

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