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1. 发明授权

US5334607A Methods for treating mycoses 失效
标题翻译：治疗真菌病的方法
公开(公告)号：US5334607A
公开(公告)日：1994-08-02
申请号：US889418
申请日：1992-05-28
申请人： Hubert Sauter , Gisela Lorenz , Gerd Steiner , Bernd Janssen , Timm Anke , Wolfgang Steglich
发明人： Hubert Sauter , Gisela Lorenz , Gerd Steiner , Bernd Janssen , Timm Anke , Wolfgang Steglich
IPC分类号： A61K31/165 , A61K31/215 , A61K31/415 , A61K31/42 , A61K31/44 , A61K31/505 , A01N37/10 , A01N37/50 , A01N43/40 , A01N43/54 , A01N43/56
CPC分类号： A61K31/42 , A61K31/165 , A61K31/215 , A61K31/415 , A61K31/44 , A61K31/505
摘要： Antimycotics containing a compound of the formula ##STR1## where .dbd.Y is .dbd.CH--OCH.sub.3, .dbd.CH--CH.sub.3, .dbd.CH--CH.sub.2 --CH.sub.3, .dbd.CH--SCH.sub.3 or .dbd.N--OCH.sub.3, and X is oxygen, or X may also be NH if Y is .dbd.N--OCH.sub.3,Z is halogen, nitro, cyano, unsubstituted or substituted organic radicals, OR.sup.12, SR.sup.13, SOR.sup.14, SO.sub.2 R.sup.15, --COOR.sup.16, --CONR.sup.17 R.sup.18, --COR.sup.19, --CR.sup.20 .dbd.NR.sup.21, --N.dbd.CR.sup.22 R.sup.23, --CR.sup.24 .dbd.N--OR.sup.25, --CR.sup.25 R.sup.26 --O--N.dbd.CR.sup.27 R.sup.28 andU, V, W can be hydrogen or one of the meanings given for Z, or where two of Z, U, V and W in adjacent positions on the phenyl ring can form an unsubstituted or substituted five- or six-membered, aromatic or aliphatic ring which may contain one to three hetero atoms (N, S, O), and R.sup.12 to R.sup.26 are identical or different and are hydrogen, unsubstituted or substituted organic radicals,are used for controlling mycoses.
摘要翻译：其中= Y为= CH-OCH 3，= CH-CH 3，= CH-CH 2 -CH 3，= CH-SCH 3或= N-OCH 3，X为氧，X可为如果Y为= N-OCH 3，Z为卤素，硝基，氰基，未取代或取代的有机基团，则为NH，OR12，SR13，SOR14，SO2R15，-COOR16，-CONR17R18，-COR19，-CR20 = NR21，-N = CR22R23，-CR24 = N-OR25，-CR25R26-ON = CR27R28，U，V，W可以是氢或Z给出的含义之一，或者其中Z，U，V和W中两个在苯基上的相邻位置环可以形成可以含有一至三个杂原子（N，S，O）的未取代或取代的五元或六元芳族或脂族环，R 12至R 26相同或不同，为氢，未取代或取代的有机自由基，用于控制真菌病。

2. 发明申请

US20060142317A1 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof 有权
标题翻译： 3-取代的3,4-二氢 - 噻吩并[2,3-d]嘧啶-4-酮衍生物，的制备和用途
公开(公告)号：US20060142317A1
公开(公告)日：2006-06-29
申请号：US10539708
申请日：2003-12-17
申请人： Margaretha Bakker , Wilfried Hornberger , Andreas Kling , Udo Lange , Helmut Mack , Achim Moeller , Reinhold Mueller , Kurt Schelhaas , Martin Schmidt , Gerd Steiner , Karsten Wicke
发明人： Margaretha Bakker , Wilfried Hornberger , Andreas Kling , Udo Lange , Helmut Mack , Achim Moeller , Reinhold Mueller , Kurt Schelhaas , Martin Schmidt , Gerd Steiner , Karsten Wicke
IPC分类号： A61K31/519 , C07D498/14
CPC分类号： C07D495/14
摘要： The invention relates to 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2 and —NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.
摘要翻译：本发明涉及在3位被5元杂芳基取代的3,4-二氢 - 噻吩并[2,3-d]嘧啶-4-酮衍生物，其可以与芳基或杂芳基稠合，其中杂芳基和如果合适，稠合的芳基或杂芳基可以具有1,2或3个彼此独立地选自C 1-5 - 烷基，C 1-5 - 烷氧基，C 1-5 - 烷硫基，卤素，CN，卤代-C 1-5 - 烷基，卤代C 1-5 - 烷氧基，羟基，-NH 2，-N（R 6）2，-NH（R 6），芳基，芳氧基，芳烷基，芳烷氧基和杂芳基，其中取代基芳基，芳氧基，芳烷基，芳烷氧基和杂芳基可以具有1,2或3个选自C 1-5 - 烷基，C 1-5 - 烷氧基，C 卤代C 1 -C 5烷基，卤素，CN，卤代-C 1-5烷基，卤代-C 1-5烷氧基，羟基，-NH 2，-N（R 6）2和-NH（R 6）。这些衍生物的制备和使用，特别是用于治疗目的，例如为了处理凹陷，同样地描述。

3. 发明申请

US20060069083A1 Pesticidal dibenzo(hetero)azepine derivatives 审中-公开
标题翻译：杀虫二苯并（异）吖庚因衍生物
公开(公告)号：US20060069083A1
公开(公告)日：2006-03-30
申请号：US10539643
申请日：2003-12-18
申请人： Gerd Steiner , Livio Tedeschi , Thomas Schmidt , Ernst Baumann , Wolfgang Deyn , Markus Kordes , Michael Hofmann , Michael Puhl , Norbert Gotz , Michael Rack , Liliana Rapado , Jacobus Kramer , Gavin Heffernan , Deborah Culbertson , Michael Treacy , Hassan Oloumi-Sadeghi , Cecille Ebuenga , Toni Bucci
发明人： Gerd Steiner , Livio Tedeschi , Thomas Schmidt , Ernst Baumann , Wolfgang Deyn , Markus Kordes , Michael Hofmann , Michael Puhl , Norbert Gotz , Michael Rack , Liliana Rapado , Jacobus Kramer , Gavin Heffernan , Deborah Culbertson , Michael Treacy , Hassan Oloumi-Sadeghi , Cecille Ebuenga , Toni Bucci
IPC分类号： A01N43/46 , A01N43/62 , A01N43/00
CPC分类号： C07D267/20 , A01N43/72 , C07D223/20 , C07D243/38 , C07D267/18 , C07D281/14 , C07D281/16 , C07D413/12
摘要： Use of compounds of formula (I): wherein X is S, O, S═O, SO2, NRa, or CRbRc; R1, R2 are halogen, OH, SH, NH2, CN, NO2, alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenyl, alkenyloxy, alkenylamino, alkenylthio, alkynyl, alkynyloxy, alkynylamino, alkynylthio, alkylsulfonyl, alkylsulfoxyl, alkenylsulfonyl, alkynylsulfoxyl, formyl, alkylcarbonyl, hydroxycarbonyl, alkoxycarbonyl, carbonyloxy, alkylcarbonyloxy, phenyloxy, alkylcarbonylamino, C(O)NRdRe, or (SO2)NRdRe, or C(═NORf)-Gp-Rf′, or a mono- or bicyclic 5- to 10-membered aromatic or heteroaromatic ringsystem, optionally substituted, which is unfused or fused to the aromatic group to which it is bonded and which, when unfused, is bonded directly or through an O, S, alkyl, or alkoxy linkage, or cycloalkyl, wherein the carbon atoms in these groups may be substituted. R3, R4 are each-independently H, alkyl, haloalkyl, alkylamino, alkoxy, cycloalkyl, wherein the carbon atoms in these groups may be substituted, or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or partially saturated mono- or bicyclic 5- to 10-membered ringsystem or 5-membered hetaryl, phenyl or benzyl, wherein the rings are optionally substituted, or R3 and R4 together form the chains —(CH2)2N+(O—)(CH2)2— or —(CH2)3N+(O−)(CH2)2—; and Ra, Rb, Rc, Rd, Re′ Rf, Rf′ G, and p are as defined in the description; m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; or the enantiomers or diastereomers, salts or esters thereof for combatting insects, arachnids, or nematodes, methods for the control of these pests and of protecting growing plants from attack or infestation by these pests by applying a pesticidally effective amount of compounds of formula I, compounds of formula I, processes for preparing them, and compositions comprising them.
摘要翻译：式（I）化合物的用途：

4. 发明授权

US06159962A 3-substituted 3,4-dihydro-thieno[2,3-D]pyrimidine derivatives and production and use of the same 有权
标题翻译： 3-取代的3,4-二氢 - 噻吩并[2,3-D]嘧啶衍生物及其制备和应用
公开(公告)号：US06159962A
公开(公告)日：2000-12-12
申请号：US445222
申请日：1999-12-06
申请人： Gerd Steiner , Uta Dullweber , Dorothea Starck , Alfred Bach , Karsten Wicke , Hans-Jurgen Teschendorf , Francisco-Javier Garcia-Ladona , Franz Emling
发明人： Gerd Steiner , Uta Dullweber , Dorothea Starck , Alfred Bach , Karsten Wicke , Hans-Jurgen Teschendorf , Francisco-Javier Garcia-Ladona , Franz Emling
IPC分类号： A61K31/519 , A61P25/00 , A61P25/24 , A61P43/00 , C07D495/04 , C07D417/06 , A61K31/551 , A61K31/559 , C07D417/14
CPC分类号： C07D495/04
摘要： 3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 are a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl group,R.sup.3 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which may be unsubstituted or mono- or disubstituted by halogen atoms, C.sub.1 -C.sub.4 -alkyl, hydroxyl, trifluoromethyl, C.sub.1 -C.sub.4 -alkoxy, amino, cyano or nitro groups, and may contain 1 nitrogen atom, or to a 5- or 6-membered ring, which may contain 1-2 oxygen atoms,A is NH or an oxygen atom,Y is CH.sub.2, CH.sub.2 --CH.sub.2, CH.sub.2 --CH.sub.2 --CH.sub.2 or CH.sub.2 --CH,Z is a nitrogen atom, carbon atom or CH, it being possible for the linkage between Y and Z also to be a double bond,and n is 2, 3 or 4, and the physiologically tolerated salts thereof.
摘要翻译： PCT No.PCT / EP98 / 03230 Sec。 371 1999年12月6日第 102（e）日期1999年12月6日PCT提交1998年5月29日PCT公布。第WO98 / 56792号公报日期：19983年12月17日 - 取代的式I的3,4-二氢噻吩并[2,3-d]嘧啶衍生物，其中R 1和R 2是氢原子或C 1 -C 4 - 烷基，R 3是苯基，吡啶基， C 1 -C 4 - 烷基，三氟甲基，三氟甲氧基，羟基，C 1 -C 4 - 烷氧基，氨基，一甲基氨基，二甲基氨基，氰基或硝基被单取代或被二取代的嘧啶基或吡嗪基， C 1 -C 4烷基，羟基，三氟甲基，C 1 -C 4 - 烷氧基，氨基，氰基或硝基可被未被取代或单取代或被二取代的苯核，并且可以含有1个氮原子或5个 - 或6-元环，其可以含有1-2个氧原子，A是NH或氧原子，Y是CH 2，CH 2 -CH 2，CH 2 -CH 2 -CH 2或CH 2 -CH，Z是氮原子，碳原子或CH，Y和Z之间的连接也可以是双键，n是2,3或4，以及其生理上耐受的盐。

5. 发明授权

US5616705A N-substituted azabicycloheptane derivatives, their preparation and use 失效
标题翻译： N-取代的氮杂双环庚烷衍生物，其制备和用途
公开(公告)号：US5616705A
公开(公告)日：1997-04-01
申请号：US632398
申请日：1996-04-19
申请人： Gerd Steiner , Rainer Munschauer , Liliane Unger , Hans-Jurgen Teschendorf , Thomas Hoger
发明人： Gerd Steiner , Rainer Munschauer , Liliane Unger , Hans-Jurgen Teschendorf , Thomas Hoger
IPC分类号： C07D401/04 , A61K31/40 , A61K31/403 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07D209/02 , C07D209/46 , C07D209/52 , C07D403/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06
CPC分类号： C07D209/52
摘要： Compounds of the formula I ##STR1## where the substituents have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.
摘要翻译： PCT No.PCT / EP94 / 03910 Sec。 371日期1996年04月19日 102（e）日期1996年4月19日PCT 1994年11月26日PCT公布。公开号WO95 / 1531200 日期6月8日，公式I I的化合物，其中取代基具有说明书中给出的含义及其制备。新型化合物适用于疾病的控制。

6. 发明授权

US5201934A Carboxamides and their use as herbicides 失效
标题翻译：羧甲酰胺及其作为除草剂的用途
公开(公告)号：US5201934A
公开(公告)日：1993-04-13
申请号：US592287
申请日：1990-10-03
申请人： Peter Muenster , Gerd Steiner , Wolfgang Freund , Bruno Wuerzer , Karl-Otto Westphalen
发明人： Peter Muenster , Gerd Steiner , Wolfgang Freund , Bruno Wuerzer , Karl-Otto Westphalen
IPC分类号： A01N43/08 , A01N43/10 , A01N43/28 , A01N43/78 , C07D307/68 , C07D333/38 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14 , C07D495/04
CPC分类号： C07D407/12 , A01N43/08 , A01N43/10 , A01N43/28 , C07D307/68 , C07D333/38 , C07D409/12 , C07D417/12
摘要： Carboxamides of the formulae Ia to Ic ##STR1## where X is oxygen or sulfur;R.sup.1 is hydrogen or substituted or unsubstituted cycloalkyl or alkyl;R.sup.2 is hydroxy, alkoxy, cyanoalkyl, substituted or unsubstituted alkenyl, alkynyl, phenyl or naphthyl, or one of the groups stated for R.sup.1 ;R.sup.3 and R.sup.4 are nitro, cyano, halogen, substituted or unsubstituted amino, alkoxy, alkylthio, substituted or unsubstituted alkenyl, alkynyl, phenyl, phenoxy or phenylthio, or one of the groups stated for R.sup.1 ;R.sup.5 is formyl, 4,5-dihydrooxazol-2-yl or COYR.sup.6 (Y.dbd.O,S);R.sup.6 is hydrogen, cycloalkyl, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkenyl or phenyl,phthalimido, tetrahydrophthalimido, succinimido, maleimido, benzotriazolyl ora group --N.dbd.CR.sup.7 R.sup.8, whereR.sup.7 and R.sup.8 are hydrogen or alkyl, and R.sup.8 may also be cycloalkyl, phenyl, or R.sup.7 and R.sup.8 together form a 4- to 7-membered alkylene chain;and if R.sup.5 is carboxyl, methoxycarbonyl or ethoxycarbonyl and R.sup.2 is hydrogen, R.sup.3 is not hydrogen and R.sup.4 is not hydrogen or methyl, and if R.sup.5 is carboxyl, methoxycarbonyl or ethoxycarbonyl and R.sup.4 is hydrogen, R.sup.3 is not hydrogen or R.sup.2 is not one of the following groups: hydrogen, C.sub.1 -C.sub.4 -alkyl, phenyl, 2-(3,4-dimethoxyphenyl)ethyl or 2,5-dichlorothien-3-yl;processes for the manufacture of compounds I and herbicidal agents containing them.
摘要翻译：式Ia至Ic的酰胺酰胺其中X是氧或硫; R1是氢或取代或未取代的环烷基或烷基; R2是羟基，烷氧基，氰基烷基，取代或未取代的链烯基，炔基，苯基或萘基，或为R1所述的一个基团; R3和R4是硝基，氰基，卤素，取代或未取代的氨基，烷氧基，烷硫基，取代或未取代的烯基，炔基，苯基，苯氧基或苯硫基，或为R1表示的基团之一; R5是甲酰基，4,5-二氢恶唑-2-基或COYR 6（Y = O，S）; R 6是氢，环烷基，取代或未取代的烷基，烯基，炔基，环烯基或苯基，邻苯二甲酰亚氨基，四氢邻苯二甲酰亚胺基，琥珀酰亚胺基，马来酰亚胺基，苯并三唑基或基团-N = CR 7 R 8，其中R 7和R 8是氢或烷基，环烷基，苯基或R7和R8一起形成4-至7-元亚烷基链; 如果R5是羧基，甲氧基羰基或乙氧基羰基，R2是氢，R3不是氢，R4不是氢或甲基，如果R5是羧基，甲氧基羰基或乙氧基羰基，R4是氢，R3不是氢或R2不是以下基团：氢，C 1 -C 4 - 烷基，苯基，2-（3,4-二甲氧基苯基）乙基或2,5-二氯噻吩-3-基; 制备化合物I和含有它们的除草剂的方法。

7. 发明授权

US4563474A Phthalimides and thienopyrrols as drugs 失效
标题翻译：邻苯二甲酰亚胺和噻吩并吡咯作为药物
公开(公告)号：US4563474A
公开(公告)日：1986-01-07
申请号：US552443
申请日：1983-11-16
申请人： Albrecht Franke , Gerd Steiner , Hans-Peter Hofmann , Claus-Dieter Muller , Hans-Jurgen Teschendorf
发明人： Albrecht Franke , Gerd Steiner , Hans-Peter Hofmann , Claus-Dieter Muller , Hans-Jurgen Teschendorf
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/425 , A61K31/428 , A61P25/20 , A61P25/24 , A61P25/26 , C07D209/48 , C07D275/04 , C07D275/06 , C07D495/04 , C07D513/04 , C07D275/02
CPC分类号： C07D209/48 , C07D275/04 , C07D275/06 , C07D495/04 , C07D513/04
摘要： Heterocyclically substituted nitriles of the formula I ##STR1## where X is SO.sub.2, CO, S, SO or CH.sub.2, A is an alkylene or alkenylene radical of not more than 6 carbon atoms, B is --CH.dbd.CH-- or S, and R.sup.1 and R.sup.2 are each hydrogen, halogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, nitro or trifluoromethyl, and their preparation and use.The novel substances are useful for treating disorders.
摘要翻译：式I的杂环取代的腈，其中X是SO 2，CO，S，SO或CH 2，A是不超过6个碳原子的亚烷基或亚烯基，B是-CH = CH-或S，和 R1和R2各自为氢，卤素，C1-C3-烷基，C1-C3-烷氧基，硝基或三氟甲基，以及它们的制备和用途。新物质可用于治疗疾病。

8. 发明授权

US4362727A 5-Substituted 9-cyanomethylene-dithieno[3,4-b:4,3-e]-azepines and therapeutic agents which contain these compounds 失效
标题翻译： 5-取代的9-氰基亚甲基二噻吩并[3,4-b：4,3-e] - 氮杂和含有这些化合物的治疗剂
公开(公告)号：US4362727A
公开(公告)日：1982-12-07
申请号：US306940
申请日：1981-09-29
申请人： Gerd Steiner , Hans-Juergen Teschendorf , Horst Kreiskott , Hans P. Hofmann
发明人： Gerd Steiner , Hans-Juergen Teschendorf , Horst Kreiskott , Hans P. Hofmann
IPC分类号： C07D495/14 , A61K31/55
CPC分类号： C07D495/14
摘要： 5-Substituted 9-cyanomethylene-dithieno[3,4-b:4',3'-e]-azepines, processes for their preparation, and therapeutic agents which contain these compounds and can be used as sedatives, hypnotic drugs, tranquillizers, neuroleptic drugs or anti-Parkinson drugs.
摘要翻译： 5-取代的9-氰基亚甲基 - 二噻吩并[3,4-b：4'，3'-e] - 氮杂，其制备方法和含有这些化合物的治疗剂，可用作镇静剂，催眠药，镇静剂，精神安定药或抗帕金森药。

9. 发明授权

US4336192A 5,6-Dihydro-11-alkylene-morphanthridin-6-ones 失效
标题翻译： 5,6-二氢-11-亚烷基 - 异佛尔酮-6-酮
公开(公告)号：US4336192A
公开(公告)日：1982-06-22
申请号：US208974
申请日：1980-11-20
申请人： Gerd Steiner , Albrecht Franke
发明人： Gerd Steiner , Albrecht Franke
IPC分类号： C07D223/20
CPC分类号： C07D223/20
摘要： 5,6-Dihydro-11-alkylene-morphanthridin-6-ones and processes for their preparation. The compounds are valuable intermediates for chemical syntheses, especially of drugs.
摘要翻译： 5,6-二氢-11-亚烷基 - 异恶唑-6-酮及其制备方法。这些化合物是用于化学合成，特别是药物的有价值的中间体。

10. 发明申请

US20080161322A1 Pyrimidine Compounds and Use Thereof 有权
标题翻译：嘧啶化合物及其用途
公开(公告)号：US20080161322A1
公开(公告)日：2008-07-03
申请号：US11628658
申请日：2005-06-03
申请人： Herve Geneste , Andreas Haupt , Wilfried Braje , Wilfried Lubisch , Gerd Steiner
发明人： Herve Geneste , Andreas Haupt , Wilfried Braje , Wilfried Lubisch , Gerd Steiner
IPC分类号： A61K31/497 , C07D401/02 , A61P25/00
CPC分类号： C07D417/12 , C07D401/12 , C07D413/12
摘要： The invention relates to pyrimidine compounds of general formula (I), and to the use of these compounds of general formula (I) and of the physiologically compatible acid addition salts of compounds (I) for producing a pharmaceutical agent for treating diseases, which respond to the influence of dopamine D3 receptor antagonists or agonists.
摘要翻译：本发明涉及通式（I）的嘧啶化合物，以及这些化合物（I）的化合物和化合物（I）的生理上相容的酸加成盐在制备用于治疗疾病的药剂中的用途，受多巴胺D 3受体拮抗剂或激动剂的影响。

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